| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominika Nielipińska, Dominika Rubiak, Agnieszka J Pietrzyk-Brzezińska, Joanna Małolepsza, Katarzyna M Błażewska, Edyta Gendaszewska-Darmac. Stapled peptides as potential therapeutics for diabetes and other metabolic diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-03. PMID:39362065. |
this comprehensive review offers insight into the technology of peptide stapling and targeting of crucial molecular pathways associated with glucose metabolism, insulin secretion, and food intake. |
2024-10-03 |
2024-10-07 |
Not clear |
| Midori Seike, Yasuko Makino, Yoko Yamashita, Hitoshi Ashid. Dietary flaxseed oil suppresses hyperglycemia and hyperinsulinemia through increasing in α-linolenic acid content in the muscle. Journal of clinical biochemistry and nutrition. vol 75. issue 2. 2024-09-30. PMID:39345289. |
lard increased plasma glucose and insulin levels at the end of feeding period, whereas flaxseed oil did not. |
2024-09-30 |
2024-10-02 |
mouse |
| Kate Phuong-Nguyen, Martin O'Hely, Greg M Kowalski, Sean L McGee, Kathryn Aston-Mourney, Timothy Connor, Malik Q Mahmood, Leni R River. The Impact of Yoyo Dieting and Resistant Starch on Weight Loss and Gut Microbiome in C57Bl/6 Mice. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339738. |
yoyo dieting resulted in short-term weight loss, which led to improved liver health and insulin tolerance but also a greater rate of weight gain compared to continuous hf feeding, as well as a different microbiota profile that was in an intermediate configuration between the control and hf states. |
2024-09-28 |
2024-10-01 |
mouse |
| Zhou Ye, Kai Huang, Xueqin Dai, Dandan Gao, Yue Gu, Jun Qian, Feng Zhang, Qiaocheng Zha. Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice. Heliyon. vol 10. issue 18. 2024-09-27. PMID:39328525. |
light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice. |
2024-09-27 |
2024-09-29 |
mouse |
| Zhou Ye, Kai Huang, Xueqin Dai, Dandan Gao, Yue Gu, Jun Qian, Feng Zhang, Qiaocheng Zha. Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice. Heliyon. vol 10. issue 18. 2024-09-27. PMID:39328525. |
furthermore, compared with ad libitum (al) feeding mice, 2 weeks of light-phase trf was found to induce insulin resistance, muscle fiber type remodeling, and changes in the expression of muscle growth-related genes, while both light-phase and dark-phase trf having a limited impact on bone quality relative to al mice. |
2024-09-27 |
2024-09-29 |
mouse |
| Sara Gargiulo, Virginia Barone, Denise Bonente, Tiziana Tamborrino, Giovanni Inzalaco, Lisa Gherardini, Eugenio Bertelli, Mario Chiariell. Integrated Ultrasound Characterization of the Diet-Induced Obesity (DIO) Model in Young Adult c57bl/6j Mice: Assessment of Cardiovascular, Renal and Hepatic Changes. Journal of imaging. vol 10. issue 9. 2024-09-27. PMID:39330437. |
long-term wd feeding increased mice body weight (bw), liver/bw ratio and body condition score (bcs), transaminases, glucose and insulin, and caused dyslipidemia and insulin resistance. |
2024-09-27 |
2024-09-29 |
mouse |
| Pedro Antonio Perez, Mark Benjamin Wiley, Alexandros Makriyannis, Nicholas Vincent DiPatrizi. Cannabinoids Block Fat-induced Incretin Release via CB Gastro hep advances. vol 3. issue 7. 2024-09-25. PMID:39318720. |
broadly, incretin signaling enhances insulin release from the endocrine pancreas and participates in the control of food intake, and therapeutics that mimic their activity have recently been developed for the treatment of type-2 diabetes and obesity. |
2024-09-25 |
2024-09-27 |
Not clear |
| Becky J Proskocil, Gina N Bash, David B Jacoby, Allison D Fryer, Zhenying Ni. Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet. American journal of physiology. Lung cellular and molecular physiology. 2024-09-24. PMID:39316677. |
feeding wild type mice a 61.6% high-fat diet resulted in significantly increased body weight, body fat, fasting glucose, fasting insulin, and reflex bronchoconstriction induced by serotonin, which was blocked by vagotomy. |
2024-09-24 |
2024-09-27 |
mouse |
| Yunting Cao, Wei Wan. Research progress on the relationship between Nesfatin-1 and glucose metabolism. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 49. issue 6. 2024-09-23. PMID:39311778. |
current research has demonstrated that nesfatin-1 can affect glucose metabolism through various mechanisms, such as inhibiting food intake, regulating enzyme activity, and improving insulin resistance, though the findings are not entirely consistent. |
2024-09-23 |
2024-09-26 |
Not clear |
| Atilla Engi. Misalignment of Circadian Rhythms in Diet-Induced Obesity. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287848. |
in fact, in a multi-oscillator system, local rhythmicity and its disruption reflects the disruption of either local clocks or central clocks, thus imposing rhythmicity on those local tissues, whereas misalignment of peripheral oscillators is due to exosome-based intercellular communication.consequently, disruption of clock genes results in dyslipidemia, insulin resistance, and obesity, while light exposure during the daytime, food intake during the daytime, and sleeping during the biological night promote circadian alignment between the central and peripheral clocks. |
2024-09-17 |
2024-09-20 |
human |
| Haruka Miyamori, Takumi Yokokawa, Motoki Miyakita, Kazuki Ozaki, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumur. CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic energy homeostasis. Diabetes. 2024-09-12. PMID:39264819. |
in this study, mice with crtc1 deficiency in mc4r-expressing cells exhibited 1) modest obesity, glucose intolerance, insulin resistance, hyperinsulinemia, and hyperlipidemia; 2) decreased systemic energy expenditure and thermogenesis; 3) suppression of melanocortin agonist-induced adaptation of energy expenditure and food intake; 4) impaired thermogenic programs and oxidative pathway in brown adipose tissue and skeletal muscle; and 5) enhanced lipogenic programs in the liver and white adipose tissue. |
2024-09-12 |
2024-09-15 |
mouse |
| Daniel Quinones, Michelle Barrow, Karin Seidle. Investigating the Impact of Ashwagandha and Meditation on Stress Induced Obesogenic Eating Behaviours. Journal of the American Nutrition Association. 2024-09-10. PMID:39254702. |
pre-clinical studies also suggest that ashwagandha possesses the capacity to regulate food intake by improving leptin and insulin sensitivity and reducing addictive behaviors through dopamine regulation. |
2024-09-10 |
2024-09-13 |
Not clear |
| Jonathan P Mochel, Jessica L Ward, Thomas Blondel, Debosmita Kundu, Maria M Merodio, Claudine Zemirline, Emilie Guillot, Ryland T Giebelhaus, Paulina de la Mata, Chelsea A Iennarella-Servantez, April Blong, Seo Lin Nam, James J Harynuk, Jan Suchodolski, Asta Tvarijonaviciute, José Joaquín Cerón, Agnes Bourgois-Mochel, Faiez Zannad, Naveed Sattar, Karin Allenspac. Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity. Scientific reports. vol 14. issue 1. 2024-09-05. PMID:39237601. |
biospecimens were collected at baseline (bas1) and after ten weeks of wd feeding (bas2) for measurement of blood pressure (bp), serum chemistry, lipoprotein profiling, blood glucose, glucagon, insulin secretion, nt-probnp, angiotensins, oxidative stress biomarkers, serum, urine, and fecal metabolomics. |
2024-09-05 |
2024-09-08 |
Not clear |
| Lu Jiang, Qing-Yang Xu, Yong-Chang Zhou, Juan Xu, Jian-Gao Fa. Spatial transcriptomics reveals the transcriptomic signatures in a mouse model of pediatric metabolic dysfunction-associated steatohepatitis. The American journal of pathology. 2024-09-02. PMID:39222909. |
after 5 weeks of feeding, wd+ccl4-treated mice showed significant liver injury without the development of insulin resistance. |
2024-09-02 |
2024-09-05 |
mouse |
| Juhi Shah, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T Porter, Maria Colon, Lauren Jun, Jeganathan R Babu, Minsub Shim, Thomas L Broderick, Layla Al-Nakkas. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201705. |
hfhs feeding also increased protein expression of brain markers of insulin resistance (pgsk-3β, p-ir), apoptosis (caspase 3), early neurofibrillary tangles (cp13), and amyloid-beta precursor (ct20). |
2024-08-29 |
2024-09-04 |
mouse |
| M Karbasian, N Panahi, R Badalzadeh, S H Shirazi-Beheshtiha, D Shahbazzad. Regulation of Neuropeptide Y Receptor Gene Expression and Hormone Level in Obese Male Rats Receiving 6-Gingerol and L-Arginine Supplementation. Archives of Razi Institute. vol 79. issue 1. 2024-08-28. PMID:39192952. |
administration of 6-gingerol and l-arginine decreased food intake, weight gain, glucose levels, insulin levels, and homeostasis model assessment-insulin resistance (homa-ir) index compared to the hcd control group. |
2024-08-28 |
2024-08-30 |
human |
| Maren Laughlin, Richard McIndoe, Sean H Adams, Renee Araiza, Julio E Ayala, Lucy Kennedy, Louise Lanoue, Louise Lantier, James Macy, Eann Malabanan, Owen P McGuinness, Rachel Perry, Daniel Port, Nathan Qi, Carol F Elias, Gerald I Shulman, David H Wasserman, K C Kent Lloy. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mammalian genome : official journal of the International Mammalian Genome Society. 2024-08-27. PMID:39191872. |
current areas of expertise include energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics. |
2024-08-27 |
2024-08-30 |
mouse |
| Xinliang Zhu, Dengcai Zhang, Yong Wang, Chuangxin Wang, Xiaoxiao Liu, Yicong Ni. Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Food & function. 2024-08-27. PMID:39189875. |
body weight, insulin level, and food intake indexes were also restored by rk. |
2024-08-27 |
2024-08-30 |
zebrafish |
| Yi Ding, Qiu-Bing Chen, Hui Xu, Dilare Adi, Yi-Wen Ding, Wen-Jun Luo, Wen-Zhuo Zhu, Jia-Chen Xu, Xiaolu Zhao, Xiong-Jie Shi, Jie Luo, Hao Yin, Xiao-Yi L. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. Journal of lipid research. 2024-08-22. PMID:39173829. |
in feeding state, glucose and insulin activate mtorc1 that phosphorylates the deubiquitylase usp20. |
2024-08-22 |
2024-08-25 |
mouse |
| Chih-Hao Wang, Tadataka Tsuji, Li-Hong Wu, Cheng-Ying Yang, Tian Lian Huang, Mari Sato, Farnaz Shamsi, Yu-Hua Tsen. Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nature communications. vol 15. issue 1. 2024-08-22. PMID:39174539. |
deletion of ednrb in adipose progenitor cells impairs cold-induced beige adipocyte formation in wat, leading to excessive weight gain, glucose intolerance, and insulin resistance upon high-fat feeding. |
2024-08-22 |
2024-08-25 |
mouse |