| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan P Mochel, Jessica L Ward, Thomas Blondel, Debosmita Kundu, Maria M Merodio, Claudine Zemirline, Emilie Guillot, Ryland T Giebelhaus, Paulina de la Mata, Chelsea A Iennarella-Servantez, April Blong, Seo Lin Nam, James J Harynuk, Jan Suchodolski, Asta Tvarijonaviciute, José Joaquín Cerón, Agnes Bourgois-Mochel, Faiez Zannad, Naveed Sattar, Karin Allenspac. Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity. Scientific reports. vol 14. issue 1. 2024-09-05. PMID:39237601. |
biospecimens were collected at baseline (bas1) and after ten weeks of wd feeding (bas2) for measurement of blood pressure (bp), serum chemistry, lipoprotein profiling, blood glucose, glucagon, insulin secretion, nt-probnp, angiotensins, oxidative stress biomarkers, serum, urine, and fecal metabolomics. |
2024-09-05 |
2024-09-08 |
Not clear |
| Lu Jiang, Qing-Yang Xu, Yong-Chang Zhou, Juan Xu, Jian-Gao Fa. Spatial transcriptomics reveals the transcriptomic signatures in a mouse model of pediatric metabolic dysfunction-associated steatohepatitis. The American journal of pathology. 2024-09-02. PMID:39222909. |
after 5 weeks of feeding, wd+ccl4-treated mice showed significant liver injury without the development of insulin resistance. |
2024-09-02 |
2024-09-05 |
mouse |
| Juhi Shah, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T Porter, Maria Colon, Lauren Jun, Jeganathan R Babu, Minsub Shim, Thomas L Broderick, Layla Al-Nakkas. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201705. |
hfhs feeding also increased protein expression of brain markers of insulin resistance (pgsk-3β, p-ir), apoptosis (caspase 3), early neurofibrillary tangles (cp13), and amyloid-beta precursor (ct20). |
2024-08-29 |
2024-09-04 |
mouse |
| M Karbasian, N Panahi, R Badalzadeh, S H Shirazi-Beheshtiha, D Shahbazzad. Regulation of Neuropeptide Y Receptor Gene Expression and Hormone Level in Obese Male Rats Receiving 6-Gingerol and L-Arginine Supplementation. Archives of Razi Institute. vol 79. issue 1. 2024-08-28. PMID:39192952. |
administration of 6-gingerol and l-arginine decreased food intake, weight gain, glucose levels, insulin levels, and homeostasis model assessment-insulin resistance (homa-ir) index compared to the hcd control group. |
2024-08-28 |
2024-08-30 |
human |
| Maren Laughlin, Richard McIndoe, Sean H Adams, Renee Araiza, Julio E Ayala, Lucy Kennedy, Louise Lanoue, Louise Lantier, James Macy, Eann Malabanan, Owen P McGuinness, Rachel Perry, Daniel Port, Nathan Qi, Carol F Elias, Gerald I Shulman, David H Wasserman, K C Kent Lloy. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mammalian genome : official journal of the International Mammalian Genome Society. 2024-08-27. PMID:39191872. |
current areas of expertise include energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics. |
2024-08-27 |
2024-08-30 |
mouse |
| Xinliang Zhu, Dengcai Zhang, Yong Wang, Chuangxin Wang, Xiaoxiao Liu, Yicong Ni. Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Food & function. 2024-08-27. PMID:39189875. |
body weight, insulin level, and food intake indexes were also restored by rk. |
2024-08-27 |
2024-08-30 |
zebrafish |
| Yi Ding, Qiu-Bing Chen, Hui Xu, Dilare Adi, Yi-Wen Ding, Wen-Jun Luo, Wen-Zhuo Zhu, Jia-Chen Xu, Xiaolu Zhao, Xiong-Jie Shi, Jie Luo, Hao Yin, Xiao-Yi L. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. Journal of lipid research. 2024-08-22. PMID:39173829. |
in feeding state, glucose and insulin activate mtorc1 that phosphorylates the deubiquitylase usp20. |
2024-08-22 |
2024-08-25 |
mouse |
| Chih-Hao Wang, Tadataka Tsuji, Li-Hong Wu, Cheng-Ying Yang, Tian Lian Huang, Mari Sato, Farnaz Shamsi, Yu-Hua Tsen. Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nature communications. vol 15. issue 1. 2024-08-22. PMID:39174539. |
deletion of ednrb in adipose progenitor cells impairs cold-induced beige adipocyte formation in wat, leading to excessive weight gain, glucose intolerance, and insulin resistance upon high-fat feeding. |
2024-08-22 |
2024-08-25 |
mouse |
| Jia Nuo Feng, Tianru Ji. Hepatic function of glucagon-like peptide-1 and its based diabetes drugs. Medical review (2021). vol 4. issue 4. 2024-08-14. PMID:39135602. |
incretins are gut-produced peptide-hormones that potentiate insulin secretion, especially after food intake. |
2024-08-14 |
2024-08-16 |
human |
| Joshua M Budd, Nicole M Notaro, Blair MacLeod, David M Mutch, David J Dyc. A ketogenic diet, regardless of fish oil content, does not affect glucose homeostasis or muscle insulin response in male rats. American journal of physiology. Endocrinology and metabolism. 2024-08-14. PMID:39140973. |
our findings suggest that kd feeding, with or without supplementation of n-3 lcpufa, does not affect whole-body glucose homeostasis or skeletal muscle insulin response under pair-feeding conditions. |
2024-08-14 |
2024-08-16 |
rat |
| Sara Baldelli, Gilda Aiello, Eliana Mansilla Di Martino, Diego Campaci, Fares M S Muthanna, Mauro Lombard. The Role of Adipose Tissue and Nutrition in the Regulation of Adiponectin. Nutrients. vol 16. issue 15. 2024-08-10. PMID:39125318. |
once considered metabolically inert, at is now recognized as a dynamic endocrine organ that regulates food intake, energy homeostasis, insulin sensitivity, thermoregulation, and immune responses. |
2024-08-10 |
2024-08-13 |
Not clear |
| Axel Labour, Marlène Lac, Lucas Frassin, Benjamin Lair, Enda Murphy, Claire Maslo, Laurent Monbrun, Marie-Lou Calmy, Marie Marquès, Nathalie Viguerie, Geneviève Tavernier, Pierre Gourdy, Donal O'Gorman, Emilie Montastier, Claire Laurens, Alexandra Montagner, Cedric Mor. GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. Cell reports. vol 43. issue 8. 2024-08-03. PMID:39096490. |
at baseline, both under a standard nutritional state and high-fat feeding, gdf15 knockout (ko) mice display normal glucose tolerance, systemic insulin sensitivity, maximal speed, and endurance running capacity when compared to wild-type littermates independent of sex. |
2024-08-03 |
2024-08-06 |
mouse |
| Giriprasad Venugopal, Rishikesh Dash, Siwani Agrawal, Sayantan Ray, Prasanta Kumar Sahoo, Balamurugan Ramadas. A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose Drink Intake in Healthy Individuals-A Randomized, Placebo-Controlled, Crossover Feeding Study. Nutrients. vol 16. issue 14. 2024-07-27. PMID:39064681. |
a novel nutraceutical supplement lowers postprandial glucose and insulin levels upon a carbohydrate-rich meal or sucrose drink intake in healthy individuals-a randomized, placebo-controlled, crossover feeding study. |
2024-07-27 |
2024-07-29 |
Not clear |
| Thomas Ms Wolever, Andreea Zurbau, Katie Koecher, Fei Au-Youn. The effect of adding protein to a carbohydrate meal on postprandial glucose and insulin responses: a systematic review and meta-analysis of acute controlled feeding trials. The Journal of nutrition. 2024-07-17. PMID:39019167. |
the effect of adding protein to a carbohydrate meal on postprandial glucose and insulin responses: a systematic review and meta-analysis of acute controlled feeding trials. |
2024-07-17 |
2024-07-20 |
Not clear |
| Takayoshi Sasak. Exploring mechanisms of insulin action and strategies to treat diabetes. Endocrine journal. vol 71. issue 7. 2024-07-16. PMID:38811207. |
in the liver, insulin regulates endoplasmic reticulum (er) stress response during feeding, whereas er stress 'response failure' contributes to the development of steatohepatitis comorbid with diabetes. |
2024-07-16 |
2024-07-18 |
mouse |
| Rubiceli Manzo, Luigui Gallardo-Becerra, Sol Díaz de León-Guerrero, Tomas Villaseñor, Fernanda Cornejo-Granados, Jonathan Salazar-León, Adrian Ochoa-Leyva, Gustavo Pedraza-Alva, Leonor Pérez-Martíne. Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000013. |
fasting glucose levels, glucose tolerance, insulin resistance, food intake, weight gain, lipid profile, hepatic steatosis, and inflammatory mediators were evaluated in serum, adipose tissue, and the colon. |
2024-07-13 |
2024-07-15 |
mouse |
| Masaji Sakaguch. The role of insulin signaling with FOXO and FOXK transcription factors. Endocrine journal. 2024-07-10. PMID:38987195. |
recent studies demonstrated that two types of forkhead-box family transcription factors, foxos and foxks, are related to the switching of insulin signals during fasting and feeding states. |
2024-07-10 |
2024-07-13 |
mouse |
| Alexis Diaz-Vegas, Kristen C Cooke, Harry B Cutler, Belinda Yau, Stewart W C Masson, Dylan Harney, Oliver K Fuller, Meg Potter, Søren Madsen, Niamh R Craw, Yiju Zhang, Cesar L Moreno, Melkam Kebede, G Gregory Neely, Jacqueline Stöckli, James G Burchfield, David E Jame. Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism. Molecular metabolism. 2024-07-03. PMID:38960128. |
we observed a strong phenotype characterised by enhanced insulin sensitivity and reduced adiposity, despite normal food intake and physical activity. |
2024-07-03 |
2024-07-10 |
mouse |
| Nathalie Esser, Stephen M Mongovin, Breanne M Barrow, Sakeneh Zraik. Gut-Specific Neprilysin Deletion Protects Against Fat-Induced Insulin Secretory Dysfunction In Male Mice. Endocrinology. 2024-07-02. PMID:38953181. |
an oral glucose tolerance test was performed at baseline and following 14 weeks of hfd feeding, during which glucose tolerance and glucose-stimulated insulin secretion (gsis) were assessed. |
2024-07-02 |
2024-07-04 |
mouse |
| Shihab Kochumon, Md Zubbair Malik, Sardar Sindhu, Hossein Arefanian, Texy Jacob, Fatemah Bahman, Rasheeba Nizam, Amal Hasan, Reeby Thomas, Fatema Al-Rashed, Steve Shenouda, Ajit Wilson, Shaima Albeloushi, Nourah Almansour, Ghadeer Alhamar, Ashraf Al Madhoun, Fawaz Alzaid, Thangavel Alphonse Thanaraj, Heikki A Koistinen, Jaakko Tuomilehto, Fahd Al-Mulla, Rasheed Ahma. Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice. Nutrients. vol 16. issue 12. 2024-06-27. PMID:38931284. |
the aim of the study was to test whether the sucrose-free cocoa butter-based high-fat diet (c-hfd) feeding in mice leads to gut dysbiosis that associates with a pathologic phenotype marked by hepatic steatosis, low-grade inflammation, perturbed glucose homeostasis, and insulin resistance, compared with control mice fed the fish oil based high-fat diet (f-hfd). |
2024-06-27 |
2024-06-29 |
mouse |