| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liping Qiao, Cindy Lu, Tianyi Zang, Brianna Dzyuba, Jianhua Sha. Maternal GLP-1 Receptor Activation Inhibits Fetal Growth. American journal of physiology. Endocrinology and metabolism. 2024-01-10. PMID:38197791. |
glucagon-like peptide 1 (glp-1) regulates food intake, insulin production, and metabolism. |
2024-01-10 |
2024-01-13 |
mouse |
| Carla Wunderle, Franziska Stumpf, Philipp Schuet. Inflammation and response to nutrition interventions. JPEN. Journal of parenteral and enteral nutrition. vol 48. issue 1. 2024-01-09. PMID:38193635. |
inflammation has been identified as a key driver for disease-related malnutrition promoting anorexia, reduced food intake, muscle loss, and on a cellular level, insulin resistance, which together stimulate catabolism. |
2024-01-09 |
2024-01-10 |
Not clear |
| Haiyan Wang, Amy Zheng, Dominic Thorley, Edward Belisario Arias, Gregory D Carte. Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2024-01-05. PMID:38181403. |
we assessed the effects of two levels of calorie restriction (cr; eating either 15% or 35% less than ad libitum, al, food intake for 8 weeks) by 24-month-old female and male rats on glucose uptake (gu) and phosphorylation of key signaling proteins (akt; amp-activated protein kinase, ampk; akt substrate of 160 kda, as160) measured in isolated skeletal muscles that underwent four incubation conditions (without either insulin or aicar, an ampk activator; with aicar alone; with insulin alone; or with insulin and aicar). |
2024-01-05 |
2024-01-08 |
rat |
| Takuya Ensho, Jun Hino, Yoko Ueda, Mikiya Miyazato, Hiroshi Iwakur. Vascular endothelial cell-specific overexpression of CNP did not improve liver fibrosis in HFFCD-induced NASH, but did improve renal lesions. Peptides. 2023-12-29. PMID:38157939. |
mice with endothelial-cell-specific overexpression of c-type natriuretic peptide (e-cnp tg mice) were shown to be protected against hepatic fibrosis and inflammation induced by high fat diet (hfd) feeding, with improved insulin sensitivity and attenuated weight gain. |
2023-12-29 |
2024-01-05 |
mouse |
| Myrem Jesame F Sarno, Dan Philip F Hernandez, Melgar O Matula. "Normal but Catastrophic" Euglycemic Diabetic Ketoacidosis Precipitated by Sodium-Glucose Cotransporter-2 Inhibitor Use: A Case Report. Cureus. vol 15. issue 11. 2023-12-25. PMID:38143642. |
eudka is more common in patients with diabetes mellitus on sglt2 inhibitors with lower mass index and decreased glycogen store which can be triggered by surgery, infection, trauma, a major illness or reduced food intake and persistent vomiting, gastroparesis, dehydration, and reduced insulin dosages. |
2023-12-25 |
2023-12-27 |
Not clear |
| Myrem Jesame F Sarno, Dan Philip F Hernandez, Melgar O Matula. "Normal but Catastrophic" Euglycemic Diabetic Ketoacidosis Precipitated by Sodium-Glucose Cotransporter-2 Inhibitor Use: A Case Report. Cureus. vol 15. issue 11. 2023-12-25. PMID:38143642. |
this is a case of a 34-year-old male, filipino, diagnosed with type 2 diabetes mellitus, who was maintained on dapagliflozin + metformin 5mg/1000mg taken twice a day with good compliance and was admitted with eudka precipitated by decreased food intake and managed with intravenous insulin. |
2023-12-25 |
2023-12-27 |
Not clear |
| Marta Pelczyńska, Ewa Miller-Kasprzak, Marcin Piątkowski, Roksana Mazurek, Mateusz Klause, Anna Suchecka, Magdalena Bucoń, Paweł Bogdańsk. The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes-New Perspectives. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136166. |
the primary mechanism underlying the action of nesfatin-1 involves an increase in insulin sensitivity and reduced food intake. |
2023-12-23 |
2023-12-25 |
human |
| Lei Hao, Chih-Yu Chen, Yong-Hui Nie, Kanakaraju Kaliannan, Jing X Kan. Differential Interventional Effects of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on High Fat Diet-Induced Obesity and Hepatic Pathology. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139090. |
to test this hypothesis, we fed c57bl/6j mice with a high-fat diet (hf) for 10 weeks to induce obesity, then divided the obese mice into three groups and continued feeding for another 10 weeks with one of the following three diets: hf, hf+n-6 (substituted half of sfa with n-6 pufas), and hf+n-3 (substituted half of sfa with n-3 pufas), followed by assessment of body weight, fat mass, insulin sensitivity, hepatic pathology, and lipogenesis. |
2023-12-23 |
2023-12-25 |
mouse |
| Ya-Jie Hu, Xu Zhang, Hong-Ming Lv, Yang Liu, Shi-Ze L. Protein O-GlcNAcylation: The sweet hub in liver metabolic flexibility from a (patho)physiological perspective. Liver international : official journal of the International Association for the Study of the Liver. 2023-12-19. PMID:38110988. |
additionally, it explains the underlying nutritional sensitivity of o-glcnacylation and discusses its mechanism of spatiotemporal modulation of insulin signal transduction and liver metabolic homeostasis during the fasting and feeding cycle. |
2023-12-19 |
2023-12-21 |
Not clear |
| Angela McNelly, Anne Langan, Danielle E Bear, Alexandria Page, Tim Martin, Fatima Seidu, Filipa Santos, Kieron Rooney, Kaifeng Liang, Simon J Heales, Tomas Baldwin, Isabelle Alldritt, Hannah Crossland, Philip J Atherton, Daniel Wilkinson, Hugh Montgomery, John Prowle, Rupert Pearse, Simon Eaton, Zudin A Puthuchear. A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed. Nature communications. vol 14. issue 1. 2023-12-15. PMID:38102152. |
patients who received ketogenic feeding had fewer hypoglycaemic events (0.0% vs. 1.6%), required less exogenous international units of insulin (0 (interquartile range 0-16) vs.78 (interquartile range 0-412) but had slightly more daily episodes of diarrhoea (53.5% vs. 42.9%) over the trial period. |
2023-12-15 |
2023-12-18 |
human |
| Claudio Perez-Leighton, Bredford Kerr, Philipp E Scherer, René Baudrand, Víctor Corté. The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour. Biological reviews of the Cambridge Philosophical Society. 2023-12-10. PMID:38072002. |
glp1 participates in metabolic adaptation to food intake, regulating insulin secretion and satiety by parallel central and peripheral signalling systems. |
2023-12-10 |
2023-12-17 |
Not clear |
| Qianfeng Xiong, Jing Wang, Kewen Huang, Wenbo Li, Lihui Zhan. Potential Role of GLP-1 Based Therapeutics in Coronary Artery Disease. Frontiers in bioscience (Landmark edition). vol 28. issue 11. 2023-12-08. PMID:38062835. |
glucagon-like peptide-1 (glp-1), an incretin hormone primarily secreted by intestinal l cells, regulates glucose metabolism by increasing insulin synthesis and secretion, decreasing plasma glucagon levels, reducing food intake, and slowing gastric emptying. |
2023-12-08 |
2023-12-17 |
Not clear |
| Song-Yang Zhang, Zahra Danaei, Kyla Bruce, Jennifer F M Chiu, Tony K T La. Acute activation of GFRAL in the area postrema contributes to glucose regulation independent of weight. Diabetes. 2023-12-08. PMID:38064571. |
herein, we report that direct acute gdf15 infusion into the area postrema of high fat fed rats increased intravenous glucose tolerance and insulin sensitivity to lower hepatic glucose production independent of changes in food intake, weight, and plasma insulin levels under conscious, unrestrained, and non-stressed conditions. |
2023-12-08 |
2023-12-17 |
rat |
| Song-Yang Zhang, Zahra Danaei, Kyla Bruce, Jennifer F M Chiu, Tony K T La. Acute activation of GFRAL in the area postrema contributes to glucose regulation independent of weight. Diabetes. 2023-12-08. PMID:38064571. |
finally, a knockdown of gfral expression in the area postrema not only negated administration of gdf15 but also metformin to increase glucose tolerance independent of changes in food intake, weight, and plasma insulin levels. |
2023-12-08 |
2023-12-17 |
rat |
| Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Khanyisani Ziqubu, Ndivhuwo Muvhulawa, Fabio Marcheggiani, Ilenia Cirilli, Bongani B Nkambule, Christo J F Muller, Albertus K Basson, Luca Tiano, Phiwayinkosi V Dludl. Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models. Pflugers Archiv : European journal of physiology. 2023-12-03. PMID:38044359. |
high-fat diet (hfd) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. |
2023-12-03 |
2023-12-10 |
Not clear |
| Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Khanyisani Ziqubu, Ndivhuwo Muvhulawa, Fabio Marcheggiani, Ilenia Cirilli, Bongani B Nkambule, Christo J F Muller, Albertus K Basson, Luca Tiano, Phiwayinkosi V Dludl. Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models. Pflugers Archiv : European journal of physiology. 2023-12-03. PMID:38044359. |
peroxisome proliferator-activated receptor γ coactivator-1α (pgc-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to hfd feeding. |
2023-12-03 |
2023-12-10 |
Not clear |
| Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Khanyisani Ziqubu, Ndivhuwo Muvhulawa, Fabio Marcheggiani, Ilenia Cirilli, Bongani B Nkambule, Christo J F Muller, Albertus K Basson, Luca Tiano, Phiwayinkosi V Dludl. Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models. Pflugers Archiv : European journal of physiology. 2023-12-03. PMID:38044359. |
in fact, available evidence suggests that partial exposure to hfd feeding (potentially during the early stages of disease development) is associated with impaired metabolic adaptations within the skeletal muscle, including mitochondrial dysfunction and reduced insulin sensitivity. |
2023-12-03 |
2023-12-10 |
Not clear |
| Junpei Yamamoto, Hironobu Takahashi, Takaharu Saito, Yuri Yamamoto, Koudai Takahashi, Koji Itakura, Makoto Kobayashi, Ryotaro Igusa, Takafumi Kobayashi, Masakazu Ichinose, Masahiro Usu. Insulin Requirements During Severe COVID-19 Were Relatively Low in Japanese Patients With Type 2 Diabetes: Two Case Reports. Cureus. vol 15. issue 10. 2023-12-01. PMID:38022370. |
insulin requirements were rapidly decreased with improvement of the respiratory condition, termination of dexamethasone, and discontinuation of tube feeding. |
2023-12-01 |
2023-12-07 |
Not clear |
| Rikke Viggers, Nicklas Højgaard-Hessellund Rasmussen, Peter Vestergaar. Effects of Incretin Therapy on Skeletal Health in Type 2 Diabetes-A Systematic Review. JBMR plus. vol 7. issue 11. 2023-12-01. PMID:38025038. |
the group of hormones known as incretins, which includes gastric inhibitory peptide (gip) and glucagon-like peptide 1 (glp-1), play a role in regulating bowel function and insulin secretion during feeding. |
2023-12-01 |
2023-12-07 |
human |
| Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Yuhui Duan, Hongyu Dai, Huilin Zhang, Yan Huang, Wanxin Fu, Weiguang Sun, Baosheng Zha. Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway. Chinese journal of natural medicines. vol 21. issue 11. 2023-11-30. PMID:38035937. |
the results manifested that mlfs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. |
2023-11-30 |
2023-12-10 |
mouse |