| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Late. Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking. PloS one. vol 14. issue 1. 2019-10-18. PMID:30682072. |
gut hormone receptors including glucagon receptor (gcgr) and the incretin hormone receptors: glucagon-like peptide 1 receptor (glp1r) and gastric inhibitory polypeptide receptor (gipr) are important drug targets for the treatment of t2dm, as they play roles in the regulation of glucose and insulin levels and of food intake. |
2019-10-18 |
2023-08-13 |
Not clear |
| Katsutaka Oishi, Chiaki Hashimot. Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice. Chronobiology international. vol 35. issue 11. 2019-10-17. PMID:30084652. |
abbreviations: ampk, adenosine monophosphate-activated protein kinase; anova, analysis of variance; df, daytime feeding; ffa, free fatty acid; homa-ir, homeostasis model assessment of insulin resistance; neat, non-exercise activity thermogenesis; nf, nighttime feeding; pi3, phosphatidylinositol 3; rf, restricted feeding; rw, running-wheel; scn, suprachiasmatic nucleus; sem, standard error of the mean; stat3, signal transducer and activator of transcription 3; t-cho, total cholesterol; tg, triglyceride; wat, white adipose tissues. |
2019-10-17 |
2023-08-13 |
mouse |
| Céline M'Kadmi, Agustina Cabral, Franco Barrile, Julien Giribaldi, Sonia Cantel, Marjorie Damian, Sophie Mary, Séverine Denoyelle, Sébastien Dutertre, Sylvie Péraldi-Roux, Jérémie Neasta, Catherine Oiry, Jean-Louis Banères, Jacky Marie, Mario Perello, Jean-Alain Fehrent. N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor. Journal of medicinal chemistry. vol 62. issue 2. 2019-10-17. PMID:30543423. |
the ghrelin receptor or growth hormone secretagogue receptor (ghsr) is a g-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. |
2019-10-17 |
2023-08-13 |
mouse |
| S Luo, Y Zhang, M Ezrokhi, Y Li, T-H Tsai, A H Cincott. Circadian peak dopaminergic activity response at the biological clock pacemaker (suprachiasmatic nucleus) area mediates the metabolic responsiveness to a high-fat diet. Journal of neuroendocrinology. vol 30. issue 1. 2019-10-16. PMID:29224246. |
however, in rats made obese and insulin resistant by high-fat diet (hfd) feeding, these coincident circadian peak activities were both markedly attenuated or abolished. |
2019-10-16 |
2023-08-13 |
rat |
| M Seo, S A Islam, S-S Moo. Acute anti-obesity effects of intracerebroventricular 11β-HSD1 inhibitor administration in diet-induced obese mice. Journal of neuroendocrinology. vol 30. issue 3. 2019-10-16. PMID:29418022. |
in conclusion, acute 11β-hsd1 inhibition in the hypothalamus could reduce food intake by decreasing er stress and increasing insulin, leptin, and mammalian target of rapamycin complex 1 (mtorc1) signalling. |
2019-10-16 |
2023-08-13 |
mouse |
| Zhouguang Wang, Sinan Khor, Dongsheng Ca. Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. The Journal of biological chemistry. vol 294. issue 13. 2019-10-16. PMID:30709906. |
of note, unlike high-calorie feeding conditions, age-dependent hif2α attenuation occurs without impaired activation of the hypothalamic ir/irs-2/akt/foxo1 pathway in response to insulin. |
2019-10-16 |
2023-08-13 |
mouse |
| Jennifer F Thorson, Ligia D Prezotto, Hillary Adams, Sandra L Petersen, Jeffrey A Clapper, Elane C Wright, William T Oliver, Bradley A Freking, Andrew P Foote, Elaine D Berry, Danny J Nonneman, Clay A Lent. Energy balance affects pulsatile secretion of luteinizing hormone from the adenohypophesis and expression of neurokinin B in the hypothalamus of ovariectomized gilts. Biology of reproduction. vol 99. issue 2. 2019-10-03. PMID:30101293. |
restricted feeding of ovariectomized gilts caused a rapid and sustained metabolic response characterized by reduced concentrations of plasma urea nitrogen, insulin, leptin, and insulin-like growth factor-1 and elevated concentrations of free fatty acids. |
2019-10-03 |
2023-08-13 |
Not clear |
| Chun-Ling Dai, Jin-Hua Gu, Fei Liu, Khalid Iqbal, Cheng-Xin Gon. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of aging. vol 70. 2019-09-27. PMID:29944994. |
these findings reveal an important role of neuronal ogt in the regulation of feeding behavior, body weight, and peripheral insulin sensitivity. |
2019-09-27 |
2023-08-13 |
mouse |
| Dorota Latek, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Pionte. Drug-induced diabetes type 2: In silico study involving class B GPCRs. PloS one. vol 14. issue 1. 2019-09-23. PMID:30650080. |
incretin hormone receptors: glp1r and gipr together with the glucagon receptor gcgr regulate food intake and insulin and glucose secretion. |
2019-09-23 |
2023-08-13 |
Not clear |
| Wei He, Ting Yuan, Dolma Choezom, Hannah Hunkler, Karthika Annamalai, Blaz Lupse, Kathrin Maedle. Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4. Scientific reports. vol 8. issue 1. 2019-09-20. PMID:29426925. |
in the present study we investigated the combined effects of high fat/high sucrose diet (hfd) feeding, ageing and tlr4-deficiency on tissue inflammation, insulin resistance and β-cell failure. |
2019-09-20 |
2023-08-13 |
mouse |
| A Kok, J Chen, B Kemp, A T M van Knegse. Review: Dry period length in dairy cows and consequences for metabolism and welfare and customised management strategies. Animal : an international journal of animal bioscience. vol 13. issue S1. 2019-09-18. PMID:31280751. |
feeding a more lipogenic diet for cows with a short or no dry period did not affect the energy balance or lactation persistency during the complete lactation, although a lipogenic diet resulted in lower plasma insulin and igf-1 concentration and greater plasma growth hormone concentration, compared with a glucogenic diet. |
2019-09-18 |
2023-08-13 |
Not clear |
| Quan Zheng, Ying Cao, Yalan Chen, Jiqiu Wang, Qiuju Fan, Xian Huang, Yiping Wang, Tianshi Wang, Xiuzhi Wang, Jiao Ma, Jinke Chen. Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1. Journal of molecular cell biology. vol 10. issue 3. 2019-09-17. PMID:29272473. |
adipocyte senp2 deficiency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feeding. |
2019-09-17 |
2023-08-13 |
mouse |
| Elizabeth F Sutton, Robbie Beyl, Kate S Early, William T Cefalu, Eric Ravussin, Courtney M Peterso. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell metabolism. vol 27. issue 6. 2019-09-17. PMID:29754952. |
early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. |
2019-09-17 |
2023-08-13 |
human |
| Konrad Szosland, Andrzej Lewinsk. Insulin resistance - "the good or the bad and ugly". Neuro endocrinology letters. vol 39. issue 5. 2019-09-17. PMID:30664340. |
diurnal, seasonal, age-related, pregnancy-associated, and illness-induced fluctuations in food intake and energy expenditure necessitate homeostatic versatility, including the capacity to vary insulin sensitivity, so as to optimize partitioning between tissues of a variable nutrient supply. |
2019-09-17 |
2023-08-13 |
Not clear |
| Christina Pric. Nutrition: reducing the hypermetabolic response to thermal injury. British journal of nursing (Mark Allen Publishing). vol 27. issue 12. 2019-09-12. PMID:29953277. |
underfeeding, aggressive feeding, feeding routes, timing of initiation of feeding and tight insulin control have all been explored extensively in the quest to understand what nutritional treatment will best attenuate the hypermetabolic response. |
2019-09-12 |
2023-08-13 |
Not clear |
| Ya Pei, Honggui Li, Yuli Cai, Jing Zhou, Xianjun Luo, Linqiang Ma, Kelly McDaniel, Tianshu Zeng, Yanming Chen, Xiaoxian Qian, Yuqing Huo, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Lulu Chen, Chaodong W. Regulation of adipose tissue inflammation by adenosine 2A receptor in obese mice. The Journal of endocrinology. vol 239. issue 3. 2019-09-11. PMID:30400017. |
in a2ar-disrupted mice, hfd feeding induced significant increases in adipose tissue inflammation, indicated by enhanced proinflammatory signaling and increased proinflammatory cytokine expression, and adipose tissue insulin resistance, indicated by a decrease in insulin-stimulated akt phosphorylation relative to those in wt mice. |
2019-09-11 |
2023-08-13 |
mouse |
| Rebecca J Brown, Areli Valencia, Megan Startzell, Elaine Cochran, Peter J Walter, H Martin Garraffo, Hongyi Cai, Ahmed M Gharib, Ronald Ouwerkerk, Amber B Courville, Shanna Bernstein, Robert J Brychta, Kong Y Chen, Mary Walter, Sungyoung Auh, Phillip Gorde. Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy. The Journal of clinical investigation. vol 128. issue 8. 2019-09-10. PMID:29723161. |
metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy. |
2019-09-10 |
2023-08-13 |
Not clear |
| Hitoshi Aonuma, Yuki Totani, Mugiho Kaneda, Ryota Nakamura, Takayuki Watanabe, Dai Hatakeyama, Varvara E Dyakonova, Ken Lukowiak, Etsuro It. Effects of 5-HT and insulin on learning and memory formation in food-deprived snails. Neurobiology of learning and memory. vol 148. 2019-09-09. PMID:29294381. |
serotonin (5-ht) plays an important role in mediating feeding, and insulin enhances the memory consolidation process following cta training. |
2019-09-09 |
2023-08-13 |
Not clear |
| Steven J Millership, Simon J Tunster, Mathew Van de Pette, Agharul I Choudhury, Elaine E Irvine, Mark Christian, Amanda G Fisher, Rosalind M John, James Scott, Dominic J Wither. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular metabolism. vol 18. 2019-09-04. PMID:30279096. |
however, our recent studies of nnat null mice on this genetic background failed to display any body weight or feeding phenotypes but revealed a defect in glucose-stimulated insulin secretion due to the ability of neuronatin to potentiate signal peptidase cleavage of preproinsulin. |
2019-09-04 |
2023-08-13 |
mouse |
| Maxim D Seferovic, Christine A Beamish, Rockann E Mosser, Shannon E Townsend, Kirk Pappan, Vincent Poitout, Kjersti M Aagaard, Maureen Ganno. Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet. American journal of physiology. Endocrinology and metabolism. vol 315. issue 6. 2019-08-26. PMID:30106624. |
we previously showed that high-fat diet (hfd) feeding induces mouse β-cell proliferation in less than 1 wk in the absence of insulin resistance. |
2019-08-26 |
2023-08-13 |
mouse |