| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharmili Edwin Thanarajah, Sandra Iglesias, Bojana Kuzmanovic, Lionel Rigoux, Klaas E Stephan, Jens C Brüning, Marc Tittgemeye. Modulation of midbrain neurocircuitry by intranasal insulin. NeuroImage. vol 194. 2019-12-20. PMID:30914385. |
insulin modulates dopamine neuron activity in midbrain and affects processes underlying food intake behaviour, including impulsivity and reward processing. |
2019-12-20 |
2023-08-13 |
human |
| Priya Pathak, Jitendra S Kanshana, BabuNageswar Kanuri, Sanjay C Rebello, Hobby Aggarwal, Kumaravelu Jagavelu, Madhu Dikshi. Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice. European journal of pharmacology. vol 855. 2019-12-20. PMID:31063772. |
after 10 weeks of hfd feeding, significant increase in the body weight/fat mass, augmented circulating lipids, glucose, insulin and inflammatory cytokines along with impaired acetylcholine induced aortic vasorelaxation and enhanced inos expression was observed in the aortic tissue of wt mice. |
2019-12-20 |
2023-08-13 |
mouse |
| Elsaid Salaheldeen, Alexa Jaume, Sonia Michael Najja. Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance. International journal of molecular sciences. vol 20. issue 13. 2019-12-17. PMID:31266142. |
in light of their differential expression, ceacam1 regulates chiefly insulin extraction, whereas ceacam2 appears to play a more important role in regulating insulin secretion and overall energy balance, including food intake, energy expenditure and spontaneous physical activity. |
2019-12-17 |
2023-08-13 |
Not clear |
| Dufang Ma, Yong Wang, Guofeng Zhou, Yongcheng Wang, Xiao L. Review: the Roles and Mechanisms of Glycoprotein 130 Cytokines in the Regulation of Adipocyte Biological Function. Inflammation. vol 42. issue 3. 2019-12-16. PMID:30661143. |
studies have shown that several gp130 cytokines, such as interleukin-6 (il-6), leukemia inhibitory factor (lif), oncostatin m (osm), ciliary neurotrophic factor (cntf), and cardiotrophin-1 (ct-1), have divergent effects on adipogenesis, lipolysis, and insulin sensitivity as well as food intake. |
2019-12-16 |
2023-08-13 |
Not clear |
| Giulia Baldini, Kevin D Phela. The melanocortin pathway and control of appetite-progress and therapeutic implications. The Journal of endocrinology. vol 241. issue 1. 2019-12-16. PMID:30812013. |
conversely, in the 'starved state' activity of agouti-related neuropeptide (agrp) and of neuropeptide y (npy)-expressing neurons is increased by decreased levels of circulating leptin and insulin and by the orexigenic hormone ghrelin to promote food intake. |
2019-12-16 |
2023-08-13 |
mouse |
| Kebin Zhang, Xiaoqin Guo, Hui Yan, Yuxin Wu, Quan Pan, James Zheng Shen, Xiaopeng Li, Yunmei Chen, Ling Li, Yajuan Qi, Zihui Xu, Wei Xie, Weiping Zhang, David Threadgill, Ling He, Daniel Villarreal, Yuxiang Sun, Morris F White, Hongting Zheng, Shaodong Gu. Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice. Endocrinology. vol 160. issue 5. 2019-12-16. PMID:30951171. |
foxo1-s253a/a mice displayed mild increases in feeding blood glucose and insulin levels but decreases in fasting blood glucose and glucagon concentrations, as well as a reduction in the ratio of pancreatic α-cells/β-cells per islet. |
2019-12-16 |
2023-08-13 |
mouse |
| Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Ca. Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models. Molecular medicine reports. vol 20. issue 1. 2019-12-16. PMID:31180544. |
the body weight, liver weight, daily food intake, daily caloric intake, serum tg, serum tc, serum insulin and serum glucose of animals treated with ca were recorded. |
2019-12-16 |
2023-08-13 |
mouse |
| Kira Derkach, Irina Zakharova, Inna Zorina, Andrey Bakhtyukov, Irina Romanova, Liubov Bayunova, Alexander Shpako. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PloS one. vol 14. issue 3. 2019-12-12. PMID:30870482. |
mf treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile and glucose sensitivity, and to a reduced fatty liver degeneration. |
2019-12-12 |
2023-08-13 |
mouse |
| Hongxia Ren, Adriana Vieira-de-Abreu, Shijun Yan, Austin M Reilly, Owen Chan, Domenico Accil. Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons. Endocrinology. vol 160. issue 9. 2019-12-11. PMID:31199472. |
using immunohistochemistry in fluorescently labeled hypothalamic glut4 neurons, we showed that ir signaling promoted hypothalamic cellular signaling responses to the rise of insulin, leptin, and amino acids associated with feeding. |
2019-12-11 |
2023-08-13 |
mouse |
| Anthony Ravussin, Yun-Hee Youm, Jil Sander, Seungjin Ryu, Kim Nguyen, Luis Varela, Gerald I Shulman, Sviatoslav Sidorov, Tamas L Horvath, Joachim L Schultze, Vishwa Deep Dixi. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell reports. vol 24. issue 5. 2019-12-10. PMID:30067966. |
here, we show that deletion of nucb2 did not affect food intake or adiposity and, instead, caused insulin resistance in mice fed a high-fat diet. |
2019-12-10 |
2023-08-13 |
mouse |
| Anthony Ravussin, Yun-Hee Youm, Jil Sander, Seungjin Ryu, Kim Nguyen, Luis Varela, Gerald I Shulman, Sviatoslav Sidorov, Tamas L Horvath, Joachim L Schultze, Vishwa Deep Dixi. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell reports. vol 24. issue 5. 2019-12-10. PMID:30067966. |
our study reveals that nucb2 links metabolic inflammation to insulin resistance without affecting weight gain and food intake. |
2019-12-10 |
2023-08-13 |
mouse |
| J Haisan, Y Inabu, W Shi, M Ob. Effects of feeding a high- or moderate-starch prepartum diet to cows on newborn dairy heifer calf responses to intravenous glucose tolerance tests early in life. Journal of dairy science. vol 102. issue 10. 2019-12-06. PMID:31421889. |
the objective of this study was to evaluate the effect of feeding a prepartum diet with a high or moderate starch content on growth and insulin sensitivity of female offspring early in life. |
2019-12-06 |
2023-08-13 |
Not clear |
| J Haisan, Y Inabu, W Shi, M Ob. Effects of feeding a high- or moderate-starch prepartum diet to cows on newborn dairy heifer calf responses to intravenous glucose tolerance tests early in life. Journal of dairy science. vol 102. issue 10. 2019-12-06. PMID:31421889. |
these findings suggest that feeding a hi prepartum diet may reduce some insulin sensitivity indicators of female offspring early in life. |
2019-12-06 |
2023-08-13 |
Not clear |
| Peng Zhang, Henry Kuang, Yanlin He, Sharon O Idiga, Siming Li, Zhimin Chen, Zhao Yang, Xing Cai, Kezhong Zhang, Matthew J Potthoff, Yong Xu, Jiandie D Li. NRG1-Fc improves metabolic health via dual hepatic and central action. JCI insight. vol 3. issue 5. 2019-12-02. PMID:29515030. |
nrg1-fc treatment triggered potent akt activation in the liver, lowered blood glucose, improved insulin sensitivity, and suppressed food intake in obese mice. |
2019-12-02 |
2023-08-13 |
mouse |
| Karla Frida Torres Flister, Bruno Araújo Serra Pinto, Lucas Martins França, Caio Fernando Ferreira Coêlho, Pâmela Costa Dos Santos, Caroline Castro Vale, Daniela Kajihara, Victor Debbas, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Pae. Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice. The Journal of nutritional biochemistry. vol 62. 2019-11-28. PMID:30300835. |
high-sucrose feeding promoted progressive metabolic and oxidative disturbances, starting from fasting and fed hyperglycemia, hyperinsulinemia, glucose intolerance and increased adiposity at 30-days; passing by insulin resistance, hypertriglyceridemia and nafld onset at 60 days; until late hepatic oxidative damage at 90 days. |
2019-11-28 |
2023-08-13 |
mouse |
| Gerald Grandl, Leon Straub, Carla Rudigier, Myrtha Arnold, Stephan Wueest, Daniel Konrad, Christian Wolfru. Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet. The Journal of physiology. vol 596. issue 19. 2019-11-25. PMID:30089335. |
short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet. |
2019-11-25 |
2023-08-13 |
Not clear |
| Klimes, Sebokova, Gasperikova, Mitkova, Kuklova, Boho. Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats. Endocrine regulations. vol 32. issue 3. 2019-11-20. PMID:10196508. |
results: high fat diet feeding resulted in an increase in fasting plasma insulin in both rat strains, while fasting plasma glucose in high fat diet fed animals remained unchanged as compared to those fed basal diet. |
2019-11-20 |
2023-08-12 |
rat |
| Klimes, Sebokova, Gasperikova, Mitkova, Kuklova, Boho. Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats. Endocrine regulations. vol 32. issue 3. 2019-11-20. PMID:10196508. |
high fat feeding resulted in an impairment of insulin action, but the administration of a-4166 restored the antilipolysis in both strains to the normal range. |
2019-11-20 |
2023-08-12 |
rat |
| Hols. Glucagon-like Peptide 1 (GLP-1): An Intestinal Hormone, Signalling Nutritional Abundance, with an Unusual Therapeutic Potential. Trends in endocrinology and metabolism: TEM. vol 10. issue 6. 2019-11-20. PMID:10407397. |
the incretin hormone, glucagon-like peptide 1 (glp-1) has many actions; namely: (1) it enhances all steps of insulin biosynthesis and potentiates glucose-induced secretion; (2) it seems to have trophic effects on pancreatic cells; (3) it inhibits glucagon secretion; (4) it inhibits hepatic glucose production and lowers blood glucose, but does not produce severe hypoglycaemia; (5) it inhibits postprandial gastrointestinal motility and secretion; and (6) it reduces appetite and food intake. |
2019-11-20 |
2023-08-12 |
Not clear |
| M El Hafidi, A Cuéllar, J Ramírez, G Baño. Effect of sucrose addition to drinking water, that induces hypertension in the rats, on liver microsomal Delta9 and Delta5-desaturase activities. The Journal of nutritional biochemistry. vol 12. issue 7. 2019-11-20. PMID:11448615. |
an increase in total calories consumed, visceral fat accumulation, insulin, triglycerides and blood pressure and a decrease in the food intake were observed in the sucrose-fed group as compared with the control group. |
2019-11-20 |
2023-08-12 |
rat |