| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Gak Jeon, Sang Bum Hong, Yunkwon Nam, Jungyeon Tae, Anji Yoo, Eun Ji Song, Kun Il Kim, Dongje Lee, Junyong Park, Sang Min Lee, Jin-Il Kim, Minho Moo. Ghrelin in Alzheimer's disease: Pathologic roles and therapeutic implications. Ageing research reviews. vol 55. 2020-04-30. PMID:31434007. |
ghrelin, which has many important physiological roles, such as stimulating food intake, regulating energy homeostasis, and releasing insulin, has recently been studied for its roles in a diverse range of neurological disorders. |
2020-04-30 |
2023-08-13 |
Not clear |
| Rose Crossin, Ashleigh Qama, Zane B Andrews, Andrew J Lawrence, Jhodie R Dunca. The effect of adolescent inhalant abuse on energy balance and growth. Pharmacology research & perspectives. vol 7. issue 4. 2020-04-29. PMID:31384470. |
there are multiple components within the central and peripheral regulation of energy balance that may be affected by adolescent inhalant abuse, such as impaired metabolic signaling, decreased food intake, altered dietary preferences, disrupted glucose tolerance and insulin release, reduced adiposity and skeletal density, and adrenal hypertrophy. |
2020-04-29 |
2023-08-13 |
Not clear |
| Arianna Mazzoli, Raffaella Crescenzo, Luisa Cigliano, Maria Stefania Spagnuolo, Rosa Cancelliere, Cristina Gatto, Susanna Ioss. Early Hepatic Oxidative Stress and Mitochondrial Changes Following Western Diet in Middle Aged Rats. Nutrients. vol 11. issue 11. 2020-04-28. PMID:31694213. |
to assess the effect of 4 weeks of high fat-high fructose feeding on whole body composition, energy balance, specific markers of oxidative stress and inflammation, and insulin sensitivity in the liver of middle-aged rats, rats (1 year) were fed a diet rich in saturated fatty acids and fructose (hff rats), mimicking the "western diet", and compared with rats of the same age that were fed a low fat diet (lf rats). |
2020-04-28 |
2023-08-13 |
rat |
| Anne J Wanders, Wendy A M Blom, Peter L Zock, Johanna M Geleijnse, Ingeborg A Brouwer, Marjan Alssem. Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials. BMJ open diabetes research & care. vol 7. issue 1. 2020-04-27. PMID:30899527. |
plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials. |
2020-04-27 |
2023-08-13 |
Not clear |
| Anne J Wanders, Wendy A M Blom, Peter L Zock, Johanna M Geleijnse, Ingeborg A Brouwer, Marjan Alssem. Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials. BMJ open diabetes research & care. vol 7. issue 1. 2020-04-27. PMID:30899527. |
eligible studies were randomized controlled feeding trials that investigated the effects of a diet high in plant-derived pufa as compared with saturated fatty acids (sfa) or carbohydrates and measured markers of glucose metabolism and insulin resistance as outcomes. |
2020-04-27 |
2023-08-13 |
Not clear |
| Linda Engström Ruud, Mafalda M A Pereira, Alain J de Solis, Henning Fenselau, Jens C Brünin. NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nature communications. vol 11. issue 1. 2020-04-24. PMID:31974377. |
selective re-expression of npy in agrp neurons attenuates the reduced feeding response and reverses the protection from insulin resistance upon optogenetic activation of agrp neurons in npy-deficient mice. |
2020-04-24 |
2023-08-13 |
mouse |
| Karen S W Leong, Thilini N Jayasinghe, José G B Derraik, Benjamin B Albert, Valentina Chiavaroli, Darren M Svirskis, Kathryn L Beck, Cathryn A Conlon, Yannan Jiang, William Schierding, Tommi Vatanen, David J Holland, Justin M O'Sullivan, Wayne S Cutfiel. Protocol for the Gut Bugs Trial: a randomised double-blind placebo-controlled trial of gut microbiome transfer for the treatment of obesity in adolescents. BMJ open. vol 9. issue 4. 2020-04-20. PMID:31005929. |
animal studies showed that germ-free mice inoculated with normal mouse gut bacteria developed obesity, insulin resistance and higher triglyceride levels, despite similar food intake. |
2020-04-20 |
2023-08-13 |
mouse |
| R M Sánchez-Hernández, D Alvarado-Martel, Y López-Plasencia, A Carrillo-Domínguez, A Jiménez-Rodríguez, J Rodríguez-Cordero, T Vera-Elzo, Á Santana Del Pino, F J Nóvoa-Mogollón, A M Wägne. Assessment of Alimentación Normal con Ajuste de Insulina (ANAIS), a Spanish version of the DAFNE programme, in people with Type 1 diabetes: a randomized controlled parallel trial. Diabetic medicine : a journal of the British Diabetic Association. vol 36. issue 8. 2020-04-13. PMID:31087451. |
to evaluate the effects of alimentación normal con ajuste de insulina (anais), a group-based, therapeutic education programme for type 1 diabetes based on a flexible insulin regimen adjusted to the individual's food intake. |
2020-04-13 |
2023-08-13 |
Not clear |
| Weidong Chai, Kevin Aylor, Zhenqi Liu, Li-Ming Gan, Erik Michaëlsson, Eugene Barret. Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 317. issue 6. 2020-04-13. PMID:31593502. |
two weeks of hfd feeding blocked insulin-mediated skeletal muscle capillary recruitment, inhibited glucose utilization, and insulin signaling to muscle. |
2020-04-13 |
2023-08-13 |
mouse |
| Weidong Chai, Kevin Aylor, Zhenqi Liu, Li-Ming Gan, Erik Michaëlsson, Eugene Barret. Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 317. issue 6. 2020-04-13. PMID:31593502. |
furthermore, azd5904 infusion during the last 2 of 4 wk of hfd feeding restored microvascular insulin sensitivity but not metabolic ir. |
2020-04-13 |
2023-08-13 |
mouse |
| Oluwabukola Omotola, Sandra Legan, Emily Slade, Ayooluwatomiwa Adekunle, Julie S Pendergas. Estradiol regulates daily rhythms underlying diet-induced obesity in female mice. American journal of physiology. Endocrinology and metabolism. vol 317. issue 6. 2020-04-13. PMID:31689145. |
additionally, restoring the daily rhythm of eating behavior in ovariectomized females with time-restricted feeding inhibited diet-induced obesity and insulin resistance. |
2020-04-13 |
2023-08-13 |
mouse |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
insulin central injection enhanced hypothalamic content of pakt/akt and cart mrna expression, decreased npy mrna expression and food intake only in sham rats, without effects in adx and adx + b rats. |
2020-04-06 |
2023-08-13 |
rat |
| Allison B Reiss, Daniel S Glass, Eric Lam, Amy D Glass, Joshua De Leon, Lora J Kasselma. Oxytocin: Potential to mitigate cardiovascular risk. Peptides. vol 117. 2020-04-02. PMID:31112739. |
the neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a cvd ancillary treatment because it moderates factors directly linked to atherosclerotic cvd such as inflammation, weight gain, food intake and insulin resistance. |
2020-04-02 |
2023-08-13 |
human |
| Louise T Dalgaar. Assessment of β-Cell Replication in Isolated Rat Islets of Langerhans. Methods in molecular biology (Clifton, N.J.). vol 2029. 2020-04-02. PMID:31273731. |
pancreatic β-cells in the islets of langerhans secrete insulin in response to the rise in glucose levels following food intake. |
2020-04-02 |
2023-08-13 |
rat |
| Yong Zhang, Jianyong Wan, Zhen Xu, Tianmiao Hua, Qingyan Su. Exercise ameliorates insulin resistance via regulating TGFβ-activated kinase 1 (TAK1)-mediated insulin signaling in liver of high-fat diet-induced obese rats. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30367484. |
hfd feeding resulted in increased body weight, visceral fat mass, serum ffas and hepatic lipid deposition, but decreased hepatic glycogen content and insulin sensitivity. |
2020-03-30 |
2023-08-13 |
rat |
| Eline N Kuipers, Ntsiki M Held, Wietse In Het Panhuis, Melanie Modder, Philip M M Ruppert, Sander Kersten, Sander Kooijman, Bruno Guigas, Riekelt H Houtkooper, Patrick C N Rensen, Mariëtte R Boo. A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice. American journal of physiology. Endocrinology and metabolism. vol 317. issue 5. 2020-03-30. PMID:31386566. |
a single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice. |
2020-03-30 |
2023-08-13 |
mouse |
| Pryscila D S Teixeira, Gisele C Couto, Isadora C Furigo, Edward O List, John J Kopchick, Jose Donat. Central growth hormone action regulates metabolism during pregnancy. American journal of physiology. Endocrinology and metabolism. vol 317. issue 5. 2020-03-30. PMID:31479305. |
our findings revealed that during pregnancy central gh action regulates food intake, fat retention, as well as the sensitivity to insulin and leptin in a cell-specific manner. |
2020-03-30 |
2023-08-13 |
mouse |
| Run-Qing Xue, Xiao-Jiang Yu, Ming Zhao, Man Xu, Qing Wu, Yan-Ling Cui, Si Yang, Dong-Ling Li, Wei-Jin Zan. Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome. Free radical biology & medicine. vol 134. 2020-03-26. PMID:30633969. |
feeding of a hfd for 22 weeks led to an irregular and even lysed cristae structure in cardiac mitochondria, which contributed to decreased mitochondrial content and atp production and increased oxygen species production, ultimately impairing insulin signaling and lipid metabolism. |
2020-03-26 |
2023-08-13 |
mouse |
| Aurèle Besse-Patin, Stewart Jeromson, Philipa Levesque-Damphousse, Blandine Secco, Mathieu Laplante, Jennifer L Estal. PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 10. 2020-03-23. PMID:30770439. |
precise modulation of hepatic glucose metabolism is crucial during the fasting and feeding cycle and is controlled by the actions of circulating insulin and glucagon. |
2020-03-23 |
2023-08-13 |
mouse |