| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alex Bach, Marta Terré, Maria Vida. Symposium review: Decomposing efficiency of milk production and maximizing profit. Journal of dairy science. vol 103. issue 6. 2020-09-25. PMID:31837781. |
feed efficiency is affected by a myriad of factors, but overall they could be clustered as follows: (1) physiological status of the cow (e.g., age, state of lactation, health, level of production, environmental conditions), (2) digestive function (e.g., feeding behavior, passage rate, rumen fermentation, rumen and hindgut microbiome), (3) metabolic partitioning (e.g., homeorhesis, insulin sensitivity, hormonal profile), (4) genetics (ultimately dictating the 2 previous aspects), and (5) nutrition (e.g., ration formulation, nutrient balance). |
2020-09-25 |
2023-08-13 |
Not clear |
| Takaoki Saneyasu, Satoshi Fukuzo, Ayana Kitashiro, Kanami Nagata, Kazuhisa Honda, Hiroshi Kamisoyam. Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks. Physiology & behavior. vol 210. 2020-09-21. PMID:31398442. |
however, a previous study has also reported that insulin fails to suppress food intake in broiler chicks. |
2020-09-21 |
2023-08-13 |
Not clear |
| Takaoki Saneyasu, Satoshi Fukuzo, Ayana Kitashiro, Kanami Nagata, Kazuhisa Honda, Hiroshi Kamisoyam. Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks. Physiology & behavior. vol 210. 2020-09-21. PMID:31398442. |
intracerebroventricular (icv) administration of 50 pmol insulin, which could decrease food intake in broiler chicks, significantly increased the akt phosphorylation rate, whereas no significant change was observed in foxo1 phosphorylation or pomc expression after icv insulin administration. |
2020-09-21 |
2023-08-13 |
Not clear |
| Takaoki Saneyasu, Satoshi Fukuzo, Ayana Kitashiro, Kanami Nagata, Kazuhisa Honda, Hiroshi Kamisoyam. Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks. Physiology & behavior. vol 210. 2020-09-21. PMID:31398442. |
these findings suggest that hypothalamic akt responds to insulin in broiler chicks, but foxo1-mediated regulation of pomc expression is not induced by insulin, which may be one of the causes of excessive food intake in broiler chickens. |
2020-09-21 |
2023-08-13 |
Not clear |
| Jerry W Spears, Karen E Lloyd, Paul Siciliano, Shannon Pratt-Phillips, Ellen W Goertzen, Sarah J McLeod, Jennifer Moore, Kristi Krafka, Jill Hyda, Whitney Round. Chromium propionate increases insulin sensitivity in horses following oral and intravenous carbohydrate administration. Journal of animal science. vol 98. issue 4. 2020-09-17. PMID:32211767. |
after an overnight fast, blood samples from the jugular vein were obtained at 0, 2, and 4 h after concentrate feeding on days 0 and 28 for the determination of glucose, nonesterified fatty acids, and insulin. |
2020-09-17 |
2023-08-13 |
Not clear |
| Dale S Edgerton, Melanie Scott, Ben Farmer, Phillip E Williams, Peter Madsen, Thomas Kjeldsen, Christian L Brand, Christian Fledelius, Erica Nishimura, Alan D Cherringto. Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery. JCI insight. vol 5. 2020-09-16. PMID:30830873. |
the second aim was to determine if peripheral delivery of a hepato-preferential insulin analog could restore the physiologic response to insulin that occurs under meal feeding conditions. |
2020-09-16 |
2023-08-13 |
Not clear |
| Garron T Dodd, Chrysovalantou E Xirouchaki, Matthew Eramo, Christina A Mitchell, Zane B Andrews, Belinda A Henry, Michael A Cowley, Tony Tigani. Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. Cell reports. vol 28. issue 11. 2020-09-16. PMID:31509751. |
deletion of ptp1b and tcptp in the hypothalami of obese mice enhances cns leptin and insulin sensitivity, represses feeding, and increases browning, to decrease adiposity and improve glucose metabolism. |
2020-09-16 |
2023-08-13 |
mouse |
| Inge B Halberg, Karsten Lyby, Karsten Wassermann, Tim Heise, Leona Plum-Mörschel, Eric Zijlstr. The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects. Clinical pharmacokinetics. vol 58. issue 11. 2020-09-08. PMID:31093929. |
the effect of food intake on the pharmacokinetics of oral basal insulin: a randomised crossover trial in healthy male subjects. |
2020-09-08 |
2023-08-13 |
human |
| Inge B Halberg, Karsten Lyby, Karsten Wassermann, Tim Heise, Leona Plum-Mörschel, Eric Zijlstr. The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects. Clinical pharmacokinetics. vol 58. issue 11. 2020-09-08. PMID:31093929. |
this randomised, open-label, four-period crossover trial investigated the effect of timing of food intake on the single-dose pharmacokinetic properties of oral insulin 338. |
2020-09-08 |
2023-08-13 |
human |
| Norimitsu Murai, Naoko Saito, Eriko Kodama, Tatsuya Iida, Kentaro Mikura, Hideyuki Imai, Mariko Kaji, Mai Hashizume, Yasuyoshi Kigawa, Go Koizumi, Rie Tadokoro, Chiho Sugisawa, Kei Endo, Toru Iizaka, Ryo Saiki, Fumiko Otsuka, Ishibashi Shun, Shoichiro Nagasak. Association of ghrelin dynamics with beta cell function in Japanese subjects with normal glucose tolerance. Clinical endocrinology. vol 91. issue 5. 2020-09-08. PMID:31408197. |
ghrelin is involved in feeding regulation and energy metabolism and is also known to inhibit insulin secretion (β). |
2020-09-08 |
2023-08-13 |
human |
| Stephanie J Alexopoulos, Sing-Young Chen, Amanda E Brandon, Joseph M Salamoun, Frances L Byrne, Christopher J Garcia, Martina Beretta, Ellen M Olzomer, Divya P Shah, Ashleigh M Philp, Stefan R Hargett, Robert T Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J Cooney, Webster L Santos, Kyle L Hoeh. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32409697. |
collectively, these data demonstrate that pharmacologic mitochondrial uncoupling with bam15 has powerful anti-obesity and insulin sensitizing effects without compromising lean mass or affecting food intake. |
2020-08-31 |
2023-08-13 |
mouse |
| Tiago Morais, Barbara Patrício, Sofia Silva Pereira, Sara Andrade, Marcos Carreira, Felipe F Casanueva, Mariana P Monteir. GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-28. PMID:30994953. |
food intake and body weight were recorded throughout the experimental period, while the percentage of white and brown adipose tissue, fasting glucose, insulin, gastro-intestinal hormonal profile, hypothalamic, and bat gene expression were assessed at endpoint. |
2020-08-28 |
2023-08-13 |
rat |
| Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Uek. Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. Molecular cell. vol 79. issue 1. 2020-08-24. PMID:32464093. |
we have found that adipose tissue macrophages produce interleukin-10 (il-10) upon feeding, which suppresses hepatic glucose production in cooperation with insulin. |
2020-08-24 |
2023-08-13 |
Not clear |
| Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Uek. Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. Molecular cell. vol 79. issue 1. 2020-08-24. PMID:32464093. |
both elevated insulin and gut-microbiome-derived lipopolysaccharide in response to feeding are required for il-10 production via the akt/mammalian target of rapamycin (mtor) pathway. |
2020-08-24 |
2023-08-13 |
Not clear |
| Evelina Charidemou, Tom Ashmore, Xuefei Li, Ben D McNally, James A West, Sonia Liggi, Matthew Harvey, Elise Orford, Julian L Griffi. A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans. JCI insight. vol 4. issue 12. 2020-08-17. PMID:31145699. |
glutamate, glutamine, and leucine increased activation of protein kinase b, suggesting that induction of de novo lipogenesis occurs via the insulin signaling cascade.conclusionthese findings provide mechanistic insight into how select amino acids induce de novo lipogenesis and insulin resistance, suggesting that high-protein feeding to tackle diabetes and obesity requires greater consideration.fundingthe research was supported by uk medical research council grants mr/p011705/1, mc_up_a090_1006 and mr/p01836x/1. |
2020-08-17 |
2023-08-13 |
human |
| Lalita Oparija-Rogenmozere, Anuradha Rajendran, Nadège Poncet, Simone M R Camargo, François Verre. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. PloS one. vol 15. issue 5. 2020-08-17. PMID:32470053. |
ex vivo treatments of isolated intestinal villi fraction demonstrated that s274 phosphorylation was stimulated by protein kinase a. rapamycin-sensitive insulin treatment and amino acids increased s297 phosphorylation, suggesting that the response to food intake might be regulated via the insulin-mtorc1 pathway. |
2020-08-17 |
2023-08-13 |
mouse |
| Kenichi Tanaka, Hirokazu Takahashi, Sayaka Katagiri, Kazuyo Sasaki, Yujin Ohsugi, Kazuki Watanabe, Islam M D Rasadul, Keiichiro Mine, Seiho Nagafuchi, Takanori Iwata, Yuichiro Eguchi, Keizo Anza. Combined effect of canagliflozin and exercise training on high-fat diet-fed mice. American journal of physiology. Endocrinology and metabolism. vol 318. issue 4. 2020-07-28. PMID:32017594. |
numerically additive improvements were found in body weight, body fat mass, blood glucose, glucose intolerance, insulin resistance, and the fatty liver of the can/wcr group, whereas can increased food intake and reduced running distance. |
2020-07-28 |
2023-08-13 |
mouse |
| Alba C Arcones, Marta Cruces-Sande, Paula Ramos, Federico Mayor, Cristina Murg. Sex Differences in High Fat Diet-Induced Metabolic Alterations Correlate with Changes in the Modulation of GRK2 Levels. Cells. vol 8. issue 11. 2020-07-22. PMID:31752326. |
herein, we report that the relative protection that is displayed by young female mice, as compared to male littermates, against some of the metabolic alterations that are induced by feeding a high fat diet (hfd), correlates with a lower upregulation of the protein levels of g protein-coupled receptor kinase (grk2), which is a key regulator of both insulin and g protein-coupled receptor signaling, in the liver and adipose tissue. |
2020-07-22 |
2023-08-13 |
mouse |
| Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang, Qiang Sh. TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding. Journal of translational medicine. vol 17. issue 1. 2020-07-16. PMID:31477129. |
trem2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding. |
2020-07-16 |
2023-08-13 |
mouse |
| Stephanie Kullmann, André Kleinridders, Dana M Small, Andreas Fritsche, Hans-Ulrich Häring, Hubert Preissl, Martin Hen. Central nervous pathways of insulin action in the control of metabolism and food intake. The lancet. Diabetes & endocrinology. vol 8. issue 6. 2020-07-14. PMID:32445739. |
central nervous pathways of insulin action in the control of metabolism and food intake. |
2020-07-14 |
2023-08-13 |
human |