| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary I Grunewald, Sunhye Lee, Rebecca Kirkland, Matthew Ross, Claire B de La Serr. Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance. Physiology & behavior. vol 199. 2020-03-19. PMID:30502357. |
cb1 activation promotes inflammation, increases food intake and impairs insulin signaling. |
2020-03-19 |
2023-08-13 |
rat |
| Hiroki Okauchi, Chiaki Hashimoto, Reiko Nakao, Katsutaka Oish. Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice. Chronobiology international. vol 36. issue 1. 2020-03-16. PMID:30212233. |
abbreviations: anova: analysis of variance; df: daytime feeding; ffa: free fatty acid; glp-1: glucagon-like peptide-1; homa-ir: homeostasis model assessment of insulin resistance; neat: non-exercise activity thermogenesis; nf: nighttime feeding; rf: restricted feeding; rw: running-wheel; scn: suprachiasmatic nucleus; se: standard error of the mean; sed: sedentary; spa: spontaneous physical activity; t-cho: total cholesterol; tg: triglyceride; wat: white adipose tissues. |
2020-03-16 |
2023-08-13 |
mouse |
| André Kleinridders, Emmanuel N Potho. Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior. Current nutrition reports. vol 8. issue 2. 2020-03-16. PMID:31001792. |
impact of brain insulin signaling on dopamine function, food intake, reward, and emotional behavior. |
2020-03-16 |
2023-08-13 |
Not clear |
| André Kleinridders, Emmanuel N Potho. Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior. Current nutrition reports. vol 8. issue 2. 2020-03-16. PMID:31001792. |
we review the effects of brain insulin action and dopaminergic signal transmission on food intake, reward, and mood as well as potential modulations of these systems to counteract the obesity epidemic. |
2020-03-16 |
2023-08-13 |
Not clear |
| Seyed Ebrahim Alavi, Peter J Cabot, Peter M Moyl. Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31050435. |
glp-1 is a therapeutic peptide secreted from the intestines following food intake, which stimulates the secretion of insulin from the pancreas. |
2020-03-16 |
2023-08-13 |
Not clear |
| Yifan Bao, Jianbo Xiao, Zebin Weng, Xinyi Lu, Xinchun Shen, Fang Wan. A phenolic glycoside from Moringa oleifera Lam. improves the carbohydrate and lipid metabolisms through AMPK in db/db mice. Food chemistry. vol 311. 2020-03-16. PMID:31877545. |
results indicated that niazirin could significantly reduce body weight, water and food intake, improve hyperglycemia, insulin resistance, inflammation, carbohydrate and lipid metabolism, non-alcoholic fatty liver. |
2020-03-16 |
2023-08-13 |
mouse |
| Dong-Jie Li, Jie Tong, Yong-Hua Li, Hong-Bo Meng, Qing-Xin Ji, Guo-Yan Zhang, Jia-Hui Zhu, Wen-Jing Zhang, Fei-Yan Zeng, Gang Huang, Xia Hua, Fu-Ming Shen, Pei Wan. Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner. Journal of pineal research. vol 67. issue 4. 2020-03-12. PMID:31541591. |
although melatonin administration did not alter food intake, it significantly alleviated fatty liver phenotypes, including the body weight gain, insulin resistance, hepatic lipid accumulation, steatohepatitis, and fibrosis in a high-fat diet (hfd)-induced nafld mouse model (in vivo). |
2020-03-12 |
2023-08-13 |
mouse |
| Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Hitomi Ogino, Minoru Maruyama, Hirohisa Miyashita, Yasufumi Miyamoto, Yusuke Moritoh, Yoshiyuki Tsujihata, Koji Takeuchi, Nobuhiro Nishigak. GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve. PloS one. vol 14. issue 9. 2020-03-06. PMID:31525244. |
gpr40/ffar1 is a gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. |
2020-03-06 |
2023-08-13 |
mouse |
| Shuai Liu, Stephanie L Borglan. Insulin actions in the mesolimbic dopamine system. Experimental neurology. vol 320. 2020-03-03. PMID:31279911. |
as a major circulating feeding related hormone, insulin crosses the brain blood barrier and acts on the central nervous system to modulate both homeostatic and non-homeostatic feeding behaviours. |
2020-03-03 |
2023-08-13 |
Not clear |
| Shuai Liu, Stephanie L Borglan. Insulin actions in the mesolimbic dopamine system. Experimental neurology. vol 320. 2020-03-03. PMID:31279911. |
the mesolimbic dopamine system is implicated in motivation and the reinforcement of food intake, and it can be delicately tuned in response to insulin. |
2020-03-03 |
2023-08-13 |
Not clear |
| Priya Crosby, Ryan Hamnett, Marrit Putker, Nathaniel P Hoyle, Martin Reed, Carolyn J Karam, Elizabeth S Maywood, Alessandra Stangherlin, Johanna E Chesham, Edward A Hayter, Lyn Rosenbrier-Ribeiro, Peter Newham, Hans Clevers, David A Bechtold, John S O'Neil. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time. Cell. vol 177. issue 4. 2020-03-02. PMID:31030999. |
besides its well-known homeostatic functions, we propose insulin and igf-1 are primary signals of feeding time to cellular clocks throughout the body. |
2020-03-02 |
2023-08-13 |
mouse |
| Naomi Dirckx, Megan C Moorer, Thomas L Clemens, Ryan C Riddl. The role of osteoblasts in energy homeostasis. Nature reviews. Endocrinology. vol 15. issue 11. 2020-02-26. PMID:31462768. |
over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. |
2020-02-26 |
2023-08-13 |
Not clear |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
chronic intracerebroventricular injection of rspo1 inhibited food intake and normalized diabetic hyperphagia; intracerebroventricular injection of rspo1 or insulin increased cart mrna in arc. |
2020-02-25 |
2023-08-13 |
rat |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
in the cart neuron cell line, rspo1 and insulin potentiated each other on perk and β-catenin, and in rats, they acted synergistically to inhibit food intake. |
2020-02-25 |
2023-08-13 |
rat |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
silencing rspo1 in vmh reduced cart expression in arc and attenuated the inhibitory effect of insulin on food intake. |
2020-02-25 |
2023-08-13 |
rat |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
rspo1 and insulin acted synergistically on phospho-erk and β-catenin signal pathways and in suppressing food intake. |
2020-02-25 |
2023-08-13 |
rat |
| Sine Paasch Schiellerup, Kirsa Skov-Jeppesen, Johanne Agerlin Windeløv, Maria Saur Svane, Jens Juul Holst, Bolette Hartmann, Mette Marie Rosenkild. Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:30863364. |
the responsible hormones appear to include glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), known as incretin hormones due to their role in regulating glucose homeostasis by enhancing insulin release in response to food intake. |
2020-02-25 |
2023-08-13 |
human |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
the present study was undertaken to reveal the functional interaction between cocaine- and amphetamine-regulated transcript (cart), a well-known anorexic peptide, and insulin within the framework of hypothalamus in the regulation of feeding behavior and body weight. |
2020-02-25 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
treatment with insulin (6 mu, icv) for a period of 7 days caused a significant decrease in food intake and body weight as compared to control. |
2020-02-25 |
2023-08-13 |
rat |
| Chor Hong Lim, Megan You Min Lee, Tomoko Soga, Ishwar Parha. Evolution of Structural and Functional Diversity of Spexin in Mammalian and Non-mammalian Vertebrate Species. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31275244. |
spx acts as a neuromodulator with multiple central and peripheral physiological roles in the regulation of insulin release, fat metabolism, feeding behavior, and reproduction. |
2020-02-25 |
2023-08-13 |
human |