| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanping Meng, Po Hao, Hongxin D. Regulatory T cells differentiation in visceral adipose tissues contributes to insulin resistance by regulating JAZF-1/PPAR-γ pathway. Journal of cellular and molecular medicine. 2023-02-03. PMID:36734198. |
first, we determined that the levels of glucose and insulin biochemical markers in the jazf-1 transgenic general feeding or high-fat groups were lower than those in the wild-type general feeding or high-fat groups. |
2023-02-03 |
2023-08-14 |
mouse |
| W Wayne Laut. Hepatalin: The missing link in prediabetes, obesity, and type 2 diabetes. Canadian journal of physiology and pharmacology. 2023-01-30. PMID:36716439. |
hepatalin is a hormone secreted by the liver in response to pulses of insulin after a mixed nutrient meal, but only if the liver receives two permissive synergistic feeding signals from the stomach. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenko. Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates. Cell metabolism. 2023-01-27. PMID:36706758. |
in obese mice, ql1005 induces reductions in body weight, food intake, insulin, fasting glucose, and triglycerides. |
2023-01-27 |
2023-08-14 |
mouse |
| Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenko. Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates. Cell metabolism. 2023-01-27. PMID:36706758. |
in a cynomolgus monkey model of obesity, ql1005 reduces body weight, food intake, insulin, and glucose in a dose-dependent manner with limited incidence of gi side effects. |
2023-01-27 |
2023-08-14 |
mouse |
| Mayuko Chikamatsu, Hiroshi Watanabe, Yuhi Shintani, Ryota Murata, Masako Miyahisa, Ayano Nishinoiri, Tadashi Imafuku, Mei Takano, Nanaka Arimura, Kohichi Yamada, Miya Kamimura, Baki Mukai, Takao Satoh, Hitoshi Maeda, Toru Maruyam. Albumin-fused long-acting FGF21 analogue for the treatment of non-alcoholic fatty liver disease. Journal of controlled release : official journal of the Controlled Release Society. 2023-01-23. PMID:36690035. |
the hfd-60-induced nafld model mice with obesity, insulin resistance, dyslipidemia and hepatic lipid accumulation were treated with hsa-fgf21 three times per week for 4 weeks starting at 12 weeks after the hfd-60 feeding. |
2023-01-23 |
2023-08-14 |
mouse |
| Wietse In Het Panhuis, Milena Schönke, Ricky Siebeler, Dorien Banen, Amanda C M Pronk, Trea C M Streefland, Salwa Afkir, Hetty C M Sips, Jan Kroon, Patrick C N Rensen, Sander Kooijma. Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 2. 2023-01-16. PMID:36645117. |
we demonstrate that cd has sex-specific effects on glucose homeostasis, as cd elevated fasting insulin levels in male mice while increasing fasting glucose levels in female mice, which appeared to be independent of behavior, food intake, and energy expenditure. |
2023-01-16 |
2023-08-14 |
mouse |
| Reza Karimi, Armin Towhidi, Mahdi Ganjkhanlou, Hamid Ghasemzadeh-Nava, Sepideh Khoee, John Kasteli. Rumen-protected glucose hastens uterine involution and increases numbers of ovarian follicles in early postpartum dairy cows. Reproduction in domestic animals = Zuchthygiene. 2023-01-16. PMID:36645321. |
feeding rpg increased serum insulin concentrations (4.59 ± 0.54 vs 3.13 ± 0.57, p < 0.05), but had no significant effects on serum glucose concentrations, dry matter intake or milk yield. |
2023-01-16 |
2023-08-14 |
cattle |
| Shuo Song, Lingling Chen, Meijuan Bai, Shuo Wang, Xiaoyi Ye, Yijun Lin, Xuemei Luo, Zixuan Li, Lingling Zhang, Xinyu Zhu, Zinan Wang, Yan Che. Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis Frontiers in nutrition. vol 9. 2023-01-09. PMID:36618695. |
time-restricted feeding ameliorates dextran sulfate sodium-induced colitis time-restricted feeding (trf) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. |
2023-01-09 |
2023-08-14 |
mouse |
| Yaoyao Chen, Boer Hong, Yuhua Zhang, Xiaolian Chen, Tong Zhang, Guohua Zhong, Xin Y. FoxO directly regulates the expression of odorant receptor genes to govern olfactory plasticity upon starvation in Bactrocera dorsalis. Insect biochemistry and molecular biology. 2023-01-07. PMID:36610504. |
taken together, the foxo-ors axis elucidated in this study provides an improved understanding of how the insulin signaling pathway senses the feeding state and certain macronutrient composition to shape olfactory plasticity, allowing flies to dynamically alter chemosensory sensitivities toward different odors. |
2023-01-07 |
2023-08-14 |
Not clear |
| Andrew G McCloskey, Michael G Miskelly, Ryan A Lafferty, Peter R Flatt, Aine M McKillo. Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice. Biochemical pharmacology. 2022-12-29. PMID:36581052. |
assessments of plasma glucose, circulating insulin, dpp-iv activity, crp, amylase, lipids, body weight and food intake were undertaken. |
2022-12-29 |
2023-08-14 |
mouse |
| K V Derkach, I O Zakharova, A A Bakhtyukov, V N Sorokoumov, V S Kuznetsova, A O Shpako. [Characterization and biological activity of new 4-oxo-1,4-dihydrocinnoline-based inhibitors of the tyrosine phosphatase PTP1B and TCPTP]. Biomeditsinskaia khimiia. vol 68. issue 6. 2022-12-27. PMID:36573409. |
pi04 significantly reduced food intake, body weight and fat, attenuated hyperglycemia, normalized glucose tolerance, basal and glucose-stimulated levels of insulin and leptin, and insulin resistance index. |
2022-12-27 |
2023-08-14 |
rat |
| Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment. Cells. vol 11. issue 24. 2022-12-23. PMID:36552776. |
insulin treatment improved blood glucose, water intake, and food intake to normoglycemic levels, but did not improve depressive-like behaviors. |
2022-12-23 |
2023-08-14 |
mouse |
| Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Oscar Charlesworth, Shengnan Qin, Yuliang Mai, Haicheng Dou, Jiake X. Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord. Frontiers in endocrinology. vol 13. 2022-12-23. PMID:36561569. |
galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological roles for the neuroendocrine axis, such as regulating food intake, insulin level and somatostatin release. |
2022-12-23 |
2023-08-14 |
human |
| Huei-Ping Tzeng, Shing-Hwa Liu, Meng-Tsan Chian. Antidiabetic Properties of Chitosan and Its Derivatives. Marine drugs. vol 20. issue 12. 2022-12-22. PMID:36547931. |
both high and low molecular weight chitosan feeding reduced insulin resistance by inhibiting lipid accumulation in the liver and adipose tissue and ameliorating chronic inflammation in diabetic rats. |
2022-12-22 |
2023-08-14 |
rat |
| Erin M McGowan, Sarah E Ehrlicher, Harrison D Stierwalt, Matthew M Robinson, Sean A Newso. Impact of 4 weeks of western diet and aerobic exercise training on whole-body phenotype and skeletal muscle mitochondrial respiration in male and female mice. Physiological reports. vol 10. issue 24. 2022-12-21. PMID:36541261. |
whole-body metabolism was measured using in-cage assessment of food intake and energy expenditure, dxa body composition analysis and insulin tolerance testing. |
2022-12-21 |
2023-08-14 |
mouse |
| F A Eugenio, J van Milgen, J Duperray, R Sergheraert, N Le Floc'. Feeding pigs amino acids as protein-bound or in free form influences postprandial concentrations of amino acids, metabolites, and insulin. Animal : an international journal of animal bioscience. vol 17. issue 1. 2022-12-21. PMID:36542911. |
feeding pigs amino acids as protein-bound or in free form influences postprandial concentrations of amino acids, metabolites, and insulin. |
2022-12-21 |
2023-08-14 |
Not clear |
| Jaewoong Lee, Byong Won Lee, Kyung Eun Kim, Hyeong Seok An, Eun Ae Jeong, Hyun Joo Shin, Seok Bo Song, Gu Seob Ro. Adzuki Bean MY59 Extract Reduces Insulin Resistance and Hepatic Steatosis in High-Fat-Fed Mice via the Downregulation of Lipocalin-2. Nutrients. vol 14. issue 23. 2022-12-11. PMID:36501079. |
thus, these findings indicate that abe feeding could improve insulin resistance and hepatic steatosis by decreasing lcn2-mediated inflammation and oxidative stress in hfd-fed mice. |
2022-12-11 |
2023-08-14 |
mouse |
| Roohollah Mohseni, Maryam Teimouri, Mohsen Safaei, Zahra Arab Sadeghabad. AMP-activated protein kinase is a key regulator of obesity-associated factors. Cell biochemistry and function. 2022-12-05. PMID:36468539. |
these factors play an important role in obesity by controlling fat metabolism, energy homeostasis, food intake, and insulin sensitivity. |
2022-12-05 |
2023-08-14 |
Not clear |
| Christine Sommer, Kjersti G Vangberg, Gunn-Helen Moen, David M Evans, Sindre Lee-Ødegård, Ingvild K Blom-Høgestøl, Line Sletner, Anne K Jenum, Christian A Drevon, Hanne L Gulseth, Kåre I Birkelan. Insulin and body mass index decrease serum soluble leptin receptor levels in humans. The Journal of clinical endocrinology and metabolism. 2022-12-02. PMID:36459457. |
test how serum soluble leptin receptor (sob-r) is influenced by glucose, insulin, body fat, body mass index (bmi), food intake and physical activity. |
2022-12-02 |
2023-08-14 |
Not clear |
| Faezeh Sadat Hosseini, Alireza Ghassempour, Massoud Amanlo. Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an Research in pharmaceutical sciences. vol 17. issue 5. 2022-11-17. PMID:36386482. |
discovery of novel inhibitors of ghrelin o-acyltransferase enzyme: an ghrelin is known as a hunger hormone and plays a pivotal role in appetite, food intake, energy balance, glucose metabolism, and insulin secretion, making it a potential target for the treatment of obesity and type 2 diabetes. |
2022-11-17 |
2023-08-14 |
Not clear |