| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heshma Alruwaili, Babak Dehestani, Carel W le Rou. Clinical Impact of Liraglutide as a Treatment of Obesity. Clinical pharmacology : advances and applications. vol 13. 2021-03-20. PMID:33732030. |
the primary mechanism of glp-1 effect on food intake, metabolism, and weight reduction is mainly due to its actions on peripheral (vagal) and central pathways and activation of hindbrain and hypothalamus. |
2021-03-20 |
2023-08-13 |
Not clear |
| Ruth B S Harri. Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 2. 2021-03-01. PMID:33206557. |
this study tested whether leptin resistance in liqs rats extended beyond a failure to inhibit food intake and examined leptin responsiveness in the hypothalamus and hindbrain of rats offered hs, liqs, or a sucrose-free diet (ns). |
2021-03-01 |
2023-08-13 |
rat |
| Audrey Melvin, Dimitrios Chantzichristos, Catriona J Kyle, Scott D Mackenzie, Brian R Walker, Gudmundur Johannsson, Roland H Stimson, Stephen O'Rahill. GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement. The Journal of clinical endocrinology and metabolism. vol 105. issue 5. 2021-02-09. PMID:31853550. |
gdf15 is a stress-induced hormone acting in the hindbrain that activates neural circuitry involved in establishing aversive responses and reducing food intake and body weight in animal models. |
2021-02-09 |
2023-08-13 |
Not clear |
| Hallie S Wald, Ananya Chandra, Anita Kalluri, Zhi Yi Ong, Matthew R Hayes, Harvey J Gril. NTS and VTA oxytocin reduces food motivation and food seeking. American journal of physiology. Regulatory, integrative and comparative physiology. vol 319. issue 6. 2020-12-28. PMID:33026822. |
one mechanism of its behavioral action is the amplification of the feeding inhibitory effects of gastrointestinal (gi) satiation signals processed by hindbrain neurons. |
2020-12-28 |
2023-08-13 |
Not clear |
| Michael J Butler, Alexis A Perrini, Lisa A Ecke. Estradiol treatment attenuates high fat diet-induced microgliosis in ovariectomized rats. Hormones and behavior. vol 120. 2020-12-21. PMID:31923417. |
we conclude that estradiol has protective effects against hfd-induced microgliosis in a region-specific manner in hypothalamic and hindbrain areas implicated in the neural control of food intake. |
2020-12-21 |
2023-08-13 |
rat |
| Bernd Coester, Christina Koester-Hegmann, Thomas A Lutz, Christelle Le Fol. Amylin/Calcitonin Receptor-Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice. Diabetes. vol 69. issue 6. 2020-10-22. PMID:32152204. |
amylin, a pancreatic hormone and neuropeptide, acts principally in the hindbrain to decrease food intake and has recently been shown to act as a neurotrophic factor to control the development of area postrema → nucleus of the solitary tract and arcuate hypothalamic nucleus → paraventricular nucleus axonal fiber outgrowth. |
2020-10-22 |
2023-08-13 |
mouse |
| Alessia Montesano, Mario Baumgart, Luigi Avallone, Luciana Castaldo, Carla Lucini, Eva Terzibasi Tozzini, Alessandro Cellerino, Livia D'Angelo, Paolo de Girolam. Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. The Journal of comparative neurology. vol 527. issue 9. 2020-09-16. PMID:30666646. |
our experiments, conducted on male specimens, show that: (a) hcrt and oxa and npy mrna and protein are localized in neurons of diencephalon and optic tectum, as well as in numerous fibers projecting through the entire neuroaxis, and are colocalized in specific nuclei; (b) in course of aging, hcrt and npy expressing neurons are localized also in telencephalon and rhombencephalon; (c) hcrt expressing neurons increased slightly in the diencephalic area of old animals and in fasted animals, whereas npy increased sharply; (d) central hcrt levels are not regulated neither in course of aging nor by food intake; and (e) central npy levels are augmented in course of aging, and regulated by food intake only in young. |
2020-09-16 |
2023-08-13 |
Not clear |
| Ruth B S Harri. Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity. American journal of physiology. Endocrinology and metabolism. vol 318. issue 5. 2020-07-29. PMID:32228323. |
previous studies indicate that inhibition of food intake by leptin is mediated by an integrated response to activation of hypothalamic and hindbrain receptors. |
2020-07-29 |
2023-08-13 |
rat |
| Cristina Velasco, Sara Comesaña, Marta Conde-Sieira, Jesús M Míguez, José L Soenga. Effects of CCK-8 and GLP-1 on fatty acid sensing and food intake regulation in trout. Journal of molecular endocrinology. vol 62. issue 3. 2020-07-24. PMID:30608904. |
therefore, we assessed in rainbow trout (oncorhynchus mykiss) the effects of intracerebroventricular treatment with 1 ng/g of cck-8 and with 2 ng/g of glp-1 on food intake, expression of neuropeptides involved in food intake control and the activity of fatty acid-sensing systems in hypothalamus and hindbrain. |
2020-07-24 |
2023-08-13 |
Not clear |
| Fredrik Anesten, Devesh Mishra, Adrià Dalmau Gasull, Linda Engström-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P Skibicka, Matti Poutanen, John-Olov Jansso. Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus. Neuroendocrinology. vol 109. issue 4. 2020-05-29. PMID:30889580. |
interleukin (il)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (glp-1) receptor stimulation. |
2020-05-29 |
2023-08-13 |
mouse |
| Ki-Suk Kim, Randy J Seeley, Darleen A Sandova. Signalling from the periphery to the brain that regulates energy homeostasis. Nature reviews. Neuroscience. vol 19. issue 4. 2019-08-23. PMID:29467468. |
previous paradigms have delegated the control of long-term energy homeostasis to the hypothalamus and short-term changes in feeding behaviour to the hindbrain. |
2019-08-23 |
2023-08-13 |
Not clear |
| Clarissa M Liu, Scott E Kanosk. Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems. Physiology & behavior. vol 193. issue Pt B. 2019-04-29. PMID:29421588. |
the present review summarizes both historic and recent research examining the homeostatic regulation of feeding with specific emphasis on hypothalamic and hindbrain circuitry that monitor and regulate various metabolic signals. |
2019-04-29 |
2023-08-13 |
Not clear |
| Sabrina N Walley, Troy A Roepk. Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Hormones and behavior. vol 101. 2019-04-15. PMID:29107582. |
feeding behaviors are controlled centrally through communication between the hindbrain and hypothalamus with inputs from the emotion and reward centers of the brain and modulated by peripheral hormones like ghrelin and leptin. |
2019-04-15 |
2023-08-13 |
Not clear |
| Sara M Freeman, Julie Ngo, Bhavdeep Singh, Megan Masnaghetti, Karen L Bales, James E Blevin. Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain. Neuroscience. vol 392. 2019-03-06. PMID:30071278. |
we therefore determined the impact of diet (hfd vs chow) and drug treatment (chronic ot infusion vs vehicle) on (1) oxtr binding in hindbrain and forebrain sites where ot suppresses food intake relative to control sites that express oxtr and (2) forebrain vasopressin 1a receptor (avpr1a) density to evaluate the specificity of any ot effects. |
2019-03-06 |
2023-08-13 |
rat |
| Ulrika Smedh, Karen A Scott, Timothy H Mora. Fourth ventricular thyrotropin induces satiety and increases body temperature in rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 314. issue 5. 2019-01-07. PMID:29351420. |
here, the hypothesis that thyrotropin acts on receptors in the hindbrain to alter food intake and/or gastric function was tested. |
2019-01-07 |
2023-08-13 |
rat |
| Diana L Williams, Nicole A Lilly, Ian J Edwards, Pallas Yao, James E Richards, Stefan Trap. GLP-1 action in the mouse bed nucleus of the stria terminalis. Neuropharmacology. vol 131. 2018-11-13. PMID:29221794. |
similarly, activation of preproglucagon (ppg) cells in the hindbrain which synthesize glp-1, reduces food intake. |
2018-11-13 |
2023-08-13 |
mouse |
| Cristina Velasco, Guillermo Moreiras, Marta Conde-Sieira, José M Leao, Jesús M Míguez, José L Soenga. Ceramide counteracts the effects of ghrelin on the metabolic control of food intake in rainbow trout. The Journal of experimental biology. vol 220. issue Pt 14. 2018-10-10. PMID:28495865. |
thus, we injected icv ghrl and ceramide alone or in combination to evaluate in hypothalamus and hindbrain changes in parameters related to the metabolic control of food intake. |
2018-10-10 |
2023-08-13 |
Not clear |
| Ari Shechter, Gary J Schwart. Gut-brain nutrient sensing in food reward. Appetite. vol 122. 2018-09-28. PMID:28007490. |
afferent fibers emerging from the vagus nerve form the main pathway by which information is relayed from the abdominal viscera to the hindbrain and eventually other higher brain regions involved in food intake. |
2018-09-28 |
2023-08-13 |
Not clear |
| Patrick Sweeney, Changhong Li, Yunlei Yan. Appetite suppressive role of medial septal glutamatergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 52. 2018-07-09. PMID:29229861. |
feeding behavior is controlled by diverse neurons and neural circuits primarily concentrated in the hypothalamus and hindbrain in mammals. |
2018-07-09 |
2023-08-13 |
Not clear |
| Pawel K Olszewski, Oscar A Klockars, Anica Klockars, Allen S Levin. Central oxytocin receptor stimulation attenuates the orexigenic effects of butorphanol tartrate. Neuroreport. vol 27. issue 14. 2018-01-08. PMID:27471903. |
as ot terminates consumption by acting by distinct hindbrain and forebrain circuits, we investigated whether stimulation of the ot receptor in the forebrain or the hindbrain [through lateral ventricular (lv) and fourth ventricular (4v) ot injections] leads to termination of food intake induced by bt. |
2018-01-08 |
2023-08-13 |
rat |