| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ivan C Alcantara, Ana Pamela Miranda Tapia, Yeka Aponte, Michael J Krashe. Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding. Nature metabolism. vol 4. issue 7. 2022-07-25. PMID:35879462. |
while pioneering work identified several hypothalamic nuclei to be involved in feeding, more recent studies have explored how neuronal populations beyond the hypothalamus, such as the mesolimbic pathway and nodes in the hindbrain, interconnect to modulate appetite. |
2022-07-25 |
2023-08-14 |
Not clear |
| Ileana Morale. Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction. Appetite. 2022-06-26. PMID:35753443. |
hindbrain structures and a complex network of interconnected hypothalamic nuclei control metabolic processes, energy expenditure, and food intake while mesocorticolimbic structures are though to control hedonic and motivational processes associated with food reward. |
2022-06-26 |
2023-08-14 |
Not clear |
| Nicholas Mellen, Leo Lane, Kimberly Iceman, Jun Cai, Boris Gourévitch, Teresa Pitt. Neonatal opioid withdrawal syndrome disrupts the ventral swallow pattern generator in germline-GCaMP6F mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557404. |
because neonate feeding behaviors are highly conserved in mammals, these findings suggest that the sagittally-sectioned mouse hindbrain provides a platform to investigate the contribution of central networks to dysphagia in nows infants. |
2022-05-13 |
2023-08-13 |
mouse |
| Ashmita Mukherjee, Adrianne M DiBrog, Elizabeth G Mietlicki-Baas. The Impact of Binge-Like Palatable Food Intake on the Endogenous Glucagon-Like Peptide-1 System in Female Rats. Behavioural brain research. 2022-04-04. PMID:35378108. |
recent work in male rats has shown that a history of binge-like palatable food intake suppresses hindbrain expression of preproglucagon (ppg), the precursor for glucagon-like peptide-1 (glp-1). |
2022-04-04 |
2023-08-13 |
rat |
| Jun Feng Lu, Meng Qing Zhu, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei W. Camptothecin effectively treats obesity in mice through GDF15 induction. PLoS biology. vol 20. issue 2. 2022-02-24. PMID:35202387. |
elevated circulating levels of growth differentiation factor 15 (gdf15) have been shown to reduce food intake and lower body weight through activation of hindbrain receptor glial-derived neurotrophic factor (gdnf) receptor alpha-like (gfral) in rodents and nonhuman primates, thus endogenous induction of this peptide holds promise for obesity treatment. |
2022-02-24 |
2023-08-13 |
mouse |
| Pawel K Olszewski, Emily E Noble, Luis Paiva, Yoichi Ueta, James E Blevin. Oxytocin as a potential pharmacological tool to combat obesity. Journal of neuroendocrinology. 2022-02-22. PMID:35192207. |
its effects on feeding have largely been attributed to limiting meal size through interactions in key regulatory brain regions governing the homeostatic control of food intake such as the hypothalamus and hindbrain in addition to key feeding reward areas such as the nucleus accumbens and ventral tegmental area. |
2022-02-22 |
2023-08-13 |
mouse |
| Marimo Sato, Shiori Minabe, Takahiro Sakono, Fumie Magata, Sho Nakamura, Youki Watanabe, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Fuko Matsud. Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation. Endocrinology. vol 162. issue 9. 2021-11-24. PMID:34161572. |
lowered glucose availability, sensed by the hindbrain, has been suggested to enhance gluconeogenesis and food intake as well as suppress reproductive function. |
2021-11-24 |
2023-08-13 |
rat |
| Marimo Sato, Shiori Minabe, Takahiro Sakono, Fumie Magata, Sho Nakamura, Youki Watanabe, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Fuko Matsud. Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation. Endocrinology. vol 162. issue 9. 2021-11-24. PMID:34161572. |
taken together, these results suggest that lowered glucose availability, sensed by 4v ependymal cells, activates hindbrain catecholaminergic and/or npy neurons followed by crh neurons in the pvn and npy neurons in the arc, thereby leading to counterregulatory responses, such as an enhancement of gluconeogenesis, increased food intake, and suppression of sex steroid secretion. |
2021-11-24 |
2023-08-13 |
rat |
| Vishwanath T Anekonda, Benjamin W Thompson, Jacqueline M Ho, Zachary S Roberts, Melise M Edwards, Ha K Nguyen, Andrew D Dodson, Tami Wolden-Hanson, Daniel W Chukri, Adam J Herbertson, James L Graham, Peter J Havel, Tomasz A Wietecha, Kevin D O'Brien, James E Blevin. Hindbrain Administration of Oxytocin Reduces Food Intake, Weight Gain and Activates Catecholamine Neurons in the Hindbrain Nucleus of the Solitary Tract in Rats. Journal of clinical medicine. vol 10. issue 21. 2021-11-18. PMID:34768597. |
hindbrain administration of oxytocin reduces food intake, weight gain and activates catecholamine neurons in the hindbrain nucleus of the solitary tract in rats. |
2021-11-18 |
2023-08-13 |
rat |
| Vishwanath T Anekonda, Benjamin W Thompson, Jacqueline M Ho, Zachary S Roberts, Melise M Edwards, Ha K Nguyen, Andrew D Dodson, Tami Wolden-Hanson, Daniel W Chukri, Adam J Herbertson, James L Graham, Peter J Havel, Tomasz A Wietecha, Kevin D O'Brien, James E Blevin. Hindbrain Administration of Oxytocin Reduces Food Intake, Weight Gain and Activates Catecholamine Neurons in the Hindbrain Nucleus of the Solitary Tract in Rats. Journal of clinical medicine. vol 10. issue 21. 2021-11-18. PMID:34768597. |
collectively, these findings support the hypothesis that ot within the hindbrain is effective at reducing food intake, weight gain, and adiposity and that nts catecholamine neurons in addition to non-catecholaminergic neurons are downstream targets of cns ot. |
2021-11-18 |
2023-08-13 |
rat |
| Tito Borner, Caroline E Geisler, Samantha M Fortin, Richard Cosgrove, Jorge Alsina-Fernandez, Mridula Dogra, Sarah Doebley, Marcos J Sanchez-Navarro, Rosa M Leon, Jane Gaisinsky, Arianna White, Ankur Bamezai, Misgana Y Ghidewon, Harvey J Grill, Richard C Crist, Benjamin C Reiner, Minrong Ai, Ricardo J Samms, Bart C De Jonghe, Matthew R Haye. GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models. Diabetes. vol 70. issue 11. 2021-11-17. PMID:34380697. |
the area postrema and nucleus tractus solitarius (ap/nts) of the hindbrain are required for food intake and body weight suppression by glp-1r ligands and processing of emetic stimuli. |
2021-11-17 |
2023-08-13 |
mouse |
| Georgina K C Dowsett, Brian Y H Lam, John A Tadross, Irene Cimino, Debra Rimmington, Anthony P Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S H Ye. A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing. Molecular metabolism. vol 53. 2021-11-10. PMID:33962048. |
the area postrema (ap) and nucleus tractus solitarius (nts) located in the hindbrain are key nuclei that sense and integrate peripheral nutritional signals and consequently regulate feeding behaviour. |
2021-11-10 |
2023-08-13 |
mouse |
| Dongdong Wang, Emily A Day, Logan K Townsend, Djordje Djordjevic, Sebastian Beck Jørgensen, Gregory R Steinber. GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nature reviews. Endocrinology. vol 17. issue 10. 2021-11-10. PMID:34381196. |
elevations in gdf15 reduce food intake and body mass in animal models through binding to glial cell-derived neurotrophic factor family receptor alpha-like (gfral) and the recruitment of the receptor tyrosine kinase ret in the hindbrain. |
2021-11-10 |
2023-08-13 |
mouse |
| Cristina Velasco, Marta Conde-Sieira, Sara Comesaña, Mauro Chivite, Jesús M Míguez, José L Soenga. Role of the G protein-coupled receptors GPR84 and GPR119 in the central regulation of food intake in rainbow trout. The Journal of experimental biology. vol 224. issue 13. 2021-07-30. PMID:34114000. |
in the second experiment, we assessed the impact of the same treatments on mrna abundance in the hypothalamus and hindbrain of neuropeptides involved in the metabolic control of food intake (npy, agrp1, pomca1 and cartpt) as well as in changes in parameters related to signalling pathways and transcription factors involved in the integrative response leading to neuropeptide production. |
2021-07-30 |
2023-08-13 |
Not clear |
| Samantha M Fortin, Jack Chen, Harvey J Grill, Matthew R Haye. The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections. Nutrients. vol 13. issue 5. 2021-07-22. PMID:34068091. |
the mesencephalic trigeminal nucleus controls food intake and body weight via hindbrain pomc projections. |
2021-07-22 |
2023-08-13 |
mouse |
| Samantha M Fortin, Jack Chen, Matthew R Haye. Hindbrain melanocortin 3/4 receptors modulate the food intake and body weight suppressive effects of the GLP-1 receptor agonist, liraglutide. Physiology & behavior. vol 220. 2021-06-21. PMID:32179053. |
hindbrain melanocortin 3/4 receptors modulate the food intake and body weight suppressive effects of the glp-1 receptor agonist, liraglutide. |
2021-06-21 |
2023-08-13 |
Not clear |
| Tito Borner, Evan D Shaulson, Misgana Y Ghidewon, Amanda B Barnett, Charles C Horn, Robert P Doyle, Harvey J Grill, Matthew R Hayes, Bart C De Jongh. GDF15 Induces Anorexia through Nausea and Emesis. Cell metabolism. vol 31. issue 2. 2021-06-01. PMID:31928886. |
growth differentiation factor 15 (gdf15) is a cytokine that reduces food intake through activation of hindbrain gfral-ret receptors and has become a keen target of interest for anti-obesity therapies. |
2021-06-01 |
2023-08-13 |
mouse |
| Wenwen Cheng, Ian Gonzalez, Warren Pan, Anthony H Tsang, Jessica Adams, Ermelinda Ndoka, Desiree Gordian, Basma Khoury, Karen Roelofs, Simon S Evers, Andrew MacKinnon, Shuangcheng Wu, Henriette Frikke-Schmidt, Jonathan N Flak, James L Trevaskis, Christopher J Rhodes, So-Ichiro Fukada, Randy J Seeley, Darleen A Sandoval, David P Olson, Clemence Blouet, Martin G Myer. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell metabolism. vol 31. issue 2. 2021-06-01. PMID:31955990. |
to understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (calcr)-containing neurons in the nts. |
2021-06-01 |
2023-08-13 |
mouse |
| Hannah Louise Zakariassen, Linu Mary John, Thomas Alexander Lut. Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases. Basic & clinical pharmacology & toxicology. vol 127. issue 3. 2021-05-17. PMID:32363722. |
in particular, signalling via neuronal circuits in the caudal hindbrain and the hypothalamus is implicated in mediating effects on food intake and energy expenditure. |
2021-05-17 |
2023-08-13 |
Not clear |
| Yolanda Diz-Chaves, Salvador Herrera-Pérez, Lucas C González-Matías, José Antonio Lamas, Federico Mall. Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress. Nutrients. vol 12. issue 11. 2021-04-15. PMID:33126672. |
these neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. |
2021-04-15 |
2023-08-13 |
Not clear |