| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Numan, D S Russel. Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain. Brain research. Molecular brain research. vol 72. issue 1. 1999-12-22. PMID:10521603. |
the expression of irs-4 mrna in the hypothalamus suggests a specific role for this factor in the signaling of one or more receptors involved hypothalamic functions including feeding, lactation, sexual and parental behaviors. |
1999-12-22 |
2023-08-12 |
rat |
| M G Dube, S P Kalra, P S Kalr. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526145. |
these findings demonstrate that orexin a receptive sites for stimulation of food intake exist primarily in a narrow band of neural tissue within the hypothalamus that is known to be involved in control of energy homeostasis. |
1999-12-21 |
2023-08-12 |
rat |
| D Gayle, S E Ilyin, C R Plata-Salamá. Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus. The American journal of physiology. vol 277. issue 4. 1999-11-17. PMID:10516261. |
feeding status and bacterial lps-induced cytokine and neuropeptide gene expression in hypothalamus. |
1999-11-17 |
2023-08-12 |
rat |
| D Gayle, S E Ilyin, C R Plata-Salamá. Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus. The American journal of physiology. vol 277. issue 4. 1999-11-17. PMID:10516261. |
this study determined the effects of feeding status on basal and lipopolysaccharide (lps)-stimulated cytokine and neuropeptide gene expression in the hypothalamus. |
1999-11-17 |
2023-08-12 |
rat |
| C M Sinton, T E Fitch, H K Gershenfel. The effects of leptin on REM sleep and slow wave delta in rats are reversed by food deprivation. Journal of sleep research. vol 8. issue 3. 1999-11-09. PMID:10476006. |
leptin (ob protein) is an adipose tissue derived circulating hormone that acts at specific receptors in the hypothalamus to reduce food intake. |
1999-11-09 |
2023-08-12 |
rat |
| A Inu. Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer research. vol 59. issue 18. 1999-10-08. PMID:10493494. |
leptin acts to control food intake and energy expenditure via neuropeptidergic effector molecules within the hypothalamus. |
1999-10-08 |
2023-08-12 |
Not clear |
| Z W Wang, Y T Zhou, T Kakuma, Y Lee, M Higa, S P Kalra, M G Dube, P S Kalra, R H Unge. Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 18. 1999-10-07. PMID:10468615. |
treatment of the high-fat-fed rats with adenovirus-leptin further increased their hyperleptinemia to 56 +/- 6 ng/ml without changing cart mrna or food intake, indicating that leptin action on hypothalamus had not been increased. |
1999-10-07 |
2023-08-12 |
rat |
| G Grignaschi, E Fanelli, I Scagnol, R Samani. Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455265. |
sibutramine dose-dependently reduced feeding caused by food-deprivation (ed50 = 5.1+/-0.8 mg kg(-1)) or by npy injection into the paraventricular nucleus of the hypothalamus (ed50 = 6.0+/-0.5 mg kg(-1)). |
1999-10-05 |
2023-08-12 |
rat |
| N Satoh, Y Ogawa, G Katsuura, Y Numata, T Tsuji, M Hayase, K Ebihara, H Masuzaki, K Hosoda, Y Yoshimasa, K Naka. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480609. |
leptin is an adipocyte-derived blood-borne satiety factor that acts directly on the hypothalamus, thereby regulating food intake and energy expenditure. |
1999-09-30 |
2023-08-12 |
human |
| M Matsuda, Y Liu, S Mahankali, Y Pu, A Mahankali, J Wang, R A DeFronzo, P T Fox, J H Ga. Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480611. |
the hypothalamus plays a central role in the regulation of energy intake and feeding behavior. |
1999-09-30 |
2023-08-12 |
human |
| M Niimi, M Sato, R Yokote, S Tada, J Takahar. Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinaemia. Journal of neuroendocrinology. vol 11. issue 8. 1999-09-20. PMID:10447798. |
this study was designed to determine whether peripherally or centrally administered leptin is effective on the short-term food intake and expression of fos protein in the hypothalamus in the otsuka long-evans tokushima fatty (oletf) or long-evans tokushima otsuka (leto) rat, as a control. |
1999-09-20 |
2023-08-12 |
mouse |
| S Dryden, M Brown, P King, G William. Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 6. 1999-09-02. PMID:10437624. |
serotonin reduces food intake when injected into the hypothalamus and may interact with other neurotransmitters in the control of appetite. |
1999-09-02 |
2023-08-12 |
rat |
| D G Baskin, T M Hahn, M W Schwart. Leptin sensitive neurons in the hypothalamus. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 5. 1999-08-26. PMID:10422733. |
it lowers food intake and body weight by acting in the hypothalamus, a region expressing an abundance of leptin receptors and a variety of neuropeptides that influence food intake and energy balance. |
1999-08-26 |
2023-08-12 |
Not clear |
| J Cardot, B Griffond, P Y Risold, S Blähser, D Fellman. Melanin-concentrating hormone-producing neurons in birds. The Journal of comparative neurology. vol 411. issue 2. 1999-08-24. PMID:10404250. |
in particular, the projections to parts of the limbic system (ventropallidal ganglia, septal complex, hypothalamus, dorsal thalamus, and epithalamus) and to structures concerned with visceral and other sensory information integration suggest that mch acts as a neuromodulator involved in a wide variety of physiological and behavioral adaptations (arousal) with regard to feeding, drinking, and reproduction. |
1999-08-24 |
2023-08-12 |
rat |
| L Brunetti, B Michelotto, G Orlando, M Vacc. Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings. European journal of pharmacology. vol 372. issue 3. 1999-08-09. PMID:10395017. |
noradrenergic and dopaminergic afferents arising from the brain stem to the hypothalamus still play a poorly characterised role in food intake control. |
1999-08-09 |
2023-08-12 |
rat |
| J Chambers, R S Ames, D Bergsma, A Muir, L R Fitzgerald, G Hervieu, G M Dytko, J J Foley, J Martin, W S Liu, J Park, C Ellis, S Ganguly, S Konchar, J Cluderay, R Leslie, S Wilson, H M Sara. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. vol 400. issue 6741. 1999-08-05. PMID:10421367. |
first, mch stimulates feeding when injected directly into rat brains; second, the messenger rna for the mch precursor is upregulated in the hypothalamus of genetically obese mice and in fasted animals; and third, mice lacking mch eat less and are lean. |
1999-08-05 |
2023-08-12 |
mouse |
| J Chambers, R S Ames, D Bergsma, A Muir, L R Fitzgerald, G Hervieu, G M Dytko, J J Foley, J Martin, W S Liu, J Park, C Ellis, S Ganguly, S Konchar, J Cluderay, R Leslie, S Wilson, H M Sara. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. vol 400. issue 6741. 1999-08-05. PMID:10421367. |
we also show that slc-1 messenger rna and protein is expressed in the ventromedial and dorsomedial nuclei of the hypothalamus, consistent with a role for slc-1 in mediating the effects of mch on feeding. |
1999-08-05 |
2023-08-12 |
mouse |
| Y Slisli, R de Beaurepair. Interleukin-1beta and calcitonin, but not corticotropin-releasing factor, alter sleep cycles when injected into the rat hypothalamic lateral paraventricular area. Neuroscience letters. vol 265. issue 1. 1999-07-14. PMID:10327198. |
we have previously shown that ii-1beta decreases food intake when injected into the lateral part of the paraventricular nucleus of the hypothalamus (pvh), and, because food intake and sleep are closely related behaviors, we tested the hypothesis that ii-1beta could alter sleep when injected into the lateral pvh area. |
1999-07-14 |
2023-08-12 |
rat |
| I E Messinis, S D Milingo. Leptin in human reproduction. Human reproduction update. vol 5. issue 1. 1999-07-13. PMID:10333369. |
this protein, by acting at the level of the hypothalamus, decreases food intake and increases energy expenditure. |
1999-07-13 |
2023-08-12 |
mouse |
| L Brunetti, G Orlando, B Michelotto, E Ragazzoni, M Vacc. Leptin stimulates prostaglandin E2 and F2alpha, but not nitric oxide production in neonatal rat hypothalamus. European journal of pharmacology. vol 369. issue 3. 1999-06-29. PMID:10225366. |
leptin, an adipocyte-derived 16 kda polypeptide hormone, has been found to regulate food intake and thermogenesis by modulating stimulatory and inhibitory pathways in the feeding circuitry of the hypothalamus, among which corticotropin releasing hormone (crh). |
1999-06-29 |
2023-08-12 |
rat |