| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the lack of specificity of neuropeptide y (npy) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and npy gene expression in the rat hypothalamus. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
to evaluate the role of neuropeptide y (npy), a potent appetite stimulant, in controlling food intake and body weight, we investigated the use of antisense oligodeoxynucleotides (odns) to inhibit npy gene expression in the hypothalamus. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the unmodified phosphodiester odn was not detectable in the hypothalamus after 7 days and had no effects on food intake. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the phosphorothioate odn was widely distributed throughout the hypothalamus but had nonselective effects, with similar changes in food intake and npy mrna levels in the antisense and missense groups, and was severely toxic. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the propyl-protected odn appeared to penetrate the hypothalamus well but had no antisense-selective effects on npy mrna levels or food intake. |
1998-06-11 |
2023-08-12 |
rat |
| F H Koegler, S Ritte. Galanin injection into the nucleus of the solitary tract stimulates feeding in rats with lesions of the paraventricular nucleus of the hypothalamus. Physiology & behavior. vol 63. issue 4. 1998-05-21. PMID:9523894. |
galanin injection into the nucleus of the solitary tract stimulates feeding in rats with lesions of the paraventricular nucleus of the hypothalamus. |
1998-05-21 |
2023-08-12 |
rat |
| F H Koegler, S Ritte. Galanin injection into the nucleus of the solitary tract stimulates feeding in rats with lesions of the paraventricular nucleus of the hypothalamus. Physiology & behavior. vol 63. issue 4. 1998-05-21. PMID:9523894. |
however, the threshold for galanin-induced feeding is lower when galanin is injected into the paraventricular nucleus of the hypothalamus (pvn) than when injected into the nts. |
1998-05-21 |
2023-08-12 |
rat |
| C L Marín Bivens, W J Thomas, B G Stanle. Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519273. |
to reveal these patterns, npy (0, 8, 24, 78, 235 pmol/10 nl) was injected into the perifornical hypothalamus (pfh) of satiated adult male rats and their subsequent food intake was monitored every minute for 24 h. for comparison, feeding patterns were similarly observed following fasts of 0, 3, 6, 9, 12, and 24 h. the results demonstrated that npy and food deprivation both produced dose- or deprivation-dependent increases in food intake that were most evident in the first 6 h. the increased intakes induced by npy were characterized by combinations of increased meal size and frequency, with the predominant effects being increases in the size of and decreased latency to eat the first meal. |
1998-05-14 |
2023-08-12 |
rat |
| K Tori. [A new pharmacological and physiological aspects of L-amino acids]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 110 Suppl 1. 1998-05-07. PMID:9503401. |
l-lysine, have been unveiled that the feeding center in the hypothalamus is a primary center nucleus to induce a neuronal plasticity responding to dietary intake of deficient nutrient in the brain and peripherally, such as sense of taste and its concentration change. |
1998-05-07 |
2023-08-12 |
rat |
| D G Baskin, R J Seeley, J L Kuijper, S Lok, D S Weigle, J C Erickson, R D Palmiter, M W Schwart. Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes. vol 47. issue 4. 1998-05-07. PMID:9568684. |
the responsiveness of the hypothalamus to the inhibitory effects of leptin on food intake and body weight is influenced by multiple factors, including deficiency of either leptin or leptin receptors (ob-r). |
1998-05-07 |
2023-08-12 |
mouse |
| P Peyon, X W Lin, B A Himick, R E Pete. Molecular cloning and expression of cDNA encoding brain preprocholecystokinin in goldfish. Peptides. vol 19. issue 2. 1998-04-13. PMID:9493851. |
we have also confirmed the presence of cck mrna in the posterior ventrolateral hypothalamus by in situ hybridization, supporting a role of cck in feeding behavior and regulation of pituitary hormone secretion. |
1998-04-13 |
2023-08-12 |
Not clear |
| K Walder, A Filippis, S Clark, P Zimmet, G R Collie. Leptin inhibits insulin binding in isolated rat adipocytes. The Journal of endocrinology. vol 155. issue 3. 1998-03-09. PMID:9488006. |
leptin is secreted from adipose tissue, and is thought to act as a 'lipostat', signalling the body fat levels to the hypothalamus resulting in adjustments to food intake and energy expenditure to maintain body weight homeostasis. |
1998-03-09 |
2023-08-12 |
rat |
| J K Elmquist, R S Ahima, C F Elias, J S Flier, C B Sape. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 2. 1998-02-24. PMID:9435263. |
the paraventricular nucleus of the hypothalamus (pvh) regulates pituitary gland function and feeding, and innervates autonomic preganglionic neurons, making it a candidate to regulate many of the responses to leptin. |
1998-02-24 |
2023-08-12 |
rat |
| G van Dijk, C de Groote, M Chavez, Y van der Werf, A B Steffens, J H Strubb. Insulin in the arcuate nucleus of the hypothalamus reduces fat consumption in rats. Brain research. vol 777. issue 1-2. 1998-02-24. PMID:9449423. |
data are accumulating that insulin acting in the central nervous system is a physiological regulator of food intake and body weight, presumably via its effect in the hypothalamus. |
1998-02-24 |
2023-08-12 |
rat |
| T E Thiele, G van Dijk, K A Yagaloff, S L Fisher, M Schwartz, P Burn, R J Seele. Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. The American journal of physiology. vol 274. issue 1. 1998-02-23. PMID:9458925. |
similar to leptin, mtii reduced 48-h food intake (1.0 nmol dose), reduced body weight at 24 and 48 h (0.1 and 1.0 nmol doses, respectively), and induced c-fos expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala. |
1998-02-23 |
2023-08-12 |
rat |
| C R Plata-Salamá. Hypothalamus and the control of feeding: fifteen decades of direct association. Nutrition (Burbank, Los Angeles County, Calif.). vol 14. issue 1. 1998-02-20. PMID:9437690. |
hypothalamus and the control of feeding: fifteen decades of direct association. |
1998-02-20 |
2023-08-12 |
Not clear |
| P J Currie, D V Coscin. Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. Neuroreport. vol 8. issue 17. 1998-02-17. PMID:9427365. |
this suggests that 5-ht(2a/2c) receptor modulation of npy feeding within the hypothalamus is localized to the pvn. |
1998-02-17 |
2023-08-12 |
Not clear |
| A Sainsbury, F Rohner-Jeanrenaud, I Cusin, K E Zakrzewska, P A Halban, R C Gaillard, B Jeanrenau. Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia. Diabetologia. vol 40. issue 11. 1998-02-11. PMID:9389418. |
neuropeptide y in the hypothalamus is a potent physiological stimulator of feeding, and may contribute to the characteristic metabolic defects of obesity when hypothalamic levels remain chronically elevated. |
1998-02-11 |
2023-08-12 |
rat |
| T Fujise, H Yoshimatsu, M Kurokawa, A Oohara, M Kang, M Nakata, T Sakat. Satiation and masticatory function modulated by brain histamine in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 217. issue 2. 1998-02-11. PMID:9452148. |
when the ha turnover rate was measured at 15 min after the scheduled feeding following fasting for less than 24 hr, the rate increased in the region including the me5, but not in the hypothalamus. |
1998-02-11 |
2023-08-12 |
rat |
| A Stricker-Krongrad, R Kozak, C Burlet, J P Nicolas, B Bec. Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435668. |
the paraventricular nucleus (pvn) of the hypothalamus is an important site for the regulation of feeding behavior. |
1998-02-09 |
2023-08-12 |
rat |