| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Matsuoka, Y Ogawa, K Hosoda, J Matsuda, H Masuzaki, T Miyawaki, N Azuma, K Natsui, H Nishimura, Y Yoshimasa, S Nishi, D B Thompson, K Naka. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia. vol 40. issue 10. 1998-01-15. PMID:9349603. |
leptin is an adipocyte-derived blood-borne satiety factor that acts on its cognate leptin receptor (ob-r) in the hypothalamus, thereby regulating food intake and energy expenditure. |
1998-01-15 |
2023-08-12 |
human |
| M P Ruffin, P C Even, M El-Ghissassi, S Nicolaidi. Metabolic action of neuropeptide Y in relation to its effect on feeding. Physiology & behavior. vol 62. issue 6. 1997-12-30. PMID:9383111. |
npy was injected into the juxtafornical hypothalamus at a dose that promotes feeding behavior (1 microg/0.5 microl) and enhances locomotor activity. |
1997-12-30 |
2023-08-12 |
Not clear |
| M Quintela, R Señaris, M L Heiman, F F Casanueva, C Diegue. Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels. Endocrinology. vol 138. issue 12. 1997-12-29. PMID:9389553. |
the site of action of leptin is likely to be the hypothalamus, since this area is important in the control of food intake and leptin receptor mrna is particularly abundant in this area. |
1997-12-29 |
2023-08-12 |
rat |
| R Parikh, J L Mark. Metabolic and orexigenic effects of intracerebroventricular neuropeptide Y are attenuated by food deprivation. Journal of neuroendocrinology. vol 9. issue 10. 1997-12-23. PMID:9355048. |
administration of neuropeptide y (npy) into the hypothalamus or cerebral ventricles has been shown to increase food intake, the secretion of hormones such as insulin, glucagon and corticosterone and to alter the metabolism of carbohydrate and lipids. |
1997-12-23 |
2023-08-12 |
rat |
| J Agata, A Masuda, M Takada, K Higashiura, H Murakami, Y Miyazaki, K Shimamot. High plasma immunoreactive leptin level in essential hypertension. American journal of hypertension. vol 10. issue 10 Pt 1. 1997-12-12. PMID:9370390. |
recently it was reported that insulin resistance was related to an elevated plasma level of leptin, which is an adipocyte-specific ob gene product and which plays a role in food intake suppression, thermogenesis, and energy expenditure through the activation of the hypothalamus. |
1997-12-12 |
2023-08-12 |
human |
| J Girar. Is leptin the link between obesity and insulin resistance? Diabetes & metabolism. vol 23 Suppl 3. 1997-12-09. PMID:9342538. |
then leptin binds to a long-form of leptin receptor in the hypothalamus (with a cytoplasmic domain of 302 amino residues) and decreases the production of neuropeptide y, a neuromediator of food intake. |
1997-12-09 |
2023-08-12 |
Not clear |
| H Nishijo, T Kita, R Tamura, S Eifuku, K Terasawa, T On. Motivation-related neuronal activity in the object discrimination task in monkey septal nuclei. Hippocampus. vol 7. issue 5. 1997-12-04. PMID:9347350. |
septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. |
1997-12-04 |
2023-08-12 |
monkey |
| E Rohner-Jeanrenaud, B Jeanrenau. Central nervous system and body weight regulation. Annales d'endocrinologie. vol 58. issue 2. 1997-09-03. PMID:9239233. |
leptin, produced and secreted by adipose tissue, is a potent anorectic agent whose main action is exerted within the hypothalamus in which it has been shown to decrease neuropeptide y, therefore food intake. |
1997-09-03 |
2023-08-12 |
mouse |
| F Jockenhövel, W F Blum, E Vogel, P Englaro, D Müller-Wieland, D Reinwein, W Rascher, W Kron. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. The Journal of clinical endocrinology and metabolism. vol 82. issue 8. 1997-08-28. PMID:9253326. |
the ob gene product leptin (ob) is a feedback signal from the adipocyte to the hypothalamus and is involved in regulation of food intake and energy expenditure in rodents. |
1997-08-28 |
2023-08-12 |
Not clear |
| J W Unger, W Lang. Insulin receptors in the pituitary gland: morphological evidence for influence on opioid peptide-synthesizing cells. Cell and tissue research. vol 288. issue 3. 1997-08-15. PMID:9134860. |
the relationship between beta-endorphin and insulin receptors provides further evidence for the hypothesis that peripheral insulin acts as a regulatory hormone in the control of body energy homeostasis via various steps of the neuroendocrine axis, including opioid peptides in the hypothalamus and pituitary known to play an important role in the regulation of feeding behaviour. |
1997-08-15 |
2023-08-12 |
rat |
| F H Koegler, S Ritte. Aqueduct occlusion does not impair feeding induced by either third or fourth ventricle galanin injection. Obesity research. vol 5. issue 3. 1997-08-12. PMID:9192401. |
exogenous galanin stimulates feeding when injected into forebrain and hindbrain sites, including the third and fourth ventricles (3v and 4v), amygdala, paraventricular nucleus of the hypothalamus (pvn), and nucleus of the solitary tract (nts). |
1997-08-12 |
2023-08-12 |
rat |
| A Sahu, C A Sninsky, S P Kalr. Evidence that hypothalamic neuropeptide Y gene expression and NPY levels in the paraventricular nucleus increase before the onset of hyperphagia in experimental diabetes. Brain research. vol 755. issue 2. 1997-08-07. PMID:9175903. |
several lines of evidence indicate that the site of npy action in transducing feeding signal may reside in the paraventricular nucleus (pvn) and neighboring sites in the hypothalamus. |
1997-08-07 |
2023-08-12 |
rat |
| J D Pomonis, A S Levine, C J Billingto. Interaction of the hypothalamic paraventricular nucleus and central nucleus of the amygdala in naloxone blockade of neuropeptide Y-induced feeding revealed by c-fos expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185555. |
neuropeptide y (npy) is a powerful inducer of food intake with a key site of action in the paraventricular nucleus (pvn) of the hypothalamus. |
1997-07-17 |
2023-08-12 |
Not clear |
| B K Smith, H R Berthoud, D A York, G A Bra. Differential effects of baseline macronutrient preferences on macronutrient selection after galanin, NPY, and an overnight fast. Peptides. vol 18. issue 2. 1997-07-14. PMID:9149292. |
in counterbalanced tests conducted on separate days, saline, galanin, or npy was infused into the paraventricular nucleus of the hypothalamus and 60-min food intake was measured. |
1997-07-14 |
2023-08-12 |
rat |
| F F Matos, V Guss, C Korpine. Effects of neuropeptide Y (NPY) and [D-Trp32]NPY on monoamine and metabolite levels in dialysates from rat hypothalamus during feeding behavior. Neuropeptides. vol 30. issue 4. 1997-05-08. PMID:8914867. |
effects of neuropeptide y (npy) and [d-trp32]npy on monoamine and metabolite levels in dialysates from rat hypothalamus during feeding behavior. |
1997-05-08 |
2023-08-12 |
rat |
| F F Matos, V Guss, C Korpine. Effects of neuropeptide Y (NPY) and [D-Trp32]NPY on monoamine and metabolite levels in dialysates from rat hypothalamus during feeding behavior. Neuropeptides. vol 30. issue 4. 1997-05-08. PMID:8914867. |
since monoamines have been suggested to be involved in npy-induced feeding, we investigated the effects of npy and [d-trp32]npy, a putative npy antagonist, on extracellular levels of norepinephrine (ne), dopamine (da), serotonin (5-ht), 3,4-dihydroxyphenyl acetic acid (dopac), homovanillic acid (hva) and 5-hydroxyindole-3-acetic acid (5-hiaa) in the hypothalamus, including the paraventricular hypothalamic nuclei (pvn), during feeding behavior. |
1997-05-08 |
2023-08-12 |
rat |
| J R Shutter, M Graham, A C Kinsey, S Scully, R Lüthy, K L Star. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes & development. vol 11. issue 5. 1997-04-24. PMID:9119224. |
the expression pattern and transcriptional regulation of art, coupled with the known actions of agouti, suggests a role for art in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and implicates this novel gene in the central control of feeding. |
1997-04-24 |
2023-08-12 |
mouse |
| F Rohner-Jeanrenaud, I Cusin, A Sainsbury, K E Zakrzewska, B Jeanrenau. The loop system between neuropeptide Y and leptin in normal and obese rodents. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 28. issue 12. 1997-04-10. PMID:9013734. |
the hypothalamus is indeed known to modulate food intake and energy partitioning, while the periphery has also been proposed to feed-back on the central nervous system (cns) to provide information on the state of body energy stores, the two together constituting a loop system connecting the brain to the periphery (1,2,3). |
1997-04-10 |
2023-08-12 |
Not clear |
| H T Bergen, C V Mobb. Ventromedial hypothalamic lesions produced by gold thioglucose do not impair induction of NPY mRNA in the arcuate nucleus by fasting. Brain research. vol 707. issue 2. 1997-03-27. PMID:8919304. |
glucose-responsive neurons in the ventromedial nucleus (vmn) of the hypothalamus alter their activity in response to changes in circulating glucose levels and these neurons have been proposed to be involved in the regulation of feeding behavior and metabolism. |
1997-03-27 |
2023-08-12 |
mouse |
| D J Haleem, S Haide. Food restriction decreases serotonin and its synthesis rate in the hypothalamus. Neuroreport. vol 7. issue 6. 1997-03-13. PMID:8817522. |
rats fed on a restricted feeding (rf) schedule of 4 h day-1 to produce a 15-20% reduction in body weight were killed before (starved) and after (fed) the presentation of food on the sixth day to compare 5-hydroxytryptamine (5-ht; serotonin) metabolism and synthesis rate in the hypothalamus with freely feeding (ff) controls. |
1997-03-13 |
2023-08-12 |
rat |