| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Jense. Regulatory peptides and control of food intake in non-mammalian vertebrates. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 128. issue 3. 2001-06-28. PMID:11246039. |
the current view of the control of food intake involves a central feeding system in the hypothalamus receiving input from peripheral systems. |
2001-06-28 |
2023-08-12 |
Not clear |
| H Zheng, C Patterson, H R Berthou. Fourth ventricular injection of CART peptide inhibits short-term sucrose intake in rats. Brain research. vol 896. issue 1-2. 2001-06-28. PMID:11277984. |
expression of cart (cocaine-amphetamine-regulated transcript) in the rat hypothalamus is modulated by nutritional status, and injection of synthetic cart peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. |
2001-06-28 |
2023-08-12 |
rat |
| Y Date, M Nakazato, S Matsukur. [A role for orexins and melanin-concentrating hormone in the central regulation of feeding behavior]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 3. 2001-06-07. PMID:11268588. |
the hypothalamus is the most important region in the control of food intake and body weight. |
2001-06-07 |
2023-08-12 |
Not clear |
| M Niim. [The role of anorectic and orexigenic peptides(CART, NPY etc)]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 3. 2001-06-07. PMID:11268591. |
leptin inhibits food intake and increase energy expenditure via an interaction with specific leptin receptors located in the hypothalamus. |
2001-06-07 |
2023-08-12 |
Not clear |
| V Di Marzo, S K Goparaju, L Wang, J Liu, S Bátkai, Z Járai, F Fezza, G I Miura, R D Palmiter, T Sugiura, G Kuno. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. vol 410. issue 6830. 2001-06-07. PMID:11298451. |
leptin is the primary signal through which the hypothalamus senses nutritional state and modulates food intake and energy balance. |
2001-06-07 |
2023-08-12 |
mouse |
| V Di Marzo, S K Goparaju, L Wang, J Liu, S Bátkai, Z Járai, F Fezza, G I Miura, R D Palmiter, T Sugiura, G Kuno. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. vol 410. issue 6830. 2001-06-07. PMID:11298451. |
however, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide y. cb1 cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus, and marijuana and anandamide stimulate food intake. |
2001-06-07 |
2023-08-12 |
mouse |
| V Di Marzo, S K Goparaju, L Wang, J Liu, S Bátkai, Z Járai, F Fezza, G I Miura, R D Palmiter, T Sugiura, G Kuno. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. vol 410. issue 6830. 2001-06-07. PMID:11298451. |
these findings indicate that endocannabinoids in the hypothalamus may tonically activate cb1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin. |
2001-06-07 |
2023-08-12 |
mouse |
| L O'Rourke, S J Yeaman, P R Shepher. Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334438. |
leptin is produced in adipose tissue and acts in the hypothalamus to regulate food intake. |
2001-05-21 |
2023-08-12 |
Not clear |
| M Liu, T Doi, L Shen, S C Woods, R J Seeley, S Zheng, A Jackman, P Ts. Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology. vol 280. issue 5. 2001-05-17. PMID:11294757. |
we demonstrate for the first time that apo aiv protein and apo aiv mrna are present in rat hypothalamus, a site intimately involved in the integration of signals for regulation of food intake and energy metabolism. |
2001-05-17 |
2023-08-12 |
rat |
| M Liu, T Doi, L Shen, S C Woods, R J Seeley, S Zheng, A Jackman, P Ts. Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology. vol 280. issue 5. 2001-05-17. PMID:11294757. |
intracerebroventricular administration of apo aiv antiserum not only stimulated feeding, but also decreased apo aiv mrna level in the hypothalamus. |
2001-05-17 |
2023-08-12 |
rat |
| W T Chance, S Sheriff, F Peng, A Balasubramania. Antagonism of NPY-induced feeding by pretreatment with cyclic AMP response element binding protein antisense oligonucleotide. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021976. |
to allow determination of the functional nature of creb mediation of npy-induced feeding, injection cannulae were implanted into the perifornical hypothalamus of 18 rats. |
2001-05-03 |
2023-08-12 |
rat |
| S Forbes, S Bui, B R Robinson, U Hochgeschwender, M B Brenna. Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 7. 2001-05-03. PMID:11259669. |
the hyperphagia results, at least in part, from the absence of induction by leptin of melanocyte stimulating hormone (msh) secretion in the hypothalamus; the msh normally then binds to melanocortin-4 receptor expressing neurons and inhibits food intake. |
2001-05-03 |
2023-08-12 |
mouse |
| J DeFalco, M Tomishima, H Liu, C Zhao, X Cai, J D Marth, L Enquist, J M Friedma. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science (New York, N.Y.). vol 291. issue 5513. 2001-04-19. PMID:11283374. |
virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. |
2001-04-19 |
2023-08-12 |
mouse |
| S Haider, D J Halee. Decreases of brain serotonin following a food restriction schedule of 4 weeks in male and female rats. Medical science monitor : international medical journal of experimental and clinical research. vol 6. issue 6. 2001-04-12. PMID:11208456. |
male and female rats fed on a restricted feeding (rf) schedule of 4 weeks to produce 20-25% reduction in body weight, were killed before (starved) and after (fed) the presentation of food to compare 5-hydroxytryptamine (5-ht) metabolism in the hypothalamus with respective freely feeding (ff) controls and to monitor sex differences in rf-induced changes of 5-ht. |
2001-04-12 |
2023-08-12 |
rat |
| E G Kokkotou, N A Tritos, J W Mastaitis, L Slieker, E Maratos-Flie. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. vol 142. issue 2. 2001-03-29. PMID:11159839. |
we have characterized mch-r messenger rna distribution in the mouse brain by in situ hybridization and have shown mch-r to be expressed in diverse brain areas implicated in the regulation of feeding, body adiposity, and sensory integration of smell and gustatory inputs, including the hypothalamus [paraventricular nucleus (magnocellular part) and dorsomedial, ventromedial, and arcuate nucleus], areas of the olfactory pathway, and the nucleus of the solitary tract. |
2001-03-29 |
2023-08-12 |
mouse |
| E Jones, A Syme. Leptin and TGF-beta synergistically regulate VIP cytokine response element transcription. Neuroreport. vol 11. issue 18. 2001-03-29. PMID:11192627. |
leptin was originally described as an adipocyte-derived cytokine that signals to the hypothalamus to regulate food intake and energy expenditure. |
2001-03-29 |
2023-08-12 |
Not clear |
| T Masaki, H Yoshimatsu, S Chiba, T Watanabe, T Sakat. Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice. Diabetes. vol 50. issue 2. 2001-03-29. PMID:11272151. |
histamine neurons are widely distributed in the brain and suppress food intake through the histamine h1 receptor (h1-r) in the hypothalamus. |
2001-03-29 |
2023-08-12 |
mouse |
| Z Díaz-Cabiale, J A Narváez, M García-Coronel, K Fux. Galanin/alpha2-adrenoceptor interactions in telencephalic and diencephalic regions of the rat. Neuroreport. vol 12. issue 1. 2001-03-22. PMID:11201077. |
these findings suggest the existence of an antagonistic galanin/alpha2 adrenoceptor interaction in the medial hypothalamus and amygdala that may be of relevance for alpha2-adrenoceptor-regulated neuroendocrine functions and food intake. |
2001-03-22 |
2023-08-12 |
rat |
| I J Clarke, B Henry, J Iqbal, J W Godin. Leptin and the regulation of food intake and the neuroendocrine axis in sheep. Clinical and experimental pharmacology & physiology. vol 28. issue 1-2. 2001-03-08. PMID:11153524. |
alterations in bodyweight (leptin status) affect the expression of a number of genes in the hypothalamus that are involved in the regulation of food intake and neuroendocrine function. |
2001-03-08 |
2023-08-12 |
Not clear |
| S O Fetissov, M M Meguid, C Chen, G Miyat. Synchronized release of dopamine and serotonin in the medial and lateral hypothalamus of rats. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113314. |
the data also illustate that food intake is coupled unequivocally to the release of dopamine and serotonin in the hypothalamus, suggesting it as a mechanism of activation of postsynaptic neurons associated with new metabolic status. |
2001-03-01 |
2023-08-12 |
rat |