| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paty Karoll Picardi, Vivian Cristine Calegari, Patricia Oliveira Prada, Patrícia de Oliveira Prada, Juliana Contin Moraes, Eliana Araújo, Maria Cristina Cintra Gomes Marcondes, Miriam Ueno, José Barreto Campello Carvalheira, Licio Augusto Velloso, Mario José Abdalla Saa. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology. vol 149. issue 8. 2008-08-26. PMID:18467448. |
the selective decrease in hypothalamic ptp1b resulted in decreased food intake, reduced body weight, reduced adiposity after high-fat feeding, improved leptin and insulin action and signaling in hypothalamus, and may also have a role in the improvement in glucose metabolism in diabetes-induced obese rats. |
2008-08-26 |
2023-08-12 |
mouse |
| N Taleux, I De Potter, C Deransart, G Lacraz, R Favier, X M Leverve, L Hue, B Guiga. Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity. International journal of obesity (2005). vol 32. issue 4. 2008-08-22. PMID:18059408. |
the amp-activated protein kinase (ampk) is involved in the control of food intake by the hypothalamus. |
2008-08-22 |
2023-08-12 |
rat |
| Waljit S Dhill. Appetite regulation: an overview. Thyroid : official journal of the American Thyroid Association. vol 17. issue 5. 2008-08-21. PMID:17542673. |
the hypothalamus is critical in the regulation of food intake containing neural circuits, which produce a number of peptides that influence food intake. |
2008-08-21 |
2023-08-12 |
Not clear |
| Waljit S Dhill. Appetite regulation: an overview. Thyroid : official journal of the American Thyroid Association. vol 17. issue 5. 2008-08-21. PMID:17542673. |
circulating factors that affect food intake mediate their effects by signaling to the hypothalamus and/or brainstem. |
2008-08-21 |
2023-08-12 |
Not clear |
| Jing-Ning Zhu, Jian-Jun Wan. The cerebellum in feeding control: possible function and mechanism. Cellular and molecular neurobiology. vol 28. issue 4. 2008-08-07. PMID:18027085. |
although the exact mechanisms underlying the cerebellar regulation of food intake is still unclear, a series of studies have demonstrated that there are neural pathways directly and/or indirectly connecting the cerebellum with several important centers for feeding control, such as the hypothalamus. |
2008-08-07 |
2023-08-12 |
Not clear |
| Derek LeRoit. Dyslipidemia and glucose dysregulation in overweight and obese patients. Clinical cornerstone. vol 8. issue 3. 2008-08-01. PMID:18452841. |
the endocannabinoid system plays an important role in regulating metabolism through its effects on food intake at the level of the hypothalamus and on body composition through peripheral effects on adipose tissue. |
2008-08-01 |
2023-08-12 |
Not clear |
| Claire Thornton, Alessandro Sardini, David Carlin. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. The Journal of biological chemistry. vol 283. issue 25. 2008-07-25. PMID:18436530. |
these data support a hypothesis that modulating basal ampk activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake. |
2008-07-25 |
2023-08-12 |
human |
| Volker Schusdziarra, Jens-Peter Zimmermann, Johannes Erdmann, Ulrich Bader, Rafael R Schic. Differential inhibition of galanin- and ghrelin-induced food intake by i.c.v. GLP-1(7-36)-amide. Regulatory peptides. vol 147. issue 1-3. 2008-07-21. PMID:18281111. |
feeding regulation involves both anorectic and orexigenic neuropeptides mainly located in the hypothalamus. |
2008-07-21 |
2023-08-12 |
rat |
| Miguel López, Ricardo Lage, Asish K Saha, Diego Pérez-Tilve, María J Vázquez, Luis Varela, Susana Sangiao-Alvarellos, Sulay Tovar, Kawtar Raghay, Sergio Rodríguez-Cuenca, Rosangela M Deoliveira, Tamara Castañeda, Rakesh Datta, Jesse Z Dong, Michael Culler, Mark W Sleeman, Clara V Alvarez, Rosalía Gallego, Christopher J Lelliott, David Carling, Matthias H Tschöp, Carlos Diéguez, Antonio Vidal-Pui. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell metabolism. vol 7. issue 5. 2008-07-17. PMID:18460330. |
thus, decreasing ampk activity in the ventromedial nucleus of the hypothalamus (vmh) is sufficient to inhibit ghrelin's effects on fas expression and feeding. |
2008-07-17 |
2023-08-12 |
Not clear |
| Saima Malik, Francis McGlone, Diane Bedrossian, Alain Daghe. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell metabolism. vol 7. issue 5. 2008-07-17. PMID:18460331. |
hedonic feeding, which can be triggered by visual or olfactory food cues, involves brain regions that play a role in reward and motivation, while homeostatic feeding is thought to be under the control of circulating hormones acting primarily on the hypothalamus. |
2008-07-17 |
2023-08-12 |
human |
| Andressa Coope, Marciane Milanski, Eliana P Araújo, Marcos Tambascia, Mário J A Saad, Bruno Geloneze, Lício A Vellos. AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS letters. vol 582. issue 10. 2008-07-09. PMID:18394428. |
thus, adiponectin acts in the hypothalamus, activating elements of the canonical insulin and leptin signaling pathways and promoting reduction of food intake. |
2008-07-09 |
2023-08-12 |
Not clear |
| V Saroja Voruganti, M Elizabeth Tejero, J Michael Proffitt, Shelley A Cole, Laura A Cox, Michael C Mahaney, Jeffery A Rogers, Jeanne H Freeland-Graves, Anthony G Comuzzi. Characterization of ghrelin in pedigreed baboons: evidence for heritability and pleiotropy. Obesity (Silver Spring, Md.). vol 16. issue 4. 2008-06-18. PMID:18239597. |
ghrelin is an orexigenic hormone that is produced primarily in the stomach, and stimulates food intake via its receptors situated in the hypothalamus. |
2008-06-18 |
2023-08-12 |
Not clear |
| Keith W Whitaker, Teresa M Reye. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology. vol 54. issue 3. 2008-06-12. PMID:18082228. |
the two cytokines elicited a comparable decrease in food intake and activated similar numbers of cells in the paraventricular nucleus of the hypothalamus (pvh), a region that plays a critical role in the regulation of appetite and metabolism (determined via expression of the immediate early gene, c-fos). |
2008-06-12 |
2023-08-12 |
Not clear |
| Benjamin C T Field, Alison M Wren, Dunstan Cooke, Stephen R Bloo. Gut hormones as potential new targets for appetite regulation and the treatment of obesity. Drugs. vol 68. issue 2. 2008-05-19. PMID:18197723. |
food intake and bodyweight are tightly regulated by the brainstem, hypothalamus and reward circuits. |
2008-05-19 |
2023-08-12 |
Not clear |
| Gavin P Reynolds, Matthew J Hill, Shona L Kir. The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics. Journal of psychopharmacology (Oxford, England). vol 20. issue 4 Suppl. 2008-05-15. PMID:16785265. |
animal studies indicate that the drugs most likely to cause weight gain, clozapine and olanzapine, have direct effects on the npy-containing neurons of the hypothalamus; these neurons mediate the effects of the circulating anorexigenic hormone leptin on the control of food intake. |
2008-05-15 |
2023-08-12 |
Not clear |
| B G Hoebel, P J Wellma. Overview of methodological approaches to the study of ingestive behavior. Current protocols in neuroscience. vol Chapter 8. 2008-05-13. PMID:18428544. |
some examples of procedures used by feeding researchers are discussed in this unit and include ablation of neural function; inhibition of behaviors by selective neurotoxins and antisense oligonucleotides; staining of sensory and motor mechanisms; electrical stimulation of the brain; local injection and microdialysis of nutrients, neurotransmitters, and drugs; autoradiography and in situ hybridization of neurotransmitters with their receptors; electrophysiological techniques for multi- and single-unit recording of cells in the hypothalamus; and gene technology using inbred strains of genetically obese mice. |
2008-05-13 |
2023-08-12 |
mouse |
| Rinko Kawagoe, Yukiyo Yamamoto, Kazuyasu Kubo, Kazushige Dobashi, Kohtaro Asayama, Yoichi Ueta, Akira Shirahat. Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus. Regulatory peptides. vol 145. issue 1-3. 2008-05-06. PMID:17950941. |
neuropeptide y (npy) and proopiomelanocortin (pomc) mrna in the hypothalamus were also examined because they are important in the regulation of food intake. |
2008-05-06 |
2023-08-12 |
rat |
| Beatriz Merino, Victoria Cano, Rocío Guzmán, Beatriz Somoza, Mariano Ruiz-Gay. Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats. Endocrinology. vol 149. issue 4. 2008-05-06. PMID:18096657. |
we have characterized, in free-feeding rats, the effect of cck-8 on 1) food intake, bw, and adiposity; 2) skeletal muscle metabolism; 3) leptin signaling pathway within the arcuate nucleus of the hypothalamus; and 4) the permeability of brain barriers to leptin. |
2008-05-06 |
2023-08-12 |
rat |
| Coralia Pérez, Teresa Fernández-Agulló, Alain J De Solís, Manuel Ros, Antonio Andrés, José M Carrascos. Effects of chronic acarbose treatment on adipocyte insulin responsiveness, serum levels of leptin and adiponectin and hypothalamic NPY expression in obese diabetic Wistar rats. Clinical and experimental pharmacology & physiology. vol 35. issue 3. 2008-04-29. PMID:18290871. |
acarbose neither decreases food intake nor reverts obesity, but decreases leptin levels and the expression of the orexigenic npy in the hypothalamus. |
2008-04-29 |
2023-08-12 |
rat |
| Rachael A Augustine, Sharon R Ladyman, David R Gratta. From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy. The Journal of physiology. vol 586. issue 2. 2008-04-23. PMID:18033810. |
thus, hormonal changes associated with pregnancy induce adaptive changes in the maternal hypothalamus, stimulating food intake and then allowing elevated food intake to be maintained in the face of elevated leptin levels, resulting in fat deposition to provide energy stores in preparation for the high metabolic demands of late pregnancy and lactation. |
2008-04-23 |
2023-08-12 |
rat |