| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher D Morrison, Scott D Reed, Tara M Henaga. Homeostatic regulation of protein intake: in search of a mechanism. American journal of physiology. Regulatory, integrative and comparative physiology. vol 302. issue 8. 2012-06-18. PMID:22319049. |
recent work suggests that the amino acid leucine regulates food intake by altering mtor and ampk signaling in the hypothalamus, while activation of gcn2 within the anterior piriform cortex contributes to the detection and avoidance of amino acid-imbalanced diets. |
2012-06-18 |
2023-08-12 |
Not clear |
| Gustavo D Pimentel, Fábio S Lira, José C Rosa, Juliana L Oliveira, Ana C Losinskas-Hachul, Gabriel I H Souza, Maria das Graças T do Carmo, Ronaldo V T Santos, Marco T de Mello, Sérgio Tufik, Marília Seelaender, Lila M Oyama, Cláudia M Oller do Nascimento, Regina H Watanabe, Eliane B Ribeiro, Luciana P Pisan. Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFκBp65 signaling in adult offspring. The Journal of nutritional biochemistry. vol 23. issue 3. 2012-06-04. PMID:21543208. |
we examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. |
2012-06-04 |
2023-08-12 |
rat |
| Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M Reye. Epigenetic dysregulation of the dopamine system in diet-induced obesity. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22220805. |
dopamine (da) system changes in response to hf diet have been observed in the hypothalamus, important in the homeostatic control of food intake, as well as within the central reward circuitry [ventral tegmental area (vta), nucleus accumbens (nac), and pre-frontal cortex (pfc)], critical for coding the rewarding properties of palatable food and important in hedonically driven feeding behavior. |
2012-06-01 |
2023-08-12 |
mouse |
| B Kerbel, S Unniappa. Nesfatin-1 suppresses energy intake, co-localises ghrelin in the brain and gut, and alters ghrelin, cholecystokinin and orexin mRNA expression in goldfish. Journal of neuroendocrinology. vol 24. issue 2. 2012-05-17. PMID:22023656. |
furthermore, co-localisation of ghrelin and nesfatin-1 was also observed in the posterior nucleus lateralis tuberis of the goldfish hypothalamus, a brain region implicated in the regulation of food intake. |
2012-05-17 |
2023-08-12 |
rat |
| B Kerbel, S Unniappa. Nesfatin-1 suppresses energy intake, co-localises ghrelin in the brain and gut, and alters ghrelin, cholecystokinin and orexin mRNA expression in goldfish. Journal of neuroendocrinology. vol 24. issue 2. 2012-05-17. PMID:22023656. |
administration of goldfish (gf) nesfatin-1 [25 ng/g body weight (bw)], suppressed food intake and the expression of mrnas encoding preproghrelin, ghrelin receptor (ghs-r 1a-1), cck and nucb2 in the forebrain of fed fish, as well as ghrelin and nucb2 mrna in the hypothalamus of unfed fish, both at 1 h post-injection. |
2012-05-17 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konture. Gut clock: implication of circadian rhythms in the gastrointestinal tract. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 62. issue 2. 2012-05-15. PMID:21673361. |
biological rhythms are responsible for daily food intake; the period of hunger and satiety is controlled by the central pacemaker, which resides in the suprachiasmatic nucleus (scn) of the hypothalamus, and communicates with tissues via bidirectional neuronal and humoral pathways. |
2012-05-15 |
2023-08-12 |
human |
| D Grahame Hardie, Fiona A Ross, Simon A Hawle. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews. Molecular cell biology. vol 13. issue 4. 2012-05-11. PMID:22436748. |
for example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. |
2012-05-11 |
2023-08-12 |
Not clear |
| Chung Owyang, Andrea Heldsinge. Vagal control of satiety and hormonal regulation of appetite. Journal of neurogastroenterology and motility. vol 17. issue 4. 2012-05-04. PMID:22148102. |
in addition to the hypothalamus, the vagus nerve is critically involved in the control of feeding by transmitting signals arising from the upper gut to the nucleus of the solitary tract. |
2012-05-04 |
2023-08-12 |
Not clear |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
this study aimed to determine whether dpp-iv inhibitor-induced elevation of portal glp-1 levels affect insulin secretion and feeding behavior via the vagal afferent nerve and hypothalamus. |
2012-05-03 |
2023-08-12 |
rat |
| Eric D Berglund, Claudia R Vianna, Jose Donato, Mi Hwa Kim, Jen-Chieh Chuang, Charlotte E Lee, Danielle A Lauzon, Peagan Lin, Laura J Brule, Michael M Scott, Roberto Coppari, Joel K Elmquis. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. The Journal of clinical investigation. vol 122. issue 3. 2012-04-30. PMID:22326958. |
reexpression of lepr only in pomc neurons in the arcuate nucleus of the hypothalamus did not reduce food intake, but partially normalized energy expenditure and modestly reduced body weight. |
2012-04-30 |
2023-08-12 |
mouse |
| Elizabeth C Cottrell, Julian G Merce. Leptin receptors. Handbook of experimental pharmacology. issue 209. 2012-04-25. PMID:22249808. |
leptin receptors are found in each of the major components of the cns "feeding" circuitry-the brainstem, hypothalamus and distributed reward centres. |
2012-04-25 |
2023-08-12 |
human |
| Bernard Thoren. Sensing of glucose in the brain. Handbook of experimental pharmacology. issue 209. 2012-04-25. PMID:22249819. |
the brain, and in particular the hypothalamus and brainstem, have been recognized for decades as important centers for the homeostatic control of feeding, energy expenditure, and glucose homeostasis. |
2012-04-25 |
2023-08-12 |
Not clear |
| P J Verhulst, S Janssen, J Tack, I Depoorter. Role of the AMP-activated protein kinase (AMPK) signaling pathway in the orexigenic effects of endogenous ghrelin. Regulatory peptides. vol 173. issue 1-3. 2012-04-19. PMID:21963822. |
ghrelin, released from the stomach, stimulates food intake through activation of the ghrelin receptor (ghs-r) located on neuropeptide y (npy)/agouti-related peptide (agrp) neurons in the hypothalamus. |
2012-04-19 |
2023-08-12 |
mouse |
| Karolina P Skibicka, Suzanne L Dickso. Ghrelin and food reward: the story of potential underlying substrates. Peptides. vol 32. issue 11. 2012-04-16. PMID:21621573. |
research investigating mechanisms underlying obesity and the control of food intake has recently experienced a major shift in focus, from the brain's hypothalamus to additional important neural circuits controlling emotion, cognition and motivated behavior. |
2012-04-16 |
2023-08-12 |
Not clear |
| Tadashi Yoshida, Laura Semprun-Prieto, Richard D Wainford, Sergiy Sukhanov, Daniel R Kapusta, Patrice Delafontain. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. vol 153. issue 3. 2012-04-16. PMID:22234465. |
angiotensin ii reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. |
2012-04-16 |
2023-08-12 |
mouse |
| Tadashi Yoshida, Laura Semprun-Prieto, Richard D Wainford, Sergiy Sukhanov, Daniel R Kapusta, Patrice Delafontain. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. vol 153. issue 3. 2012-04-16. PMID:22234465. |
intracerebroventricular ang ii infusion (50 ng/kg · min) caused a reduction of food intake, and ang ii dose dependently reduced npy and orexin expression in the hypothalamus cultured ex vivo. |
2012-04-16 |
2023-08-12 |
mouse |
| Melissa J Chee, Christopher J Price, Michael A Statnick, William F Colmer. Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus. The Journal of physiology. vol 589. issue Pt 13. 2012-04-13. PMID:21502286. |
nociceptin or orphanin fq (n/ofq) stimulates food intake when injected into the ventromedial nucleus of the hypothalamus (vmn). |
2012-04-13 |
2023-08-12 |
Not clear |
| Noriko Amiya, Kanta Mizusawa, Yuki Kobayashi, Takeshi Yamanome, Masafumi Amano, Akiyoshi Takahash. Food deprivation increases the expression of the prepro-orexin gene in the hypothalamus of the barfin flounder, Verasper moseri. Zoological science. vol 29. issue 1. 2012-04-10. PMID:22233495. |
these results show that fasting regulates orexin mrna in the hypothalamus and suggest that orexin is involved in feeding regulation in barfin flounder. |
2012-04-10 |
2023-08-12 |
Not clear |
| Makoto Hamao, Hisashi Matsuda, Seikou Nakamura, Souichi Nakashima, Shunsuke Semura, Saori Maekubo, Sachiyo Wakasugi, Masayuki Yoshikaw. Anti-obesity effects of the methanolic extract and chakasaponins from the flower buds of Camellia sinensis in mice. Bioorganic & medicinal chemistry. vol 19. issue 20. 2012-03-29. PMID:21925888. |
the n-buoh-soluble fraction and chakasaponin ii suppressed mrna levels of neuropeptide y (npy), an important regulator of body weight through its effects on food intake and energy expenditure, in the hypothalamus. |
2012-03-29 |
2023-08-12 |
mouse |
| Makoto Hamao, Hisashi Matsuda, Seikou Nakamura, Souichi Nakashima, Shunsuke Semura, Saori Maekubo, Sachiyo Wakasugi, Masayuki Yoshikaw. Anti-obesity effects of the methanolic extract and chakasaponins from the flower buds of Camellia sinensis in mice. Bioorganic & medicinal chemistry. vol 19. issue 20. 2012-03-29. PMID:21925888. |
these findings suggested that the active saponins suppressed the appetite signals in the hypothalamus through stimulation of the capsaicin-sensitive sensory nerves, probably vagal afferent nerves, or enhancement of 5-ht release from the ilea, leading to reduced food intake and body weight gain. |
2012-03-29 |
2023-08-12 |
mouse |