| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica Santollo, Dachun Yao, Genevieve Neal-Perry, Anne M Etge. Middle-aged female rats retain sensitivity to the anorexigenic effect of exogenous estradiol. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22522024. |
next, we investigated whether genes that mediate the estrogenic inhibition of food intake are similarly responsive to e2 by measuring gene expression of the anorexigenic genes corticotropin-releasing hormone (crh), proopiomelanocortin (pomc), the long form of the leptin receptor (lepr) and serotonin 2c receptors (5ht2cr) and the orexigenic genes agouti-related peptide (agrp), neuropeptide y (npy), prepromelanin-concentrating hormone (pmch) and orexin in the hypothalamus of young and middle-aged ovx rats treated with e2. |
2012-09-27 |
2023-08-12 |
rat |
| Jun-Ping Wen, Chune Liu, Wen-Kai Bi, Ya-Ting Hu, Qingshi Chen, Huibing Huang, Ji-Xing Liang, Lian-Tao Li, Li-Xiang Lin, Gang Che. Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons. The Journal of endocrinology. vol 214. issue 2. 2012-09-26. PMID:22582096. |
adiponectin secreted from adipose tissues plays a role in the regulation of energy homeostasis, food intake, and reproduction in the hypothalamus. |
2012-09-26 |
2023-08-12 |
rat |
| Faith K McDaniel, Brent M Molden, Sameer Mohammad, Giovanna Baldini, Lakisha McPike, Paola Narducci, Susana Granell, Giulia Baldin. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH). The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22544740. |
melanocortin-4 receptor (mc4r) is a g-protein-coupled receptor expressed in the hypothalamus where it controls feeding behavior. |
2012-09-20 |
2023-08-12 |
Not clear |
| Lei Liu, Zhigang Song, Ardashir Sheikhahmadi, Hongchao Jiao, Hai Li. Effect of corticosterone on gene expression of feed intake regulatory peptides in laying hens. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 162. issue 4. 2012-09-20. PMID:22554475. |
in conclusion, these results suggest that cort plays a unique role in some special neuropeptides (e.g., ghrelin, cart, pomc, cck and mcrs) and a dynamic balance between these appetite-associated peptides in the hypothalamus and the gastrointestinal tract defines the feeding status of cort-exposed laying hens. |
2012-09-20 |
2023-08-12 |
Not clear |
| Clare L Adam, Patricia A Findlay, Raymond P Aitken, John S Milne, Jacqueline M Wallac. In vivo changes in central and peripheral insulin sensitivity in a large animal model of obesity. Endocrinology. vol 153. issue 7. 2012-09-20. PMID:22593271. |
here we examined in vivo peripheral and central insulin sensitivity, and whether central insensitivity in terms of the voluntary food intake (vfi) response occurs within the hypothalamus or at blood-brain transfer level, during obesity and after subsequent weight loss. |
2012-09-20 |
2023-08-12 |
Not clear |
| Edward M Stricke. Neurochemical and behavioral analyses of the lateral hypothalamic syndrome: a look back. Behavioural brain research. vol 231. issue 2. 2012-09-12. PMID:22245255. |
his early research clarified key issues regarding the effects of electrolytic lesions of the ventromedial or ventrolateral hypothalamus on food intake in rats, a subject of paramount interest during the 1950s and 1960s. |
2012-09-12 |
2023-08-12 |
human |
| Carina S Solon, Daniel Franci, Letícia M Ignacio-Souza, Talita Romanatto, Erika A Roman, Ana P Arruda, Joseane Morari, Adriana S Torsoni, Everardo M Carneiro, Licio A Vellos. Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino acids. vol 42. issue 6. 2012-09-10. PMID:21818562. |
thus, the aminoacid, taurine, exerts a potent anorexigenic action in the hypothalamus and enhances the effect of insulin on the control of food intake. |
2012-09-10 |
2023-08-12 |
rat |
| Claudia Juárez, Elvira Morgado, Stefan M Waliszewski, Armando J Martínez, Enrique Meza, Mario Cab. Synchronization of PER1 protein in parabrachial nucleus in a natural model of food anticipatory activity. The European journal of neuroscience. vol 35. issue 9. 2012-09-10. PMID:22471601. |
scheduled food intake synchronizes several nuclei in the brain, and the hypothalamus has received particular attention. |
2012-09-10 |
2023-08-12 |
human |
| Pawel K Olszewski, Jan Rozman, Josefin A Jacobsson, Birgit Rathkolb, Siv Strömberg, Wolfgang Hans, Anica Klockars, Johan Alsiö, Ulf Risérus, Lore Becker, Sabine M Hölter, Ralf Elvert, Nicole Ehrhardt, Valérie Gailus-Durner, Helmut Fuchs, Robert Fredriksson, Eckhard Wolf, Thomas Klopstock, Wolfgang Wurst, Allen S Levine, Claude Marcus, Martin Hrabě de Angelis, Martin Klingenspor, Helgi B Schiöth, Manfred W Kiliman. Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS genetics. vol 8. issue 3. 2012-09-04. PMID:22438821. |
expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time pcr showed differential expression of a subset of neuropeptide or neuropeptide receptor mrnas between wt and nbea+/- mice in the sated state and in response to food deprivation, but not to feeding reward. |
2012-09-04 |
2023-08-12 |
mouse |
| Gregory L Florant, Jessica E Heal. The regulation of food intake in mammalian hibernators: a review. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 182. issue 4. 2012-08-27. PMID:22080368. |
it is well known from lesion experiments in non-hibernators that the hypothalamus is the main brain region controlling food intake and therefore body mass. |
2012-08-27 |
2023-08-12 |
Not clear |
| Dayne Beccano-Kelly, Jenni Harve. Leptin: a novel therapeutic target in Alzheimer's disease? International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22254146. |
it is well established that the hormone leptin circulates in the plasma in amounts proportional to body fat content and it regulates food intake and body weight via its actions in the hypothalamus. |
2012-08-23 |
2023-08-12 |
Not clear |
| Gustavo D Pimentel, Thayana O Micheletti, Fernanda Pace, José C Rosa, Ronaldo V T Santos, Fabio S Lir. Gut-central nervous system axis is a target for nutritional therapies. Nutrition journal. vol 11. 2012-08-23. PMID:22490672. |
at this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. |
2012-08-23 |
2023-08-12 |
Not clear |
| Francisco Javier Bermudez-Silva, Pierre Cardinal, Daniela Cot. The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. Journal of psychopharmacology (Oxford, England). vol 26. issue 1. 2012-08-21. PMID:21824982. |
here we critically discuss the role of the endocannabinoid signalling in brain structures, such as the hypothalamus and reward-related areas, and its interaction with neurotransmitter and neuropeptide systems involved in the regulation of food intake and body weight. |
2012-08-21 |
2023-08-12 |
human |
| Maitrayee Sahu, David G Litvin, Abhiram Sah. Phosphodiesterase-3B is expressed in proopiomelanocortin and neuropeptide Y neurons in the mouse hypothalamus. Neuroscience letters. vol 505. issue 2. 2012-08-16. PMID:22001576. |
leptin signaling in the hypothalamus is obligatory for normal food intake and body weight homeostasis. |
2012-08-16 |
2023-08-12 |
mouse |
| Xiang-Rong Sun, Ming Tang, Zheng-Yao Jian. [Effect of motilin receptor agonist-erythromycin on the glucose responsive neurons in hypothalamus of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 21. issue 3. 2012-08-06. PMID:21162186. |
in order to explore the mechanism of central motilin-induced feeding behavior, the effects of erythromycin, a motilin receptor agonist, on glucose responsive neurons in hypothalamus were observed. |
2012-08-06 |
2023-08-12 |
rat |
| Ji-Yao Li, Biaoxin Chai, Weizhen Zhang, Xiaobin Wu, Chao Zhang, Danielle Fritze, Zefeng Xia, Cam Patterson, Michael W Mulhollan. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC neuroscience. vol 12. 2012-07-26. PMID:21955513. |
the arcuate nucleus of the hypothalamus regulates food intake. |
2012-07-26 |
2023-08-12 |
Not clear |
| Wataru Iio, Yuka Tokutake, Noriko Matsukawa, Takamitsu Tsukahara, Shigeru Chohnan, Atsushi Toyod. Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats. Biochemical and biophysical research communications. vol 421. issue 2. 2012-07-09. PMID:22503976. |
hypothalamic malonyl-coa controlled feeding behavior and elevation of malonyl-coa in the hypothalamus induced inhibition of food intake. |
2012-07-09 |
2023-08-12 |
rat |
| Wataru Iio, Yuka Tokutake, Noriko Matsukawa, Takamitsu Tsukahara, Shigeru Chohnan, Atsushi Toyod. Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats. Biochemical and biophysical research communications. vol 421. issue 2. 2012-07-09. PMID:22503976. |
our findings suggest that the suppression of body weight gain caused by social defeat stress is caused by anorexic feeding behavior via an increased concentration of malonyl-coa in the hypothalamus. |
2012-07-09 |
2023-08-12 |
rat |
| Agustina Cabral, Olga Suescun, Jeffrey M Zigman, Mario Perell. Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363652. |
ghrelin administration directly into the paraventricular nucleus of the hypothalamus also induces c-fos within the crf-producing neurons and the hypothalamic-pituitary-adrenal axis, without any significant effect on the food intake. |
2012-06-29 |
2023-08-12 |
mouse |
| N Cummings, K A Shields, J E Curran, K Bozaoglu, J Trevaskis, K Gluschenko, G Cai, A G Comuzzie, T D Dyer, K R Walder, P Zimmet, G R Collier, J Blangero, J B M Jowet. Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. International journal of obesity (2005). vol 36. issue 2. 2012-06-22. PMID:21407171. |
the sh3-domain grb2-like (endophilin)-interacting protein 1 (sgip1) gene has been shown to be differentially expressed in the hypothalamus of lean versus obese israeli sand rats (psammomys obesus), and is suspected of having a role in regulating food intake. |
2012-06-22 |
2023-08-12 |
human |