| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenyan He, Linh Lieu, Yanbin Dong, Sadia Afrin, Dominic Chau, Anita Kabahizi, Briana Wallace, Jianhong Cao, Eun-Sang Hwang, Ting Yao, Yiru Huang, Jennifer Okolo, Bo Cheng, Yong Gao, Ling Hu, Kevin W William. PERK in POMC neurons connects celastrol with metabolism. JCI insight. vol 6. issue 18. 2021-10-09. PMID:34549728. |
chemically lowering protein kinase r-like er kinase (perk) activity within the hypothalamus leads to decreased food intake and body weight. |
2021-10-09 |
2023-08-13 |
mouse |
| Yi Wang, Adelaide Bernard, Fanny Comblain, Xinyu Yue, Christophe Paillart, Sumei Zhang, Jeremy F Reiter, Christian Vaiss. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. The Journal of clinical investigation. vol 131. issue 9. 2021-10-05. PMID:33938449. |
using targeted deletion of primary cilia, we found that cilia in the paraventricular nucleus of the hypothalamus (pvn) were essential to restrict food intake. |
2021-10-05 |
2023-08-13 |
mouse |
| Kristie B Yu, Elaine Y Hsia. Roles for the gut microbiota in regulating neuronal feeding circuits. The Journal of clinical investigation. vol 131. issue 10. 2021-10-05. PMID:33998595. |
we discuss effects of the gut microbiota on the vagus nerve and brain regions including the hypothalamus, mesolimbic system, and prefrontal cortex, which play key roles in regulating feeding behavior. |
2021-10-05 |
2023-08-13 |
Not clear |
| Eunjin Kwon, Young-Hwan J. Activation of the ARC Frontiers in neural circuits. vol 14. 2021-10-04. PMID:33250721. |
activation of the arc proopiomelanocortin (pomc) neurons in the arcuate nucleus of the hypothalamus (arc) plays an essential role in the control of food intake and energy expenditure. |
2021-10-04 |
2023-08-13 |
Not clear |
| Carlos F Aylwin, Alejandro Lomnicz. Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism. Current opinion in endocrine and metabolic research. vol 14. 2021-10-02. PMID:32905232. |
in the arcuate nucleus (arc) of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. |
2021-10-02 |
2023-08-13 |
Not clear |
| Yuko Nakamura, Mariko Takahashi, Yukiko Inoue, Shintaro Yanagimoto, Kazuo Okanoya, Shinsuke Koik. Nutrient infusion evoked magnetic resonance imaging signal in the human hypothalamus. Nutritional neuroscience. 2021-09-30. PMID:34590989. |
the hypothalamus receives ingested nutrient information via ascending gut-related projections and plays a significant role in the regulation of food intake. |
2021-09-30 |
2023-08-13 |
human |
| Vanessa Feistauer, Joana Fisch, Carolina Kalkmann da Silva Oliveira, Márcia Giovenardi, Silvana Almeid. Restriction and hyperlipidic diets during pregnancy, lactation and adult life modified the expression of dopaminergic system related genes both in female mice and their adult offspring. Brain research bulletin. vol 162. 2021-09-29. PMID:32619693. |
two main cerebral areas are responsible for controlling feeding through hunger and food reward: the hypothalamus (hpt) and the ventral tegmental area (vta), respectively. |
2021-09-29 |
2023-08-13 |
mouse |
| Yewei Wang, Dandan Wang, Yan Chen, Xinyu Fang, Lingfang Yu, Chen Zhan. A Novel Synthetic Interfering Peptide Tat-3L4F Attenuates Olanzapine-Induced Weight Gain Through Disrupting Crosstalk Between Serotonin Receptor 2C and Protein Phosphatase and Tensin Homolog in Rats. The international journal of neuropsychopharmacology. vol 23. issue 8. 2021-09-21. PMID:32710540. |
serotonin 5-ht2c receptor (htr2c) plays a critical role in hyperphagia and weight gain induced by aaps, and expression of phosphatase tensin homolog (pten) in the hypothalamus also affects feeding behavior and weight change. |
2021-09-21 |
2023-08-13 |
rat |
| Karim Nagi, Abdella M Habi. Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity. Cellular signalling. vol 83. 2021-09-08. PMID:33713808. |
ghrelin acts on regions of the hypothalamus to regulate feeding behavior and glucose homeostasis through its g protein-coupled receptor. |
2021-09-08 |
2023-08-13 |
Not clear |
| L Dearden, S Buller, I C Furigo, D S Fernandez-Twinn, S E Ozann. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Molecular metabolism. vol 42. 2021-09-07. PMID:32919096. |
we aimed to define how maternal obesity impacts early development of the hypothalamus to program lasting dysfunction in feeding regulatory pathways. |
2021-09-07 |
2023-08-13 |
Not clear |
| Marine Adlanmerini, Hoang Cb Nguyen, Brianna M Krusen, Clare W Teng, Caroline E Geisler, Lindsey C Peed, Bryce J Carpenter, Matthew R Hayes, Mitchell A Laza. Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:33021965. |
here we report that, in contrast with females, male mice lacking circadian nuclear receptors rev-erbα and -β in the tuberal hypothalamus (hdko mice) gained excessive weight on an obesogenic high-fat diet due to both decreased energy expenditure and increased food intake during the light phase. |
2021-09-07 |
2023-08-13 |
mouse |
| Chrysostomos Charalambous, Marek Lapka, Tereza Havlickova, Kamila Syslova, Magdalena Sustkova-Fiserov. Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin. International journal of molecular sciences. vol 22. issue 1. 2021-09-07. PMID:33379212. |
the endocannabinoid/cb1r system as well as the central ghrelin signalling with its growth hormone secretagogoue receptors (ghs-r1a) are importantly involved in food intake and reward/reinforcement processing and show distinct overlaps in distribution within the relevant brain regions including the hypothalamus (food intake), the ventral tegmental area (vta) and the nucleus accumbens (nac) (reward/reinforcement). |
2021-09-07 |
2023-08-13 |
rat |
| Jia Zheng, Ling Zhang, Jiayi Liu, Yanli Li, Junqing Zhan. Long-Term Effects of Maternal Low-Protein Diet and Post-weaning High-Fat Feeding on Glucose Metabolism and Hypothalamic POMC Promoter Methylation in Offspring Mice. Frontiers in nutrition. vol 8. 2021-09-07. PMID:34485357. |
however, little information is known about the mechanisms linking maternal protein restriction combined with post-weaning high-fat (hf) feeding with altered expression of brain neurotransmitters, and investigations into the epigenetic modifications of hypothalamus in offspring have not been fully elucidated. |
2021-09-07 |
2023-08-13 |
mouse |
| Thang M Le, Ding-Lieh Liao, Jaime Ide, Sheng Zhang, Simon Zhornitsky, Wuyi Wang, Chiang-Shan R L. The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus. International journal of obesity (2005). vol 44. issue 5. 2021-09-06. PMID:31796869. |
the hypothalamus plays an important role in regulating body weight through its interactions with multiple brain circuits involved in distinct aspects of feeding behavior. |
2021-09-06 |
2023-08-13 |
Not clear |
| Vanessa Oliveira, Anne E Kwitek, Curt D Sigmund, Lisa L Morselli, Justin L Grob. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension (Dallas, Tex. : 1979). vol 77. issue 4. 2021-09-06. PMID:33611936. |
new evidence supports a major change in molecular signaling within agrp (agouti-related peptide) neurons of the arcuate nucleus of the hypothalamus during prolonged obesity and the existence of multiple distinct subtypes of agrp neurons that individually contribute to control of feeding, rmr, or blood pressure. |
2021-09-06 |
2023-08-13 |
Not clear |
| Vanessa C Bobbo, Daiane F Engel, Carlos Poblete Jara, Natalia F Mendes, Roberta Haddad-Tovolli, Thais P Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A Velloso, Eliana P Arauj. Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis. Journal of neuroinflammation. vol 18. issue 1. 2021-09-04. PMID:34465367. |
interleukin-6 (il6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure. |
2021-09-04 |
2023-08-13 |
Not clear |
| Danai Barlampa, Maria Sotiria Bompoula, Alexandra Bargiota, Sophia Kalantaridou, George Mastorakos, Georgios Valsamaki. Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS. Nutrients. vol 13. issue 2. 2021-09-03. PMID:33562540. |
on the other hand, the hypothalamus plays a crucial role in many important functions of the body, including weight balance, food intake, and reproduction. |
2021-09-03 |
2023-08-13 |
Not clear |
| Xiyi Hu, Linglian Kong, Chuanpi Xiao, Qidong Zhu, Zhigang Son. The AMPK-mTOR signaling pathway is involved in regulation of food intake in the hypothalamus of stressed chickens. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 258. 2021-09-02. PMID:33991669. |
the ampk-mtor signaling pathway is involved in regulation of food intake in the hypothalamus of stressed chickens. |
2021-09-02 |
2023-08-13 |
Not clear |
| b' V Hainer, I Aldhoon Hainerov\\xc3\\xa1, M Kune\\xc5\\xa1ov\\xc3\\xa1, R Taxov\\xc3\\xa1 Braunerov\\xc3\\xa1, H Zamrazilov\\xc3\\xa1, B Bendlov\\xc3\\xa. Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R). Physiological research. vol 69. issue Suppl 2. 2021-08-31. PMID:33094623.' |
enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. |
2021-08-31 |
2023-08-13 |
Not clear |
| Yang-Wen Hsieh, Yi-Wen Tsai, Hsin-Hung Lai, Chi-Yu Lai, Chiu-Ya Lin, Guor Mour He. Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish. Biomedicines. vol 9. issue 8. 2021-08-30. PMID:34440144. |
the functions of anorexigenic neurons secreting proopiomelanocortin (pomc)/alpha-melanocyte-stimulating hormone (α-msh) of the melanocortin system in the hypothalamus in vertebrates are energy homeostasis, food intake, and body weight regulation. |
2021-08-30 |
2023-08-13 |
zebrafish |