| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessia Montesano, Mario Baumgart, Luigi Avallone, Luciana Castaldo, Carla Lucini, Eva Terzibasi Tozzini, Alessandro Cellerino, Livia D'Angelo, Paolo de Girolam. Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. The Journal of comparative neurology. vol 527. issue 9. 2020-09-16. PMID:30666646. |
orexin a (oxa) and neuropeptide y (npy) are two hypothalamic neuropeptides involved in the regulation of feeding behavior and food intake in all vertebrates. |
2020-09-16 |
2023-08-13 |
Not clear |
| Alessia Montesano, Mario Baumgart, Luigi Avallone, Luciana Castaldo, Carla Lucini, Eva Terzibasi Tozzini, Alessandro Cellerino, Livia D'Angelo, Paolo de Girolam. Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. The Journal of comparative neurology. vol 527. issue 9. 2020-09-16. PMID:30666646. |
the present study addressed the age related changes in expression and distribution of orexin a (its precursor is also known as hypocretin-hcrt) and npy, and their regulation by food intake in the short-lived vertebrate model nothobranchius furzeri. |
2020-09-16 |
2023-08-13 |
Not clear |
| Alessia Montesano, Mario Baumgart, Luigi Avallone, Luciana Castaldo, Carla Lucini, Eva Terzibasi Tozzini, Alessandro Cellerino, Livia D'Angelo, Paolo de Girolam. Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. The Journal of comparative neurology. vol 527. issue 9. 2020-09-16. PMID:30666646. |
our experiments, conducted on male specimens, show that: (a) hcrt and oxa and npy mrna and protein are localized in neurons of diencephalon and optic tectum, as well as in numerous fibers projecting through the entire neuroaxis, and are colocalized in specific nuclei; (b) in course of aging, hcrt and npy expressing neurons are localized also in telencephalon and rhombencephalon; (c) hcrt expressing neurons increased slightly in the diencephalic area of old animals and in fasted animals, whereas npy increased sharply; (d) central hcrt levels are not regulated neither in course of aging nor by food intake; and (e) central npy levels are augmented in course of aging, and regulated by food intake only in young. |
2020-09-16 |
2023-08-13 |
Not clear |
| Jinxin Wang, Elizabeth R Gilbert, Mark A Clin. Hypothalamic mechanisms associated with neuropeptide K-induced anorexia in Japanese quail (Coturnix japonica). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 237. 2020-09-10. PMID:31404649. |
in conclusion, results provide insights into understanding npk-induced changes in hypothalamic physiology and feeding behavior, and suggest that the anorexigenic effects of npk involve the arc and pvn, with increased crf and melanocortin and reduced npy signaling. |
2020-09-10 |
2023-08-13 |
Not clear |
| Xingxing Deng, Luo Lei, Dengyue Yuan, Zonglin Zheng, Chengke Zhu, Hui Luo, Hua Ye, Dongmei Li, Jian Wang, Baohai Li, Guangjun Lv, Chaowei Zho. Cloning, expression profiling, and effects of fasting status on neuropeptide Y in Schizothorax davidi. Journal of food biochemistry. vol 43. issue 7. 2020-09-07. PMID:31353745. |
to better comprehend the mechanism that neuropeptide y (npy) regulates feeding in schizothorax davidi, we cloned and identified the full-length cdna sequence of the npy gene in this species using race technology. |
2020-09-07 |
2023-08-13 |
Not clear |
| Xingxing Deng, Luo Lei, Dengyue Yuan, Zonglin Zheng, Chengke Zhu, Hui Luo, Hua Ye, Dongmei Li, Jian Wang, Baohai Li, Guangjun Lv, Chaowei Zho. Cloning, expression profiling, and effects of fasting status on neuropeptide Y in Schizothorax davidi. Journal of food biochemistry. vol 43. issue 7. 2020-09-07. PMID:31353745. |
however, to date, no studies have reported on the biological function of npy in the feeding of s. davidi. |
2020-09-07 |
2023-08-13 |
Not clear |
| Shu-Chen Chu, Pei-Ni Chen, Ching-Han Yu, Yih-Shou Hsieh, Dong-Yih Ku. Double immunofluorescent evidence that oxidative stress-associated activation of JNK/AP-1 signaling participates in neuropeptide-mediated appetite control. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 11. 2020-09-07. PMID:31519469. |
changes in feeding behavior and expression levels of hypothalamic npy, cart, cfos, cjun, phosphorylated jnk (pjnk), as well as those of anti-oxidative enzymes, including superoxide dismutase (sod), glutathione peroxidase (gp) and glutathione s-transferase (gst), were examined and compared. |
2020-09-07 |
2023-08-13 |
rat |
| Shu-Chen Chu, Pei-Ni Chen, Ching-Han Yu, Yih-Shou Hsieh, Dong-Yih Ku. Double immunofluorescent evidence that oxidative stress-associated activation of JNK/AP-1 signaling participates in neuropeptide-mediated appetite control. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 11. 2020-09-07. PMID:31519469. |
following amph treatment, food intake and npy expression decreased, whereas the other proteins expression and ap-1/dna binding activity increased. |
2020-09-07 |
2023-08-13 |
rat |
| Chi Kin Ip, Lei Zhang, Aitak Farzi, Yue Qi, Ireni Clarke, Felicia Reed, Yan-Chuan Shi, Ronaldo Enriquez, Chris Dayas, Bret Graham, Denovan Begg, Jens C Brüning, Nicola J Lee, Diana Hernandez-Sanchez, Gopana Gopalasingam, Julia Koller, Ramon Tasan, Günther Sperk, Herbert Herzo. Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell metabolism. vol 30. issue 1. 2020-08-31. PMID:31031093. |
here we uncover a previously unknown feeding stimulatory pathway that is activated under conditions of stress in combination with calorie-dense food; npy neurons in the central amygdala are responsible for an exacerbated response to a combined stress and high-fat-diet intervention. |
2020-08-31 |
2023-08-13 |
Not clear |
| Chi Kin Ip, Lei Zhang, Aitak Farzi, Yue Qi, Ireni Clarke, Felicia Reed, Yan-Chuan Shi, Ronaldo Enriquez, Chris Dayas, Bret Graham, Denovan Begg, Jens C Brüning, Nicola J Lee, Diana Hernandez-Sanchez, Gopana Gopalasingam, Julia Koller, Ramon Tasan, Günther Sperk, Herbert Herzo. Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell metabolism. vol 30. issue 1. 2020-08-31. PMID:31031093. |
using food intake and energy expenditure as readouts, we demonstrate that selective activation of central amygdala npy neurons results in increased food intake and decreased energy expenditure. |
2020-08-31 |
2023-08-13 |
Not clear |
| Nicola J Lee, Ireni M Clarke, Ayse Zengin, Ronaldo F Enriquez, Vanj Nagy, Josef M Penninger, Paul A Baldock, Herbert Herzo. RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. Journal of neuroendocrinology. vol 31. issue 2. 2020-08-17. PMID:30633834. |
rank deletion specifically in neuropeptide y (npy) neurones has been shown to enhance the ability of the skeleton to match increases in body weight caused by high-fat diet feeding, likely via the modulation of npy levels. |
2020-08-17 |
2023-08-13 |
mouse |
| Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, Masamitsu Nakazat. Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents. The Journal of endocrinology. vol 244. issue 1. 2020-07-13. PMID:31539874. |
leap2 did not inhibit neuropeptide y (npy)-induced food intake or des-acyl ghrelin-induced reduction in body temperature, indicating that the inhibitory effects of leap2 were specific for ghsr. |
2020-07-13 |
2023-08-13 |
rat |
| Zhenyan He, Yong Gao, Linh Lieu, Sadia Afrin, Jianhong Cao, Natalie J Michael, Yanbin Dong, Jia Sun, Hongbo Guo, Kevin W William. Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons - Implications for energy balance and glucose control. Molecular metabolism. vol 28. 2020-06-22. PMID:31446151. |
moreover, the acute activities of pomc and npy neurons have been directly linked to feeding behavior, body weight, and glucose metabolism. |
2020-06-22 |
2023-08-13 |
Not clear |
| Tsung-Wei Huang, Sheng-Tien Li, Duan-Yu Chen, Tai-Horng Youn. Neuropeptide Y increases differentiation of human olfactory receptor neurons through the Y1 receptor. Neuropeptides. vol 78. 2020-04-30. PMID:31526523. |
neuropeptide y (npy) is not only a neurotrophic factor in the rodent olfactory system but also an orexigenic peptide that regulates feeding behavior. |
2020-04-30 |
2023-08-13 |
human |
| Linda Engström Ruud, Mafalda M A Pereira, Alain J de Solis, Henning Fenselau, Jens C Brünin. NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nature communications. vol 11. issue 1. 2020-04-24. PMID:31974377. |
selective re-expression of npy in agrp neurons attenuates the reduced feeding response and reverses the protection from insulin resistance upon optogenetic activation of agrp neurons in npy-deficient mice. |
2020-04-24 |
2023-08-13 |
mouse |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
insulin central injection enhanced hypothalamic content of pakt/akt and cart mrna expression, decreased npy mrna expression and food intake only in sham rats, without effects in adx and adx + b rats. |
2020-04-06 |
2023-08-13 |
rat |
| Yiming Chen, Rachel A Essner, Seher Kosar, Oliver H Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A Knigh. Sustained NPY signaling enables AgRP neurons to drive feeding. eLife. vol 8. 2020-02-26. PMID:31033437. |
sustained npy signaling enables agrp neurons to drive feeding. |
2020-02-26 |
2023-08-13 |
Not clear |
| Yiming Chen, Rachel A Essner, Seher Kosar, Oliver H Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A Knigh. Sustained NPY signaling enables AgRP neurons to drive feeding. eLife. vol 8. 2020-02-26. PMID:31033437. |
here we show that neuropeptide y (npy) is uniquely required for the long-lasting effects of agrp neurons on feeding behavior. |
2020-02-26 |
2023-08-13 |
Not clear |
| Yiming Chen, Rachel A Essner, Seher Kosar, Oliver H Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A Knigh. Sustained NPY signaling enables AgRP neurons to drive feeding. eLife. vol 8. 2020-02-26. PMID:31033437. |
deletion of npy, but not agrp or gaba, abolished optically-stimulated feeding, and this was rescued by npy re-expression selectively in agrp neurons. |
2020-02-26 |
2023-08-13 |
Not clear |