| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
furthermore, ip injection of spx was effective in reducing food intake with parallel attenuation in transcript expression of npy, agrp, npy type 5 receptor (npy5r), and ghrelin receptor (ghsr) in the hypothalamus, and these inhibitory effects could be blocked by galr3 but not galr2 antagonism. |
2021-11-18 |
2023-08-13 |
mouse |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
through galr3 activation, this spx signal can act within the hypothalamus to trigger feedback inhibition on feeding by differential modulation of feeding regulators (npy and agrp) and their receptors (npy5r, ghsr, lepr, and mc4r) involved in the feeding circuitry within the cns. |
2021-11-18 |
2023-08-13 |
mouse |
| Joana Duarte-Neves, Cláudia Cavadas, Luís Pereira de Almeid. Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33558582. |
furthermore, intranasal administration of npy did not alter body weight gain, food intake, amount of body fat nor cholesterol or triglycerides levels. |
2021-11-11 |
2023-08-13 |
mouse |
| Mei Wang, Shaoqi Xu, Ya Li, Ni Tang, Hu Chen, Shupeng Zhang, Yanling Liu, Jun Wang, Defang Chen, Xin Zhang, Zhiqiong L. Identification, tissue distribution, and anorexigenic effect of amylin in Siberian sturgeon (Acipenser baeri). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 263. 2021-11-11. PMID:34534676. |
these results show that amylin inhibits feeding in siberian sturgeon by down-regulating the appetite-stimulating factor npy and up-regulating the appetite-suppressing factors somatostatin, mc4r, cck, and insulin. |
2021-11-11 |
2023-08-13 |
Not clear |
| Lei Zhang, Felicia Reed, Herbert Herzo. Leptin signalling on arcuate NPY neurones controls adiposity independent of energy balance or diet composition. Journal of neuroendocrinology. vol 32. issue 9. 2021-10-25. PMID:32885528. |
furthermore, under obesogenic conditions such as a high-fat diet, a lack of lepr signalling on npy neurones results in significant increases in food intake and concomitant reductions in energy expenditure, leading to accelerated accumulation of fat mass. |
2021-10-25 |
2023-08-13 |
Not clear |
| Frederick Wasinski, Franco Barrile, João A B Pedroso, Paula G F Quaresma, Willian O Dos Santos, Edward O List, John J Kopchick, Mario Perelló, Jose Donat. Ghrelin-induced Food Intake, but not GH Secretion, Requires the Expression of the GH Receptor in the Brain of Male Mice. Endocrinology. vol 162. issue 7. 2021-10-07. PMID:33972988. |
in contrast, agrp ghr ko mice showed no changes in the hypothalamic npy and ghsr mrnas and conserved ghrelin-induced food intake and c-fos expression in the arh. |
2021-10-07 |
2023-08-13 |
mouse |
| Michael L M Rocha, Priscilla P Fernandes, Frank Tenório, Alex C Manhães, Penha C Barrada. Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and α-MSH anorexigenic molecules in the arcuate/paraventricular pathway and lateral hypothalamus in male rats. Brain research. vol 1743. 2021-10-04. PMID:32473258. |
in rat offspring, a 0% protein diet during the first 10 days of lactation results in leptin resistance and in alterations in: feeding behavior, serum leptin and neuropeptide y (npy) levels in the hypothalamic arcuate nucleus (arc)/paraventricular (pvn) pathway. |
2021-10-04 |
2023-08-13 |
rat |
| Xingqin Wang, Zhen Tian, Jie Ma, Zhanpeng Feng, Yichao Ou, Mingfeng Zhou, Junjie Peng, Yunfei Lv, Guodong Gao, Songtao Q. NPY alterations induced by chronic morphine exposure affect the maintenance and reinstatement of morphine conditioned place preference. Neuropharmacology. vol 181. 2021-09-23. PMID:33027625. |
neuropeptide y (npy) is one of the main orexigenic peptides that play vital roles in food intake and energy metabolism. |
2021-09-23 |
2023-08-13 |
Not clear |
| Yea-Jin Park, Divina C Cominguez, Hyo-Jung Kim, Jong-Sik Jin, Duck-Jae Koh, Seo-Young Kim, Young-Woo Lim, Young-Bae Park, Hyo-Jin A. Therapeutic effects of Gambi-jung for the treatment of obesity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34182414. |
moreover, gbj and es reduced food intake by suppressing the mrna levels of orexigenic peptides, agouti-related protein (agrp) and neuropeptide-y (npy), as well as ampk in the brain of hfd-induced obese mice. |
2021-09-08 |
2023-08-13 |
mouse |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
this study aimed to investigate the changes in catecholamine and indolamine metabolism in response to the central action of neuropeptide y (npy) in different feeding statuses and the underlying mechanisms. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
central npy significantly decreased l-tyrosine concentration, the precursor of catecholamines under feeding condition, but not under fasting condition. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
the concentration of 3-methoxy-4-hydroxyphenylglycol was significantly reduced under feeding condition, but did not change under fasting condition by npy. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
however, no effects of npy on indolamine metabolism were found in either feeding status. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
therefore, the mechanism of action of catecholamines with central npy under feeding condition was elucidated in experiment 2. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
central npy significantly attenuated diencephalic gene expression of catecholaminergic synthetic enzymes, such as tyrosine hydroxylase, l-aromatic amino acid decarboxylase, and gtp cyclohydrolase i after 30 min of feeding. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
in experiment 3, co-injection of α-methyl-l-tyrosine, an inhibitor of tyrosine hydroxylase with npy, moderately attenuated the orexigenic effect of npy, accompanied by a significant positive correlation between food intake and hva levels. |
2021-08-30 |
2023-08-13 |
Not clear |
| Phuong V Tran, Yui Tamura, Cuong V Pham, Mohamed Z Elhussiny, Guofeng Han, Vishwajit S Chowdhury, Mitsuhiro Furus. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides. vol 89. 2021-08-30. PMID:34229214. |
in conclusion, central npy modifies a part of catecholamine metabolism, which is illustrated by the involvement of dopamine transmission and metabolism under feeding but not fasting conditions. |
2021-08-30 |
2023-08-13 |
Not clear |
| Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Oanh Vu, Clara Tabea Schoeder, Jens Meiler, Simone Prömel, Anette Kaise. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation. Journal of molecular biology. vol 433. issue 13. 2021-08-24. PMID:33865871. |
the neuropeptide y (npy) family is a peptide-activated g protein-coupled receptor system conserved across all bilaterians, and is involved in food intake, learning, and behavior. |
2021-08-24 |
2023-08-13 |
Not clear |
| Masaki Tanaka, Shunji Yamada, Yoshihisa Watanab. The Role of Neuropeptide Y in the Nucleus Accumbens. International journal of molecular sciences. vol 22. issue 14. 2021-08-03. PMID:34298907. |
the physiological and behavioral effects of npy are mainly mediated through y1, y2, and y5 receptor subtypes, which are expressed in regions regulating food intake, fear and anxiety, learning and memory, depression, and posttraumatic stress. |
2021-08-03 |
2023-08-13 |
Not clear |
| Cristina Velasco, Marta Conde-Sieira, Sara Comesaña, Mauro Chivite, Jesús M Míguez, José L Soenga. Role of the G protein-coupled receptors GPR84 and GPR119 in the central regulation of food intake in rainbow trout. The Journal of experimental biology. vol 224. issue 13. 2021-07-30. PMID:34114000. |
in the second experiment, we assessed the impact of the same treatments on mrna abundance in the hypothalamus and hindbrain of neuropeptides involved in the metabolic control of food intake (npy, agrp1, pomca1 and cartpt) as well as in changes in parameters related to signalling pathways and transcription factors involved in the integrative response leading to neuropeptide production. |
2021-07-30 |
2023-08-13 |
Not clear |