| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuna Zhang, Guihong Liu, Haiyan Ding, Bingge Fa. High expression of CNOT6L contributes to the negative development of type 2 diabetes. Scientific reports. vol 14. issue 1. 2024-10-21. PMID:39433858. |
cnot6l is involved in glucose metabolism, insulin secretion regulation, pancreatic beta-cell proliferation, and apoptosis. |
2024-10-21 |
2024-10-24 |
Not clear |
| Miwon Ahn, Sangeeta Dhawan, Erika M McCown, Pablo A Garcia, Supriyo Bhattacharya, Roland Stein, Debbie C Thurmon. Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis. Diabetologia. 2024-10-15. PMID:39404845. |
beta cell-specific pak1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis. |
2024-10-15 |
2024-10-17 |
mouse |
| Yu Jiang, Jia-Qi Guo, Ya Wu, Peng Zheng, Shao-Fan Wang, Meng-Chen Yang, Gen-Shan Ma, Yu-Yu Ya. Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity. Therapeutic advances in endocrinology and metabolism. vol 15. 2024-10-09. PMID:39381518. |
prolonged or excessive ers in adipocytes can aggravate lipolysis, insulin resistance, and apoptosis and affect the bioactive molecule production. |
2024-10-09 |
2024-10-11 |
Not clear |
| Zhang Yong, Chen Mimi, Li Yingjie, Guo Yichen, Yu Yansu, Zhou Zhi, Lu Hui, Yao Si, Wu Chongming, Zhang Xiaopo, Ma Ning, Lu Weiyin. Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis. Frontiers in pharmacology. vol 15. 2024-10-08. PMID:39376609. |
mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis. |
2024-10-08 |
2024-10-10 |
rat |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. The Journal of biological chemistry. 2024-09-29. PMID:39342996. |
others have reported that mir-146a-5p overexpression is associated with β cell apoptosis and impaired insulin secretion. |
2024-09-29 |
2024-10-02 |
mouse |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. The Journal of biological chemistry. 2024-09-29. PMID:39342996. |
additionally, inhibition of mir-146a-5p increased insulin secretion, mitochondrial dna copy number, respiration rate, and atp production further, rna sequencing data showed enrichment of pathways related to insulin secretion, apoptosis, and mitochondrial function when the expression levels of mir-146a-5p were altered. |
2024-09-29 |
2024-10-02 |
mouse |
| Tamsheel Fatima Roohi, K L Krishna, Faiyaz Shakee. Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish model. BMC pharmacology & toxicology. vol 25. issue 1. 2024-09-28. PMID:39334288. |
treatment efficacy was assessed by measuring serum glucose and insulin levels and antioxidant, er stress, apoptosis, and proinflammatory markers. |
2024-09-28 |
2024-10-01 |
zebrafish |
| Esther García-Díez, María Elvira López-Oliva, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339687. |
the cc-supplemented diet also ameliorated oxidative stress, downregulated apoptosis, and improved insulin signalling and glucose homeostasis. |
2024-09-28 |
2024-10-01 |
rat |
| Esther García-Díez, María Elvira López-Oliva, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339687. |
the combination of cc and metformin boosted several benefits as certain parameters related to morphological and structural alterations, apoptosis, oxidative stress, glucose homeostasis, and insulin resistance, were improved in comparison to animals receiving the cc-supplemented diet or metformin alone; these include the following: apoptotic index, bax, hepatic insulin receptor or glutathione content, among others. |
2024-09-28 |
2024-10-01 |
rat |
| Warisara Parichatikanond, Sudhir Pandey, Supachoke Mangmoo. Exendin-4 exhibits cardioprotective effects against high glucose-induced mitochondrial abnormalities: Potential role of GLP-1 receptor and mTOR signaling. Biochemical pharmacology. 2024-09-22. PMID:39307319. |
mitochondrial dysfunction is associated with hyperglycemic conditions and insulin resistance leading to cellular damage and apoptosis of cardiomyocytes in diabetic cardiomyopathy. |
2024-09-22 |
2024-09-26 |
Not clear |
| Hediye Fahandezh Saadi, Mozhdeh Zamani, Farhad Koohpeyma, Alireza Raeisi, Zahra Amirahmadi, Narges Rezaei, Zahra Joolidehpoor, Mesbah Shams, Sanaz Dastghai. Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats. Molecular biology reports. vol 51. issue 1. 2024-09-18. PMID:39292293. |
chronic er stress increases inflammation, insulin resistance, and apoptosis. |
2024-09-18 |
2024-09-20 |
rat |
| Atilla Engi. Adipose Tissue Hypoxia in Obesity: Clinical Reappraisal of Hypoxia Hypothesis. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287857. |
hypoxia contributes to several biological functions, such as angiogenesis, cell proliferation, apoptosis, inflammation, and insulin resistance (ir). |
2024-09-17 |
2024-09-20 |
human |
| Ayse Basak Engin, Evren Doruk Engin, Atilla Engi. Macrophage Activation Syndrome in Coinciding Pandemics of Obesity and COVID-19: Worse than Bad. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287877. |
following viral invasion, sars-cov-2 infection reduces insulin secretion via either inducing β-cell apoptosis or reducing intensity of angiotensin-converting enzyme 2 (ace2) receptors and leads to new-onset diabetes. |
2024-09-17 |
2024-09-20 |
human |
| Ting Yang, Lingling Qiu, Shihao Chen, Zhixiu Wang, Yong Jiang, Hao Bai, Yulin Bi, Guobin Chan. RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication. Animals : an open access journal from MDPI. vol 14. issue 17. 2024-09-14. PMID:39272286. |
functional enrichment analysis indicated that some circrnas might be involved in regulating the replication of the alv-j virus by influencing some pathways like glycolysis/gluconeogenesis, the nod-like receptor signaling pathway, mapk signaling pathway, p53 signaling pathway, toll-like receptor signaling pathway, insulin signaling pathway, and apoptosis. |
2024-09-14 |
2024-09-16 |
Not clear |
| Xiuxiu Yuan, Yu Zhang, Siyi Wang, Zhiyu D. Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and Frontiers in pharmacology. vol 15. 2024-09-12. PMID:39263577. |
in cell experiments, insulin promoted hcecs proliferation, improved their ability to migrate, and inhibited apoptosis. |
2024-09-12 |
2024-09-14 |
human |
| Hussam A Bukhari, Muhammad Afzal, Fahad A Al-Abbasi, Ryan A Sheikh, May M Alqurashi, Azizah Salim Bawadood, Sami I Alzarea, Abdulaziz Alamri, Nadeem Sayyed, Imran Kazm. In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions. Scientific reports. vol 14. issue 1. 2024-09-04. PMID:39232184. |
various diabetic parameters (blood glucose, insulin, hba1c), lipid profile, inflammatory (tnf-α, il-1β, il-6 and nf-κb), antioxidant enzymes (cat, sod and gsh), oxidative stress indicators (mda), apoptosis marker (caspase-3), hepatic markers (alt and ast), and histopathological changes were assessed. |
2024-09-04 |
2024-09-08 |
human |
| Hongyang Zhu, You Yu, Yuting Li, Shiyao Chang, Yuhui Li. Puerarin ameliorates high glucose-induced MIN6 cell injury by activating PINK1/Parkin-mediated mitochondrial autophagy. Heliyon. vol 10. issue 16. 2024-09-03. PMID:39224278. |
subsequently, cellular insulin secretion was measured using enzyme-linked immunosorbent assay (elisa), apoptosis rate by flow cytometry, mitochondrial membrane potential alteration by jc-1, cellular ros production by the dcfh-da fluorescent probe, and fusion of cellular autophagosomes and lysosomes through adenoviral infection analysis. |
2024-09-03 |
2024-09-05 |
Not clear |
| Hongyang Zhu, You Yu, Yuting Li, Shiyao Chang, Yuhui Li. Puerarin ameliorates high glucose-induced MIN6 cell injury by activating PINK1/Parkin-mediated mitochondrial autophagy. Heliyon. vol 10. issue 16. 2024-09-03. PMID:39224278. |
puerarin intervention markedly attenuated ros production, restored mitochondrial membrane potential, induced pink/parkin-mediated mitochondrial autophagy, suppressed activation of the mitochondrial apoptotic pathway, mitigated apoptosis, and enhanced insulin secretion in a high glucose (hg) environment. |
2024-09-03 |
2024-09-05 |
Not clear |
| Luis Antonio Flores-López, Sergio Enríquez-Flores, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Gabriel López-Velázquez, Rubí Viedma-Rodríguez, Alejandro Ávalos-Rodríguez, Alejandra Contreras-Ramos, Clara Ortega-Camarill. Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review). Molecular medicine reports. vol 30. issue 5. 2024-09-02. PMID:39219257. |
diabetes mellitus is a disease characterized by insulin resistance and chronic hyperglycemia, mainly due to the loss of pancreatic β‑cells caused by an increase in the rate of apoptosis. |
2024-09-02 |
2024-09-04 |
Not clear |
| Junxia Yu, Ningyan Tian, Yanfen Hu, Ting Ji. RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK. International immunopharmacology. vol 142. issue Pt A. 2024-09-01. PMID:39217877. |
in vivo experiments demonstrated that srankl-in-3 down-regulated insulin secretion levels by significantly ameliorating pancreatic tissue damage and mitigating apoptosis of high glucose induced β-cells. |
2024-09-01 |
2024-09-04 |
rat |