| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Chen, M Hanaoka, Y Droma, P Chen, N F Voelkel, K Kub. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. The European respiratory journal. vol 35. issue 4. 2010-06-18. PMID:19897563. |
the expression of et(a) receptor, apoptosis index, caspase-3 activity, matrix metalloproteinase (mmp)-2 and mmp-9 activity, and tumour necrosis factor (tnf)-alpha and interleukin (il)-1beta concentrations were measured in the lung tissue. |
2010-06-18 |
2023-08-12 |
rat |
| Hyun Soon Lee, Chi Young Son. Effects of TGF-beta on podocyte growth and disease progression in proliferative podocytopathies. Kidney & blood pressure research. vol 33. issue 1. 2010-06-17. PMID:20185928. |
we provide evidence that increasedtgf-beta/smad signaling activity by hyperplastic podocytes may lead to mesangial cell matrix overproduction and eventually to podocyte apoptosis and/or detachment, culminating in the development of glomerulosclerosis. |
2010-06-17 |
2023-08-12 |
Not clear |
| Eun-Mee Kim, Eun-Jung Shin, Ji Hyun Choi, Hyo Jin Son, Il-Seon Park, Tong H Joh, Onyou Hwan. Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20368330. |
the present study shows that matrix metalloproteinase (mmp)-3 plays a role in the er stress-induced apoptosis. |
2010-06-17 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Niccola Funel, Godefridus J Peters, Marco Del Chiaro, Leyla A Erozenci, Enrico Vasile, Leticia G Leon, Luca E Pollina, Annemieke Groen, Alfredo Falcone, Romano Danesi, Daniela Campani, Henk M Verheul, Ugo Bogg. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer research. vol 70. issue 11. 2010-06-17. PMID:20460539. |
pre-mir-21 transfection significantly decreased antiproliferative effects and apoptosis induction by gemcitabine, whereas matrix metalloproteinase (mmp)-2/mmp-9 and vascular endothelial growth factor expression were upregulated. |
2010-06-17 |
2023-08-12 |
Not clear |
| Christian Calles, Maren Schneider, Filippina Macaluso, Tereza Benesova, Jean Krutmann, Peter Schroede. Infrared A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. The Journal of investigative dermatology. vol 130. issue 6. 2010-06-15. PMID:20130591. |
ira-responsive genes include the categories extracellular matrix, calcium homeostasis, stress signaling, and apoptosis. |
2010-06-15 |
2023-08-12 |
human |
| Yuying Chen, Zhanxiang Wang, Pingan Chang, Liuxin Xiang, Feng Pan, Jianjun Li, Jinyan Jiang, Lan Zou, Li Yang, Zhiheng Bian, Houjie Lian. The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas. International journal of cancer. vol 127. issue 1. 2010-06-14. PMID:19904749. |
focal adhesion kinase (fak) plays an important role in apoptosis, survival and cell adhesion between cells and their extracellular matrix. |
2010-06-14 |
2023-08-12 |
human |
| Albrecht Reichle, Thomas Vog. Systems biology: a therapeutic target for tumor therapy. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. vol 1. issue 1. 2010-06-09. PMID:19308694. |
tumor-related activities that seem to be operationally induced by the division of function, such as inflammation, neoangiogenesis, warburg effect, immune response, extracellular matrix remodeling, cell proliferation rate, apoptosis, coagulation effects, present itself from a systems perspective as an enhancement of complexity. |
2010-06-09 |
2023-08-12 |
Not clear |
| Pei-Li Yao, Yi-Chen Lin, John H Richbur. Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biology of reproduction. vol 82. issue 3. 2010-06-07. PMID:19828778. |
previously, we reported that sertoli cell injury in rodents after mono-(2-ethylhexyl) phthalate (mehp) exposure results in the activation of matrix metalloproteinase 2 (mmp2) and increases the sensitivity of germ cells to undergo apoptosis. |
2010-06-07 |
2023-08-12 |
mouse |
| Nick Hornigold, Rachel A Craven, Jeff N Keen, Tim Johnson, Rosamonde E Banks, Andrew F Moone. Upregulation of Hic-5 in glomerulosclerosis and its regulation of mesangial cell apoptosis. Kidney international. vol 77. issue 4. 2010-06-04. PMID:20010548. |
glomerulosclerosis is characterized by the loss of glomerular cells by apoptosis and deposition of collagen type i into the normal collagen iv-containing mesangial matrix. |
2010-06-04 |
2023-08-12 |
rat |
| Ding Yu, Zi-hui Wang, Li-yuan Zh. [Mechanism of arsenic trioxide-induced apoptosis in hepatic blastoma cells HepG2]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 25. issue 2. 2010-06-03. PMID:12795834. |
to investigate the mechanism of arsenic trioxide (as(2)o(3)) induced apoptosis in hepatic blastoma cells hepg2 and its effects on cell nuclear matrix related protein promyelocytic leukaemia (pml). |
2010-06-03 |
2023-08-12 |
Not clear |
| Christopher M Kramer, Albert J Sinusas, David E Sosnovik, Brent A French, Frank M Benge. Multimodality imaging of myocardial injury and remodeling. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51 Suppl 1. 2010-06-03. PMID:20395347. |
targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. |
2010-06-03 |
2023-08-12 |
Not clear |
| Kuzhuvelil B Harikumar, Bokyung Sung, Manoj K Pandey, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwa. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20103608. |
this correlated with the down-regulation of bcl-2, cellular inhibitor of apoptosis protein-2, cyclin d1, cyclooxygenase-2, intercellular adhesion molecule-1, matrix metalloproteinase-9, and vascular endothelial growth factor, which are all regulated by the activation of the transcription factor nf-kappab. |
2010-05-28 |
2023-08-12 |
human |
| Koo-Hyun Chung, Kiran Bhadriraju, Tighe A Spurlin, Robert F Cook, Anne L Plan. Nanomechanical properties of thin films of type I collagen fibrils. Langmuir : the ACS journal of surfaces and colloids. vol 26. issue 5. 2010-05-28. PMID:20104910. |
the mechanical cues that adherent cells derive from the extracellular matrix (ecm) can effect dramatic changes in cell migration, proliferation, differentiation, and apoptosis. |
2010-05-28 |
2023-08-12 |
Not clear |
| Martin J Barron, Steven J Brookes, Jennifer Kirkham, Roger C Shore, Charlotte Hunt, Aleksandr Mironov, Nicola J Kingswell, Joanne Maycock, C Adrian Shuttleworth, Michael J Dixo. A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta. Human molecular genetics. vol 19. issue 7. 2010-05-27. PMID:20067920. |
animals affected by the mutation have severe defects of enamel bio-mineralization associated with absence of full-length amelogenin protein in the developing enamel matrix, loss of ameloblast phenotype, increased ameloblast apoptosis and formation of multi-cellular masses. |
2010-05-27 |
2023-08-12 |
mouse |
| Atsuko Ishizuya-Oka, Takashi Hasebe, Yun-Bo Sh. Apoptosis in amphibian organs during metamorphosis. Apoptosis : an international journal on programmed cell death. vol 15. issue 3. 2010-05-25. PMID:20238476. |
functional studies of th response genes using transgenic frogs and culture techniques have shown that apoptosis of larval epithelial cells can be induced by th either cell-autonomously or indirectly through interactions with extracellular matrix (ecm) components of the underlying basal lamina. |
2010-05-25 |
2023-08-12 |
xenopus_laevis |
| Pedro Geraldes, George L Kin. Activation of protein kinase C isoforms and its impact on diabetic complications. Circulation research. vol 106. issue 8. 2010-05-24. PMID:20431074. |
pkc has been associated with vascular alterations such as increases in permeability, contractility, extracellular matrix synthesis, cell growth and apoptosis, angiogenesis, leukocyte adhesion, and cytokine activation and inhibition. |
2010-05-24 |
2023-08-12 |
Not clear |
| Francis Thomas, Jeff M P Holly, Raj Persad, Amit Bahl, Claire M Perk. Fibronectin confers survival against chemotherapeutic agents but not against radiotherapy in DU145 prostate cancer cells: involvement of the insulin like growth factor-1 receptor. The Prostate. vol 70. issue 8. 2010-05-13. PMID:20127733. |
tumor growth is influenced by an increase in cell proliferation and a reduction in apoptosis; both of which are affected by alterations in extracellular matrix (ecm). |
2010-05-13 |
2023-08-12 |
Not clear |
| Ronan J Kelly, John C Morri. Transforming growth factor-beta: a target for cancer therapy. Journal of immunotoxicology. vol 7. issue 1. 2010-05-11. PMID:19916703. |
transforming growth factor-beta (tgf-beta) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. |
2010-05-11 |
2023-08-12 |
Not clear |
| Sarah Shapiro, Olga Khodalev, Haim Bitterman, Ron Auslender, Nitza Laha. Different activation forms of MMP-2 oppositely affect the fate of endothelial cells. American journal of physiology. Cell physiology. vol 298. issue 4. 2010-05-10. PMID:20071690. |
detachment of endothelial cells (ecs) from the extracellular matrix (ecm) is required not only for angiogenesis, but also for ec apoptosis. |
2010-05-10 |
2023-08-12 |
Not clear |
| Gerard F Clunn, Peter S Sever, Alun D Hughe. Calcium channel regulation in vascular smooth muscle cells: synergistic effects of statins and calcium channel blockers. International journal of cardiology. vol 139. issue 1. 2010-05-05. PMID:19523699. |
we hypothesize that statins promote a more differentiated vsmc phenotype that results in upregulation of l-type calcium channels and restoration of a ccb-sensitive calcium influx pathway in vsmc, favourably affecting the balance that exists between vsmc proliferation, apoptosis and matrix metalloproteinase production with an associated increase in stability of atheromatous plaques. |
2010-05-05 |
2023-08-12 |
human |