| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemehsadat Seyedaghamiri, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Javad Mahmoudi, Aytak Khabbaz, Saeed Sadigh-Etegha. Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice. Molecular biology reports. vol 48. issue 2. 2021-05-18. PMID:33523373. |
the extent of apoptosis in the hippocampal tissue was further determined by tunel assay and histological assessment. |
2021-05-18 |
2023-08-13 |
mouse |
| Fatemehsadat Seyedaghamiri, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Javad Mahmoudi, Aytak Khabbaz, Saeed Sadigh-Etegha. Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice. Molecular biology reports. vol 48. issue 2. 2021-05-18. PMID:33523373. |
it was also identified that sericin can substantially suppress the apoptosis in the hippocampal tissue. |
2021-05-18 |
2023-08-13 |
mouse |
| Mzia Zhvania, Nina Gogokhia, Yousef Tizabi, Nadezhda Japaridze, Nino Pochkidze, Nino Lomidze, Fuad Rzayev, Eldar Gasimo. Behavioral and neuroanatomical effects on exposure to White noise in rats. Neuroscience letters. vol 728. 2021-05-17. PMID:32224224. |
specifically, noise resulted in neuronal apoptosis, chromatolysis, cytoplasmic organelle destruction, and glial activation in medial geniculate body and hippocampus, as well as mild alterations in amygdala. |
2021-05-17 |
2023-08-13 |
rat |
| Haijin Huang, Cuicui Hu, Lin Xu, Xiaoping Zhu, Lili Zhao, Jia Mi. The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-17. PMID:32296010. |
rat hippocampal tissue specimens were investigated using the tunel assay for apoptosis. |
2021-05-17 |
2023-08-13 |
rat |
| Paula Pierozan, Daiane Cattani, Oskar Karlsso. Hippocampal neural stem cells are more susceptible to the neurotoxin BMAA than primary neurons: effects on apoptosis, cellular differentiation, neurite outgrowth, and DNA methylation. Cell death & disease. vol 11. issue 10. 2021-05-17. PMID:33099583. |
hippocampal neural stem cells are more susceptible to the neurotoxin bmaa than primary neurons: effects on apoptosis, cellular differentiation, neurite outgrowth, and dna methylation. |
2021-05-17 |
2023-08-13 |
rat |
| Kexing Wan, Fuxiu Mao, Qiongqiong Li, Limin Wang, Zhiguo Wei, Ping Wang, Xinhua Liao, Mengsi Xu, Jin Huang, Zemin Pan, Chengtan Wang, Jian Luo, Rui Gao, Shangquan Ga. Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury. Aging. vol 13. issue 2. 2021-05-17. PMID:33323541. |
compared to wild-type mice, transgenic mice demonstrated reduced degradation of the dna repair factor poly [adp-ribose] polymerase 1 (parp 1) in the hippocampus, indicating decreased hippocampal apoptosis rate, and a greater number of surviving hippocampal neurons during the first week post-tgi. |
2021-05-17 |
2023-08-13 |
mouse |
| Jianing Fan, Long Li, Pengxia Qu, Yugang Diao, Yingjie Su. κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649775. |
it was demonstrated that u50488h significantly reduced the neural function score of rats with pocd induced by cpb, relieved cognitive dysfunction, reduced hippocampal neuron damage, inhibited the rate of apoptosis, repaired oxidative stress injury and protected against brain damage caused by cpb. |
2021-05-17 |
2023-08-13 |
rat |
| Yu Wang, Xinjun Cai, Zhiheng Wu, Leilei Tang, Lingqun Lu, Yinyin Xu, Xiaogang Ba. Tetrandrine attenuates ischemia/reperfusion‑induced neuronal damage in the subacute phase. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649825. |
in addition, neuronal apoptosis in the cortex and hippocampus following ischemia was assessed by nissl staining and tunel assay. |
2021-05-17 |
2023-08-13 |
rat |
| Yu Wang, Xinjun Cai, Zhiheng Wu, Leilei Tang, Lingqun Lu, Yinyin Xu, Xiaogang Ba. Tetrandrine attenuates ischemia/reperfusion‑induced neuronal damage in the subacute phase. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649825. |
tet also prevented neuronal apoptosis in the cortex and hippocampus region. |
2021-05-17 |
2023-08-13 |
rat |
| Hongning Jia, Mingwei Qu, Guimei Fan, Huijun Wu, Limin Wan. miR-499-5p suppresses C-reactive protein and provides neuroprotection in hypoxic-ischemic encephalopathy in neonatal rat. Neuroscience research. vol 161. 2021-05-14. PMID:31812653. |
tunel staining assay was applied to evaluate neuronal cell apoptosis in the hippocampus after administration of mir-499-5p in hie rat model. |
2021-05-14 |
2023-08-13 |
rat |
| Hua Li, Li-Ying Lin, Yan Zhang, Yoon Lim, Mehreen Rahman, Andrew Beck, Mohammed Al-Hawwas, Shiqing Feng, Larisa Bobrovskaya, Xin-Fu Zho. Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice. Neuroscience. vol 438. 2021-05-14. PMID:32413397. |
abnormal morphologic changes were found in the dentate gyrus (dg) of the hippocampus in pro-bdnf ko mice, and western blot confirmed significant cell apoptosis in pro-bdnf ko mice brains. |
2021-05-14 |
2023-08-13 |
mouse |
| Zeljka Brkic, Ana Zivanovic, Miroslav Adzi. Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression. Neuroscience. vol 451. 2021-05-14. PMID:33039525. |
therefore, in this study we investigated whether the effects of seven-day lipopolysaccharide (lps) treatment on glucocorticoid receptor (gr) could be associated with apoptosis and alterations in energy metabolism in hippocampus of female and male wistar rats with depressive-like behavior. |
2021-05-14 |
2023-08-13 |
rat |
| Tiejun Liu, Bin Wang, Gai Li, Xiaoliu Dong, Guannan Yu, Qingzeng Qian, Likun Duan, Hongxia Li, Zhao Jia, Jing Ba. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33147380. |
tunel stains reflect hippocampal neuron apoptosis. |
2021-05-14 |
2023-08-13 |
rat |
| Tiejun Liu, Bin Wang, Gai Li, Xiaoliu Dong, Guannan Yu, Qingzeng Qian, Likun Duan, Hongxia Li, Zhao Jia, Jing Ba. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33147380. |
adenovirus infection of mir-214 inhibitor reduced neuron apoptosis and maintained mitochondrial function in the hippocampus of rats exposed to 2% sevoflurane. |
2021-05-14 |
2023-08-13 |
rat |
| Haiyang Zhang, Mian Wei, Qinghong Sun, Tianyuan Yang, Xiangyu Lu, Xiujing Feng, Miao Song, Lin Cui, Honggang Fa. Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-13. PMID:32810585. |
furthermore, the jnk inhibitor sp600125 relieved crs-induced hippocampal mitochondrial dysfunction, apoptosis via the mitochondrial apoptotic pathway, and learning and memory dysfunction. |
2021-05-13 |
2023-08-13 |
rat |
| Haiyang Zhang, Mian Wei, Qinghong Sun, Tianyuan Yang, Xiangyu Lu, Xiujing Feng, Miao Song, Lin Cui, Honggang Fa. Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-13. PMID:32810585. |
together, these results suggest that lyc alleviates hippocampal oxidative stress, mitochondrial dysfunction, and apoptosis by inhibiting the ros/jnk signaling pathway, thereby improving crs-induced hippocampal injury and learning and memory dysfunction. |
2021-05-13 |
2023-08-13 |
rat |
| Walaa A Keshk, Walaa S Elseady, Naglaa I Sarhan, Doaa H Zineldee. Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32172517. |
curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus. |
2021-05-11 |
2023-08-13 |
rat |
| Milagros Bürgi, Gabriela Inés Aparicio, Aquiles Dorella, Ricardo Kratje, Camila Scorticati, Marcos Ogger. Novel erythropoietin-based therapeutic candidates with extra N-glycan sites that block hematopoiesis but preserve neuroplasticity. Biotechnology journal. vol 16. issue 5. 2021-05-11. PMID:33471394. |
hepo-derivatives were produced by cho.k1 cells, affinity-purified and functionally analyzed studying their in vitro and in vivo ea, their in vitro neuronal plasticity in hippocampal neurons and their neuroprotective action by rescuing hippocampal neurons from apoptosis. |
2021-05-11 |
2023-08-13 |
human |
| Yue Yang, Lei Yang, Yu Wu, Jun Yua. [Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 2. 2021-05-11. PMID:33966704. |
methods sixty 7-day-old sd rats were assigned into five groups:control group(without any intervention),dex group(intraperitoneal injection of 25 μg/kg dex),sevoflurane group(3% sevoflurane treatment for 4 hours),sevoflurane+dex group(inhalation of 3% sevoflurane after injection of 25 μg/kg dex for 4 hours),and sevoflurane+dex+wnt inhibitor group(wnt inhibitor xav393 and 25 μg/kg dex were injected and 3% sevoflurane was inhaled for 4 hours).three weeks later,morris water maze was used to detect the cognitive function;tdt-mediated dutp nick end labeling(tunel)staining was performed to detect the apoptosis of hippocampal neurons;neuronal nuclei (neun) staining was conducted to detect the survival of hippocampal neurons;western blot was carried out to detect the expression of apoptosis-related proteins.the expression of the factors involved in wnt/gsk-3β/β-catenin signaling pathway was detected by fluorescence quantitative polymerase chain reaction,and western blot. |
2021-05-11 |
2023-08-13 |
rat |
| Seyed Reza Mokhtari Sangdehi, Akbar Hajizadeh Moghaddam, Mojtaba Ranjba. Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury. The International journal of neuroscience. 2021-05-10. PMID:33287594. |
cerebral ischemia/reperfusion (i/r) causes memory and learning impairments and apoptosis in the hippocampus. |
2021-05-10 |
2023-08-13 |
Not clear |