| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-min Sun, Hong-qiang Hao, Wei-na Kong, Ling-yun Liu, Xi-qing Cha. [Effect of intracerebroventricular injection of rAAV-HIF-1α on hippocampal neuronal apoptosis in a rat model of Alzheimer disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 12. 2013-05-20. PMID:21177188. |
to observe the effect of intracerebroventricular injection of raav-hif-1α on hippocampal neuronal apoptosis in a rat model of alzheimer disease (ad). |
2013-05-20 |
2023-08-12 |
rat |
| Xi-Ji Shu, Wei Liu, Lei Zhang, Rong Yang, Hui-Ling Yi, Chang-Lei Li, Yan-Jie Ye, Yong-Xun A. Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia. Neuroscience letters. vol 512. issue 2. 2013-05-07. PMID:22330749. |
in the present study, adult male sprague-dawley rats were subjected with permanent ligation of the bilateral common carotid arteries to investigate the roles of b7t on cognitive function, neuronal apoptosis and neurogenesis in the hippocampus. |
2013-05-07 |
2023-08-12 |
rat |
| Xi-Ji Shu, Wei Liu, Lei Zhang, Rong Yang, Hui-Ling Yi, Chang-Lei Li, Yan-Jie Ye, Yong-Xun A. Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia. Neuroscience letters. vol 512. issue 2. 2013-05-07. PMID:22330749. |
immunohistochemical results showed that b7t reduced neuronal apoptosis in the hippocampal ca1 region as compared with ischemia rats, and b7t treatment increased neurogenesis in the hippocampus. |
2013-05-07 |
2023-08-12 |
rat |
| Gang Wu, Rong-liang Xue, Jian-rui Lv, Wei Li, Xiao-ming Le. [Fas and TNFR1 expressions after cerebral ischemia and reperfusion in rats: association with cell apoptosis and the effects of Bcl-2 overexpression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 31. issue 8. 2013-05-02. PMID:21868309. |
to investigate the effect of bcl-2 overexpression on fas and tnfr1-mediated apoptosis and its possible mechanism in rat hippocampus following global ischemia/reperfusion (ir). |
2013-05-02 |
2023-08-12 |
rat |
| Johannes Boltze, Uwe R Schmidt, Doreen M Reich, Alexander Kranz, Klaus G Reymann, Maria Strassburger, Donald Lobsien, Daniel-Christoph Wagner, Annette Förschler, Wolf-Rüdiger Schäbit. Determination of the therapeutic time window for human umbilical cord blood mononuclear cell transplantation following experimental stroke in rats. Cell transplantation. vol 21. issue 6. 2013-05-01. PMID:22182968. |
further, influence of hucb mncs on necrosis and apoptosis in postischemic neural tissue was investigated in hippocampal slices cultures. |
2013-05-01 |
2023-08-12 |
human |
| Jing Wang, Xue Bai, Yongxing Chen, Yanxin Zhao, Xueyuan Li. Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139767. |
homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. |
2013-04-23 |
2023-08-12 |
rat |
| Jing Wang, Xue Bai, Yongxing Chen, Yanxin Zhao, Xueyuan Li. Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139767. |
these findings demonstrated that calcineurin activation and downregulation of 14-3-3ε may be one of the mechanisms of hcy-induced apoptosis of hippocampal neurons. |
2013-04-23 |
2023-08-12 |
rat |
| Hai-Jian Zhang, Chong Li, Guang-Yi Zhan. ATPA induced GluR5-containing kainite receptor S-nitrosylation via activation of GluR5-Gq-PLC-IP(3)R pathway and signalling module GluR5·PSD-95·nNOS. The international journal of biochemistry & cell biology. vol 44. issue 12. 2013-04-22. PMID:23000395. |
here our researches found that glur5-kar selective agonist atpa stimulation activated the nonclassical glur5-kar-gq-plc-ip(3)r pathway and the signalling module glur5·psd-95·nnos (the former is more important), led to ca(2+) release from intracellular calcium stores endoplasmic reticulum (er) to cytoplasm and extracellular calcium indrawal, respectively, which further resulted in nnos activation and glur5-kar s-nitrosylation, and then inhibited glur5-mediated whole-cell current attenuation and induced apoptosis in primary cultured hippocampal neurons. |
2013-04-22 |
2023-08-12 |
Not clear |
| Ronald A Merrill, Andrew M Slupe, Stefan Strac. N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival. The FEBS journal. vol 280. issue 2. 2013-04-11. PMID:22583914. |
phosphomimetic substitution of ser20, ser21, and ser22 renders bβ2 cytosolic, blocks drp1 dephosphorylation and mitochondrial fragmentation, and abolishes the ability of bβ2 overexpression to induce apoptosis in cultured hippocampal neurons. |
2013-04-11 |
2023-08-12 |
Not clear |
| Nuan Wang, Xianming Chen, Deqin Geng, Hongli Huang, Hao Zho. Ginkgo biloba leaf extract improves the cognitive abilities of rats with D-galactose induced dementia. Journal of biomedical research. vol 27. issue 1. 2013-04-05. PMID:23554791. |
y-maze, cresyl violet staining, tunel assays and immunohistochemistry staining were performed to detect learning and memory abilities, morphological changes in the hippocampus, neuronal apoptosis and the expressing level of phospho-pkb, respectively. |
2013-04-05 |
2023-08-12 |
rat |
| G Nilufer Yonguc, Yavuz Dodurga, Ayse Kurtulus, Bora Boz, Kemalettin Aca. Caspase 1, caspase 3, TNF-alpha, p53, and Hif1-alpha gene expression status of the brain tissues and hippocampal neuron loss in short-term dichlorvos exposed rats. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:23053939. |
the aim of this study was to examine caspase 1, caspase-3 and also cell apoptosis related genes as p53, tumor necrosis factor-alpha, hypoxia inducible factor 1-alpha expressions in hippocampus, cerebellum, cortex, and to estimate total hippocampal neuron number in ddvp treated rats. |
2013-04-04 |
2023-08-12 |
human |
| G Nilufer Yonguc, Yavuz Dodurga, Ayse Kurtulus, Bora Boz, Kemalettin Aca. Caspase 1, caspase 3, TNF-alpha, p53, and Hif1-alpha gene expression status of the brain tissues and hippocampal neuron loss in short-term dichlorvos exposed rats. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:23053939. |
short-term exposure to dichlorvos leads to neuronal loss in hippocampus and tnf-alpha rapidly and potently induces apoptosis and also several caspases as possible participants in the apoptotic cascade. |
2013-04-04 |
2023-08-12 |
human |
| Yan Zhou, Ze-qiang Qu, Yuan-shan Zeng, Yu-kun Lin, Yan Li, Peter Chung, Ricky Wong, Urban Häg. Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 7-8. 2013-03-26. PMID:21242065. |
the aim of this study was to investigate if preadministration with ganoderma lucidum spore (gls) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (icv) injection of streptozotocin (stz), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. |
2013-03-26 |
2023-08-12 |
rat |
| Chang-Mu Chen, Cheng-Tien Wu, Chih-Kang Chiang, Bor-Wu Liao, Shing-Hwa Li. C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815824. |
c/ebp homologous protein (chop) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. |
2013-03-21 |
2023-08-12 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Chih-Kang Chiang, Bor-Wu Liao, Shing-Hwa Li. C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815824. |
in this study, we explored the role of chop in the hippocampal cell apoptosis and memory performance injury under an induced er stress condition. |
2013-03-21 |
2023-08-12 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Chih-Kang Chiang, Bor-Wu Liao, Shing-Hwa Li. C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815824. |
tunicamycin can induce er stress and cell apoptosis in mouse hippocampus. |
2013-03-21 |
2023-08-12 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Chih-Kang Chiang, Bor-Wu Liao, Shing-Hwa Li. C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815824. |
compared with wild type mice, chop-/- mice showed an enhanced hippocampal cell apoptosis, worse performance in memory-related behavioral tests, and attenuated ire-1 expression under tunicamycin treatment. |
2013-03-21 |
2023-08-12 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Chih-Kang Chiang, Bor-Wu Liao, Shing-Hwa Li. C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815824. |
taken together, these results suggest that chop may play a protective role in the hippocampal cell apoptosis and impairment of memory performance. |
2013-03-21 |
2023-08-12 |
mouse |
| Mehdi Mehdizadeh, Fataneh Dabaghian, Akram Nejhadi, Hassan Fallah-Huseini, Samira Choopani, Nima Shekarriz, Nima Molavi, Arghavan Basirat, Farzaneh Mohammadzadeh Kazorgah, Alireza Samzadeh-Kermani, Sara Soleimani As. Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain. Cell journal. vol 14. issue 3. 2013-03-20. PMID:23508562. |
the present study considers the effects of zingiber officinale on mdma-induced spatial memory impairment and apoptosis in the hippocampus of male rats. |
2013-03-20 |
2023-08-12 |
rat |
| b' Nicolas Martin, Carine Bossenmeyer-Pouri\\xc3\\xa9, Violette Koziel, Rozat Jazi, Sandra Audonnet, Paul Vert, Jean-Louis Gu\\xc3\\xa9ant, Jean-Luc Daval, Gr\\xc3\\xa9gory Pouri\\xc3\\xa. Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats. PloS one. vol 7. issue 11. 2013-03-14. PMID:23173039.' |
we confirmed that such a short hypoxia led to brain neurogenesis within the ensuing weeks, along with reduced apoptosis in the hippocampus involving activation of erk1/2 and repression of p38 and death-associated protein (dap) kinase. |
2013-03-14 |
2023-08-12 |
rat |