| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Pang, Xue Leng, Hao Lu, Hongpeng Yang, Nan Song, Long Tan, Yugang Jiang, Changjiang Gu. Depletion of intracellular zinc induces apoptosis of cultured hippocampal neurons through suppression of ERK signaling pathway and activation of caspase-3. Neuroscience letters. vol 552. 2014-05-15. PMID:23954826. |
thus, the results indicate that tpen induces apoptosis of hippocampal neurons through inhibition of erk and, in turn, activation of caspase-3. |
2014-05-15 |
2023-08-12 |
Not clear |
| Fabian D Liechti, Denis Grandgirard, David Leppert, Stephen L Lei. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity. vol 82. issue 4. 2014-05-12. PMID:24491581. |
hippocampal apoptosis and cortical necrosis are histopathological correlates of neurofunctional sequelae in rodent models and are frequently observed in autopsy studies of patients who die of pm. |
2014-05-12 |
2023-08-12 |
rat |
| Fabian D Liechti, Denis Grandgirard, David Leppert, Stephen L Lei. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity. vol 82. issue 4. 2014-05-12. PMID:24491581. |
animals were sacrificed at 42 h postinfection, and their brains were assessed by histomorphometry for hippocampal apoptosis and cortical necrosis. |
2014-05-12 |
2023-08-12 |
rat |
| Fabian D Liechti, Denis Grandgirard, David Leppert, Stephen L Lei. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity. vol 82. issue 4. 2014-05-12. PMID:24491581. |
both compounds, while exhibiting disparate mmp and tace inhibitory profiles, decreased hippocampal apoptosis and cortical injury. |
2014-05-12 |
2023-08-12 |
rat |
| Minxuan Sun, Sabine M Hölter, Jens Stepan, Lillian Garrett, Just Genius, Elisabeth Kremmer, Martin Hrabě de Angelis, Wolfgang Wurst, D Chichung Lie, Laure Bally-Cuif, Matthias Eder, Dan Rujescu, Jochen Gra. Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function. Mammalian genome : official journal of the International Mammalian Genome Society. vol 24. issue 9-10. 2014-05-09. PMID:24096375. |
free intracellular ca(2+) levels were increased and apoptosis was enhanced in the hippocampus of o377 mutants. |
2014-05-09 |
2023-08-12 |
mouse |
| Nancy Ho, Marilyn S Sommers, Irwin Luck. Effects of diabetes on hippocampal neurogenesis: links to cognition and depression. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23680701. |
the effects of diabetes on brain and behavioral functions in experimental models of type 1 and type 2 diabetes are reviewed, with a focus on the negative impact of impaired hippocampal neurogenesis, dendritic remodeling and increased apoptosis. |
2014-05-08 |
2023-08-12 |
Not clear |
| Daowen Si, Haitao Wang, Qian Wang, Chengyun Zhang, Jingyu Sun, Zhigang Wang, Zuofeng Zhang, Yuxin Zhan. Progesterone treatment improves cognitive outcome following experimental traumatic brain injury in rats. Neuroscience letters. vol 553. 2014-05-08. PMID:23954829. |
this study was aimed to investigate the inhibitory effects of prog on inflammation and apoptosis in the hippocampus after tbi and its influence on the cognitive outcome. |
2014-05-08 |
2023-08-12 |
rat |
| Daowen Si, Haitao Wang, Qian Wang, Chengyun Zhang, Jingyu Sun, Zhigang Wang, Zuofeng Zhang, Yuxin Zhan. Progesterone treatment improves cognitive outcome following experimental traumatic brain injury in rats. Neuroscience letters. vol 553. 2014-05-08. PMID:23954829. |
in conclusion, post-tbi prog administration may attenuate inflammation and apoptosis in the hippocampus, and this may be one of the mechanisms by which prog improves cognitive outcome following tbi. |
2014-05-08 |
2023-08-12 |
rat |
| Marta Nowacka, Ewa Obuchowic. BDNF and VEGF in the pathogenesis of stress-induced affective diseases: an insight from experimental studies. Pharmacological reports : PR. vol 65. issue 3. 2014-04-24. PMID:23950576. |
it has been reported that the rise in the concentration of pro-inflammatory cytokines and persistent up-regulation of glucocorticoid expression in the brain and periphery increases the excitotoxic effect on ca3 pyramidal neurons in the hippocampus resulting in dendritic atrophy, apoptosis of neurons and possibly inhibition of neurogenesis in adult brain. |
2014-04-24 |
2023-08-12 |
Not clear |
| Krithi Irmady, Katherine A Jackman, Victoria A Padow, Neelam Shahani, Laura Andres Martin, Leandro Cerchietti, Klaus Unsicker, Costantino Iadecola, Barbara L Hempstea. Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573298. |
induction of this ligand/receptor system is pathologically relevant, as a decrease in apoptosis, after oxygen-glucose deprivation, is observed in hippocampal neurons or slices after delivery of function-blocking antibodies to p75(ntr) or prongf and in p75(ntr) and ngf haploinsufficient slices. |
2014-04-22 |
2023-08-12 |
mouse |
| Qiao-Yun Wang, Feng Liu, Feng-Jie Wu, Jin-Lian L. [Effects of ginsenoside Rg1 on the expressions of p-eRK1/2 and p-JNK in local cerebral ischemia/reperfusion injury rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 33. issue 2. 2014-04-10. PMID:23646480. |
to study the possible anti-apoptotic mechanism of ginsenoside rg1 on the apoptosis of hippocampal neuron after cerebral ischemia/reperfusion (i/r) injury rats. |
2014-04-10 |
2023-08-12 |
rat |
| Xiaoqin Tan, Xueling Guo, Huiguo Li. Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein. Saudi medical journal. vol 34. issue 7. 2014-04-09. PMID:23860889. |
melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating b-cell lymphoma-2 and down-regulating b-cell lymphoma-2-associated x protein. |
2014-04-09 |
2023-08-12 |
Not clear |
| Bin Deng, Xingchun Gou, Hai Chen, Liya Li, Haixing Zhong, Hao Xu, Fengliang Jiang, Zhijing Zhao, Qiang Wang, Lixian X. Targeted delivery of neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury. Biomaterials. vol 34. issue 34. 2014-03-26. PMID:23942209. |
tat-lbd-ngn2 promoted the outgrowth of neuronal neurite, increased the survival rate and alleviated apoptosis of hippocampal neurons exposed to oxygen glucose deprivation in vitro. |
2014-03-26 |
2023-08-12 |
mouse |
| Alena Borovaya, Olga Olisova, Thomas Ruzicka, Miklós Sárd. Does isotretinoin therapy of acne cure or cause depression? International journal of dermatology. vol 52. issue 9. 2014-03-25. PMID:23962262. |
it was suggested that isotretinoin in high concentrations inhibits hippocampal neurogenesis and induces apoptosis of hippocampal cells. |
2014-03-25 |
2023-08-12 |
Not clear |
| Daniela Giuliani, Alessandra Ottani, Davide Zaffe, Maria Galantucci, Flavio Strinati, Renzo Lodi, Salvatore Guarin. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of learning and memory. vol 104. 2014-03-20. PMID:23726868. |
hippocampus reduced activity of c-jun n-terminal kinases, extracellular signal-regulated kinases and p38, which have an established role not only in phosphorylation of tau protein but also in inflammation and apoptosis, was also found. |
2014-03-20 |
2023-08-12 |
mouse |
| Daniela Giuliani, Alessandra Ottani, Davide Zaffe, Maria Galantucci, Flavio Strinati, Renzo Lodi, Salvatore Guarin. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of learning and memory. vol 104. 2014-03-20. PMID:23726868. |
consistently, decrease in tumor necrosis factor-α level, up-regulation of bcl-2, and down-regulation of bax and the downstream executioner caspase-3, also occurred in the hippocampus of 3xtg-ad mice after treatment with tabiano's spa-water, thus suggesting that it is also able to modulate inflammation and apoptosis. |
2014-03-20 |
2023-08-12 |
mouse |
| Seong Hee Kim, Kwangsoo Kim, Ji Hyun Ahn, Hee Kyung Chan. Increased expression of tumor necrosis factor-alpha in the rat hippocampus after acute homocysteine administration. Journal of epilepsy research. vol 1. issue 1. 2014-03-20. PMID:24649438. |
this paper evaluated the effect of acute homocysteine administration on inflammatory cytokine tumor necrosis factor-alpha (tnf-α) expression and neuronal apoptosis in the rat hippocampus and investigated the effects of vitamin c treatment on homocysteine-induced inflammation and neuronal death. |
2014-03-20 |
2023-08-12 |
rat |
| Ying Cheng, Joshua G Corbin, Richard J Lev. Programmed cell death is impaired in the developing brain of FMR1 mutants. Developmental neuroscience. vol 35. issue 4. 2014-03-19. PMID:23900139. |
both fmr1 mutant strains demonstrated decreased apoptosis in neocortex, hippocampus, and basolateral amygdala, impaired cytochrome c and procaspase-9 release from mitochondria despite intact bax translocation, increased expression of the antiapoptotic protein, bcl-xl, and increased number of neurons. |
2014-03-19 |
2023-08-12 |
mouse |
| Parham Reisi, Gholam Reza Dashti, Molud Shabrang, Bahman Rashid. The effect of vitamin E on neuronal apoptosis in hippocampal dentate gyrus in rabbits fed with high-cholesterol diets. Advanced biomedical research. vol 3. 2014-03-14. PMID:24627850. |
the effect of vitamin e on neuronal apoptosis in hippocampal dentate gyrus in rabbits fed with high-cholesterol diets. |
2014-03-14 |
2023-08-12 |
Not clear |
| N Sun, J R Hao, X Y Li, X H Yin, Y Y Zong, G Y Zhang, C Ga. GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats. Cell death & disease. vol 4. 2014-03-12. PMID:23949220. |
global cerebral ischemia/reperfusion (i/r) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. |
2014-03-12 |
2023-08-12 |
rat |