| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Jiang, Jin-Tai Yu, Xi-Chen Zhu, Meng-Shan Tan, Hui-Fu Wang, Lei Cao, Qiao-Quan Zhang, Jian-Quan Shi, Li Gao, Hao Qin, Ying-Dong Zhang, Lan Ta. Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease. Pharmacological research. vol 81. 2014-12-15. PMID:24602800. |
meanwhile, app/ps1 mice received intraperitoneal injection of temsirolimus (20mg/kg) every 2 days for 60 days, and brain aβ burden, autophagy biomarkers, cellular apoptosis in hippocampus, and spatial cognitive functions were assessed. |
2014-12-15 |
2023-08-12 |
mouse |
| Teng Jiang, Jin-Tai Yu, Xi-Chen Zhu, Meng-Shan Tan, Hui-Fu Wang, Lei Cao, Qiao-Quan Zhang, Jian-Quan Shi, Li Gao, Hao Qin, Ying-Dong Zhang, Lan Ta. Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease. Pharmacological research. vol 81. 2014-12-15. PMID:24602800. |
meanwhile, temsirolimus attenuated cellular apoptosis in hippocampus of app/ps1 mice, which was accompanied by an improvement in spatial learning and memory abilities. |
2014-12-15 |
2023-08-12 |
mouse |
| b' D Mango, G Barbato, S Piccirilli, M B Panico, M Feligioni, C Schepisi, M Graziani, V Porrini, M Benarese, A Lanzillotta, M Pizzi, S Pieraccini, M Sironi, F Blandini, F Nicoletti, N B Mercuri, B P Imbimbo, R Nistic\\xc3\\xb. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacological research. vol 81. 2014-12-15. PMID:24630950.' |
finally, chf5074 significantly reduced the apoptosis in hippocampal neurons exposed to ogd, as revealed by cleaved-caspase-3 immunoreactivity and tunel staining. |
2014-12-15 |
2023-08-12 |
Not clear |
| Jackeline Moraes Malheiros, Daniele Suzete Persike, Leticia Urbano Cardoso de Castro, Talita Rojas Cunha Sanches, Lúcia da Conceição Andrade, Alberto Tannús, Luciene Covola. Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Epilepsy research. vol 108. issue 4. 2014-12-14. PMID:24630048. |
reduced hippocampal manganese-enhanced mri (memri) signal during pilocarpine-induced status epilepticus: edema or apoptosis? |
2014-12-14 |
2023-08-12 |
rat |
| Jackeline Moraes Malheiros, Daniele Suzete Persike, Leticia Urbano Cardoso de Castro, Talita Rojas Cunha Sanches, Lúcia da Conceição Andrade, Alberto Tannús, Luciene Covola. Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Epilepsy research. vol 108. issue 4. 2014-12-14. PMID:24630048. |
we analyzed hippocampal caspase-3 activation (to evaluate apoptosis), t2 relaxometry (tissue water content) and aquaporin 4 expression (water-channel protein) of rats subjected to short periods of pilocarpine-induced se. |
2014-12-14 |
2023-08-12 |
rat |
| Jackeline Moraes Malheiros, Daniele Suzete Persike, Leticia Urbano Cardoso de Castro, Talita Rojas Cunha Sanches, Lúcia da Conceição Andrade, Alberto Tannús, Luciene Covola. Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Epilepsy research. vol 108. issue 4. 2014-12-14. PMID:24630048. |
based on apoptosis and tissue water content analysis, the low hippocampal memri signal 30min after se can potentially be attributed to local edema rather than to cell death. |
2014-12-14 |
2023-08-12 |
rat |
| D Feng, W Wang, Y Dong, L Wu, J Huang, Y Ma, Z Zhang, S Wu, G Gao, H Qi. Ceftriaxone alleviates early brain injury after subarachnoid hemorrhage by increasing excitatory amino acid transporter 2 expression via the PI3K/Akt/NF-κB signaling pathway. Neuroscience. vol 268. 2014-12-12. PMID:24631672. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining and western blot analysis of cleaved caspase 3 showed that cef decreased hippocampal neuronal apoptosis following sah. |
2014-12-12 |
2023-08-12 |
rat |
| W Wang, X D Yu, X Mo, H B Zhang, D M Zh. Limb ischemic preconditioning attenuates cerebral ischemic injury in rat model. Perfusion. vol 29. issue 3. 2014-12-09. PMID:24002779. |
therefore, potential protective effects of limb ischemic preconditioning (lip) on subsequent ischemic injury of the brain were investigated by evaluating anti-inflammatory effects and apoptosis of pyramidal neurons in the ca1 hippocampus. |
2014-12-09 |
2023-08-12 |
rat |
| W Wang, X D Yu, X Mo, H B Zhang, D M Zh. Limb ischemic preconditioning attenuates cerebral ischemic injury in rat model. Perfusion. vol 29. issue 3. 2014-12-09. PMID:24002779. |
therefore, in a mcao rat model, we have proved that lip pretreatment can protect the brain from infarction after ischemic injury and induce ischemic tolerance, potentially, by reducing il-17 to provide anti-inflammatory effects and attenuate apoptosis of hippocampal neuronal cells. |
2014-12-09 |
2023-08-12 |
rat |
| Ikram Ullah, Hyun Young Park, Myeong Ok Ki. Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons. CNS neuroscience & therapeutics. vol 20. issue 4. 2014-12-09. PMID:24393263. |
anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ros-activated ampk pathway in hippocampal neurons. |
2014-12-09 |
2023-08-12 |
Not clear |
| Michele Longoni Calió, Darci Sousa Marinho, Gui Mi Ko, Renata Rodrigues Ribeiro, Adriana Ferraz Carbonel, Lila Missae Oyama, Milene Ormanji, Tatiana Pinoti Guirao, Pedro Luiz Calió, Luciana Aparecida Reis, Manuel de Jesus Simões, Telma Lisbôa-Nascimento, Alice Teixeira Ferreira, Clélia Rejane Antônio Bertoncin. Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free radical biology & medicine. vol 70. 2014-12-09. PMID:24525001. |
transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. |
2014-12-09 |
2023-08-12 |
rat |
| Jun-Li Zhen, Wei-Ping Wang, Jing-Jing Zhou, Zhen-Zhen Qu, Hai-Bo Fang, Ran-Ran Zhao, Yan Lu, Hong-Chao Wang, Hong-Min Zan. Chronic intermittent hypoxic preconditioning suppresses pilocarpine-induced seizures and associated hippocampal neurodegeneration. Brain research. vol 1563. 2014-12-08. PMID:24680745. |
both hypoxic preconditioning protocols reduced the frequency and severity of srs, suppressed post-ictal [ca(2+)]i elevations, and inhibited neuronal apoptosis in the rat hippocampus compared to pilocarpine alone, but cihh was more effective than cinh. |
2014-12-08 |
2023-08-12 |
rat |
| Cornelle W Noorlander, Deodata Tijsseling, Ellen V S Hessel, Willem B de Vries, Jan B Derks, Gerard H A Visser, Pierre N E de Graa. Antenatal glucocorticoid treatment affects hippocampal development in mice. PloS one. vol 9. issue 1. 2014-12-03. PMID:24465645. |
we investigated the effects of dexamethasone treatment on anatomical changes, apoptosis and proliferation in the hippocampus, hippocampal volume and on total body weight. |
2014-12-03 |
2023-08-12 |
mouse |
| Cornelle W Noorlander, Deodata Tijsseling, Ellen V S Hessel, Willem B de Vries, Jan B Derks, Gerard H A Visser, Pierre N E de Graa. Antenatal glucocorticoid treatment affects hippocampal development in mice. PloS one. vol 9. issue 1. 2014-12-03. PMID:24465645. |
dexamethasone treatment increased the number of apoptotic cells in the hippocampus until birth, but postnatally no effects of dexamethasone treatment on apoptosis were found. |
2014-12-03 |
2023-08-12 |
mouse |
| Senthilvelan Manohar, Samson Jamesdaniel, Richard Salv. Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Neurotoxicity research. vol 25. issue 4. 2014-12-01. PMID:24277158. |
using a focused apoptosis gene array, we analyzed the early cisplatin-induced changes in gene expression in the hippocampus of adult sprague-dawley rats and compared the results to those from the inferior colliculus, a non-mitotic auditory region resistant to cisplatin-induced cell death. |
2014-12-01 |
2023-08-12 |
rat |
| Yunfeng Wang, Chunhua Wan, Shanshan Yu, Lixiang Yang, Bing Li, Ting Lu, Yongfeng Bi, Junkang Jiang, Gang Cu. Upregulated expression of NF-YC contributes to neuronal apoptosis via proapoptotic protein bim in rats' brain hippocampus following middle cerebral artery occlusion (MCAO). Journal of molecular neuroscience : MN. vol 52. issue 4. 2014-11-25. PMID:24014123. |
upregulated expression of nf-yc contributes to neuronal apoptosis via proapoptotic protein bim in rats' brain hippocampus following middle cerebral artery occlusion (mcao). |
2014-11-25 |
2023-08-12 |
rat |
| Flávio Afonso Gonçalves Mourão, Hércules Ribeiro Leite, Luciana Estefani Drumond de Carvalho, Talita Hélen Ferreira E Vieira, Mauro Cunha Xavier Pinto, Daniel de Castro Medeiros, Ian Lara Lamounier Andrade, Daniela Fontes Gonçalves, Grace Schenatto Pereira, Márcio Flávio Dutra Moraes, André Ricardo Massensin. Neuroprotective effect of exercise in rat hippocampal slices submitted to in vitro ischemia is promoted by decrease of glutamate release and pro-apoptotic markers. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24903976. |
our results suggest that physical exercise protects hippocampal slices from the effects of oxygen and glucose deprivation, probably by a mechanism involving both the decrease of glutamatergic excitotoxicity and apoptosis induction. |
2014-11-21 |
2023-08-13 |
rat |
| Jie Gao, He Wang, Yuan Liu, Ying-Yu Li, Can Chen, Liang-Ming Liu, Ya-Min Wu, Sen Li, Ce Yan. Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. Medical science monitor : international medical journal of experimental and clinical research. vol 20. 2014-11-18. PMID:24675061. |
glutamate and gaba imbalance promotes neuronal apoptosis in hippocampus after stress. |
2014-11-18 |
2023-08-12 |
Not clear |
| Pranay Srivastava, Rajesh S Yadav, Lalit P Chandravanshi, Rajendra K Shukla, Yogesh K Dhuriya, Lalit K S Chauhan, Hari N Dwivedi, Aditiya B Pant, Vinay K Khann. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. Toxicology and applied pharmacology. vol 279. issue 3. 2014-11-17. PMID:24952339. |
exposure to arsenic (20mg/kg body weight, p.o) for 28 days in rats resulted to decrease the expression of chrm2 receptor gene associated with mitochondrial dysfunctions as evident by decrease in the mitochondrial membrane potential, activity of mitochondrial complexes and enhanced apoptosis both in the frontal cortex and hippocampus in comparison to controls. |
2014-11-17 |
2023-08-13 |
rat |
| Mei Ling Jin, Sun Young Park, Young Hun Kim, Jeong-Il Oh, Sang Joon Lee, Geuntae Par. The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells. Neurotoxicology. vol 41. 2014-11-14. PMID:24486958. |
the neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and er stress-associated apoptosis in hippocampal ht22 cells. |
2014-11-14 |
2023-08-12 |
Not clear |