| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele Caraglia, Monica Marra, Caterina Viscomi, Anna Maria D'Alessandro, Alfredo Budillon, Giuseppina Meo, Claudio Arra, Antonio Barbieri, Ulf R Rapp, Alfonso Baldi, Pierfrancesco Tassone, Salvatore Venuta, Alberto Abbruzzese, Pierosandro Tagliaferr. The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways. International journal of cancer. vol 121. issue 10. 2007-11-30. PMID:17657738. |
interferon alpha (ifnalpha) induces an egf-ras-->raf-1-->erk dependent survival pathway counteracting apoptosis induced by the cytokine. |
2007-11-30 |
2023-08-12 |
mouse |
| Carol D Curtis, Varsha S Likhite, Ian X McLeod, John R Yates, Ann M Nardull. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer research. vol 67. issue 21. 2007-11-27. PMID:17975005. |
the complementary abilities of er alpha and nm23-h1 together to influence gene expression, cell migration, and apoptosis could be key factors in helping to determine tumor cell fate. |
2007-11-27 |
2023-08-12 |
human |
| Tomohiro Okunaga, Yoshishige Urata, Shinji Goto, Takayuki Matsuo, Shingo Mizota, Keisuke Tsutsumi, Izumi Nagata, Takahito Kondo, Yoshito Ihar. Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951181. |
thus, overexpression of crt modulates radiation-induced apoptosis by suppressing akt signaling through the up-regulation of pp2ac alpha expression via altered ca(2+) homeostasis. |
2007-11-26 |
2023-08-12 |
human |
| N Azoitei, A Brey, T Busch, S Fulda, G Adler, T Seufferlei. Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. Oncogene. vol 26. issue 45. 2007-11-21. PMID:17471239. |
here, we report that expression and consequent activation of tnk1 enables tumor necrosis factor alpha (tnfalpha)-induced apoptosis by selectively inhibiting tnfalpha-induced activation of nuclear factor-kappab (nf-kappab). |
2007-11-21 |
2023-08-12 |
Not clear |
| Kwang Seok Ahn, Gautam Sethi, Ta-Hsiang Chao, Saskia T C Neuteboom, Madan M Chaturvedi, Michael A Palladino, Anas Younes, Bharat B Aggarwa. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood. vol 110. issue 7. 2007-11-06. PMID:17609425. |
here we demonstrate that salinosporamide a potentiated the apoptosis induced by tumor necrosis factor alpha (tnf), bortezomib, and thalidomide, and this correlated with down-regulation of gene products that mediate cell proliferation (cyclin d1, cyclooxygenase-2 [cox-2], and c-myc), cell survival (bcl-2, bcl-xl, cflip, traf1, iap1, iap2, and survivin), invasion (matrix metallopro-teinase-9 [mmp-9] and icam-1), and angiogenesis (vascular endothelial growth factor [vegf]). |
2007-11-06 |
2023-08-12 |
Not clear |
| David Y Zhang, Yong Li, Syed M Abbas Rizvi, Changfa Qu, John Kearsley, Barry J Alle. Cytotoxicity of breast cancer cells overexpressing HER2/neu by 213Bi-Herceptin radioimmunoconjugate. Cancer letters. vol 218. issue 2. 2007-10-30. PMID:15670895. |
(213)bi-herceptin alpha conjugate (ac) was specifically cytotoxic to these cell lines in a her2 level-dependent fashion, resulting in the cellular death through apoptosis. |
2007-10-30 |
2023-08-12 |
human |
| Ruud Oerlemans, Josefien Vink, Ben A C Dijkmans, Yehuda G Assaraf, Marjolein van Miltenburg, Joost van der Heijden, Ilan Ifergan, Willem F Lems, Rik J Scheper, Gertjan J L Kaspers, Jacqueline Cloos, Gerrit Janse. Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis. Annals of the rheumatic diseases. vol 66. issue 10. 2007-10-29. PMID:17267514. |
sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis. |
2007-10-29 |
2023-08-12 |
human |
| Ji Miao, George G Chen, Jing-Ping Yun, Suk-Ying Chun, Zi-Zheng Zheng, Rocky L K Ho, Ernest C W Chak, Ning-Shao Xia, Paul B S La. Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17503221. |
finally, overexpression of bim el, l, s and all alpha isoforms induced apoptosis in hcc cells, while overexpression of bim beta isoforms showed no effects on cell survival after 5-fu treatment. |
2007-10-26 |
2023-08-12 |
human |
| Ji Miao, George G Chen, Jing-Ping Yun, Suk-Ying Chun, Zi-Zheng Zheng, Rocky L K Ho, Ernest C W Chak, Ning-Shao Xia, Paul B S La. Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17503221. |
in conclusion, bim alpha isoforms appears to have a role in the regulation of apoptosis in hcc cells, which may contribute to not only the growth of tumor cells but also the sensitivity of hcc cells to chemotherapy. |
2007-10-26 |
2023-08-12 |
human |
| Yihui Pei, Da Xing, Xuejuan Gao, Lei Liu, Tongsheng Che. Real-time monitoring full length bid interacting with Bax during TNF-alpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17520191. |
bid, a member of the pro-apoptotic bcl-2 protein family, is activated through caspase-8-mediated cleavage into a truncated form (p15 tbid) during tnf-alpha(tumor necrosis factor alpha)-induced apoptosis. |
2007-10-26 |
2023-08-12 |
Not clear |
| Cuixia Tian, Grace K Kron, Kevin M Dischert, James N Higginbotham, James E Crow. Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells. Immunology. vol 119. issue 1. 2007-10-24. PMID:16764687. |
the expression level of the il-13 receptor alpha 1 chain, a key component of the il-13 receptor/il-4 type ii receptor, and the response to il-13 treatment for protection against apoptosis in neonatal b cells were similar to those of the adult b cells. |
2007-10-24 |
2023-08-12 |
human |
| K L Schavolt, J A Pietenpo. p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17404570. |
p53 and delta np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, dna repair and apoptosis. |
2007-10-24 |
2023-08-12 |
human |
| R Demiralay, N Gürsan, H Erde. Regulation of nicotine-induced apoptosis of pulmonary artery endothelial cells by treatment of N-acetylcysteine and vitamin E. Human & experimental toxicology. vol 26. issue 7. 2007-10-18. PMID:17884964. |
regulation of nicotine-induced apoptosis of pulmonary artery endothelial cells by treatment of n-acetylcysteine and vitamin e. this study investigated the frequency of apoptosis in rat pulmonary artery endothelial cells after intraperitoneal nicotine injection, examining the roles of the inflammatory markers myeloperoxidase (mpo), tumour necrosis factor alpha (tnf-alpha), and vascular endothelial growth factor (vegf) in nicotine-induced vascular damage and the protective effects of two known antioxidant agents, n-acetylcysteine (nac) and vitamin e. female wistar rats were divided into four groups, each composed of nine rats: negative control group, positive control group, nac-treated group (500 mg/kg), and vitamin e-treated group (500 mg/kg). |
2007-10-18 |
2023-08-12 |
rat |
| Sophie Malagarie-Cazenave, Nathalie Andrieu-Abadie, Bruno Ségui, Valérie Gouazé, Claudine Tardy, Olivier Cuvillier, Thierry Levad. Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death. Expert reviews in molecular medicine. vol 4. issue 28. 2007-10-12. PMID:14987386. |
tnf-[alpha] is a multifaceted cytokine that controls a wide range of immune responses in mammals, including induction of programmed cell death (also called apoptosis). |
2007-10-12 |
2023-08-12 |
human |
| Martin Reidy, Pius Zihlmann, Jeffrey A Hubbell, Heike Hal. Activation of cell-survival transcription factor NFkappaB in L1Ig6-stimulated endothelial cells. Journal of biomedical materials research. Part A. vol 77. issue 3. 2007-10-11. PMID:16493660. |
moreover, blocking of alpha(v)beta(3) interaction with l1ig6 was correlated with induction of apoptosis. |
2007-10-11 |
2023-08-12 |
human |
| Paola Poma, Monica Notarbartolo, Manuela Labbozzetta, Annamaria Maurici, Valeria Carina, Alessandra Alaimo, Michele Rizzi, Daniele Simoni, Natale D'Alessandr. The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis. International journal of molecular medicine. vol 20. issue 3. 2007-10-11. PMID:17671737. |
in comparison with mcf-7, mcf-7r lacks estrogen receptor alpha (eralpha) and overexpressess p-glycoprotein (p-gp), different iaps (inhibitory of apoptosis proteins) and cox-2. |
2007-10-11 |
2023-08-12 |
Not clear |
| Daniel E Voth, Dale Howe, Robert A Heinze. Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. Infection and immunity. vol 75. issue 9. 2007-10-10. PMID:17606599. |
reduced parp cleavage was also observed in cells treated with tumor necrosis factor alpha to induce extrinsic apoptosis. |
2007-10-10 |
2023-08-12 |
human |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine and vitamin E on nicotine-induced apoptosis of cardiac cells. Journal of applied toxicology : JAT. vol 27. issue 3. 2007-10-09. PMID:17216608. |
this study was conducted to investigate the frequency of apoptosis in rat cardiomyocytes after intratraperitoneal nicotine injection, in order to examine the roles of inflammatory markers [myeloperoxidase (mpo) and tumor necrosis factor alpha (tnf-alpha)] in nicotine-induced cardiac damage and to determine the protective effects of three known antioxidant agents (n-acetylcysteine (nac), erdosteine and vitamin e) on nicotine toxicity in the heart. |
2007-10-09 |
2023-08-12 |
rat |
| A Orzechowsk. Possible implications of redox-sensitive tumour cell transformation; lessons from cell culture studies. Polish journal of veterinary sciences. vol 10. issue 2. 2007-10-09. PMID:17882938. |
these include either hypoxia-promoted apoptosis signal inducing kinase 1 (ask-1), hypoxia inducing factor 1 alpha (hif-1alpha) and glycolysis, or normoxia-promoted activating protein-1 (ap-1) or hyperoxia-induced nuclear factor kappa b (nf-kappab). |
2007-10-09 |
2023-08-12 |
Not clear |
| Aejaz Sayeed, Santhi D Konduri, Wensheng Liu, Sanjay Bansal, Fengzhi Li, Gokul M Da. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer research. vol 67. issue 16. 2007-10-04. PMID:17699779. |
estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. |
2007-10-04 |
2023-08-12 |
human |