| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binru Zheng, Jia Shang, Yuanqing Wei, Qianqian Tao, Jizhou Yin, An Kang, Rui Liu, Hongzhen Lian, Shuying Ha. Chemoproteomic profiling by bioorthogonal probes to reveal the novel targets of acrylamide in microglia. Journal of hazardous materials. vol 484. 2024-12-05. PMID:39637805. |
aa was found to induce neurotoxicity by binding to newly identified targets, proteasome 26s subunit, non atpase 9 (psmd9) and nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 5 (ndufa5), interfering with the ubiquitin-proteasome system, and inducing mitochondria-dependent apoptosis. |
2024-12-05 |
2024-12-08 |
Not clear |
| Haibo Xie, Yuansheng Duan, Pengcheng Zhou, Yu Li, Jihong Gao, Ruixuan Cheng, Zhibing Liu, Jiaxiang Zhang, Qixing Zh. TNF-α-downregulated SIRT1 regulates mitochondrial-autophagy and apoptosis in renal vascular endothelial cells involved in trichloroethylene-induced immune kidney injury. International immunopharmacology. vol 143. issue Pt 2. 2024-10-30. PMID:39476564. |
this study investigated how trichloroethylene (tce) sensitization-induced tumor necrosis factor alpha (tnf-α) deposition in renal vascular endothelial cells affects apoptosis and its underlying mechanisms. |
2024-10-30 |
2024-11-02 |
mouse |
| L Li, Y Liao, Z Y Li. [Mechanism of protective effect of metformin against septic cardiomyopathy based on the P38 MAPK/JNK signaling pathway]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 58. issue 10. 2024-10-20. PMID:39428241. |
ultrasound imaging system was used to detect cardiac function, and tunel method was used to detect apoptosis rate of myocardial tissues; real-time fluorescence quantitative polymerase chain reaction (rt-qpcr) was used to detect the levels of mrna of jnk, p38 mapk of p38 mapk signaling pathway in the myocardial tissues of mice; plasma creatine kinase isoenzyme (ck-mb), brain natriuretic peptide (bnp), tumor necrosis factor alpha (tnf-α), and interleukin 6 (il-6) levels were measured by enzyme-linked immunosorbent assay (elisa) in all groups of mice; and protein kinase c, and protein kinase c levels were measured by protein blotting in cardiac muscle tissue. |
2024-10-20 |
2024-10-23 |
mouse |
| Fengqin Luo, Juan Zhang, Yunfei Miao, Danhong Wu, Hongxia Shen, Man L. Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway. The international journal of biochemistry & cell biology. 2024-10-12. PMID:39395636. |
paeoniflorin alleviated mechanical abnormal pain, decreased levels of ionized calcium binding adapter molecule-1 (iba-1), glial fibrillary acidic protein, heat shock protein 90 alpha family class a member 1 (hsp90aa1, inflammatory factor) and high mobility group box 1 (hmgb1, inflammation-related protein), and inhibited neuronal apoptosis in chronic constrictive injury rats or lipopolysaccharide-induced bv-2 cells. |
2024-10-12 |
2024-10-15 |
mouse |
| Bojie Ma, Chaode Gu, Renwei Lu, Panpan Lian, Wentong Wang, Zhiqiang Huang, Zhonglan Su, Hongwei Wan. Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions. International immunopharmacology. vol 143. issue Pt 1. 2024-10-10. PMID:39388894. |
karyopherin subunit alpha 2 (kpna2), a nuclear transport protein involved in cellular activities such as differentiation, proliferation, apoptosis, and immune response, has emerged as a potential biomarker in several diseases. |
2024-10-10 |
2024-10-13 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Rilong Jin, Chen Li, Yute Yang, Jie Xi. AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling. Clinical and experimental pharmacology & physiology. vol 51. issue 11. 2024-10-03. PMID:39358837. |
aebp1-overexpressed lentiviral vectors increased relative cell viability, alkaline phosphatase (alp) staining, alizarin red staining and osteoblastic differentiation markers including osteocalcin (ocn), osteopontin (opn), collagen type i alpha 1 (col1a1), runt-related transcription factor 2 (runx2) and bone morphogenetic protein 2 (bmp2), but decreased cell apoptosis rate in mc3t3-e1 cells under dex treatment; besides, aebp1-overexpressed lentiviral vectors positively regulated p-pi3k and p-akt expressions. |
2024-10-03 |
2024-10-05 |
Not clear |
| Seda Kocak, Ibrahim Guner, Muhittin Onur Yaman, Tugba Ekiz Yilmaz, Emine Elif Guzel Meydanli, Nermin Yelmen, Gulderen Sahi. Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats. Medeniyet medical journal. vol 39. issue 3. 2024-10-01. PMID:39350576. |
alpha b-crystallin ameliorates imbalance of redox homeostasis, inflammation and apoptosis in an acute lung injury model with rats. |
2024-10-01 |
2024-10-03 |
rat |
| Fan Chen, Zian Zhang, Wenzhe Wang, Chang Liu, Zhenchao Huang, Chaoqun Yu, Zhen Jia, Haining Zhan. Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-09-29. PMID:39342268. |
epa was incorporated into the culture medium, followed by assays to evaluate cell viability, calcium (ca²⁺) influx, apoptosis, reactive oxygen species (ros) levels, and collagen type ii alpha (col-2a) expression. |
2024-09-29 |
2024-10-01 |
human |
| Zhaowenbin Zhang, Chen Fan, Qing Xu, Feng Guo, Wenbo Li, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang, Jiang Chan. A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-28. PMID:39340818. |
the underlining mechanisms include stimulation of integrin subunit alpha 2 expression in dermal fibroblasts to accelerate wound healing, and induction of apoptosis of hypertrophic scar fibroblasts by directly stimulating the n-acylsphingosine amidohydrolase 2 expression in hypertrophic scar fibroblasts, and indirectly upregulating the secretion of cathepsin k in dermal fibroblasts. |
2024-09-28 |
2024-10-01 |
rabbit |
| Nataly de Dios, Rodrigo Riedel, Malena Schanton, Paula Balestrini, Luciano Pérez, Antonio Pérez-Pérez, Tomás Etcheverry, Roberto Casale, Mariana Farina, Víctor Sánchez-Margalet, Julieta Maymó, Cecilia Varon. Placental apoptosis increased by hypoxia inducible factor-1 stabilization is counteracted by leptin†. Biology of reproduction. vol 111. issue 3. 2024-09-15. PMID:38924703. |
obtained data demonstrate that hypoxia-inducible factor-1 alpha stabilization induces apoptosis in human placenta and leptin counteracts this effect, reinforcing its role as a survival cytokine. |
2024-09-15 |
2024-09-18 |
human |
| Liangping Li, Zetian Huang, Yuying Huang, Yongkun Li, Xuesong Ma, Pingping Li, Wenqing Du, Hui Wang, Yufei Zhao, Shulan Zeng, Yan Peng, Guohai Zhan. Pomalidomide sensitizes lung cancer cells to TRAIL/CDDP-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit. Bioorganic chemistry. vol 153. 2024-09-12. PMID:39265523. |
pomalidomide sensitizes lung cancer cells to trail/cddp-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit. |
2024-09-12 |
2024-09-15 |
Not clear |
| Lorena Palacios-Navarro, Leodan A Crispin, Juan P Muñoz, Gloria M Cala. Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells. Diagnostics (Basel, Switzerland). vol 14. issue 16. 2024-09-01. PMID:39202273. |
the results indicated that in the mcf-7 human breast cancer cell line, e2 and curcumin decreased cell proliferation and the colony-forming capacity and down-regulated protein expression as well as important molecules associated with cell proliferation, such as pcna and estrogen receptor alpha; genes associated with the epithelial-mesenchymal transition, such as β-catenin, vimentin, and e-cadherin; and molecules associated with apoptosis. |
2024-09-01 |
2024-09-04 |
human |
| Xunqi Zhang, Yanxiao Han, Chenliu Fan, Yang Jiang, Wen Jiang, Chengyun Zhen. Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption. International immunopharmacology. vol 141. 2024-08-19. PMID:39159563. |
subsequently, mrna sequencing of egcg-treated mm.1s cells revealed a significant upregulation of genes associated with endoplasmic reticulum stress (ers), including p-eif2α (phosphorylation-eukaryotic translation initiation factor 2 alpha), atf4 (activating transcription factor 4), chop (c/ebp homologous protein, ddit3), and puma (p53 upregulated modulator of apoptosis, bbc3), which were confirmed at the protein level by western blotting. |
2024-08-19 |
2024-08-22 |
mouse |
| Xuewen Tao, Haowei Wei, Shuai Mao, Jincheng Wang, Cailin Xue, Weiwei Yu, Yuze Shi, Yang Liu, Beicheng Su. SEC24C suppresses the propagation and chemoresistance of hepatocellular carcinoma by promoting unfolded protein response-related apoptosis. Bioscience trends. 2024-07-31. PMID:39085101. |
mechanistically, sec24c was found to interact with eukaryotic translation initiation factor 2 alpha kinase 3 (eif2ak3 or perk) and activate the downstream upr-related apoptosis. |
2024-07-31 |
2024-08-03 |
human |
| Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xia. Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075912. |
we found that prolongation of oxygen-glucose deprivation activated the er stress pathway protein kinase-like endoplasmic reticulum kinase (perk)/eukaryotic translation initiation factor 2 subunit alpha (eif2α)-activating transcription factor 4 (atf4)-c/ebp homologous protein (chop), increased neuronal apoptosis, and induced autophagy. |
2024-07-30 |
2024-08-02 |
Not clear |
| T Jin, H Zheng, X Feng, T Wu, K Yang, Y Huan. MiR-539-3p Alleviates Apoptosis and Extracellular Matrix Degradation in Chondrocytes of Childhood-Onset Osteoarthritis by Targeting RUNX2. Physiological research. vol 73. issue 3. 2024-07-19. PMID:39027958. |
further experiments demonstrated that mir-539-3p targeting runx2 effectively lessened apoptosis, inflammation, and ecm degradation in oa chondrocytes, accompanied by changes in key molecular markers like reduced caspase-3 and matrix etallopeptidase 13 (mmp-13) levels, and increased b-cell lymphoma 2 (bcl-2) and collagen type x alpha 1 chain (col2a1). |
2024-07-19 |
2024-07-21 |
Not clear |
| Somdattaa Ra. The neuroprotective potential of magnesium in Parkinson's disease. Magnesium research. vol 36. issue 4. 2024-07-02. PMID:38953416. |
pathogenic mechanisms implicated in the development of parkinson disease (pd) are multifaceted and include alpha synuclein aggregation, oxidative stress due to generation of reactive oxygen species (ros), mitochondrial dysfunction, apoptosis, imbalance of trace elements as well as endoplasmic reticulum stress, and inflammation. |
2024-07-02 |
2024-07-06 |
Not clear |
| Manal A Othman, Mariwan Husni, Wael Amin Nasr El-Din, Abdel-Halim Salem, Nasir Sarwani, Aisha Rashid, Raouf Fade. Prenatal aripiprazole induces alterations of rat placenta: a histological, immunohistochemical and ultrastructural study. Journal of molecular histology. 2024-05-07. PMID:38713244. |
immunohistochemistry was done using anti-pcna (proliferating cell nuclear antigen), anti-bax (for apoptosis) and anti-vascular endothelial growth factor alpha (vegfa). |
2024-05-07 |
2024-05-27 |
rat |
| Ji Eun Kim, Min Jee Jo, So Yeon Bae, Shin Young Ahn, Gang Jee Ko, Young Joo Kwo. Mitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity. Scientific reports. vol 14. issue 1. 2024-05-02. PMID:38698042. |
inhibition of sirt3 through sirna transfection exacerbated apoptosis, impaired the expression of the amp-activated protein kinase-peroxisome proliferator-activated receptor gamma coactivator 1 alpha (ampk-pgc1α) pathway, and worsened mitochondrial dysfunction induced by csa treatment. |
2024-05-02 |
2024-05-05 |
mouse |