| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Gauthier, P Laprise, E Cardin, C Harnois, A Plourde, J C Reed, A Vézina, P H Vacho. Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathways. Journal of cellular biochemistry. vol 82. issue 2. 2002-02-15. PMID:11527158. |
herein, we report that (1) the inhibition of signal transduction molecules/pathways revealed striking differences in their impact on cell survival in the jejunum and colon (e.g., the inhibition of p125fak induced apoptosis with a significantly greater extent in the jejunum [approximately 43%] than in the colon [approximately 24%]); (2) sharp distinctions between the two segments were noted in the modulatory effects of the various treatments on bcl-2 homolog steady-state levels (e.g., inhibition of tyrosine kinase activities in the jejunum down-regulated all anti-apoptotics analyzed while increasing bax, whereas the same treatment in the colon down-regulated bcl-x(l) only and increased all pro-apoptotics); and (3) in addition to their differential impact on cell survival and bcl-2 homolog expression, the mek/erk and p13-k/akt pathways were found to be distinctively regulated in the jejunum and colon mucosae (e.g., insulin in the jejunum increased p42erk-2 activation without affecting that of p57akt, whereas the same treatment in the colon decreased p42erk-2 activation while increasing that of p57akt). |
2002-02-15 |
2023-08-12 |
human |
| Zhe Jiang, Eldad Zacksenhau. Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma. The Journal of cell biology. vol 156. issue 1. 2002-02-14. PMID:11777937. |
our results suggest that transient activation of rb induces cancer by extending cell survival and that the dual effects of rb on cell proliferation and apoptosis impose an inherent caveat to the use of the rb pathway for long-term cancer therapy. |
2002-02-14 |
2023-08-12 |
mouse |
| Lan F Qin, Irene O L N. Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells. Cancer letters. vol 175. issue 1. 2002-02-04. PMID:11734333. |
induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells. |
2002-02-04 |
2023-08-12 |
human |
| Lan F Qin, Irene O L N. Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells. Cancer letters. vol 175. issue 1. 2002-02-04. PMID:11734333. |
we investigated cisplatin-induced apoptosis and the effects on cell cycle-related proteins and cell cycle changes. |
2002-02-04 |
2023-08-12 |
human |
| E C Azmiti. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain research bulletin. vol 56. issue 5. 2002-02-01. PMID:11750787. |
modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. |
2002-02-01 |
2023-08-12 |
Not clear |
| P Inguaggiato, L Gonzalez-Michaca, A J Croatt, J J Haggard, J Alam, K A Nat. Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney international. vol 60. issue 6. 2002-01-29. PMID:11737592. |
we examined the effect of overexpression of ho-1 on cell growth, expression of p21, and susceptibility to apoptosis. |
2002-01-29 |
2023-08-12 |
Not clear |
| Marina Konopleva, Twee Tsao, Peter Ruvolo, Irina Stiouf, Zeev Estrov, Clinton E Leysath, Shourong Zhao, David Harris, Shirong Chang, C Ellen Jackson, Mark Munsell, Nanjoo Suh, Gordon Gribble, Tadashi Honda, W Stratford May, Michael B Sporn, Michael Andreef. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood. vol 99. issue 1. 2002-01-28. PMID:11756188. |
in the current study the effects of the c-28 methyl ester of cddo, cddo-me, were analyzed on cell growth and apoptosis of leukemic cell lines and primary acute myelogenous leukemia (aml). |
2002-01-28 |
2023-08-12 |
Not clear |
| J Jiao, G Chen, M Huan. [Effect of rhTFAR19 protein on cell cycle and apoptosis of MCF-7 induced by gamma-ray]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 22. issue 2. 2002-01-23. PMID:11776632. |
[effect of rhtfar19 protein on cell cycle and apoptosis of mcf-7 induced by gamma-ray]. |
2002-01-23 |
2023-08-12 |
human |
| J Jiao, G Chen, M Huan. [Effect of rhTFAR19 protein on cell cycle and apoptosis of MCF-7 induced by gamma-ray]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 22. issue 2. 2002-01-23. PMID:11776632. |
to investigate the effect of protein product of tfar19, an apoptosis-related gene previously cloned from leukemia cell line tf-1 cultured in medium deprived of growth factor, on cell cycle and apoptosis of human breast cancer induced by gamma-ray. |
2002-01-23 |
2023-08-12 |
human |
| N Smeulders, A S Woolf, D T Wilco. Smooth muscle differentiation and cell turnover in mouse detrusor development. The Journal of urology. vol 167. issue 1. 2002-01-17. PMID:11743361. |
we systematically analyzed detrusor muscle differentiation in normal mice with a focus on cell turnover (proliferation and apoptosis) as well as on expression of the muscle specific proteins alpha-smooth muscle actin and desmin. |
2002-01-17 |
2023-08-12 |
mouse |
| S Grösch, I Tegeder, E Niederberger, L Bräutigam, G Geisslinge. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 14. 2002-01-15. PMID:11606477. |
to evaluate the involvement of cox-dependent and cox-independent mechanisms further, we assessed the effects of celecoxib (selective cox-2 inhibitor) and sc560 (selective cox-1 inhibitor) on cell survival, cell cycle distribution, and apoptosis in three colon cancer cell lines, which differ in their expression of cox-2. |
2002-01-15 |
2023-08-12 |
mouse |
| R W McMurray, S Suwannaroj, K Ndebele, J K Jenkin. Differential effects of sex steroids on T and B cells: modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 69. issue 1. 2002-01-14. PMID:11641617. |
there was a more modest effect of estrogen and testosterone on cell cycling and apoptosis in b lymphocyte cell lines, suggesting that estrogen and testosterone are inhibitory to t but not b cell lines. |
2002-01-14 |
2023-08-12 |
Not clear |
| R W McMurray, S Suwannaroj, K Ndebele, J K Jenkin. Differential effects of sex steroids on T and B cells: modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 69. issue 1. 2002-01-14. PMID:11641617. |
estrogen and testosterone were not antagonistic or synergistic to each other in their effects on cell cycle phase distribution, and only minimally synergistic for apoptosis. |
2002-01-14 |
2023-08-12 |
Not clear |
| M Belicchi Ferrari, F Bisceglie, G Pelosi, P Tarasconi, R Albertini, S Pinell. New methyl pyruvate thiosemicarbazones and their copper and zinc complexes: synthesis, characterization, X-ray structures and biological activity. Journal of inorganic biochemistry. vol 87. issue 3. 2002-01-14. PMID:11730895. |
tests on cell proliferation of human leukemic cell line u937 showed that the copper complex cu(et-mpt)cl x h2o is the most active compound among those reported even though it is not able to induce apoptosis. |
2002-01-14 |
2023-08-12 |
human |
| S Unlu, G Clunn, M Schachter, C Demoliou-Mason, A D Hughe. Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein. Journal of cardiovascular pharmacology. vol 38. issue 2. 2002-01-11. PMID:11483865. |
the effects of lovastatin on cell proliferation, dna synthesis, and apoptosis were prevented by coincubation with mevalonate and geranylgeranyl pyrophosphate, but not by farnesyl pyrophosphate. |
2002-01-11 |
2023-08-12 |
human |
| Y Saikawa, T Kubota, Y Otani, M Kitajima, I M Modli. Cyclin D1 antisense oligonucleotide inhibits cell growth stimulated by epidermal growth factor and induces apoptosis of gastric cancer cells. Japanese journal of cancer research : Gann. vol 92. issue 10. 2002-01-11. PMID:11676861. |
in this study, we attempted to examine the therapeutic effect of cyclin d1 antisense oligonucleotides (as/d1) on cell proliferation and apoptosis of the gastric cancer cell line mkn-74, in the presence and absence of egf-stimulation. |
2002-01-11 |
2023-08-12 |
Not clear |
| R Falchetti, M P Fuggetta, G Lanzilli, M Tricarico, G Ravagna. Effects of resveratrol on human immune cell function. Life sciences. vol 70. issue 1. 2002-01-03. PMID:11764009. |
because many of the biological activities of resveratrol, like the inhibition of cyclooxygenase, induction of cd95 signaling-dependent apoptosis, effects on cell division cycle and modulation of nf-kb activation, suggest a possible effect on the immune system, we evaluated the in vitro effects of resveratrol in three immune response models: i) development of cytokine-producing cd4+ and cd8+ t cells induced by stimulation of peripheral blood mononuclear cells (pbmc) with anti-cd3/anti-cd28; ii) specific antigen-induced generation of cytotoxic t lymphocytes; iii) natural killer (nk) activity of pbmc. |
2002-01-03 |
2023-08-12 |
human |
| W Piao, J Yoo, D K Lee, H J Hwang, J H Ki. Induction of G(2)/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells. Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728380. |
we studied the effect of dw2282-,[(s)-(+)-4-phenyl-1-[n-(4-aminobenzoyl)-indoline-5-sulfonyl-4,5-dihydro-2-imidazolone].hydrochloride], a newly developed anti-cancer agent, on cell proliferation, cell cycle progression, and induction of apoptosis in human promyelocytic leukemia (hl-60) cells. |
2002-01-02 |
2023-08-12 |
human |
| Z Q Ning, J Li, R J Arcec. Activating mutations of c-kit at codon 816 confer drug resistance in human leukemia cells. Leukemia & lymphoma. vol 41. issue 5-6. 2001-12-31. PMID:11378569. |
although stimulation of mutant c-kit-bearing mo7e cells with stem cell factor (scf), a ligand for c-kit, does not have a significant effect on cell proliferation, scf further inhibits apoptosis induced by cytotoxic agents. |
2001-12-31 |
2023-08-12 |
human |
| B Ohlsson, K Borg, J F Rehfeld, J Axelson, F Sundle. The method of administration of cholecystokinin determines the effects evoked in the pancreas. Pancreas. vol 23. issue 1. 2001-12-28. PMID:11451154. |
the aim of this study was as follows: (i) to compare the effect of continuous infusion and of intermittent injections of cck-8s on cell proliferation, weight gain, and induction of apoptosis and (ii) to examine the effect of injections of cck-8s on cck-a receptor gene expression in the rat pancreas. |
2001-12-28 |
2023-08-12 |
rat |