| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clare J Wilhelm, Marina Guizzett. Fetal Alcohol Spectrum Disorders: An Overview from the Glia Perspective. Frontiers in integrative neuroscience. vol 9. 2016-01-21. PMID:26793073. |
delayed oligodendrocyte development and increased oligodendrocyte precursor apoptosis has also been reported in experimental models of fasd, which may be linked to altered myelination/white matter integrity found in fasd children. |
2016-01-21 |
2023-08-13 |
Not clear |
| Andrew V Caprariello, Courtney E Batt, Ingrid Zippe, Rita R Romito-DiGiacomo, Molly Karl, Robert H Mille. Apoptosis of Oligodendrocytes during Early Development Delays Myelination and Impairs Subsequent Responses to Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 41. 2016-01-19. PMID:26468203. |
despite robust developmental plasticity, mbp-icp9-induced oligodendrocyte apoptosis compromised the rate and extent of adult remyelination. |
2016-01-19 |
2023-08-13 |
mouse |
| Amber L Southwell, Sonia Franciosi, Erika B Villanueva, Yuanyun Xie, Laurie A Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A Pouladi, Ernest S Smith, William J Bowers, Maurice Zauderer, Michael R Hayde. Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease. Neurobiology of disease. vol 76. 2015-12-14. PMID:25662335. |
semaphorin 4d (sema4d) is a transmembrane signaling molecule that modulates a variety of processes central to neuroinflammation and neurodegeneration including glial cell activation, neuronal growth cone collapse and apoptosis of neural precursors, as well as inhibition of oligodendrocyte migration, differentiation and process formation. |
2015-12-14 |
2023-08-13 |
mouse |
| M José Mansilla, Carme Costa, Herena Eixarch, Vanja Tepavcevic, Mireia Castillo, Roland Martin, Catherine Lubetzki, Marie-Stéphane Aigrot, Xavier Montalban, Carmen Espej. Hsp70 regulates immune response in experimental autoimmune encephalomyelitis. PloS one. vol 9. issue 8. 2015-11-12. PMID:25153885. |
accordingly, hsp70 deficiency did not influence the vulnerability to apoptosis of oligodendrocyte precursor cells (opcs) in culture. |
2015-11-12 |
2023-08-13 |
mouse |
| Jelle Praet, Caroline Guglielmetti, Zwi Berneman, Annemie Van der Linden, Peter Ponsaert. Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neuroscience and biobehavioral reviews. vol 47. 2015-08-07. PMID:25445182. |
in this review we extensively describe the physico-chemical mode of action of cuprizone and discuss the molecular and enzymatic mechanisms by which cuprizone induces metabolic stress, oligodendrocyte apoptosis, myelin degeneration and eventually axonal and neuronal pathology. |
2015-08-07 |
2023-08-13 |
mouse |
| Jelle Praet, Caroline Guglielmetti, Zwi Berneman, Annemie Van der Linden, Peter Ponsaert. Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neuroscience and biobehavioral reviews. vol 47. 2015-08-07. PMID:25445182. |
in addition, we describe the dual effector function of the immune system which tightly controls demyelination by effective induction of oligodendrocyte apoptosis, but in contrast also paves the way for fast and efficient remyelination by the secretion of neurotrophic factors and the clearance of cellular and myelinic debris. |
2015-08-07 |
2023-08-13 |
mouse |
| Masahiro Kuroiwa, Masahiko Watanabe, Hiroyuki Katoh, Kaori Suyama, Daisuke Matsuyama, Takeshi Imai, Joji Mochid. Effect of amiloride on endoplasmic reticulum stress response in the injured spinal cord of rats. The European journal of neuroscience. vol 40. issue 7. 2015-06-29. PMID:24905230. |
after traumatic spinal cord injury (sci), endoplasmic reticulum (er) stress exacerbates secondary injury, leading to expansion of demyelination and reduced remyelination due to oligodendrocyte precursor cell (opc) apoptosis. |
2015-06-29 |
2023-08-13 |
rat |
| Hajime Abe, Takeshi Tanaka, Masayuki Kimura, Sayaka Mizukami, Nobuya Imatanaka, Yumi Akahori, Toshinori Yoshida, Makoto Shibutan. Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring. Toxicology letters. vol 234. issue 3. 2015-06-22. PMID:25704630. |
these results suggest that maternal exposure to 0.4% cpz decreases proliferative type-2 progenitor cells via endoplasmic reticulum stress-mediated apoptosis and inhibition of cholinergic signals to intermediate-stage progenitor cells following reduced oligodendrocyte production and suppression of the brain-derived neurotrophic factor signaling cascade. |
2015-06-22 |
2023-08-13 |
rat |
| Tim Clarner, Katharina Janssen, Lara Nellessen, Martin Stangel, Thomas Skripuletz, Barbara Krauspe, Franz-Martin Hess, Bernd Denecke, Clara Beutner, Bettina Linnartz-Gerlach, Harald Neumann, Luc Vallières, Sandra Amor, Kim Ohl, Klaus Tenbrock, Cordian Beyer, Markus Kip. CXCL10 triggers early microglial activation in the cuprizone model. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 7. 2015-06-08. PMID:25725102. |
in this study, we used the cuprizone model to investigate the temporal and causal relationship of oligodendrocyte apoptosis and early microglia activation. |
2015-06-08 |
2023-08-13 |
mouse |
| Tim Clarner, Katharina Janssen, Lara Nellessen, Martin Stangel, Thomas Skripuletz, Barbara Krauspe, Franz-Martin Hess, Bernd Denecke, Clara Beutner, Bettina Linnartz-Gerlach, Harald Neumann, Luc Vallières, Sandra Amor, Kim Ohl, Klaus Tenbrock, Cordian Beyer, Markus Kip. CXCL10 triggers early microglial activation in the cuprizone model. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 7. 2015-06-08. PMID:25725102. |
genome-wide gene expression studies revealed the induction of distinct chemokines, among them cxcl10, ccl2, and ccl3 in cuprizone-mediated oligodendrocyte apoptosis. |
2015-06-08 |
2023-08-13 |
mouse |
| Wajih Bukhari, Michael H Barnett, Kerri Prain, Simon A Broadle. Molecular pathogenesis of neuromyelitis optica. International journal of molecular sciences. vol 13. issue 10. 2015-04-21. PMID:23202933. |
demyelination occurs during the inflammatory process and is probably secondary to oligodendrocyte apoptosis subsequent to loss of trophic support from astrocytes. |
2015-04-21 |
2023-08-12 |
Not clear |
| Frederick Ga. Staphylococcal immune complexes and myelinolytic toxin in early acute multiple sclerosis lesions-An immunohistological study supported by multifactorial cluster analysis and antigen-imprint isoelectric focusing. Multiple sclerosis and related disorders. vol 2. issue 3. 2015-04-17. PMID:25877728. |
while a myelinolytic transportable toxin may be an important component in the pathogenesis of demyelination, in oligodendrocyte apoptosis, and in deviant immune responses within the cns, the detection of other as yet unidentified staphylococcal-positive and negative oligoclonal bands points to the involvement of a cocktail of transportable antigens leaking in a similar manner into the cns from the paranasal sinus mucosal tissues where these molecules are conserved by the resident flora to manipulate and subvert the normal processes of local and systemic immunity. |
2015-04-17 |
2023-08-13 |
Not clear |
| Jinzhou Feng, Tao Tao, Weiping Yan, Cindy Si Chen, Xinyue Qi. Curcumin inhibits mitochondrial injury and apoptosis from the early stage in EAE mice. Oxidative medicine and cellular longevity. vol 2014. 2014-12-28. PMID:24868317. |
the exact pathophysiological change concerning mitochondrial injury and oligodendrocyte apoptosis in ms and eae model is still unknown. |
2014-12-28 |
2023-08-13 |
mouse |
| Jinlong Wei, Kejun Du, Qinzhen Cai, Lisha Ma, Zhenzhen Jiao, Jinrong Tan, Zhou Xu, Jingxia Li, Wenjin Luo, Jingyuan Chen, Jimin Gao, Dongyun Zhang, Chuanshu Huan. Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner. Toxicology. vol 325. 2014-12-18. PMID:25193092. |
the modes of action of lead neurotoxic effects include disturbance of neurotransmitter storage and release, damage of mitochondria, as well as induction of apoptosis in neurons, cerebrovascular endothelial cells, astroglia and oligodendroglia. |
2014-12-18 |
2023-08-13 |
Not clear |
| Qiyan Cai, Zhongxiang Yao, Hongli L. Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion. Brain research. vol 1560. 2014-12-15. PMID:24632336. |
although inflammation and oligodendrocyte apoptosis are believed to be involved in the pathogenesis of wmls, effective therapies have not been identified yet. |
2014-12-15 |
2023-08-12 |
rat |
| Qiyan Cai, Zhongxiang Yao, Hongli L. Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion. Brain research. vol 1560. 2014-12-15. PMID:24632336. |
on the 30th day after surgery, inflammation, oligodendrocyte apoptosis, and myelin damage in the ischemic white matter were more severe and evident than in the sham control group. |
2014-12-15 |
2023-08-12 |
rat |
| Qiyan Cai, Zhongxiang Yao, Hongli L. Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion. Brain research. vol 1560. 2014-12-15. PMID:24632336. |
treatment with catalpol significantly suppressed white matter inflammation and attenuated oligodendrocyte apoptosis and myelin damage. |
2014-12-15 |
2023-08-12 |
rat |
| Ning Hao, Guangming Lü, Xiaodong Liu, Bin Yu, Huiqun Wu, Dafeng Ji, Yaofu Li, Xiao Ha. Potential role of microRNA: identification and functional analysis of microRNA in corticospinal tract after unilateral lesions of the medullary pyramid. Neuroscience letters. vol 564. 2014-11-26. PMID:24513234. |
the bioinformatics analysis indicated that changes in mirna and target mrna expression affected rostral regeneration, including negative regulation of apoptosis, positive regulation of cell proliferation, cell adhesion, oligodendrocyte development etc. |
2014-11-26 |
2023-08-12 |
Not clear |
| Jee Youn Lee, Tae Young Yun. Ghrelin inhibits oligodendrocyte cell death by attenuating microglial activation. Endocrinology and metabolism (Seoul, Korea). vol 29. issue 3. 2014-10-13. PMID:25309797. |
therefore, in the present study, we examined whether ghrelin inhibits microglia activation and thereby inhibits oligodendrocyte apoptosis. |
2014-10-13 |
2023-08-13 |
Not clear |
| Ming Feng, Yaqing Shu, Yu Yang, Xueping Zheng, Rui Li, Yuge Wang, Yongqiang Dai, Wei Qiu, Zhengqi Lu, Xueqiang H. Ulinastatin attenuates experimental autoimmune encephalomyelitis by enhancing anti-inflammatory responses. Neurochemistry international. vol 64. 2014-10-06. PMID:24274996. |
we recently found that uti has a neuroprotective effect on eae by reducing oligodendrocyte apoptosis and demyelination. |
2014-10-06 |
2023-08-12 |
mouse |