| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenguang Chang, Junfang Ten. Prox1 is essential for oligodendrocyte survival and regulates oligodendrocyte apoptosis via the regulation of NOXA. Acta biochimica et biophysica Sinica. vol 50. issue 7. 2018-11-05. PMID:29931031. |
further study demonstrated that prox1 knockdown promoted oligodendrocyte apoptosis and activated noxa, a pro-apoptotic member of the bcl-2 protein family. |
2018-11-05 |
2023-08-13 |
Not clear |
| Lin Qiao, Jianhua Fu, Xindong Xue, Yongyan Shi, Li Yao, Wanjie Huang, Jun Li, Dan Zhang, Na Liu, Xin Tong, Yanna Du, Yuqing Pa. Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436652. |
in the rat model of hypoxia‑ischemia‑induced pvl, oligodendrocyte injury and myelinization disorders were observed, in addition to neuron injury, a decrease in mature neurons and the co‑presence of apoptosis and autophagy. |
2018-08-30 |
2023-08-13 |
rat |
| SunJa Kim, Jacek Bielawski, Hyunmin Yang, Yu Kong, Beiyan Zhou, Jianrong L. Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Glia. vol 66. issue 3. 2018-08-23. PMID:29193293. |
both fty720- and cym5422-treated mice displayed a significant reduction in oligodendrocyte apoptosis and astrocyte and microglial activation in comparison to vehicle-treated groups, which was associated with decreased production of proinflammatory mediators and down-regulation of astrocytic s1pr1 protein. |
2018-08-23 |
2023-08-13 |
mouse |
| Xue Fang, Dingya Sun, Zhihong Wang, Zhongwang Yu, Weili Liu, Yingyan Pu, Dan Wang, Aijun Huang, Mingdong Liu, Zhenghua Xiang, Cheng He, Li Ca. MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis. Neuroscience bulletin. vol 33. issue 6. 2018-07-24. PMID:28717866. |
in vitro, the conditioned supernatant of mouse microglia overexpressing mir-30a promoted the apoptosis of oligodendrocyte precursor cells (opcs), and inhibited opc differentiation. |
2018-07-24 |
2023-08-13 |
mouse |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
p53-mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing er-mitochondria interaction and e2f1 expression. |
2018-04-26 |
2023-08-13 |
rat |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
oligodendrocyte apoptosis mediated demyelination is a pathological change characteristic of compressed spinal cord injury (csci). |
2018-04-26 |
2023-08-13 |
rat |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
however, the mechanism of demyelination due to oligodendrocyte apoptosis is not known. |
2018-04-26 |
2023-08-13 |
rat |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
to understand the possible mechanism of oligodendrocyte apoptosis, caspase-12 and cytochrome c were analyzed to explore the relationship between oligodendrocyte apoptosis and endoplasmic reticulum(er)-mitochondria interaction. |
2018-04-26 |
2023-08-13 |
rat |
| Lan Ma, Hai-Jun Yu, Sheng-Wei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shan-Quan Su. p53-Mediated oligodendrocyte apoptosis initiates demyelination after compressed spinal cord injury by enhancing ER-mitochondria interaction and E2F1 expression. Neuroscience letters. vol 644. 2018-04-26. PMID:28237798. |
these results demonstrated that over-expression of p53 could mediate oligodendrocyte apoptosis thus resulting in demyelination in two ways; by enhancing er-mitochondria interaction and by triggering the e2f1 mediated apoptosis pathway. |
2018-04-26 |
2023-08-13 |
rat |
| Yunhong Li, Rui Zhang, Xiaolin Hou, Yumei Zhang, Feijia Ding, Fan Li, Yao Yao, Yin Wan. Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586011. |
microglia activation triggers oligodendrocyte precursor cells apoptosis via hsp60. |
2018-03-26 |
2023-08-13 |
Not clear |
| Filip Petković, Iain L Campbell, Berta Gonzalez, Bernardo Castellan. Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation. Glia. vol 64. issue 12. 2018-01-05. PMID:27535761. |
in addition, transgenic production of il-6 did not alter initial oligodendrocyte (ol) apoptosis and oligodendrocyte precursor cell recruitment to the lesion site, but it impaired early ol differentiation, possibly due to impaired removal of degraded myelin. |
2018-01-05 |
2023-08-13 |
mouse |
| Éva Sághy, Éva Sipos, Péter Ács, Kata Bölcskei, Krisztina Pohóczky, Ágnes Kemény, Zoltán Sándor, Éva Szőke, György Sétáló, Sámuel Komoly, Erika Pinté. TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis. Glia. vol 64. issue 12. 2018-01-05. PMID:27568827. |
trpa1 deficiency is protective in cuprizone-induced demyelination-a new target against oligodendrocyte apoptosis. |
2018-01-05 |
2023-08-13 |
Not clear |
| Katie J Schenning, Kevin K Noguchi, Lauren Drew Martin, Francesca M Manzella, Omar H Cabrera, Gregory A Dissen, Ansgar M Brambrin. Isoflurane exposure leads to apoptosis of neurons and oligodendrocytes in 20- and 40-day old rhesus macaques. Neurotoxicology and teratology. vol 60. 2018-01-01. PMID:27876652. |
previously we reported that a 5-hour exposure of 6-day-old (p6) rhesus macaques to isoflurane triggers robust neuron and oligodendrocyte apoptosis. |
2018-01-01 |
2023-08-13 |
Not clear |
| Katie J Schenning, Kevin K Noguchi, Lauren Drew Martin, Francesca M Manzella, Omar H Cabrera, Gregory A Dissen, Ansgar M Brambrin. Isoflurane exposure leads to apoptosis of neurons and oligodendrocytes in 20- and 40-day old rhesus macaques. Neurotoxicology and teratology. vol 60. 2018-01-01. PMID:27876652. |
brains exposed to isoflurane displayed neuron and oligodendrocyte apoptosis distributed throughout cortex and white matter, respectively. |
2018-01-01 |
2023-08-13 |
Not clear |
| Ryoya Hashimoto, Kei Hori, Tomoo Owa, Satoshi Miyashita, Kenichi Dewa, Norihisa Masuyama, Kazuhisa Sakai, Yoneko Hayase, Yusuke Seto, Yukiko U Inoue, Takayoshi Inoue, Noritaka Ichinohe, Yoshiya Kawaguchi, Haruhiko Akiyama, Schuichi Koizumi, Mikio Hoshin. Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mechanisms of development. vol 140. 2017-12-27. PMID:26940020. |
in addition, we observed altered proliferation of opcs, resulting in a decrease in oligodendrocyte numbers that accompanied an attenuation of the differentiation and an increased rate of apoptosis. |
2017-12-27 |
2023-08-13 |
mouse |
| M C Lombardo, R Barresi, E Bilotta, F Gargano, P Pantano, M Sammartin. Demyelination patterns in a mathematical model of multiple sclerosis. Journal of mathematical biology. vol 75. issue 2. 2017-12-06. PMID:28039494. |
we focus on the early inflammatory phase of the disease characterized by activated local microglia, with the recruitment of a systemically activated immune response, and by oligodendrocyte apoptosis. |
2017-12-06 |
2023-08-13 |
Not clear |
| Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Elisa Alvares, Venera Cardil. Krabbe's leukodystrophy: Approaches and models in vitro. Journal of neuroscience research. vol 94. issue 11. 2017-11-13. PMID:27638610. |
in parallel, it is now understood that the presence of globoid cells precedes oligodendrocyte apoptosis and demyelination. |
2017-11-13 |
2023-08-13 |
Not clear |
| Jorge I Vélez, Francisco Lopera, Hardip R Patel, Angad S Johar, Yeping Cai, Dora Rivera, Carlos Tobón, Andrés Villegas, Diego Sepulveda-Falla, Shaun G Lehmann, Simon Easteal, Claudio A Mastronardi, Mauricio Arcos-Burgo. Mutations modifying sporadic Alzheimer's disease age of onset. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171. issue 8. 2017-09-21. PMID:27573710. |
these variants are harbored in genes implicated in neuron apoptosis, neurogenesis, inflammatory processes linked to ad, oligodendrocyte differentiation, and memory processes. |
2017-09-21 |
2023-08-13 |
Not clear |
| Sae Mi Hwang, Tae Gi Uhm, Seol Kyung Lee, Su-Kang Kong, Kyung Hwa Jung, Bert Binas, Young Gyu Chai, Sung Woo Park, Il Yup Chun. Olig2 is expressed late in human eosinophil development and controls Siglec-8 expression. Journal of leukocyte biology. vol 100. issue 4. 2017-09-12. PMID:27154355. |
in the present study, we report that oligodendrocyte transcription factor 2 is expressed in human eosinophils and involved in transcriptional activation of the gene encoding sialic acid binding immunoglobulin-like lectin 8 (siglec-8), a late eosinophil-differentiation marker known to exert eosinophil apoptosis. |
2017-09-12 |
2023-08-13 |
human |
| Elena Georgiou, Kyriaki Sidiropoulou, Jan Richter, Christos Papaneophytou, Irene Sargiannidou, Alexia Kagiava, Georg von Jonquieres, Christina Christodoulou, Matthias Klugmann, Kleopas A Kleop. Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28100454. |
furthermore, immunofluorescence and morphological analysis revealed improvement in demyelination, oligodendrocyte apoptosis, inflammation, and astrogliosis, all typical features of this leukodystrophy model in both brain and spinal cord. |
2017-05-29 |
2023-08-13 |
mouse |