| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nune Darbinian, Michael E Selze. Oligodendrocyte pathology in fetal alcohol spectrum disorders. Neural regeneration research. vol 17. issue 3. 2021-11-03. PMID:34380877. |
rodent models of fetal alcohol syndrome and human studies have shown suppressed oligodendrocyte differentiation and apoptosis of oligodendrocyte precursor cells. |
2021-11-03 |
2023-08-13 |
mouse |
| John W Prineas, John D E Parrat. Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination. Journal of neuropathology and experimental neurology. vol 80. issue 10. 2021-11-03. PMID:34553215. |
oligodendrocyte apoptosis was observed in intact myelinated tissue bordering areas of active demyelination. |
2021-11-03 |
2023-08-13 |
Not clear |
| Brett S Marro, Martin P Hosking, Thomas E Lan. CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis. Future virology. vol 7. issue 4. 2021-10-21. PMID:22582084. |
during chronic disease, cxcr2 signaling on oligodendroglia protects these cells from apoptosis and restricts the severity of demyelination. |
2021-10-21 |
2023-08-12 |
mouse |
| Brian E Leonar. The concept of depression as a dysfunction of the immune system. Current immunology reviews. vol 6. issue 3. 2021-10-20. PMID:21170282. |
in addition to the resulting decrease in the synthesis of brain serotonin, this leads to the formation of neurotoxins such as the glutamate agonist quinolinic acid and contributes to the increase in apoptosis of astrocytes, oligodendroglia and neurons.the importance of the inflammation hypothesis of depression lies in raising the possibility that psychotropic drugs that have a central anti-inflammatory action might provide a new generation of antidepressants. |
2021-10-20 |
2023-08-12 |
Not clear |
| Jeesan Lee, Oscar David Villarreal, Xiaoru Chen, Stéphanie Zandee, Yoon Kow Young, Cynthia Torok, Nathalie Lamarche-Vane, Alexandre Prat, Serge Rivest, David Gosselin, Stéphane Richar. QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis. Cell reports. vol 33. issue 13. 2021-10-13. PMID:33378678. |
during the cuprizone diet, mice with qki-deficient microglia are inefficient at supporting central nervous system (cns) remyelination and cause the recruited oligodendrocyte precursor cells to undergo apoptosis. |
2021-10-13 |
2023-08-13 |
mouse |
| Ahdeah Pajoohesh-Ganji, Molly Karl, Eric Garrison, Nana Adwoa Osei-Bonsu, Cheryl Clarkson-Paredes, Julie Ahn, Robert H Mille. Developmental ablation of mature oligodendrocytes exacerbates adult CNS demyelination. Brain, behavior, & immunity - health. vol 7. 2021-10-01. PMID:34589870. |
we show that during development, oligodendrocyte apoptosis results in transient reductions in myelination and functional deficits that recover after 10-14 days. |
2021-10-01 |
2023-08-13 |
mouse |
| Miguel García-Grimshaw, Amado Jiménez-Ruiz, José Luis Ruiz-Sandoval, Carlos Cantú-Brito, Erwin Chiquet. Osmotic demyelination syndrome in patients with non-Hodgkin lymphoma: a case report and literature review. The International journal of neuroscience. 2021-09-24. PMID:33765889. |
osmotic demyelination syndrome (ods) is a non-inflammatory process of the central nervous system caused by extracellular osmotic changes, which leads to oligodendrocyte apoptosis and disruption of myelin sheaths, usually affecting patients with underlying systemic conditions that impose susceptibility to osmotic stress. |
2021-09-24 |
2023-08-13 |
Not clear |
| Sina Mojaverrostami, Parichehr Pasbakhsh, Soheila Madadi, Saeid Nekoonam, Davood Zarini, Leila Noori, Elham Shiri, Mohamad Salama, Kazem Zibara, Iraj Ragerdi Kashan. Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis. Metabolic brain disease. vol 35. issue 7. 2021-08-20. PMID:32638202. |
in conclusion, cr regimen can promote remyelination potential in a cpz-demyelinating mouse model of ms by increasing oligodendrocyte generation while decreasing their apoptosis. |
2021-08-20 |
2023-08-13 |
mouse |
| Mahmoud I Youssef, Yiting Zhou, Ibrahim H Eissa, Yanhui Wang, Jing Zhang, Lei Jiang, Weiwei Hu, Jianhua Qi, Zhong Che. Tetradecyl 2,3-dihydroxybenzoate alleviates oligodendrocyte damage following chronic cerebral hypoperfusion through IGF-1 receptor. Neurochemistry international. vol 138. 2021-07-30. PMID:32387468. |
the protection of abg-001 on the white matter was related to an amelioration of the oligodendrocyte apoptosis and demyelination rather than promoting remyelination. |
2021-07-30 |
2023-08-13 |
mouse |
| Dongdong Liu, Yushu Dong, Gen Li, Zheng Zou, Guangzhi Hao, Hua Feng, Pengyu Pan, Guobiao Lian. Melatonin Attenuates White Matter Injury via Reducing Oligodendrocyte Apoptosis After Subarachnoid Hemorrhage in Mice. Turkish neurosurgery. vol 30. issue 5. 2021-06-28. PMID:32705666. |
melatonin attenuates white matter injury via reducing oligodendrocyte apoptosis after subarachnoid hemorrhage in mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Dongdong Liu, Yushu Dong, Gen Li, Zheng Zou, Guangzhi Hao, Hua Feng, Pengyu Pan, Guobiao Lian. Melatonin Attenuates White Matter Injury via Reducing Oligodendrocyte Apoptosis After Subarachnoid Hemorrhage in Mice. Turkish neurosurgery. vol 30. issue 5. 2021-06-28. PMID:32705666. |
to determine whether melatonin (mlt) mitigates white matter (wm) injury by attenuating nod-like receptor family pyrin domain-containing 3 (nlrp3)-associated oligodendrocyte apoptosis after subarachnoid hemorrhage (sah). |
2021-06-28 |
2023-08-13 |
mouse |
| Liang Zhou, Yang-Chun Ma, Xue Tang, Wei-Ya Li, Ying Ma, Run-Ling Wan. Identification of the potential dual inhibitor of protein tyrosine phosphatase sigma and leukocyte common antigen-related phosphatase by virtual screen, molecular dynamic simulations and post-analysis. Journal of biomolecular structure & dynamics. vol 39. issue 1. 2021-06-18. PMID:31842717. |
owing to their inhibitory role in regulating oligodendrocyte differentiation and apoptosis, protein tyrosine phosphatase sigma (ptpσ) and leukocyte common antigen-related phosphatase (lar) play a crucial potential role in treating spinal cord injury (sci) disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Baichuan Li, Yang Xu, Yong Quan, Qiyan Cai, Yifan Le, Teng Ma, Zhi Liu, Guangyan Wu, Fei Wang, Chuncha Bao, Hongli L. Inhibition of RhoA/ROCK Pathway in the Early Stage of Hypoxia Ameliorates Depression in Mice ACS chemical neuroscience. vol 11. issue 17. 2021-06-18. PMID:32667781. |
then, we demonstrated that demyelination was associated with failures of oligodendrocyte precursor cell proliferation and differentiation and increased apoptosis of oligodendrocytes. |
2021-06-18 |
2023-08-13 |
mouse |
| Kalpana Kumari Barhwal, Suryanarayan Biswal, Tapas Chandra Nag, Om Prakash Chaurasia, Sunil Kumar Hot. Class switching of carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia. Free radical biology & medicine. vol 161. 2021-06-18. PMID:33035636. |
the demyelination of ca3 neurons was associated with increased apoptosis of both oligodendrocyte precursor cells (opcs) and mature oligodendrocytes (ols), peroxidation of myelin lipids, and nitration induced reduced expression of carbonic anhydrase ii (caii). |
2021-06-18 |
2023-08-13 |
rat |
| Chang Xu, Liang Mao, He Tian, Sen Lin, Xiaoguang Zhao, Jiaquan Lin, Daoyong Li, Xian Li, Xifan Me. MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury. Neuroscience letters. vol 750. 2021-05-10. PMID:33647394. |
mical1 (molecule interacting with casl 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury. |
2021-05-10 |
2023-08-13 |
Not clear |
| Yong Tan, Haijun Yu, Shanquan Sun, Shengwei Gan, Rui Gong, Ke-Jie Mou, Jun Xue, Shiye Xu, Jiangfeng Wu, Lan M. Honokiol exerts protective effects on neural myelin sheaths after compressed spinal cord injury by inhibiting oligodendrocyte apoptosis through regulation of ER-mitochondrial interactions. The journal of spinal cord medicine. 2021-04-08. PMID:33830903. |
honokiol exerts protective effects on neural myelin sheaths after compressed spinal cord injury by inhibiting oligodendrocyte apoptosis through regulation of er-mitochondrial interactions. |
2021-04-08 |
2023-08-13 |
Not clear |
| Yu-Shan Wan, Yi You, Qian-Yun Ding, Yi-Xin Xu, Han Chen, Rong-Rong Wang, Yu-Wen Huang, Zhong Chen, Wei-Wei Hu, Lei Jian. Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice. Acta pharmacologica Sinica. 2021-04-07. PMID:33824460. |
we revealed that the protective effect of triptolide resulted from its inhibition of oligodendrocyte apoptosis via increasing the phosphorylation of the src/akt/gsk3β pathway. |
2021-04-07 |
2023-08-13 |
mouse |
| Nune Darbinian, Armine Darbinyan, Nana Merabova, Ahsun Bajwa, Gabriel Tatevosian, Diana Martirosyan, Huaqing Zhao, Michael E Selzer, Laura Goetz. Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain. Neurobiology of disease. vol 148. 2021-03-23. PMID:33189883. |
experimental rodent models of fas have shown dysregulation of cytokine expression leading to apoptosis of oligodendrocyte precursor cells (opcs) and altered oligodendrocyte (ol) differentiation, but whether this is representative of human fas pathogenesis has not been determined. |
2021-03-23 |
2023-08-13 |
human |
| Hanin Abdulbaset Abo Taleb, Badrah Saeed Alghamd. Neuroprotective Effects of Melatonin during Demyelination and Remyelination Stages in a Mouse Model of Multiple Sclerosis. Journal of molecular neuroscience : MN. vol 70. issue 3. 2021-02-08. PMID:31713152. |
this model of experimental ms in mice is widely used because cuprizone administration causes an artificial demyelination reaction through oligodendrocyte apoptosis, while its withdrawal leads to spontaneous remyelination. |
2021-02-08 |
2023-08-13 |
mouse |
| Anna Nellessen, Stella Nyamoya, Adib Zendedel, Alexander Slowik, Christoph Wruck, Cordian Beyer, Athanassios Fragoulis, Tim Clarne. Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model. Metabolic brain disease. vol 35. issue 2. 2021-01-29. PMID:31529356. |
we found increased oligodendrocyte apoptosis and loss, pronounced neuroinflammation and higher levels of axonal damage in cuprizone-fed nrf2-deficient animals when compared to wild type controls. |
2021-01-29 |
2023-08-13 |
mouse |