| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Palumbo, Christopher D Toscano, Laura Parente, Roberto Weigert, Francesca Bosett. The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. Journal of neurochemistry. vol 121. issue 3. 2012-05-24. PMID:21699540. |
these data indicate that the pge₂ ep2 receptor contributes to oligodendrocyte apoptosis and open possible new therapeutic approaches for multiple sclerosis. |
2012-05-24 |
2023-08-12 |
Not clear |
| Stefanie Gaupp, Joseph Arezzo, Dipankar J Dutta, Gareth R John, Cedric S Rain. On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter? Journal of neuropathology and experimental neurology. vol 70. issue 12. 2012-02-10. PMID:22082665. |
although molecular mechanisms underlying hypomyelination in this and other tg models remain largely unknown, we present preliminary findings on oligodendrocyte progenitor cell (opc) cultures in which, although opc expressed ccr2, the receptor for ccl2, treatment with ccl2 had no significant effect on opc proliferation, differentiation, or apoptosis. |
2012-02-10 |
2023-08-12 |
mouse |
| Yaqing Shu, Yu Yang, Wei Qiu, Zhengqi Lu, Ying Li, Jian Bao, Ming Feng, Xueqiang H. Neuroprotection by ulinastatin in experimental autoimmune encephalomyelitis. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21667278. |
furthermore, ulinastatin treatment increased the expression of nerve growth factor and brain-derived neurotrophic factor, and protected against oligodendrocyte apoptosis. |
2012-01-27 |
2023-08-12 |
mouse |
| Sujata Saraswat Ohri, Melissa A Maddie, Yongmei Zhao, Mengsheng S Qiu, Michal Hetman, Scott R Whittemor. Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury. Glia. vol 59. issue 10. 2011-11-29. PMID:21638341. |
furthermore, analyses of hindlimb locomotion demonstrated a significant functional recovery that correlated with an increase in white-matter sparing, transcript levels of myelin basic protein, and claudin 11 and decreased oligodendrocyte apoptosis in chop null mice in contrast to wt animals. |
2011-11-29 |
2023-08-12 |
mouse |
| Emanuele Tirotta, Richard M Ransohoff, Thomas E Lan. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis. Glia. vol 59. issue 10. 2011-11-29. PMID:21656856. |
cxcr2 signaling protects oligodendrocyte progenitor cells from ifn-γ/cxcl10-mediated apoptosis. |
2011-11-29 |
2023-08-12 |
mouse |
| Emanuele Tirotta, Richard M Ransohoff, Thomas E Lan. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis. Glia. vol 59. issue 10. 2011-11-29. PMID:21656856. |
here we show that treatment of mouse oligodendrocyte progenitor cell (opc)-enriched cultures with ifn-γ resulted in a dose-dependent increase in apoptosis. |
2011-11-29 |
2023-08-12 |
mouse |
| Emanuele Tirotta, Richard M Ransohoff, Thomas E Lan. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis. Glia. vol 59. issue 10. 2011-11-29. PMID:21656856. |
these findings demonstrate a previously unappreciated role for cxcl10 in contributing to neuropathology by promoting oligodendrocyte apoptosis and emphasize the potential relevance in targeting cxcl10 in treating human demyelinating diseases including multiple sclerosis (ms). |
2011-11-29 |
2023-08-12 |
mouse |
| Krishna Dummula, Govindaiah Vinukonda, Philip Chu, Yiping Xing, Furong Hu, Sabrina Mailk, Anna Csiszar, Caroline Chua, Peter Mouton, Robert J Kayton, Joshua C Brumberg, Rashmi Bansal, Praveen Ballab. Bone morphogenetic protein inhibition promotes neurological recovery after intraventricular hemorrhage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 34. 2011-11-07. PMID:21865450. |
we found that ivh resulted in apoptosis and reduced proliferation of oligodendrocyte progenitors, as well as arrested maturation of preoligodendrocytes in rabbits. |
2011-11-07 |
2023-08-12 |
human |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
in oligodendrocyte progenitor cell (opc) cultures, il-11 restricted caspase 9 activation and apoptosis, and it increased myelination in opc-neuron cocultures. |
2011-10-24 |
2023-08-12 |
mouse |
| Lukas Haider, Marie T Fischer, Josa M Frischer, Jan Bauer, Romana Höftberger, Gergö Botond, Harald Esterbauer, Christoph J Binder, Joseph L Witztum, Hans Lassman. Oxidative damage in multiple sclerosis lesions. Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21653539. |
oxidized dna was mainly seen in oligodendrocyte nuclei, which in part showed signs of apoptosis. |
2011-08-26 |
2023-08-12 |
human |
| Vicente Molina, Sergi Papiol, Javier Sanz, Araceli Rosa, Bárbara Arias, Mar Fatjó-Vilas, Julia Calama, Ana I Hernández, Joemir Bécker, Lourdes Fañaná. Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients. NeuroImage. vol 56. issue 1. 2011-07-29. PMID:21296169. |
protein p53, encoded by tp53 gene, has a central role in the control of apoptosis and is involved in oligodendrocyte development. |
2011-07-29 |
2023-08-12 |
human |
| Manjeet K Paintlia, Ajaib S Paintlia, Avtar K Singh, Inderjit Sing. Synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21143599. |
synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis. |
2011-03-22 |
2023-08-12 |
Not clear |
| Arundhati Jana, Kalipada Paha. Sphingolipids in multiple sclerosis. Neuromolecular medicine. vol 12. issue 4. 2011-03-10. PMID:20607622. |
although the etiology of ms is poorly known, new insights suggest oligodendrocyte apoptosis as one of the critical events followed by glial activation and infiltration of lymphocytes and macrophages. |
2011-03-10 |
2023-08-12 |
Not clear |
| Fang Sun, Chien-Liang Glenn Lin, Dana McTigue, Xiu Shan, C Amy Tovar, Jacqueline C Bresnahan, Michael S Beatti. Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. Glia. vol 58. issue 11. 2011-02-28. PMID:20607865. |
effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. |
2011-02-28 |
2023-08-12 |
Not clear |
| Fang Sun, Chien-Liang Glenn Lin, Dana McTigue, Xiu Shan, C Amy Tovar, Jacqueline C Bresnahan, Michael S Beatti. Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. Glia. vol 58. issue 11. 2011-02-28. PMID:20607865. |
wallerian degeneration in the dorsal columns (dc) after spinal cord injury (sci) is associated with microglial activation and prolonged oligodendrocyte (ol) apoptosis that may contribute to demyelination and dysfunction after sci. |
2011-02-28 |
2023-08-12 |
Not clear |
| Ikuo Tsunoda, Robert S Fujinam. Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 3. 2010-11-23. PMID:19894121. |
during the chronic phase, about 1 month after infection, virus infects glial cells and macrophages, and induces inflammatory demyelination with oligodendrocyte apoptosis and axonal degeneration in the white matter of the spinal cord. |
2010-11-23 |
2023-08-12 |
mouse |
| Jennifer A Barrie, Paul Montague, Saadia Karim, Douglas Kirkham, Klaus-Armin Nave, Thomas J Anderson, Ian R Griffiths, Mark McLaughli. Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20175203. |
the rumpshaker mutation of the murine myelin proteolipid protein 1 (plp1) gene generates misfolded plp/dm20 protein, resulting in dysmyelination, increased oligodendrocyte apoptosis, and death prior to p40 when expressed on the c57 bl/6 background. |
2010-10-26 |
2023-08-12 |
mouse |
| Xiaohong Li, Meijuan Yan, Ling Hu, Linlin Sun, Fupeng Zhang, Huoyan Ji, Jing Jiang, Ping Wang, Haiou Liu, Ying Gao, Tao Tao, Xingxin He, Chun Cheng, Aiguo She. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20155814. |
involvement of src-suppressed c kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. |
2010-09-16 |
2023-08-12 |
rat |
| Xiaohong Li, Meijuan Yan, Ling Hu, Linlin Sun, Fupeng Zhang, Huoyan Ji, Jing Jiang, Ping Wang, Haiou Liu, Ying Gao, Tao Tao, Xingxin He, Chun Cheng, Aiguo She. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20155814. |
as excessive release of tnf-alpha and no were major mediators in autoimmune diseases and correlated with oligodendrocyte cell death, we further investigated whether ssecks participated in oligodendrocyte apoptosis. |
2010-09-16 |
2023-08-12 |
rat |
| Xiaohong Li, Meijuan Yan, Ling Hu, Linlin Sun, Fupeng Zhang, Huoyan Ji, Jing Jiang, Ping Wang, Haiou Liu, Ying Gao, Tao Tao, Xingxin He, Chun Cheng, Aiguo She. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20155814. |
the results from antibody neutralization and no inhibition suggested that the oligodendrocyte apoptosis may be due to the production of astrocyte-derived proinflammatory factors (tnf-alpha and no). |
2010-09-16 |
2023-08-12 |
rat |