| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wencan Li, Xiang Liu, Zheng Liu, Qichang Xing, Renzhu Liu, Qinxuan Wu, Yixiang Hu, Jiani Zhan. The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review. Frontiers in pharmacology. vol 15. 2024-07-18. PMID:39021834. |
growing evidence suggests that myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, and advanced glycation end product deposition were the main pathologic mechanisms of dcm. |
2024-07-18 |
2024-07-20 |
Not clear |
| Song Zhang, Mitchell C Lock, Michelle Tie, I Caroline McMillen, Kimberley J Botting, Janna L Morriso. Cardiac programming in the placentally restricted sheep fetus in early gestation. The Journal of physiology. 2024-07-08. PMID:38975864. |
while there was no change in the proportion of cardiomyocytes that were proliferating in the early gestation pr heart, there was an increase in measures of apoptosis, and markers of autophagy and pathological hypertrophy in the pr fetal heart. |
2024-07-08 |
2024-07-11 |
human |
| Weixuan Chen, Daniel Rams, Maciej Zając, Raghad Albalawi, Andrew J Atkinson, Abimbola J Aminu, Malgorzata Mazur, Mateusz K Hołda, Jerzy Walocha, Krzysztof Gil, Marcin Kuniewicz, Halina Dobrzynsk. Morphology of human sinoatrial node and its surrounding right atrial muscle in the global obesity pandemic-does fat matter? Frontiers in medicine. vol 11. 2024-07-06. PMID:38966523. |
the impacts of aging and obesity on fibrosis, apoptosis and cellular hypertrophy were investigated in the sn and ra. |
2024-07-06 |
2024-07-08 |
human |
| Xi Yao, Xinyue Huang, Jianghua Chen, Weiqiang Lin, Jingyan Tia. Roles of non-coding RNA in diabetic cardiomyopathy. Cardiovascular diabetology. vol 23. issue 1. 2024-07-02. PMID:38951895. |
diabetic cardiomyopathy (dcm) is characterized by cardiomyocyte hypertrophy, myocardial fibrosis, apoptosis, ventricular remodeling, and cardiac dysfunction in individuals with diabetes, ultimately leading to heart failure and mortality. |
2024-07-02 |
2024-07-04 |
human |
| Bingyan Hou, Dan Yu, Haotian Bai, Xiaowei D. Research progress of miRNA in heart failure: prediction and treatment. Journal of cardiovascular pharmacology. 2024-06-26. PMID:38922572. |
this review summarizes the multiple roles of mirnas in the prediction and treatment of heart failure (hf), including the molecular mechanisms regulating cell apoptosis, myocardial fibrosis, cardiac hypertrophy and ventricular remodelling, and highlights the importance of mirnas in the prognosis of hf. |
2024-06-26 |
2024-06-29 |
Not clear |
| Zhi-Hua Deng, Yao-Xin Chen, Xue-Gao, Jing-Yu Yang, Xia-Ying Wei, Guo-Xing Zhang, Jin-Xian Qia. Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway. Biochemical pharmacology. 2024-06-23. PMID:38909785. |
the results showed that msc-exos could not only reduce the elevation of rvsp, right ventricular hypertrophy and the degree of pulmonary vascular remodeling in hph rats, but also reduce the proliferation, migration and apoptosis resistance of pasmcs. |
2024-06-23 |
2024-06-26 |
rat |
| Waruna Thotamune, Sithurandi Ubeysinghe, Kendra K Shrestha, Mahmoud Elhusseiny Mostafa, Michael C Young, Ajith Karunarathn. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling. The Journal of biological chemistry. 2024-06-20. PMID:38901558. |
emerging evidence indicates pathological molecular signatures in deeper endomembrane βars signaling, likely contributing to conditions such as cardiomyocyte hypertrophy and apoptosis. |
2024-06-20 |
2024-06-23 |
Not clear |
| Lingji Li, Ranran Xi, Bing Gao, Yonglei Zeng, Qiang Ma, Tiantian Gong, Jing Wan. Research progress of autophagy in heart failure. American journal of translational research. vol 16. issue 5. 2024-06-17. PMID:38883358. |
in the context of heart failure, autophagy coexists with apoptosis and necrosis, influencing myocardial hypertrophy and ventricular remodeling. |
2024-06-17 |
2024-06-19 |
Not clear |
| Han Xu, Ouyang Li, Dayoung Kim, Mengjuan Xue, Zhijun Bao, Fan Yan. Aged microbiota exacerbates cardiac failure by PPARα/PGC1α pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 7. 2024-06-11. PMID:38823462. |
the epicardium of aged fmt recipients shows fat accumulation, accompanied by cardiomyocyte hypertrophy, cardiac fibrosis and increased cellular apoptosis. |
2024-06-11 |
2024-06-14 |
mouse |
| Linna Zhao, Yiping Qin, Yangong Liu, Liping An, Weizhe Liu, Chuang Zhang, Qiuhang Song, Cheng Dai, Juanjuan Zhang, Aiying L. The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-07. PMID:38847482. |
the results demonstrated that txg alleviated hfpef by reducing the expressions of genes associated with myocardial hypertrophy, fibrosis and apoptosis. |
2024-06-07 |
2024-06-10 |
mouse |
| Linna Zhao, Yiping Qin, Yangong Liu, Liping An, Weizhe Liu, Chuang Zhang, Qiuhang Song, Cheng Dai, Juanjuan Zhang, Aiying L. The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-07. PMID:38847482. |
in conclusion, txg alleviates myocardial hypertrophy, fibrosis and apoptosis through the activation of the ire1α/xbp1s signalling pathway, suggesting its potential beneficial effects on hfpef patients. |
2024-06-07 |
2024-06-10 |
mouse |
| Jiang Lai, Chunxiao L. Review on the pharmacological effects and pharmacokinetics of scutellarein. Archiv der Pharmazie. 2024-06-07. PMID:38849327. |
these mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia-reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. |
2024-06-07 |
2024-06-10 |
Not clear |
| Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. |
deficiency of igfbp2 attenuated the urine protein, renal pathological injury and glomeruli hypertrophy of dkd mice induced by stz, and knockdown or deletion of igfbp2 alleviated podocytes apoptosis induced by high concentration of glucose or in dkd mouse. |
2024-05-25 |
2024-05-31 |
mouse |
| Man Xu, Li-Peng Li, Xi He, Xing-Zhu Lu, Xue-Yuan Bi, Qi Li, Xiao-Rong Xu. Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-08. PMID:38717442. |
moreover, hsf1 small-interfering rna reduced the metformin-mediated improvements in mitochondrial morphology and the uprmt by suppressing hypertrophic signals and cardiomyocyte apoptosis. |
2024-05-08 |
2024-05-27 |
rat |
| Alireza Mousavian, Mohammad Abdollahi, Negin Haddada. Talus Avascular Necrosis as a Rare Complication of Cushing's Disease: A Case Report. Cureus. vol 16. issue 4. 2024-05-06. PMID:38707157. |
mechanisms behind avn in hypercortisolism involve fat cell hypertrophy, fat embolization, osteocyte apoptosis, and glucocorticoid-induced hypertension. |
2024-05-06 |
2024-05-08 |
Not clear |
| Jianan Wang, Shiying Liu, Lihong Sun, Zhanping Kong, Jiamin Chai, Jigang Wen, Xuan Tian, Nan Chen, Chengli X. Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia. Scientific reports. vol 14. issue 1. 2024-05-03. PMID:38702334. |
chronic hypoxia for 14 days led to increased myocyte hypertrophy, fibrosis, apoptosis, and mitochondrial dysfunction, coupled with reduced protein levels of leptin signaling pathways in myocardial tissues. |
2024-05-03 |
2024-05-06 |
rat |
| Mengyang Song, He Wang, Caixia Liu, Sijie Jin, Bin Liu, Wei Su. Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease. Frontiers in pharmacology. vol 15. 2024-05-03. PMID:38698813. |
recent studies have found that ncrnas interact with hippo pathway components to regulate myocardial fibrosis, cardiomyocyte proliferation, apoptosis, and hypertrophy and play an important role in cardiovascular disease. |
2024-05-03 |
2024-05-05 |
human |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we predicted that the transcription factors stat, srf, gata4, tp53, and foxo are the key regulators of cardiomyocyte hypertrophy and apoptosis in hcm in alignment with experiments. |
2024-04-27 |
2024-04-30 |
mouse |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we also predicted potential combination drug targets for hcm (e.g., mavacamten plus ros inhibitors) preventing or reversing hcm phenotype (i.e., hypertrophic growth, apoptosis, and metabolic remodeling) in cardiomyocytes. |
2024-04-27 |
2024-04-30 |
mouse |
| Lijun Zhang, Fang Xie, Fengmei Zhang, Beiyao L. The potential roles of exosomes in pathological cardiomyocyte hypertrophy mechanisms and therapy: A review. Medicine. vol 103. issue 17. 2024-04-26. PMID:38669371. |
exosomes from cardiomyocytes, endothelial cells, fibroblasts, and stem cells are key in regulating processes like cardiac hypertrophy, cardiomyocyte survival, apoptosis, fibrosis, and angiogenesis within the context of cardiovascular diseases. |
2024-04-26 |
2024-04-29 |
Not clear |