| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wan. Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251334. |
in this study, we found that niclosamide could not only inhibit proliferation and promote apoptosis of oral cancer cells, but also inhibited vm formation in vitro and in vivo through downregulation of the expression of vm-related genes vegfa, mmp2, rock1 and cdc42. |
2018-08-23 |
2023-08-13 |
human |
| Bruna Cristine de Almeida, Natalia Garcia, Giovana Maffazioli, Laura Gonzalez dos Anjos, Edmund Chada Baracat, Katia Candido Carvalh. Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. International journal of molecular sciences. vol 19. issue 1. 2018-07-27. PMID:29295562. |
we identified four differentially expressed mirnas with the same profile when compared with patients' samples, which strongly interacted with relevant genes, including apoptosis regulator (bcl2), epidermal growth factor receptor (egfr), vascular endothelial growth factor a (vegfa), insulin like growth factor 1 receptor (igf1r),serine/threonine kinase (raf1), receptor tyrosine kinase (met), and bhlh transcription factor (mycn). |
2018-07-27 |
2023-08-13 |
Not clear |
| Chenglin Qin, Wenzhang Zha, Rengen Fan, Huimin Ding, Yonghua Xu, Chen Wan. MicroRNA‑302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA. Molecular medicine reports. vol 16. issue 5. 2018-06-11. PMID:28849033. |
microrna‑302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting vegfa. |
2018-06-11 |
2023-08-13 |
human |
| Chenglin Qin, Wenzhang Zha, Rengen Fan, Huimin Ding, Yonghua Xu, Chen Wan. MicroRNA‑302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA. Molecular medicine reports. vol 16. issue 5. 2018-06-11. PMID:28849033. |
knockdown of vegfa expression led to reduced hcc cell proliferation and invasion, and increased apoptosis rates, similar to mir‑302a overexpression, which suggested that vegfa may be a functional downstream target of mir‑302a in hcc. |
2018-06-11 |
2023-08-13 |
human |
| Hai-Li Lang, Guo-Wen Hu, Bo Zhang, Wei Kuang, Yong Chen, Lei Wu, Guo-Hai X. Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2. Oncology reports. vol 38. issue 2. 2018-04-03. PMID:28656228. |
finally, gain-/loss-of-function studies revealed that the overexpression of linc-ccat2 in huvecs activated vegfa and tgfβ, promoted angiogenesis, promoted bcl-2 expression and inhibited bax and caspase-3 expression, thus decreasing apoptosis. |
2018-04-03 |
2023-08-13 |
Not clear |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Peng Yao, Jiangbin Wu, Daniel Lindner, Paul L Fo. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Nucleic acids research. vol 45. issue 13. 2017-10-10. PMID:28520992. |
ectopically expressed mir-574-3p binds multiple rna recognition motif (rrm) domains of hnrnp l, synergizes with mir-297, reduces vegfa mrna translation, and triggers apoptosis, thereby suppressing tumorigenesis. |
2017-10-10 |
2023-08-13 |
human |
| Y Hu, Y Qiu, E Yagüe, W Ji, J Liu, J Zhan. miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer. Cell death & disease. vol 7. issue 6. 2017-10-09. PMID:27362808. |
taken together, our data suggest that mir-205 enhances chemosensitivity of breast cancer cells to tac chemotherapy by suppressing both vegfa and fgf2, leading to evasion of apoptosis. |
2017-10-09 |
2023-08-13 |
mouse |
| Xiaochuan Wang, Ping Cao, Jian Liu, Peng Du, Zhiqiong Wang, Wei Chen, Chang Liu, Yifei W. 5-Aminolaevulinic Acid-Based Photodynamic Therapy Restrains Pathological Hyperplasia of Fibroblasts. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-05-26. PMID:28052053. |
results ala-pdt inhibited proliferation delayed cell cycle progress, promoted apoptosis of fibroblasts, and suppressed its growth-promoting effect on vascular endothelial cells, and decreased expression of tgf-β1, α-sma, collagen i, collagen iii, vegfa, and bfgf. |
2017-05-26 |
2023-08-13 |
Not clear |
| S L Li, X H Ma, J F Ji, H Li, W Liu, F Z Lu, S T Wu, Y Zhan. miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-28. PMID:27819721. |
mir-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting vegfa. |
2017-02-28 |
2023-08-13 |
human |
| Hongwei Chen, Yun Tia. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Bioscience trends. vol 10. issue 6. 2017-02-08. PMID:27916780. |
functional analysis including cck-8 assay and flow cytometry revealed that overexpression of vegfa or inhibition of mir-15a-5p promoted cell proliferation, suppressed cell apoptosis and reduced matrix degradation in oa chondrocytes. |
2017-02-08 |
2023-08-13 |
human |
| Hongwei Chen, Yun Tia. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Bioscience trends. vol 10. issue 6. 2017-02-08. PMID:27916780. |
moreover, rescue assays carried out with both expression of vegfa and mir-15a-5p demonstrated that mir-15a-5p contributes to cell apoptosis and matrix degradation via inhibiting vegfa. |
2017-02-08 |
2023-08-13 |
human |
| Ali Salajegheh, Haleh Vosgha, Atiqur Md Rahman, Moein Amin, Robert Anthony Smith, Alfred King-Yin La. Modulatory role of miR-205 in angiogenesis and progression of thyroid cancer. Journal of molecular endocrinology. vol 55. issue 3. 2016-08-19. PMID:26342107. |
transfection of mir-205 into the cancer cell lines caused significant reduction of vegfa protein and significant inhibition in cell proliferation, arrest in g0-g1 of the cell cycle and promotion of total apoptosis (p<0.05). |
2016-08-19 |
2023-08-13 |
Not clear |
| Paola Cipriani, Paola Di Benedetto, Hermann Dietrich, Piero Ruscitti, Vasiliki Liakouli, Francesco Carubbi, Ilenia Pantano, Onorina Berardicurti, Roswitha Sgonc, Roberto Giacomell. Searching for a good model for systemic sclerosis: the molecular profile and vascular changes occurring in UCD-200 chickens strongly resemble the early phase of human systemic sclerosis. Archives of medical science : AMS. vol 12. issue 4. 2016-08-01. PMID:27478465. |
vascular injury and endothelial cell (ec) apoptosis are the earliest events in systemic sclerosis (ssc), before the onset of fibrosis, and stromal cell-derived factor 1 (sdf-1), vascular endothelial growth factor (vegfa), endothelin-1 (et-1) and platelet-derived growth factors (pdgf-bb) represent the key molecules to study the link between vascular injury and fibrosis during ssc. |
2016-08-01 |
2023-08-13 |
human |
| Wei Wei, Yanqin Wang, Xiaoming Yu, Lan Ye, Yuhua Jiang, Yufeng Chen. Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-07-26. PMID:26439224. |
this study therefore investigated the effect and correlation of tp53, bcl-2, and vegfa genes on cell proliferation and apoptosis of esophagus carcinoma. |
2016-07-26 |
2023-08-13 |
Not clear |
| Gürkan Bal, Matthias E Futschik, Daniela Hartl, Frauke Ringel, Julian Kamhieh-Milz, Viktor Sterzer, Jörg D Hoheisel, Mohamed S S Alhamdani, Abdulgabar Salam. Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling. British journal of haematology. vol 172. issue 4. 2016-06-21. PMID:26628061. |
in addition to oncoproteins and tumour-suppressor proteins, including apoptosis regulator bcl2, breast cancer type 1 susceptibility protein (brca1), fanconi anaemia complementation group c (fancc) and vascular endothelial growth factor a (vegfa), we detected six anti-nuclear autoantibodies in a subset of itp patients: anti-pcna, anti-smd, anti-ro/ssa60, anti-ro/ssa52, anti-la/ssb and anti-rnpc antibodies. |
2016-06-21 |
2023-08-13 |
Not clear |
| Philippe Kieffer-Kwon, Christine Happel, Thomas S Uldrick, Dhivya Ramalingam, Joseph M Ziegelbaue. KSHV MicroRNAs Repress Tropomyosin 1 and Increase Anchorage-Independent Growth and Endothelial Tube Formation. PloS one. vol 10. issue 8. 2016-05-10. PMID:26263384. |
functionally, mir-k2 increases viability of unanchored human umbilical vein endothelial cells (huvec) by inhibiting anoikis (apoptosis after cell detachment), enhances tube formation of huvecs, and enhances vegfa expression. |
2016-05-10 |
2023-08-13 |
human |
| Hong-Yan Ge, Zhong-Jing Han, Pei Tian, Wen-Jie Sun, Da-Xi Xue, Yu Bi, Zhang-Hui Yang, Ping Li. VEGFA Expression Is Inhibited by Arsenic Trioxide in HUVECs through the Upregulation of Ets-2 and miRNA-126. PloS one. vol 10. issue 8. 2016-05-09. PMID:26274316. |
recently, studies have shown that ato can induce apoptosis in leukemic cells and blood vessel endothelial cells in a time- and dose-dependent manner through the inhibition of vascular endothelial growth factor a (vegfa) production. |
2016-05-09 |
2023-08-13 |
human |
| Hong-Yan Ge, Zhong-Jing Han, Pei Tian, Wen-Jie Sun, Da-Xi Xue, Yu Bi, Zhang-Hui Yang, Ping Li. VEGFA Expression Is Inhibited by Arsenic Trioxide in HUVECs through the Upregulation of Ets-2 and miRNA-126. PloS one. vol 10. issue 8. 2016-05-09. PMID:26274316. |
these results demonstrate that ato inhibits the growth of huvecs and induces apoptosis by downregulating vegfa. |
2016-05-09 |
2023-08-13 |
human |
| Fan-Chang Zeng, Ming-Qiang Zeng, Liang Huang, Yong-Lin Li, Ben-Min Gao, Jun-Jie Chen, Rui-Zhi Xue, Zheng-Yan Tan. Downregulation of VEGFA inhibits proliferation, promotes apoptosis, and suppresses migration and invasion of renal clear cell carcinoma. OncoTargets and therapy. vol 9. 2016-04-25. PMID:27110129. |
downregulation of vegfa inhibits proliferation, promotes apoptosis, and suppresses migration and invasion of renal clear cell carcinoma. |
2016-04-25 |
2023-08-13 |
Not clear |