| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Wang, Chun-Yi Lyu, Yue-Hua Jiang, Xue-Yan Dong, Yan Wang, Zong-Hong Li, Jin-Xin Wang, Rui-Rong X. A drug-biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Molecular diversity. vol 25. issue 4. 2021-10-28. PMID:32676746. |
the results suggest that luteolin and quercetin are the main active components of sbd against adverse-risk aml, and affected drug resistance, apoptosis, immune regulation and angiogenesis through the core targets akt1, mapk1, il6, egfr, src, vegfa and tp53. |
2021-10-28 |
2023-08-13 |
Not clear |
| Xingbao Fang, Yan Cai, Yongping Xu, Hong Zhan. Exosome-mediated lncRNA SNHG11 regulates angiogenesis in pancreatic carcinoma through miR-324-3p/VEGFA axis. Cell biology international. 2021-10-22. PMID:34519129. |
rescue assays validated that the inhibitory effect of snhg11 depletion on cell proliferation, migration, and angiogenesis could be reversed by mir-324-3p downregulation or vegfa upregulation, and the promoting effect of snhg11 silence on cell apoptosis could be rescued by transfection of mir-324-3p inhibitor or pcdna3.1-vegfa. |
2021-10-22 |
2023-08-13 |
human |
| Yan Gao, Ting Zou, Wentong Liang, Zhijun Zhang, Mingrong Qi. Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis. Cancer gene therapy. vol 28. issue 6. 2021-10-18. PMID:33139818. |
overexpressed hand2-as1 or downregulated mir-21-5p inhibited cell proliferation, migration, and invasion while promoting cell apoptosis, in association with increased expression of proteins in vegfa signaling pathway. |
2021-10-18 |
2023-08-13 |
mouse |
| Yang-Yang Duan, Yong Chai, Nai-Li Zhang, Dong-Mei Zhao, Cheng Yan. Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury. Journal of molecular neuroscience : MN. vol 71. issue 3. 2021-10-04. PMID:32901373. |
by using flow cytometry and western blotting, we found that microtubule stabilization treatment inhibited apoptosis and migration of endothelial cells and pericytes but promoted proliferation and survival of endothelial cells and pericytes through upregulated expression of vascular endothelial growth factor a (vegfa), vegf receptor 2, platelet-derived growth factor-b (pdgfb), pdgf receptor β, and angiopoietin-1 after sci. |
2021-10-04 |
2023-08-13 |
rat |
| Bum Jun Kim, Yoo Jin Kim, Sung-Hwa Sohn, Bohyun Kim, Hee Jung Sul, Hyeong Su Kim, Dae Young Zan. Tivantinib inhibits the VEGF signaling pathway and induces apoptosis in gastric cancer cells with c-MET or VEGFA amplification. Investigational new drugs. vol 38. issue 6. 2021-09-10. PMID:32361789. |
tivantinib inhibits the vegf signaling pathway and induces apoptosis in gastric cancer cells with c-met or vegfa amplification. |
2021-09-10 |
2023-08-13 |
human |
| N G J Costermans, N M Soede, F van Tricht, M Blokland, B Kemp, J Keijer, K J Teerd. Follicular fluid steroid profile in sows: relationship to follicle size and oocyte quality†. Biology of reproduction. vol 102. issue 3. 2021-08-20. PMID:31786607. |
transcriptome analysis of granulosa cells of healthy follicles of sows with a high percentage high-quality cocs showed higher abundance of transcripts involved in ovarian steroidogenesis (e.g., cyp19a2 and 3, por, vegfa) and growth (igf1) and differential abundance of transcripts involved in granulosa cell apoptosis (e.g., gadd45a, inhbb). |
2021-08-20 |
2023-08-13 |
Not clear |
| Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Lian. Paeoniflorin alleviates endothelial dysfunction caused by overexpression of soluble fms-like tyrosine kinase 1 and soluble endoglin in preeclampsia via VEGFA upregulation. Bioscience, biotechnology, and biochemistry. vol 85. issue 4. 2021-07-26. PMID:33590855. |
individual treatment or cotreatment of sflt-1 and seng inhibited migration, invasion and tube formation, enhanced apoptosis, and decreased vegfa expression in huvecs. |
2021-07-26 |
2023-08-13 |
human |
| Qian Zhang, Li Lei, Di Jin. Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000256. |
collectively, these findings indicated that serpine1 significantly contributed to the proliferation and apoptosis of tnbc cells by regulating vegfa expression. |
2021-07-06 |
2023-08-13 |
human |
| Mengnan Ma, Jinbi Zhang, Xiaomeng Gao, Wang Yao, Qifa Li, Zengxiang Pa. miR-361-5p Mediates SMAD4 to Promote Porcine Granulosa Cell Apoptosis through VEGFA. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32899767. |
mir-361-5p mediates smad4 to promote porcine granulosa cell apoptosis through vegfa. |
2021-06-24 |
2023-08-13 |
Not clear |
| Mengnan Ma, Jinbi Zhang, Xiaomeng Gao, Wang Yao, Qifa Li, Zengxiang Pa. miR-361-5p Mediates SMAD4 to Promote Porcine Granulosa Cell Apoptosis through VEGFA. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32899767. |
vascular endothelial growth factor a (vegfa) is downregulated during follicular atresia in porcine ovaries and serves as an inhibitor of apoptosis in granulosa cells. |
2021-06-24 |
2023-08-13 |
Not clear |
| Hanqing Tang, Shitian Zhang, Cenhan Huang, Keming Li, Qiuhua Zhao, Xiaohua L. MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway. International heart journal. vol 62. issue 3. 2021-06-10. PMID:33994507. |
silenced vegfa expression significantly inhibited inhibitor effect on increasing cell viability and promoted apoptosis. |
2021-06-10 |
2023-08-13 |
rat |
| Wensi Chen, Shiping He, Daoman Xian. Hypoxia-induced retinal pigment epithelium cell-derived bFGF promotes the migration and angiogenesis of HUVECs through regulating TGF-β1/smad2/3 pathway. Gene. vol 790. 2021-06-07. PMID:33964379. |
after cell culture in hypoxia conditions, the cell viability, apoptosis, and the expressions of bfgf and vascular endothelial growth factor a (vegfa) in human rpes were detected by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), flow cytometry, western blot, rt-qpcr, or elisa. |
2021-06-07 |
2023-08-13 |
human |
| Wensi Chen, Shiping He, Daoman Xian. Hypoxia-induced retinal pigment epithelium cell-derived bFGF promotes the migration and angiogenesis of HUVECs through regulating TGF-β1/smad2/3 pathway. Gene. vol 790. 2021-06-07. PMID:33964379. |
hypoxia culture decreased the cell viability and promoted the apoptosis as well as the expressions of bfgf and vegfa in rpes. |
2021-06-07 |
2023-08-13 |
human |
| Min Liu, Huimin Liu, Jing Zhou, Zhuojun Y. miR‑140‑5p inhibits the proliferation of multiple myeloma cells by targeting VEGFA. Molecular medicine reports. vol 23. issue 1. 2021-05-11. PMID:33200797. |
further experiments indicated that vegfa overexpression promoted cell viability, migration and invasion and suppressed apoptosis of mm cells, and that the mir‑140‑5p mimic partially reversed the effects of vegfa overexpression. |
2021-05-11 |
2023-08-13 |
Not clear |
| Honglue Lu, Fei Kan. Down-regulating NEAT1 inhibited the viability and vasculogenic mimicry formation of sinonasal squamous cell carcinoma cells via miR-195-5p/VEGFA axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33146672. |
overexpressed vegfa promoted the viability and capillary-like tube formation of snscc cells yet suppressed their apoptosis, while silencing vegfa led to the opposite results. |
2021-04-12 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
porcine luteal cells were incubated with vaspin (0.1-10 ng/ml) for 24 h to 72 h and then mrna and protein expression of angiogenesis: vascular endothelial growth factor (vegfa), fibroblast growth factor 2 (fgf2), angiopoietin 1 (angpt1), vegfa receptors (vegfr1, vegfr2), apoptosis: caspase 3, bcl-2-like protein 4 (bax), b-cell lymphoma (bcl2), and proliferation: proliferating cells nuclear antigen (pcna), cyclin a factors as well as secretion of vegfa, fgf2, angt1 were measured by real-time polymerase chain reaction (pcr), immunoblotting and enzyme-linked immunosorbent assay (elisa), respectively. |
2021-03-15 |
2023-08-13 |
Not clear |
| Yao Liu, Li-Li Wang, Shuo Chen, Zhi-Hong Zong, Xue Guan, Yang Zha. LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1. Journal of cellular and molecular medicine. 2021-01-09. PMID:29799152. |
overexpression of lncrna abhd11-as1 promoted the proliferation, g1-s progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin d1, cdk1, cdk2, cdk4, bcl-xl and vegfa; and down-regulated p16, while abhd11-as1 down-regulation has the opposite effect. |
2021-01-09 |
2023-08-13 |
mouse |
| Mehran Ghaderi, Carlos Fernández Moro, Soledad Pouso Elduayen, Emilie Hultin, Caroline Sophie Verbeke, Mikael Björnstedt, Joakim Dillne. Genome-wide transcriptome profiling of ex-vivo precision-cut slices from human pancreatic ductal adenocarcinoma. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32493953. |
pathway over-representation analysis suggested that vegfa together with the ptgs2 gene were upregulated at the same time as hif-1-triggered cell apoptosis via nf-ĸb and the ap-1 activating factor was induced. |
2020-12-04 |
2023-08-13 |
human |
| Shuang Zheng, Feng Lin, Meng Zhang, Ning Mu, Xiaogang Ge, Junhui F. Long non-coding RNA AK001058 regulates tumor growth and angiogenesis in colorectal cancer via methylation of ADAMTS12. American journal of translational research. vol 11. issue 9. 2020-09-30. PMID:31632580. |
ak001058 overexpression also decreased cell apoptosis, worsened microvessel morphology and increased the expression of vegfa and angiopoietin ii. |
2020-09-30 |
2023-08-13 |
mouse |
| Lijun Wang, Fei Zhao, Zhongqing Xiao, Liang Ya. Exosomal microRNA-205 is involved in proliferation, migration, invasion, and apoptosis of ovarian cancer cells via regulating VEGFA. Cancer cell international. vol 19. 2020-09-29. PMID:31719795. |
exosomal microrna-205 is involved in proliferation, migration, invasion, and apoptosis of ovarian cancer cells via regulating vegfa. |
2020-09-29 |
2023-08-13 |
Not clear |