| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ameyar, A Atfi, Z Cai, R Stancou, V Shatrov, A Bettaïeb, S Chouaï. Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway. The Journal of biological chemistry. vol 273. issue 44. 1998-12-01. PMID:9786905. |
these results provide strong evidence indicating that tumor acquisition of resistance to the cytotoxic action of tnf may occur either independently or at a level downstream of jnk activation and suggest that jnk activation is not linked to ceramide pathway in tnf-mediated apoptosis. |
1998-12-01 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
furthermore, tnf alpha-induced apoptosis in these cells is inhibited by expression of a dominant negative mutant of rac 1 but it is not affected by a similar mutant of rho a. |
1998-11-25 |
2023-08-12 |
human |
| F Benigni, S Sacco, L Aloe, P Ghezz. Intracerebroventricular injection of anti-Fas activates the hypothalamus-pituitary-adrenal axis and induces peripheral interleukin-6 and serum amyloid A in mice: comparison with other ligands of the tumor necrosis factor/nerve growth factor receptor superfamily. The American journal of pathology. vol 153. issue 5. 1998-11-25. PMID:9811328. |
fas is a receptor of the tumor necrosis factor (tnf)/ nerve growth factor (ngf) receptor superfamily that mediates apoptosis and some inflammatory changes. |
1998-11-25 |
2023-08-12 |
mouse |
| B Beutler, F Bazzon. TNF, apoptosis and autoimmunity: a common thread? Blood cells, molecules & diseases. vol 24. issue 2. 1998-11-23. PMID:9645922. |
tnf, apoptosis and autoimmunity: a common thread? |
1998-11-23 |
2023-08-12 |
Not clear |
| B Beutler, F Bazzon. TNF, apoptosis and autoimmunity: a common thread? Blood cells, molecules & diseases. vol 24. issue 2. 1998-11-23. PMID:9645922. |
a subset of cytokine mediators belonging to the tumor necrosis factor (tnf) family cause apoptosis, acting through receptors and signaling pathways that have recently come to light. |
1998-11-23 |
2023-08-12 |
Not clear |
| M A Alexander-Miller, M A Derby, A Sarin, P A Henkart, J A Berzofsk. Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes. The Journal of experimental medicine. vol 188. issue 8. 1998-11-17. PMID:9782116. |
we previously reported a potential mechanism for this deletion: tumor necrosis factor (tnf)-alpha-mediated apoptosis resulting from stimulation with supraoptimal peptide-major histocompatibility complex. |
1998-11-17 |
2023-08-12 |
Not clear |
| S Y Lee, D R Kaufman, A L Mora, A Santana, M Boothby, Y Cho. Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways. The Journal of experimental medicine. vol 188. issue 7. 1998-11-16. PMID:9763618. |
thus, although tnf can cause apoptosis and may prove useful in the treatment of malignancies, most cells are resistant to tnf-induced cell death unless de novo protein synthesis is inhibited. |
1998-11-16 |
2023-08-12 |
Not clear |
| F J Johannes, J Horn, G Link, E Haas, K Siemienski, H Wajant, K Pfizenmaie. Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes. European journal of biochemistry. vol 257. issue 1. 1998-11-10. PMID:9799101. |
all transfectants showed a reduced sensitivity to tumor-necrosis-factor (tnf)-induced apoptosis, which correlated with the amount of transgene expressed and with an enhanced basal transcription rate of nf-kappab-driven genes including the inhibitor of apoptosis protein 2 (ciap2) and tnf-receptor-associated protein 1 (traf1). |
1998-11-10 |
2023-08-12 |
human |
| J S Pobe. Activation and injury of endothelial cells by cytokines. Pathologie-biologie. vol 46. issue 3. 1998-11-05. PMID:9769910. |
we have studied the signaling pathways used by tnf that lead to new gene expression (endothelial cell activation) or apoptosis (endothelial cell injury). |
1998-11-05 |
2023-08-12 |
human |
| J S Pobe. Activation and injury of endothelial cells by cytokines. Pathologie-biologie. vol 46. issue 3. 1998-11-05. PMID:9769910. |
however, tnf can cause apoptosis of ec when cells are co-treated with either the protein synthesis inhibitor cycloheximide (chx) or the lipid mediator ceramide (cer). |
1998-11-05 |
2023-08-12 |
human |
| J S Pobe. Activation and injury of endothelial cells by cytokines. Pathologie-biologie. vol 46. issue 3. 1998-11-05. PMID:9769910. |
the pathways leading to apoptosis following treatment with tnf + chx and tnf + cer are different since only tnf + chx is blocked by the caspase inhibitors crma protein or the peptide zvad.fmk while only tnf + cer is blocked by the anti apoptotic proteins bcl-2, bcl-xl or al. |
1998-11-05 |
2023-08-12 |
human |
| H Nishitoh, M Saitoh, Y Mochida, K Takeda, H Nakano, M Rothe, K Miyazono, H Ichij. ASK1 is essential for JNK/SAPK activation by TRAF2. Molecular cell. vol 2. issue 3. 1998-11-02. PMID:9774977. |
the apoptosis signal-regulating kinase 1 (ask1) is activated by tnf and stimulates jnk activation. |
1998-11-02 |
2023-08-12 |
Not clear |
| K Braun, G Hölzl, O Pusch, M Hengstschläge. Deregulated expression of CDK2- or CDK3-associated kinase activities enhances c-Myc-induced apoptosis. DNA and cell biology. vol 17. issue 9. 1998-10-28. PMID:9778038. |
however, both molecules heavily elevated the incidence of apoptosis induced by tnf together with myc. |
1998-10-28 |
2023-08-12 |
Not clear |
| M C Miller, C M Woods, M E Murphy, A Elkins, B F Spielvogel, I H Hal. Relationship between amine-carboxyboranes and TNF alpha for the regulation of cell growth in different tumor cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 4. 1998-10-21. PMID:9755812. |
the low-molecular weight amine-carboxyboranes appear to play an identical function as tnf alpha in its role to cause dna breaks and fragmentation to cause apoptosis. |
1998-10-21 |
2023-08-12 |
Not clear |
| M C Yeung, A S La. Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells. The Journal of biological chemistry. vol 273. issue 39. 1998-10-15. PMID:9737981. |
despite what is known about the early signaling events in tumor necrosis factor (tnf) alpha-induced apoptosis, characterization of the downstream events remains largely undefined. |
1998-10-15 |
2023-08-12 |
human |
| C Y Wang, M W Mayo, R G Korneluk, D V Goeddel, A S Baldwi. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science (New York, N.Y.). vol 281. issue 5383. 1998-10-07. PMID:9733516. |
tumor necrosis factor alpha (tnf-alpha) binding to the tnf receptor (tnfr) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa b (nf-kappab), which suppresses apoptosis by an unknown mechanism. |
1998-10-07 |
2023-08-12 |
Not clear |
| T S Griffith, W A Chin, G C Jackson, D H Lynch, M Z Kubi. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 6. 1998-10-06. PMID:9743343. |
the observation that tnf-related apoptosis-inducing ligand (trail), a member of the tnf cytokine family, induces apoptosis in a number of different tumor cell types led us to compare the tumoricidal effects of trail to those of other tnf family molecules on human melanoma cells. |
1998-10-06 |
2023-08-12 |
human |
| P Tesarová, J Kvasnicka, A Umlaufová, J Homolková, M Jirsa, V Tesa. [Soluble TNF and IL-2 receptors in patients with breast carcinoma]. Casopis lekaru ceskych. vol 137. issue 11. 1998-09-24. PMID:9727208. |
tnf alpha may mediate apoptosis and necrosis of cancer cells, the exact role of il-2 remains to be elucidated. |
1998-09-24 |
2023-08-12 |
Not clear |
| K Akassoglou, J Bauer, G Kassiotis, M Pasparakis, H Lassmann, G Kollias, L Prober. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. The American journal of pathology. vol 153. issue 3. 1998-09-24. PMID:9736029. |
we demonstrate that local production of tnf by central nervous system glia potently and selectively induces oligodendrocyte apoptosis and myelin vacuolation in the context of an intact blood-brain barrier and absence of immune cell infiltration into the central nervous system parenchyma. |
1998-09-24 |
2023-08-12 |
mouse |
| H Takahashi, Y Hashimoto, M Kinouchi, H Iizuk. Interferon-gamma-dependent induction of manganese superoxide dismutase activity of SV40-transformed human keratinocytes by anti-Fas antibody and by TNF-alpha. Journal of dermatological science. vol 16. issue 3. 1998-09-18. PMID:9651816. |
fas antigen and tumor necrosis factor (tnf) receptor are the cell surface proteins, stimulation of which induces apoptosis of keratinocytes. |
1998-09-18 |
2023-08-12 |
human |