| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M X Wu, Z Ao, K V Prasad, R Wu, S F Schlossma. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Science (New York, N.Y.). vol 281. issue 5379. 1998-08-25. PMID:9703517. |
one such gene that protects cells from apoptosis induced by fas or tumor necrosis factor type alpha (tnf), iex-1l, is described here. |
1998-08-25 |
2023-08-12 |
Not clear |
| M X Wu, Z Ao, K V Prasad, R Wu, S F Schlossma. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Science (New York, N.Y.). vol 281. issue 5379. 1998-08-25. PMID:9703517. |
its transcription induced by tnf was decreased in cells with defective nf-kappab activation, rendering them sensitive to tnf-induced apoptosis, which was abolished by transfection with iex-1l. |
1998-08-25 |
2023-08-12 |
Not clear |
| D J Van Antwerp, S J Martin, I M Verma, D R Gree. Inhibition of TNF-induced apoptosis by NF-kappa B. Trends in cell biology. vol 8. issue 3. 1998-08-24. PMID:9695819. |
inhibition of tnf-induced apoptosis by nf-kappa b. tumour necrosis factor (tnf) is an inflammatory cytokine possessing a unique property: it can induce cells to undergo apoptosis. |
1998-08-24 |
2023-08-12 |
Not clear |
| D J Van Antwerp, S J Martin, I M Verma, D R Gree. Inhibition of TNF-induced apoptosis by NF-kappa B. Trends in cell biology. vol 8. issue 3. 1998-08-24. PMID:9695819. |
it has been suggested therefore that a gene, or set of genes, is induced upon tnf receptor activation that downregulates the apoptosis signal. |
1998-08-24 |
2023-08-12 |
Not clear |
| S A Marsters, J P Sheridan, R M Pitti, J Brush, A Goddard, A Ashkenaz. Identification of a ligand for the death-domain-containing receptor Apo3. Current biology : CB. vol 8. issue 9. 1998-08-18. PMID:9560343. |
tnf is expressed primarily by activated lymphocytes and macrophages and induces gene transcription or apoptosis in target cells [2,3]. |
1998-08-18 |
2023-08-12 |
human |
| S A Marsters, J P Sheridan, R M Pitti, J Brush, A Goddard, A Ashkenaz. Identification of a ligand for the death-domain-containing receptor Apo3. Current biology : CB. vol 8. issue 9. 1998-08-18. PMID:9560343. |
caspase inhibitors blocked apoptosis induction by apo3l, as did a dominant-negative mutant of the cell death adaptor protein fas-associated death domain protein (fadd/mort1), which is critical for apoptosis induction by tnf [3]. |
1998-08-18 |
2023-08-12 |
human |
| R Halenbeck, H MacDonald, A Roulston, T T Chen, L Conroy, L T William. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. Current biology : CB. vol 8. issue 9. 1998-08-18. PMID:9560346. |
induction of apoptosis by death receptors such as fas or tumour necrosis factor (tnf) r1 leads to distinct changes in cell morphology, activation of the caspase protease cascade, and the degradation of nuclear chromatin by activated nucleases. |
1998-08-18 |
2023-08-12 |
mouse |
| A D Katsen, B Vollmar, P Mestres-Ventura, M D Menge. Cell surface and nuclear changes during TNF-alpha-induced apoptosis in WEHI 164 murine fibrosarcoma cells. A correlative light, scanning, and transmission electron microscopical study. Virchows Archiv : an international journal of pathology. vol 433. issue 1. 1998-08-13. PMID:9692829. |
tumour necrosis factor (tnf)-alpha-induced apoptosis is associated with several nuclear and cell surface alterations, in particular with the condensation of chromatin and the fragmentation of the cell nucleus, formation of blebs on the cell surface and breakdown of the plasma membrane. |
1998-08-13 |
2023-08-12 |
Not clear |
| A Amsterdam, A Dantes, K Hosokawa, C P Schere-Levy, F Kotsuji, D Aharon. Steroid regulation during apoptosis of ovarian follicular cells. Steroids. vol 63. issue 5-6. 1998-08-12. PMID:9618793. |
for example, tumor necrosis factor (tnf) may trigger granulosa cell apoptosis at early stage of follicular development, while camp/p53 signals may trigger this process only in mature preovulatory granulosa cells. |
1998-08-12 |
2023-08-12 |
Not clear |
| P Krajcsi, W S Wol. Inhibition of tumor necrosis factor and interferon triggered responses by DNA viruses. Seminars in cell & developmental biology. vol 9. issue 3. 1998-08-12. PMID:9665872. |
tnf, which is secreted by activated monocytes and lymphocytes, induces apoptosis as well as expression of genes involved in the inflammatory and immune responses. |
1998-08-12 |
2023-08-12 |
Not clear |
| P Krajcsi, W S Wol. Inhibition of tumor necrosis factor and interferon triggered responses by DNA viruses. Seminars in cell & developmental biology. vol 9. issue 3. 1998-08-12. PMID:9665872. |
depending on the dna virus and the viral proteins, the following mechanisms to prevent tnf receptor- and fas-induced apoptosis are used: (1) absorption of extracellular tnf by secreted homologs of the tnf receptor; (2) degradation of fas; (3) inhibition of the assembly of fadd and caspase 8 with tnfr1 and fas; (4) direct inhibition of proapoptotic caspase enzymatic activity; and (5) inhibition of the proapoptotic members of the bcl-2 family. |
1998-08-12 |
2023-08-12 |
Not clear |
| A A Nanj. Apoptosis and alcoholic liver disease. Seminars in liver disease. vol 18. issue 2. 1998-08-03. PMID:9606815. |
tumor necrosis factor (tnf) acting through its receptors can induce apoptosis in hepatocytes. |
1998-08-03 |
2023-08-12 |
Not clear |
| R L Jilka, R S Weinstein, T Bellido, A M Parfitt, S C Manolaga. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 13. issue 5. 1998-08-03. PMID:9610743. |
we report that murine osteoblastic mc3t3-e1 cells underwent apoptosis following removal of serum, or addition of tumor necrosis factor (tnf), as indicated by terminal deoxynucleotidyl transferase-mediated dutp-nick end labeling and dna fragmentation studies. |
1998-08-03 |
2023-08-12 |
human |
| L Bogin, M Z Papa, S Polak-Charcon, H Degan. TNF-induced modulations of phospholipid metabolism in human breast cancer cells. Biochimica et biophysica acta. vol 1392. issue 2-3. 1998-07-30. PMID:9630635. |
flow cytometry and transmission electron microscopy analysis demonstrated that in human breast cancer cells (mcf7) tnf induces cell cycle arrest in g0+g1/s, accompanied by apoptosis. |
1998-07-30 |
2023-08-12 |
human |
| L Bogin, M Z Papa, S Polak-Charcon, H Degan. TNF-induced modulations of phospholipid metabolism in human breast cancer cells. Biochimica et biophysica acta. vol 1392. issue 2-3. 1998-07-30. PMID:9630635. |
the results indicate that tnf specifically modulates the kinetics of membrane-bound enzymes of the rate determining steps in phosphatidylcholine biosynthesis, possibly as part of early events involved in apoptosis. |
1998-07-30 |
2023-08-12 |
human |
| L C Penning, R G Schipper, D Vercammen, A A Verhofstad, T Denecker, R Beyaert, P Vandenabeel. Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine. vol 10. issue 6. 1998-07-15. PMID:9632528. |
rat/mouse t cell hybridoma-derived pc60 r55/r75 cells were used as a model to study tumour necrosis factor (tnf)-induced apoptosis. |
1998-07-15 |
2023-08-12 |
human |
| L C Penning, R G Schipper, D Vercammen, A A Verhofstad, T Denecker, R Beyaert, P Vandenabeel. Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine. vol 10. issue 6. 1998-07-15. PMID:9632528. |
these results suggest that a decrease of intracellular spm levels rather then odc activity per se is involved in the sensitization towards apoptosis induced by tnf or alphafas. |
1998-07-15 |
2023-08-12 |
human |
| W Declercq, G Denecker, W Fiers, P Vandenabeel. Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 1. 1998-07-09. PMID:9647248. |
cooperation of both tnf receptors in inducing apoptosis: involvement of the tnf receptor-associated factor binding domain of the tnf receptor 75. |
1998-07-09 |
2023-08-12 |
Not clear |
| H Qian, G J Hausman, M M Compton, M J Azain, D L Hartzell, C A Bail. Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues. Biochemical and biophysical research communications. vol 246. issue 3. 1998-07-02. PMID:9618269. |
the present study suggests that expression of ppar gamma may be directly involved in the leptin-induced adipocyte apoptosis signal pathway, whereas ucp2 and tnf alpha may play roles in the leptin-induced lipolysis process. |
1998-07-02 |
2023-08-12 |
rat |
| D K Giri, B B Aggarwa. Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. The Journal of biological chemistry. vol 273. issue 22. 1998-07-01. PMID:9593751. |
in the present report, we investigated apoptosis induction by tumor necrosis factor (tnf) in two human t cell lines, jurkat and hut-78. |
1998-07-01 |
2023-08-12 |
human |