| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriella de Oliveira, Lucas de Andrade Rodrigues, André Acácio Souza da Silva, Lays Cristina Gouvea, Renata Cristina Lima Silva, Estela Sasso-Cerri, Paulo Sérgio Cerr. Reduction of osteoclast formation and survival following suppression of cytokines by diacerein in periodontitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-16. PMID:39013222. |
diacerein inhibits osteoclastogenesis by decreasing tnf and il1b mrna levels, resulting in decreased rankl/opg ratio, and induces apoptosis in osteoclasts of alveolar process of rat molars with periodontitis. |
2024-07-16 |
2024-07-19 |
rat |
| Valentina R Minciacchi, Christina Karantanou, Jimena Bravo, Raquel S Pereira, Costanza Zanetti, Theresa Krack, Rahul Kumar, Katrin Bankov, Sylvia Hartmann, Brian Jp Huntly, Eshwar Meduri, Wolfram Ruf, Daniela S Kraus. Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression. Blood advances. 2024-07-12. PMID:38996202. |
using annexin a5 (anxa 5), a calcium-binding protein known for apoptosis, which we discovered to be differentially expressed in the bone marrow microenvironment (bmm) of mice with acute myeloid (aml) versus chronic myeloid leukemia, as a model system, we unravel here a circuit in which aml-derived tumor necrosis factor (tnf)α dose-dependently reduces anxa5 in the bmm. |
2024-07-12 |
2024-07-15 |
mouse |
| Dengyong Zheng, Xinglin Ruan, Qiang Wu, Yuliang Qiu, Shiwei Rua. Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Experimental and therapeutic medicine. vol 28. issue 2. 2024-07-10. PMID:38979022. |
yishen jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the tnf signal pathway. |
2024-07-10 |
2024-07-12 |
mouse |
| Dengyong Zheng, Xinglin Ruan, Qiang Wu, Yuliang Qiu, Shiwei Rua. Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Experimental and therapeutic medicine. vol 28. issue 2. 2024-07-10. PMID:38979022. |
the results of the transcriptomic and enrichment analyses showed that the mechanisms of ysjzd may be associated with inflammation, oxidation, apoptosis and the tnf signal pathway. |
2024-07-10 |
2024-07-12 |
mouse |
| Wenyu Wu, Wanning Lan, Xin Jiao, Axue Shao, Peng Wu, Kai Wang, Shaofeng Zha. Mechanisms underlying the therapeutic effects of Gang Huo Qing wen granules in the treatment of influenza based on network pharmacology, molecular docking and molecular dynamics. Scientific reports. vol 14. issue 1. 2024-07-09. PMID:38982082. |
ghqwg's effects are mediated via genes involved in inflammation, apoptosis, and oxidative stress, as well as the tnf and il-17 signaling pathways, according to go and kegg pathway enrichment analysis. |
2024-07-09 |
2024-07-12 |
Not clear |
| Qiumin Deng, Luxuan Chen, Gui Zhang, Langxia Liu, Shi-Ming Luo, Xuejuan Ga. TRIAL-based combination therapies in cancers. International immunopharmacology. vol 138. 2024-07-06. PMID:38971105. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) shows promising therapeutic potential in cancer treatment as it is able to trigger extrinsic apoptotic pathways by binding to the cognate death receptor, causing broad-spectrum apoptosis in cancer cells with negligible toxicity to normal cells. |
2024-07-06 |
2024-07-12 |
Not clear |
| Mengqi Zheng, Yunjiao Zhai, Yanbo Yu, Jing Shen, Shuzheng Chu, Enrico Focaccia, Wenyu Tian, Sui Wang, Xuesong Liu, Xi Yuan, Yue Wang, Lixiang Li, Bingcheng Feng, Zhen Li, Xiaohuan Guo, Ju Qiu, Cuijuan Zhang, Jiajie Hou, Yiyuan Sun, Xiaoyun Yang, Xiuli Zuo, Mathias Heikenwalder, Yanqing Li, Detian Yuan, Shiyang L. TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response. Cell metabolism. 2024-07-06. PMID:38971153. |
mechanistically, excessive tumor necrosis factor (tnf) produced at the onset of colitis interferes with bile-acid detoxification through the receptor-interacting serine/threonine-protein kinase 1/extracellular signal-regulated kinase pathway in intestinal epithelial cells, leading to bile acid overload in the endoplasmic reticulum and consequent apoptosis. |
2024-07-06 |
2024-07-12 |
Not clear |
| Dapeng Zhao, Jian Song, Chongyao J. Endoplasmic reticulum stress regulates apoptosis and chemotherapeutic via enhancing TNFRSF10B recycling to the cell membrane in triple-negative breast cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2024-07-05. PMID:38967737. |
the expression and cell surface levels of tnf receptor superfamily member 10b (tnfrsf10b) are associated with apoptosis and chemotherapy. |
2024-07-05 |
2024-07-11 |
Not clear |
| Lei Liu, Shaik Althaf Hussain, Xiaoyan H. Fisetin reduces the resistance of MOLT-4 and K562 cells to TRAIL-induced apoptosis through upregulation of TRAIL receptors. Naunyn-Schmiedeberg's archives of pharmacology. 2024-06-25. PMID:38918236. |
tnf-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that is capable of apoptosis induction selectively in tumor cells. |
2024-06-25 |
2024-06-29 |
Not clear |
| Biao Song, Xin Ning, Lan Guo, Weida Liu, Hongzhong Ji. Comparative Proteomics Analysis Reveals Distinct Molecular Phenotype and Biomarkers in Patients with Erythrodermic Atopic Dermatitis and Erythrodermic Psoriasis. Inflammation. 2024-06-14. PMID:38877357. |
ead demonstrated a more pronounced inflammation tone, characterized by th1/th2/th22/il-1-dominant patterns, as well as increased tnf superfamily, th17, and apoptosis markers. |
2024-06-14 |
2024-06-17 |
Not clear |
| Diego Rojas-Rivera, Sebastián Beltrán, Francisco Muñoz-Carvajal, Pablo Ahumada-Montalva, Lorena Abarzúa, Laura Gomez, Fernanda Hernandez, Cristian A Bergmann, Luis Labrador, Melissa Calegaro-Nassif, Mathieu J M Bertrand, Patricio A Manque, Ute Woehlbie. The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis. Autophagy. 2024-06-14. PMID:38873940. |
tnf promotes inflammation by inducing ripk1 kinase-dependent apoptosis or necroptosis. |
2024-06-14 |
2024-06-16 |
Not clear |
| Diego Rojas-Rivera, Sebastián Beltrán, Francisco Muñoz-Carvajal, Pablo Ahumada-Montalva, Lorena Abarzúa, Laura Gomez, Fernanda Hernandez, Cristian A Bergmann, Luis Labrador, Melissa Calegaro-Nassif, Mathieu J M Bertrand, Patricio A Manque, Ute Woehlbie. The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis. Autophagy. 2024-06-14. PMID:38873940. |
we determine that mscs succumb to ripk1 kinase-dependent apoptosis upon tnf sensing and necroptosis when caspases are inactivated. |
2024-06-14 |
2024-06-16 |
Not clear |
| Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Hiroko Matsumoto, Yuichiro Okada, Kazumune Arikawa, Takato Nomoto, Koichi Hiratsuk. 18‑α‑glycyrrhetinic acid induces apoptosis in gingival fibroblasts exposed to phenytoin. Experimental and therapeutic medicine. vol 28. issue 1. 2024-06-13. PMID:38868612. |
these results demonstrated that 18α-ga induced apoptosis through the activation of the fas and tnf pathways in the death receptor signaling pathway in gingival fibroblasts treated with pht. |
2024-06-13 |
2024-06-15 |
human |
| Jing Sun, Wen-Juan Xu, Lin-Ying Zhong, Jian-Bo Chen, Ling Don. [UPLC-QE-Orbitrap-MS combined with network pharmacology to explore differential components and mechanisms of raw and scorched rhubarb for treatment of ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812196. |
network pharmacology and molecular docking suggested that free anthraquinones, gallic acid, and 5-hmf may act on core targets such as b-cell lymphoma-2(bcl2), epidermal growth factor receptor(egfr), tumor necrosis factor(tnf), and caspase-3(casp3) and influence the signaling pathways such as phosphoinositide-3-kinase/protein kinase b(pi3k/akt), hypoxia inducible factor-1(hif-1), tnf, and mitogen-activated protein kinase(mapk), so as to regulate the inflammation response, oxidative stress, and cell apoptosis to relieve uc symptoms. |
2024-05-30 |
2024-06-17 |
mouse |
| Carlos Matellan, Ciarán Kennedy, Miren Itxaso Santiago-Vela, Johanna Hochegger, Méabh B Ní Chathail, Amanda Wu, Christopher Shannon, Helen M Roche, Seema S Aceves, Catherine Godson, Mario C Manres. The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast-Monocyte Interactions. Journal of immunology (Baltimore, Md. : 1950). 2024-05-03. PMID:38700420. |
tnf superfamily member 12 (tnfsf12, or tnf-like weak inducer of apoptosis [tweak]) has gained interest as a mediator of chronic inflammation. |
2024-05-03 |
2024-05-05 |
human |
| Ana Catarina Cristovão-Silva, Maria Carolina Accioly Brelaz-de-Castro, Elis Dionisio da Silva, Ana Cristina Lima Leite, Lizandra Beatriz Amorim Alves Santiago, Juliana Maria da Conceição, Robert da Silva Tiburcio, Davi Pereira de Santana, Danilo Cesar Galindo Bedor, Breno Ítalo Valença de Carvalho, Luiz Felipe Gomes Rebello Ferreira, Rafael de Freitas E Silva, Valéria Rêgo Alves Pereira, Marcelo Zaldini Hernande. Trypanosoma cruzi Killing and Immune Response Boosting by Novel Phenoxyhydrazine-Thiazole against Chagas Disease. Experimental parasitology. 2024-04-09. PMID:38593864. |
liz311 induced the secretion of tnf, ifnγ, il-2, il-4, il-10, and il-17, cell death by apoptosis, decreased acidic compartment formation, and induced changes in the mitochondrial membrane potential. |
2024-04-09 |
2024-04-12 |
human |
| Zigang Shen, Zhuojun Ke, Qiong Yang, Samson Teweldeberhan Ghebremichael, Tangxin Li, Tian Li, Jie Chen, Xianzhi Meng, Heng Xiang, Chunfeng Li, Zeyang Zhou, Guoqing Pan, Ping Che. Transcriptomic changes in the microsporidia proliferation and host responses in congenitally infected embryos and larvae. BMC genomics. vol 25. issue 1. 2024-04-01. PMID:38556880. |
for the transcriptome of b. mori infected with n. bombycis, beyond numerous degs related to dna replication and repair, mrna surveillance pathway, rna transport, protein biosynthesis, and proteolysis, with the progression of infection, a large number of degs related to immune and infection pathways, including phagocytosis, apoptosis, tnf, toll-like receptor, nf-kappa b, fc epsilon ri, and some diseases, were successively identified. |
2024-04-01 |
2024-04-03 |
Not clear |
| Lei Xu, Yang Zhang, Qian Tao, Tong Xu, Feng-Qin Lee, Li-Shuang Deng, Zhijie Jian, Jun Zhao, Yanting Yang, Siyuan Lai, Yuan-Cheng Zhou, Zhi-Wen Xu, Ling Zh. Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation. Frontiers in microbiology. vol 15. 2024-03-29. PMID:38550870. |
go and kegg enrichment analysis indicated that the differentially expressed genes were primarily enriched in pathways such as tnf, nod-like receptor, jak-stat, mapk, il-17 and apoptosis signaling. |
2024-03-29 |
2024-03-31 |
mouse |
| Zhen Shang, Weipeng Shi, Haitao Fu, Yingze Zhang, Tengbo Y. Identification of key autophagy-related genes and pathways in spinal cord injury. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504116. |
go and kegg pathway enrichment analysis showed that these 129 genes were mainly involved in the process of cell apoptosis, angiogenesis, il-1 production, and inflammatory reactions, the tnf signaling pathway and the p53 signaling pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Lijuan Xiong, Kexin Lin, Tianmu He, Xingyan Liu, Rui Yuan, Xiaofei Li, Jianyong Zhan. A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice. Basic & clinical pharmacology & toxicology. 2024-03-13. PMID:38477401. |
kegg enrichment analysis revealed that 75 hub genes were mainly enriched in tnf, il-17 and apoptosis signalling pathways. |
2024-03-13 |
2024-03-15 |
mouse |