| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Su. Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. Cell proliferation. 2024-07-24. PMID:39045886. |
mechanistically, rev-erbα knockdown in np cells aggravated rhil1β-induced nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome activation, exacerbating the imbalanced ecm and np cell apoptosis. |
2024-07-24 |
2024-07-26 |
Not clear |
| Lili Shi, Yingying Xu, Chao Zhao, Guangjin Qu, Ming Ha. Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. In vitro cellular & developmental biology. Animal. 2024-07-22. PMID:39039329. |
furthermore, silencing of tribbles homolog 3 (trib3) could markedly reduce hg-induced huvec apoptosis, ros level, the expressions of txnip, cleaved caspase3, nlrp3, and caspase1, indicating trib3 inhibition protected huvecs against hg-induced vascular endothelial injury. |
2024-07-22 |
2024-07-25 |
human |
| Mallika Shekhar, Omer Iqbal, Adarsh Dharan, Hanin El-Khateeb, Kavya Jatavallabhula, Ping Bu, Charles Bouchar. The Role of NLRP3 Inflammasome in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Medical research archives. vol 12. issue 1. 2024-07-19. PMID:39026932. |
the role of nlrp3 inflammasome in causing ocular surface disease and keratinocyte apoptosis is not fully explored. |
2024-07-19 |
2024-07-21 |
human |
| Bo Deng, Ruyu Xian, Yuan Shu, Haohan Xia, Chengcheng Fen. Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030268. |
in contrast, transfection of exogenous mir-223-3p inhibitors into the mcmecs resulted in not only significantly increased apoptosis of the cells, but also significant suppression of nlrp3 and pro-apoptotic proteins in the cells. |
2024-07-19 |
2024-07-22 |
mouse |
| Bo Deng, Ruyu Xian, Yuan Shu, Haohan Xia, Chengcheng Fen. Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030268. |
mir-223-3p may mediate the modulatory effects of pae on mcmec survival or apoptosis through targeting nlrp3 and regulating apoptosis-associated proteins. |
2024-07-19 |
2024-07-22 |
mouse |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Domenico Caputo, Marco Rovaris, Mario Cleric. Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients. Neurobiology of disease. 2024-07-12. PMID:38996986. |
p2x7r activation can also result in apoptosis as a consequence of the activation of the caspase cascade via p2x7r-dependent stimulation of the nlrp3 inflammasome. |
2024-07-12 |
2024-07-15 |
human |
| Mingxin Pei, Ke Deng, Yanling Che. Role and mechanism of endoplasmic reticulum stress and NLRP3 inflammasome in acute kidney injury. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 49. issue 3. 2024-07-06. PMID:38970510. |
additionally, the nlrp3 inflammasome can mediate the recognition of endogenous and exogenous danger signal molecules by the host, subsequently activating caspase-1, pro-inflammatory cytokines such as il-1β and il-18, inducing inflammatory responses, and promoting apoptosis of renal cells. |
2024-07-06 |
2024-07-11 |
Not clear |
| Rajath Ramachandran, Abdul Manan, Jei Kim, Sangdun Cho. NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders. Experimental & molecular medicine. 2024-06-30. PMID:38945951. |
to understand the diverse behavior of nlrp3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. |
2024-06-30 |
2024-07-03 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
interference with gpr4 inactivates nlrp3 inflammasome signaling by inhibiting lpar1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. |
2024-06-27 |
2024-06-30 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
western blot was employed to detect the expression of proteins related to apoptosis and nlrp3 inflammasome signaling. |
2024-06-27 |
2024-06-30 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
to be concluded, gpr4 deficiency inactivates nlrp3 inflammasome signaling by inhibiting lpar1 expression to ameliorate ogd/r -induced inflammation and apoptosis of cardiomyocytes. |
2024-06-27 |
2024-06-30 |
Not clear |
| Yidan Liang, Wenqiao Fu, Yin Tang, Hongjiang Ye, Yanglingxi Wang, Chao Sun, Yi Xiang, Weiming Xiong, Min Cui, Yuanlin Chen, Ting Wang, Yongbing Den. Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage. Molecular neurobiology. 2024-06-27. PMID:38935231. |
endoplasmic reticulum (er) stress-induced apoptosis and nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3(nlrp3)-associated pyroptosis can contribute to the escalation of neuroinflammatory responses, leading to increased brain damage. |
2024-06-27 |
2024-06-29 |
mouse |
| Qing-Xiang Zheng, Qing-Lin Liu, Wen-Na Sun, Xin-Yu Jiang, Tao Zen. Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice. Toxicology. vol 506. 2024-06-26. PMID:38924947. |
mechanistically, acute ethanol consumption suppressed dmf-induced activation of the nlr family pyrin domain-containing protein 3 (nlrp3) inflammasome, while long-term moderate ethanol consumption promoted hepatocyte apoptosis in the mouse liver. |
2024-06-26 |
2024-06-29 |
mouse |
| Heliang Ni, Xiangdong Hu, Nannan Yang, Xiaoyang Liu, Wenyang Cai, Rui Zhong, Tiancheng Wang, Mingxi Yu, Shuang Tan. Roundup Toxicological research. vol 40. issue 3. 2024-06-24. PMID:38911547. |
in summary, our findings indicated that the premature senescence of granulosa cells caused by mitochondrial ros-triggered nlrp3 inflammasome activation might contribute to the ovarian toxicity of roundup, in addition to its known effects on steroidogenesis and apoptosis. |
2024-06-24 |
2024-06-26 |
mouse |
| Jiawei Chen, Xiandong Zhu, Ziqiong Wang, Michael Rützler, Qiaohong Lu, Hongjie Xu, Roland Andersson, Yinwei Dai, Zouwen Shen, Giuseppe Calamita, Shangjing Xie, Yongheng Bai, Bicheng Che. Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways. International immunopharmacology. vol 137. 2024-06-21. PMID:38906007. |
moreover, we demonstrate that rg100204 reduced apoptosis in the lungs of rat sap animals, and reduces nf-κb signaling, nlrp3, expression, while profoundly increasing the nrf2-dependent anti oxidative stress response. |
2024-06-21 |
2024-06-24 |
mouse |
| Nada Hashim, Rasha Babiker, Riham Mohammed, Mohammed Mustahsen Rehman, Nallan Csk Chaitanya, Bakri Gobar. NLRP3 Inflammasome in Autoinflammatory Diseases and Periodontitis Advance in the Management. Journal of pharmacy & bioallied sciences. vol 16. issue Suppl 2. 2024-06-17. PMID:38882867. |
by boosting cytokines that promote inflammation in the periodontal ligament fibroblasts and triggering apoptosis in osteoblasts, the nlrp3 inflammasome regulates immune cell activity. |
2024-06-17 |
2024-06-19 |
Not clear |
| Yingying Qian, Ning Zhao, Ming Wang, Zhiguo Zou, Kewei Xi. P2X7 receptor deficiency attenuates cisplatin-induced kidney injury via inhibiting NLRP3 inflammasome activation. Biochemical pharmacology. 2024-06-16. PMID:38880358. |
compared with wild-type mice, p2x7r -/- mice showed decreased expression of nlrp3, apoptosis-associated speck-like protein containing a caspase recruitment domain (asc), cleaved caspase-1, and cleaved il-1β in kidney tissue after cisplatin administration, and the apoptosis of renal tubular epithelial cells were also decreased. |
2024-06-16 |
2024-06-19 |
mouse |
| Wei Zhang, Menglong Zou, Jia Fu, Yin Xu, Ying Zh. Autophagy: A potential target for natural products in the treatment of ulcerative colitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-06-12. PMID:38865850. |
a growing number of studies have established that autophagy can interplay with endoplasmic reticulum stress, gut microbiota, apoptosis, and the nlrp3 inflammasome, all of which contribute to the pathogenesis of uc. |
2024-06-12 |
2024-06-15 |
Not clear |
| Qian Wu, Rui Li, Yifei You, Wei Cheng, Yan Li, Yan Feng, Yuqin Fan, Yan Wan. Lung microbiota participated in fibrous microplastics (MPs) aggravating OVA-induced asthma disease in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-08. PMID:38851522. |
in addition, mp fibers exposure induced lung epithelial cells apoptosis, disruption of epithelial barrier integrity and activation of nlrp3 related signaling pathways. |
2024-06-08 |
2024-06-11 |
mouse |