| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaveh Tabrizian, Jafar Shahraki, Mohadeseh Bazzi, Ramin Rezaee, Hosseinali Jahantigh, Mahmoud Hashemzae. Neuro-Protective Effects of Resveratrol on Carbon Monoxide-Induced Toxicity in Male Rats. Phytotherapy research : PTR. vol 31. issue 9. 2017-09-25. PMID:28635041. |
acute carbon monoxide (co) poisoning causes neurotoxicity through induction of necrosis, apoptosis, lipid peroxidation and oxidative stress. |
2017-09-25 |
2023-08-13 |
rat |
| Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas, Mahesh Choolani, Ariff Bongs. Human Umbilical Cord Wharton's Jelly Stem Cell Conditioned Medium Induces Tumoricidal Effects on Lymphoma Cells Through Hydrogen Peroxide Mediation. Journal of cellular biochemistry. vol 117. issue 9. 2017-09-19. PMID:27392313. |
we used a battery of assays (mtt, propidium iodide, mitochondria membrane potential, apoptosis, cell cycle, oxidative stress enzymes, hydrogen peroxide, mitochondrial superoxide, hydroxyl radical, peroxynitrile anion, and lipid peroxidation) to test this mechanism. |
2017-09-19 |
2023-08-13 |
human |
| Xiaoliang Li, Ping Xin, Changfu Wang, Zhibin Wang, Qiuhong Wang, Haixue Kuan. Mechanisms of Traditional Chinese Medicine in the Treatment of Mammary Gland Hyperplasia. The American journal of Chinese medicine. vol 45. issue 3. 2017-09-19. PMID:28359197. |
in this paper, we elaborate the mechanism of tcm in the treatment of mgh from the perspectives of sexual hormone levels, the expression of er and pr, hemorheology, free radical activity and lipid peroxidation, vegf and bfgf, cell proliferation activities, anti-apoptosis gene bcl-2, promoting apoptosis gene bax, erk, and tumor suppressor gene. |
2017-09-19 |
2023-08-13 |
Not clear |
| Lukas Probst, Jasmin Dächert, Barbara Schenk, Simone Fuld. Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death. Biochemical pharmacology. vol 140. 2017-08-18. PMID:28595877. |
rsl3 triggers lipid peroxidation and cell death also in fas-associated death domain (fadd)-deficient cells which are resistant to death receptor-induced apoptosis indicating that the induction of ferroptosis may bypass apoptosis resistance. |
2017-08-18 |
2023-08-13 |
Not clear |
| O N Voskresenskaya, N B Zakharova, M V Ivano. [Mechanisms of development of chronic cerebral ischemia in arterial hypertension]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 2. 2017-08-10. PMID:28374696. |
to study a relationship of arterial hypertension (ah) severity with the cerebral blood flow and structural changes in the brain matter, processes of lipid peroxidation and antioxidant defense, parameters of homeostasis, indicators of endothelial dysfunction and apoptosis. |
2017-08-10 |
2023-08-13 |
Not clear |
| Yunus Ugan, Mustafa Nazıroğlu, Mehmet Şahin, Mehmet Ayku. Anti-tumor Necrosis Factor Alpha (Infliximab) Attenuates Apoptosis, Oxidative Stress, and Calcium Ion Entry Through Modulation of Cation Channels in Neutrophils of Patients with Ankylosing Spondylitis. The Journal of membrane biology. vol 249. issue 4. 2017-07-28. PMID:26956056. |
intracellular ca(2+) concentration, lipid peroxidation, apoptosis, caspase 3, and caspase 9 values were high in neutrophils of as patients and were reduced with infliximab treatment. |
2017-07-28 |
2023-08-13 |
Not clear |
| Jasmine Sati, Biraja Prasad Mohanty, Mohan Lal Garg, Ashwani Kou. Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study. PloS one. vol 11. issue 7. 2017-07-20. PMID:27414401. |
therefore, it may be suggested that raised lpo could be responsible for triggering apoptosis in the silibinin+dmba/tpa group. |
2017-07-20 |
2023-08-13 |
mouse |
| Jasmine Sati, Biraja Prasad Mohanty, Mohan Lal Garg, Ashwani Kou. Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study. PloS one. vol 11. issue 7. 2017-07-20. PMID:27414401. |
thus, supporting the theory of augmented lpo levels resulting in increased apoptosis in the skin tumors treated with silibinin. |
2017-07-20 |
2023-08-13 |
mouse |
| Junguo Ma, Yiyi Feng, Siyu Jiang, Xiaoyu L. Altered cellular metabolism of HepG2 cells caused by microcystin-LR. Environmental pollution (Barking, Essex : 1987). vol 225. 2017-06-29. PMID:28336091. |
further research showed that the cyp inducers omeprazole, ethanol, and rifampicin inhibited cell viability, in particular, ethanol, a cyp2e1 inducer, induced ros generation, lipid peroxidation, and apoptosis in hepg2 cells treated with mc-lr. |
2017-06-29 |
2023-08-13 |
human |
| S Shabalala, C J F Muller, J Louw, R Johnso. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life sciences. vol 180. 2017-06-29. PMID:28478263. |
oxidative stress, lipid peroxidation, apoptosis as well as dysregulation of autophagy, has been implicated as a major contributor associated with doxorubicin-induced cardiotoxicity. |
2017-06-29 |
2023-08-13 |
Not clear |
| Mason Breitzig, Charishma Bhimineni, Richard Lockey, Narasaiah Kolliput. 4-Hydroxy-2-nonenal: a critical target in oxidative stress? American journal of physiology. Cell physiology. vol 311. issue 4. 2017-06-06. PMID:27385721. |
as a reactive aldehyde, and a product of lipid peroxidation, studies corroborate its ability to disrupt signal transduction and protein activity, as well as induce inflammation and trigger cellular apoptosis in conditions of oxidative stress. |
2017-06-06 |
2023-08-13 |
Not clear |
| Qing Chen, Xin Zhang, Jin-Yan Zhao, Xiao-Ning Lu, Peng-Sheng Zheng, Xiang Xu. Oxidative damage of the male reproductive system induced by paraquat. Journal of biochemical and molecular toxicology. vol 31. issue 3. 2017-06-05. PMID:27762473. |
further investigation found that pq resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. |
2017-06-05 |
2023-08-13 |
rat |
| Yeter Topcu-Tarladacalisir, Melike Sapmaz-Metin, Turan Karac. Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Renal failure. vol 38. issue 10. 2017-05-18. PMID:27758164. |
in this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (mpo) and tumor necrosis factor-alpha (tnf-α), interleukin-1 beta (il-1β), il-6, il-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (mda) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, fas, and fas ligand (fas-l)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). |
2017-05-18 |
2023-08-13 |
rat |
| Tamil Selvan Anthonymuthu, Elizabeth Megan Kenny, Hülya Bayı. Therapies targeting lipid peroxidation in traumatic brain injury. Brain research. vol 1640. issue Pt A. 2017-05-01. PMID:26872597. |
in this review, we critically evaluate previous attempts to use non-specific antioxidants as neuroprotectors and emphasize new approaches based on recent breakthroughs in understanding of enzymatic mechanisms of lipid peroxidation associated with specific death pathways, particularly apoptosis. |
2017-05-01 |
2023-08-13 |
Not clear |
| Sakshi Mishra, Prachi Tewari, Bhushan P Chaudhari, Premendra D Dwivedi, Haushila P Pandey, Mukul Da. Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes. International journal of cancer. vol 139. issue 9. 2017-05-01. PMID:27389473. |
further, the elucidation of molecular mechanisms of tumor initiation by don (0.42-3.37 nmol/ml) in hacat keratinocytes, revealed (i) enhanced ros generation with cell cycle phase arrest in g0/g1 phase, (ii) increase in levels of 8-oxog (6-24 hr) and γh2ax protein, (iii) significant enhancement in oxidative stress marker enzymes lpo, gsh, gr with concomitant decrease in antioxidant enzymes catalase, gpx, gst, sod and mitochondrial membrane potential after don (1.68 nmol) treatment, (iv) suppression of nrf2 translocation to nucleus, enhanced phosphorylation with subsequent activation erk1/2, p38 and jnk mapk's following don (1.68 nmol) treatment, (v) overexpression of c-jun, c-fos proteins, upregulation of bax along with downregulation of bcl-2 proteins, (vi) increase in cytochrome-c, caspase-9, caspase-3 and poly adp ribose polymerase levels leads to apoptosis. |
2017-05-01 |
2023-08-13 |
mouse |
| Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmit. Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28106777. |
six-day-old wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (gclc)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (nrf2/keap1, and nfκb), reduced pro-apoptotic effectors (poly (adp-ribose) polymerase-1 (parp-1), apoptosis inducing factor (aif), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (mmp) 2, and inhibitor of metalloproteinase (timp) 1/2). |
2017-04-24 |
2023-08-13 |
human |
| Ramazan Uygur, Cevat Aktas, Veli Caglar, Emine Uygur, Hasan Erdogan, Oguz Aslan Oze. Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. Toxicology and industrial health. vol 32. issue 5. 2017-04-18. PMID:24318767. |
these data suggested that melatonin has beneficial effects against arsenic-induced testicular damage by decreasing morphological damage, germ cell apoptosis, lipid peroxidation, and oxidative stress. |
2017-04-18 |
2023-08-12 |
rat |
| Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekp. Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats. Acta neurobiologiae experimentalis. vol 77. issue 1. 2017-04-14. PMID:28379220. |
neurobehavioural deficits, brain oedema, blood-brain barrier (bbb) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. |
2017-04-14 |
2023-08-13 |
rat |
| Bibi Marjan Razavi, Hossein Hosseinzadeh, Khalil Abnous, Alireza Khoei, Mohsen Imenshahid. Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon. Toxicology and industrial health. vol 32. issue 7. 2017-04-13. PMID:27353299. |
although increased production of lipid peroxidation by dzn in rat aorta has been shown previously, the effects of dzn on oxidative stress-induced apoptosis in vascular system have not been evaluated. |
2017-04-13 |
2023-08-13 |
rat |
| Sibel Bektas, Kemal Karakaya, Murat Can, Burak Bahadir, Berrak Guven, Nilsen Erdogan, Sukru Oguz Ozdama. The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia/reperfusion injury. The Kaohsiung journal of medical sciences. vol 32. issue 7. 2017-04-10. PMID:27450022. |
this study showed that tdf and ptx supplementation may be helpful in preventing free oxygen radical damage, lipid peroxidation, hepatocyte necrosis, and apoptosis in liver ir injury and minimizing liver damage. |
2017-04-10 |
2023-08-13 |
rat |