| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Chen, Xin Zhang, Jin-Yan Zhao, Xiao-Ning Lu, Peng-Sheng Zheng, Xiang Xu. Oxidative damage of the male reproductive system induced by paraquat. Journal of biochemical and molecular toxicology. vol 31. issue 3. 2017-06-05. PMID:27762473. |
further investigation found that pq resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. |
2017-06-05 |
2023-08-13 |
rat |
| Yeter Topcu-Tarladacalisir, Melike Sapmaz-Metin, Turan Karac. Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Renal failure. vol 38. issue 10. 2017-05-18. PMID:27758164. |
in this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (mpo) and tumor necrosis factor-alpha (tnf-α), interleukin-1 beta (il-1β), il-6, il-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (mda) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, fas, and fas ligand (fas-l)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). |
2017-05-18 |
2023-08-13 |
rat |
| Tamil Selvan Anthonymuthu, Elizabeth Megan Kenny, Hülya Bayı. Therapies targeting lipid peroxidation in traumatic brain injury. Brain research. vol 1640. issue Pt A. 2017-05-01. PMID:26872597. |
in this review, we critically evaluate previous attempts to use non-specific antioxidants as neuroprotectors and emphasize new approaches based on recent breakthroughs in understanding of enzymatic mechanisms of lipid peroxidation associated with specific death pathways, particularly apoptosis. |
2017-05-01 |
2023-08-13 |
Not clear |
| Sakshi Mishra, Prachi Tewari, Bhushan P Chaudhari, Premendra D Dwivedi, Haushila P Pandey, Mukul Da. Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes. International journal of cancer. vol 139. issue 9. 2017-05-01. PMID:27389473. |
further, the elucidation of molecular mechanisms of tumor initiation by don (0.42-3.37 nmol/ml) in hacat keratinocytes, revealed (i) enhanced ros generation with cell cycle phase arrest in g0/g1 phase, (ii) increase in levels of 8-oxog (6-24 hr) and γh2ax protein, (iii) significant enhancement in oxidative stress marker enzymes lpo, gsh, gr with concomitant decrease in antioxidant enzymes catalase, gpx, gst, sod and mitochondrial membrane potential after don (1.68 nmol) treatment, (iv) suppression of nrf2 translocation to nucleus, enhanced phosphorylation with subsequent activation erk1/2, p38 and jnk mapk's following don (1.68 nmol) treatment, (v) overexpression of c-jun, c-fos proteins, upregulation of bax along with downregulation of bcl-2 proteins, (vi) increase in cytochrome-c, caspase-9, caspase-3 and poly adp ribose polymerase levels leads to apoptosis. |
2017-05-01 |
2023-08-13 |
mouse |
| Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmit. Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28106777. |
six-day-old wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (gclc)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (nrf2/keap1, and nfκb), reduced pro-apoptotic effectors (poly (adp-ribose) polymerase-1 (parp-1), apoptosis inducing factor (aif), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (mmp) 2, and inhibitor of metalloproteinase (timp) 1/2). |
2017-04-24 |
2023-08-13 |
human |
| Ramazan Uygur, Cevat Aktas, Veli Caglar, Emine Uygur, Hasan Erdogan, Oguz Aslan Oze. Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. Toxicology and industrial health. vol 32. issue 5. 2017-04-18. PMID:24318767. |
these data suggested that melatonin has beneficial effects against arsenic-induced testicular damage by decreasing morphological damage, germ cell apoptosis, lipid peroxidation, and oxidative stress. |
2017-04-18 |
2023-08-12 |
rat |
| Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekp. Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats. Acta neurobiologiae experimentalis. vol 77. issue 1. 2017-04-14. PMID:28379220. |
neurobehavioural deficits, brain oedema, blood-brain barrier (bbb) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. |
2017-04-14 |
2023-08-13 |
rat |
| Bibi Marjan Razavi, Hossein Hosseinzadeh, Khalil Abnous, Alireza Khoei, Mohsen Imenshahid. Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon. Toxicology and industrial health. vol 32. issue 7. 2017-04-13. PMID:27353299. |
although increased production of lipid peroxidation by dzn in rat aorta has been shown previously, the effects of dzn on oxidative stress-induced apoptosis in vascular system have not been evaluated. |
2017-04-13 |
2023-08-13 |
rat |
| Sibel Bektas, Kemal Karakaya, Murat Can, Burak Bahadir, Berrak Guven, Nilsen Erdogan, Sukru Oguz Ozdama. The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia/reperfusion injury. The Kaohsiung journal of medical sciences. vol 32. issue 7. 2017-04-10. PMID:27450022. |
this study showed that tdf and ptx supplementation may be helpful in preventing free oxygen radical damage, lipid peroxidation, hepatocyte necrosis, and apoptosis in liver ir injury and minimizing liver damage. |
2017-04-10 |
2023-08-13 |
rat |
| Fatemeh Forouzanfar, Hossein Hosseinzadeh, Alireza Ebrahimzadeh Bideskan, Hamid R Sadeghni. Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats. Phytotherapy research : PTR. vol 30. issue 12. 2017-03-30. PMID:27515127. |
b. serrata and akba significantly improved neurological deficit and reduced brain infarction, neuronal cell loss and apoptosis and also attenuated lipid peroxidation while increasing glutathione content and superoxide dismutase activity in the cerebral cortex following a stroke. |
2017-03-30 |
2023-08-13 |
rat |
| Wen-Juan Li, Lu Li, Weng-Ya Zhen, Le-Feng Wang, Meng Pan, Jia-Qian Lv, Fan Wang, Yu-Fei Yao, Shao-Ping Nie, Ming-Yong Xi. Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 99. 2017-03-14. PMID:27913287. |
apoptosis, ros generation and lipid peroxidation in the immune organs of the immunosuppressed animals were ameliorated by psg-1. |
2017-03-14 |
2023-08-13 |
mouse |
| Guo-Yun Liu, Qiang Zhai, Jia-Zhuang Chen, Zhuo-Qing Zhang, Jie Yan. 2,2'-Fluorine mono-carbonyl curcumin induce reactive oxygen species-Mediated apoptosis in Human lung cancer NCI-H460 cells. European journal of pharmacology. vol 786. 2017-03-10. PMID:27266668. |
and then, the generation of reactive oxygen species can disrupt the intracellular redox balance, induce lipid peroxidation, cause the collapse of the mitochondrial membrane potential and ultimately lead to apoptosis. |
2017-03-10 |
2023-08-13 |
human |
| Ayaz Shahid, Rashid Ali, Nemat Ali, Syed Kazim Hasan, Preeti Bernwal, Shekh Mohammad Afzal, Abul Vafa, Sarwat Sultan. Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 92. 2017-03-09. PMID:27020533. |
however, pre-treatment with catechin at a dose of 20 and 40 mg/kg significantly decreased ldh, lpo, b(a)p metabolizing enzymes and increased anti-oxidant armory as well as regulated apoptosis and inflammation in lungs. |
2017-03-09 |
2023-08-13 |
mouse |
| Maryam Ghorbani, Amir Hooshang Mohammadpour, Khalil Abnous, Ahmad Reza Movassaghi, Javad Raouf Sarshoori, Shabnam Shahsavand, Mahmoud Hashemzaei, Seyed Adel Moalle. G-CSF administration attenuates brain injury in rats following carbon monoxide poisoning via different mechanisms. Environmental toxicology. vol 32. issue 1. 2017-03-02. PMID:26502830. |
different complex mechanisms lead to co neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. |
2017-03-02 |
2023-08-13 |
rat |
| Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh, Fariborz Samin. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 87. 2017-02-21. PMID:28061405. |
intraperitoneal administration of cur significantly attenuated oxidative stress and lipid peroxidation, prevented apoptosis, and increased antioxidant defense mechanism activity in the tissues versus the control group (p<0.05). |
2017-02-21 |
2023-08-13 |
rat |
| Francesca Uberti, Claudio Bardelli, Vera Morsanuto, Sabrina Ghirlanda, Claudio Molinar. Role of vitamin D BMC gastroenterology. vol 16. issue 1. 2017-02-10. PMID:27717330. |
consequent inflammation produces free radicals by mitochondria thus causing lipid peroxidation, oxidative and acidic stress, which can lead to cell apoptosis. |
2017-02-10 |
2023-08-13 |
Not clear |
| Reggie Surya, Cécile Héliès-Toussaint, Océane C Martin, Thierry Gauthier, Françoise Guéraud, Sylviane Taché, Nathalie Naud, Isabelle Jouanin, Céline Chantelauze, Denys Durand, Charlotte Joly, Estelle Pujos-Guillot, Fabrice H Pierre, Laurence Hu. Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats. Carcinogenesis. vol 37. issue 6. 2017-02-06. PMID:26992899. |
highlighting the importance of lipid peroxidation and neoformation of secondary aldehydes like 4-hydroxy-2-nonenal (hne), we optimized the depletion of carbonyl compounds in the fecal water which turned out to abolish the differential apoptosis in both cell lines. |
2017-02-06 |
2023-08-13 |
mouse |
| Govindhan Annamalai, Suresh Kathiresan, Nagappan Kannappa. [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-01-31. PMID:27470359. |
our results indicated that [6]-shogaol induces apoptosis as evidenced by loss of cell viability, enhanced ros, lipid peroxidation results in altered mitochondrial membrane potential, increased dna damage in hep-2 cells. |
2017-01-31 |
2023-08-13 |
Not clear |
| J S Oliveira, A A N Silva, V A Silv. Phytotherapy in reducing glycemic index and testicular oxidative stress resulting from induced diabetes: a review. Brazilian journal of biology = Revista brasleira de biologia. vol 0. 2017-01-12. PMID:27409225. |
plant extracts were evaluated according to their effects on blood glucose and insulin levels, antioxidant enzymes and oxidant levels, lipid peroxidation, total protein, testosterone levels, gonadosomatic index, diameter of seminiferous tubules, seminiferous epithelium height and integrity, number of germ cells at stage vii and apoptosis in the seminiferous epithelium, sperm production, motility, viability and morphology. |
2017-01-12 |
2023-08-13 |
Not clear |
| Charlette Tiloke, Alisa Phulukdaree, Anil A Chuturgoo. The Antiproliferative Effect of Moringa oleifera Crude Aqueous Leaf Extract on Human Esophageal Cancer Cells. Journal of medicinal food. vol 19. issue 4. 2016-12-16. PMID:27074620. |
moe possesses antiproliferative effects on sno ec cells by increasing lipid peroxidation, dna fragmentation, and induction of apoptosis. |
2016-12-16 |
2023-08-13 |
human |