| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luyao Xu, Benson O A Botchway, Songou Zhang, Jingying Zhou, Xuehong Li. Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30337851. |
nf-κb signaling pathway plays a significant role in the pathophysiological mechanisms of sci including increase in inflammation, augmentation of damage caused by free radicals and lipid peroxidation as well as facilitation of apoptosis and axonal demyelination. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mahyar Dorrigiv, Armin Zareiyan, Hossein Hosseinzade. Garlic (Allium sativum) as an antidote or a protective agent against natural or chemical toxicities: A comprehensive update review. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-29. PMID:32068926. |
it has been shown that garlic and its major components can ameliorate the toxicity of different agents in brain, kidney, blood, liver, embryo, spleen, pancreas, heart, reproductive system in part through radical scavenging, antioxidant effect, reducing lipid peroxidation, anti-inflammatory, chelating agent, cytoprotective activities, increase protein synthesis in damaged tissues, suppressing apoptosis, modulation of p53, phosphoinositide 3-kinase, akt, nuclear factor (erythroid-derived 2)-like 2, antioxidant responsive element, p38 mapk, inducible nitric oxide synthase, cyclooxygenase-2, cytosolic phospholipases a2, cleaved-caspase-9, cleaved-caspase-3 bcl-2, bcl-2-associated x, peroxisome proliferator-activated receptor gamma, nf-jb, nuclear factor-kappab signaling pathways and cytochrome p450 enzymes. |
2020-09-29 |
2023-08-13 |
Not clear |
| Gadah I Al-Bashe. Green tea activity and iron overload induced molecular fibrogenesis of rat liver. Saudi journal of biological sciences. vol 26. issue 3. 2020-09-28. PMID:30899168. |
thereafter, we studied the effects of agte on iron overload-induced lipid peroxidation, anti-oxidant depletion, liver cell injury and apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Bahareh Sadat Yousefsani, Nasim Akbarizadeh, Jalal Pourahma. The antioxidant and neuroprotective effects of Zolpidem on acrylamide-induced neurotoxicity using Wistar rat primary neuronal cortical culture. Toxicology reports. vol 7. 2020-09-28. PMID:32025499. |
thereafter, different neural toxicity endpoints caused by acrylamide including ros formation, lipid peroxidation, mitochondrial membrane potential collapse, lysosomal membrane integrity, and apoptosis were determined. |
2020-09-28 |
2023-08-13 |
rat |
| Michal Pardo, Itzhak Katra, James J Schaeur, Yinon Rudic. Mitochondria-mediated oxidative stress induced by desert dust in rat alveolar macrophages. GeoHealth. vol 1. issue 1. 2020-09-28. PMID:32158977. |
the dust samples induced cell death through apoptosis, mitochondrial dysfunction, and increased mitochondrial lipid peroxidation. |
2020-09-28 |
2023-08-13 |
rat |
| Liquan Wu, Xiaoxing Xiong, Xiaomin Wu, Yingze Ye, Zhihong Jian, Zeng Zhi, Lijuan G. Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32194375. |
during reperfusion especially, superoxide anion free radicals, hydroxyl free radicals, and nitric oxide (no) are produced, which can cause lipid peroxidation, inflammation and cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Zhongjie Yu, Qi Li, Jing Wang, Yali Yu, Yin Wang, Qihui Zhou, Peifeng L. Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field. Nanoscale research letters. vol 15. issue 1. 2020-09-28. PMID:32436107. |
due to the strong oxidation potential, the excess ros induced by nanoparticles can result in the damage of biomolecules and organelle structures and lead to protein oxidative carbonylation, lipid peroxidation, dna/rna breakage, and membrane structure destruction, which further cause necrosis, apoptosis, or even mutagenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xu She, Bin Lan, Haomei Tian, Biao Tan. Cross Talk Between Ferroptosis and Cerebral Ischemia. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32848555. |
distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Minlin Jiang, Meng Qiao, Chuanliang Zhao, Juan Deng, Xuefei Li, Caicun Zho. Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers. Translational lung cancer research. vol 9. issue 4. 2020-09-28. PMID:32953528. |
unlike apoptosis and autophagy, this new rcd is an iron-dependent cell death with features of lethal accumulation of reactive oxygen species (ros) and over production of lipid peroxidation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hongjing Zhao, Yu Wang, Menghao Guo, Mengyao Mu, Hongxian Yu, Mingwei Xin. Grass carps co-exposed to environmentally relevant concentrations of cypermethrin and sulfamethoxazole bear immunodeficiency and are vulnerable to subsequent Aeromonas hydrophila infection. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 3. 2020-09-15. PMID:32663629. |
cmn or/and smz exposure led to oxidative damage (consumption of antioxidant enzymes (superoxide dismutase and catalase)) and lipid peroxidation (accumulation of malondialdehyde), induced apoptosis (increases in tunel index, bax/bcl-2, p53, puma and caspase family expression). |
2020-09-15 |
2023-08-13 |
human |
| Xiao Qi, Yuanxiao Zhang, Hang Guo, Yu Hai, Yane Luo, Tianli Yu. Mechanism and intervention measures of iron side effects on the intestine. Critical reviews in food science and nutrition. vol 60. issue 12. 2020-09-10. PMID:31232087. |
lipid peroxidation procedurally appears, ferroptosis, apoptosis and necrosis are often induced, subsequently, mitochondrial damage, endoplasmic reticulum dysfunction and even cell death occur. |
2020-09-10 |
2023-08-13 |
Not clear |
| Ercan Baş, Mustafa Naziroğl. Selenium attenuates docetaxel-induced apoptosis and mitochondrial oxidative stress in kidney cells. Anti-cancer drugs. vol 30. issue 4. 2020-09-09. PMID:30875346. |
laser confocal microscope fluorescence intensity of apoptosis (annexin v and propidium iodide), mitochondrial membrane depolarization, reactive oxygen species production, and lipid peroxidation levels were increased in the cells by the dtx treatments, although cell number, cell viability, reduced glutathione and glutathione peroxidase values were decreased by the treatments. |
2020-09-09 |
2023-08-13 |
human |
| M A Artyukhova, Y Y Tyurina, C T Chu, T M Zharikova, H Bayır, V E Kagan, P S Timashe. Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing. Free radical biology & medicine. vol 144. 2020-09-07. PMID:31201850. |
the high efficiency and relative simplicity of a new genome editing tool, crispr/cas9, make its applications attractive for deciphering molecular changes driving pd-related impairments of redox metabolism and lipid peroxidation in relation to mishandling of iron, aggregation and oligomerization of alpha-synuclein and mitochondrial injury as well as in mechanisms of mitophagy and programs of regulated cell death (apoptosis and ferroptosis). |
2020-09-07 |
2023-08-13 |
Not clear |
| Silpa Sabnam, Arttatrana Pa. Relevance of Erk1/2-PI3K/Akt signaling pathway in CEES-induced oxidative stress regulates inflammation and apoptosis in keratinocytes. Cell biology and toxicology. vol 35. issue 6. 2020-09-01. PMID:30805762. |
on the other hand, cees exposure disrupts the protein carbonylation (pc) and lipid peroxidation (lpo) in keratinocytes leading to inflammation, crash of the cell-cell communication, cell cycle deregulation, and apoptosis via erk1/2-pi3k/akt pathways. |
2020-09-01 |
2023-08-13 |
Not clear |
| Pedro A Dionísio, Sara R Oliveira, Maria M Gaspar, Maria J Gama, Margarida Castro-Caldas, Joana D Amaral, Cecilia M P Rodrigue. Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease. Cell death & disease. vol 10. issue 11. 2020-08-26. PMID:31690718. |
moreover, mptp led to dna fragmentation, caspase-3 activation, lipid peroxidation and bax expression in wt mice, in the absence of caspase-8 cleavage, suggesting intrinsic apoptosis. |
2020-08-26 |
2023-08-13 |
mouse |
| Nadia-Cristina López-Vanegas, Gerardo Hernández, María Maldonado-Vega, José-Víctor Calderón-Salina. Leukocyte apoptosis, TNF-α concentration and oxidative damage in lead-exposed workers. Toxicology and applied pharmacology. vol 391. 2020-08-17. PMID:32004562. |
lead-exposed workers had high lead concentrations in blood (med 69.8 vs. 1.7 μg/dl), low δ-alad activity (med 149 vs. 1100 nmol pbg/h/ml), high lipid peroxidation (med 0.86 vs. 0.69 nmol/ml) and high erythrocytes apoptosis (med 0.81 vs. 0.50% ps externalization) in relation to non-lead exposed workers. |
2020-08-17 |
2023-08-13 |
Not clear |
| Shaolong Zhang, Xiuli Yi, Xin Su, Zhe Jian, Tingting Cui, Sen Guo, Tianwen Gao, Chunying Li, Shuli Li, Qian Xia. Ginkgo biloba extract protects human melanocytes from H Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-14. PMID:31148371. |
in the present study, we found that egb761 effectively protected melanocytes against oxidative stress-induced apoptosis and alleviated the excessive accumulation of reactive oxygen species (ros) and lipid peroxidation by enhancing the activity of antioxidative enzymes. |
2020-08-14 |
2023-08-13 |
human |
| Cristina Pérez-Patiño, Junwei Li, Isabel Barranco, Emilio A Martínez, Heriberto Rodriguez-Martínez, Jordi Roca, Inmaculada Parrill. The proteome of frozen-thawed pig spermatozoa is dependent on the ejaculate fraction source. Scientific reports. vol 9. issue 1. 2020-08-13. PMID:30679492. |
this study, performed in two experiments, looked for proteomic quantitative differences between ft-sperm samples differing in post-thaw viability, motility, apoptosis, membrane lipid peroxidation and nuclear dna fragmentation. |
2020-08-13 |
2023-08-13 |
Not clear |
| Shengchuan Cao, Yuan Bian, Xin Zhou, Qiuhuan Yuan, Shujian Wei, Li Xue, Feihong Yang, Qianqian Dong, Wenjun Wang, Boyuan Zheng, Jian Zhang, Zheng Wang, Ziqi Han, Kehui Yang, Haiying Rui, Ying Zhang, Feng Xu, Yuguo Che. A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis. Biochemical and biophysical research communications. vol 522. issue 2. 2020-08-12. PMID:31784085. |
in conclusion, aldh2 activation by alda-1 has a protective effect in cerulein-induced ap by mitigating apoptosis in pancreatic acinar cells by alleviating lipid peroxidation. |
2020-08-12 |
2023-08-13 |
mouse |
| Somaiah Chinnapaka, Guoxing Zheng, Aoshuang Chen, Gnanasekar Munirathina. Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H Free radical biology & medicine. vol 143. 2020-07-22. PMID:31446057. |
ncx4040 significantly induced hydrogen peroxide formation with ensuing oxidative stress and mitochondrial depolarization resulting in lipid peroxidation, cell cycle arrest, inhibition of colony growth and induction of apoptosis in pc3 cells. |
2020-07-22 |
2023-08-13 |
Not clear |