| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
the expression of apoptosis and metastasis related molecules were detected by rt-pcr and western blot, respectively, in u251 and t98g cells with hdac1 knockdown. |
2018-04-23 |
2023-08-13 |
mouse |
| Jianyun Zhao, Chengzhi Xie, Holly Edwards, Guan Wang, Jeffrey W Taub, Yubin G. Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells. Oncotarget. vol 8. issue 4. 2018-02-22. PMID:28030834. |
we found that inhibition of both hdac1 and hdac2 was necessary to decrease the expression of brca1, chk1, and rad51, enhance cytarabine- or daunorubicin-induced dna damage and apoptosis, and abrogate cytarabine- or daunorubicin-induced cell cycle checkpoint activation in aml cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Feng Yin, Kuan Hu, Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu, Yongye Liang, Zigang L. SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics. vol 7. issue 5. 2018-01-05. PMID:28435453. |
the systematic mechanistic elucidation of the dual gene silencing effects indicated the inactivation of both the hdac1 and the k-ras gene, thereby causing apoptosis, proliferation inhibition and cell cycle arrest in treated mia paca-2 cells. |
2018-01-05 |
2023-08-13 |
Not clear |
| Tianyi Zhang, Zhentao Sheng, Wei D. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mechanisms of development. vol 141. 2017-12-26. PMID:27378074. |
inactivation of hdac1 and its homolog hdac2 or addition of hdac inhibitors in mammalian systems induces apoptosis, cell cycle arrest, and developmental defects. |
2017-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Tianyi Zhang, Zhentao Sheng, Wei D. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mechanisms of development. vol 141. 2017-12-26. PMID:27378074. |
in this study, we show that inactivation of rpd3, the only hdac1 and hdac2 ortholog in drosophila, induced apoptosis and clone elimination in the developing eye and wing imaginal discs. |
2017-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Yajiao Zhou, Fang Gan, Lili Hou, Xuan Zhou, Yassin Abdulrahim Adam Ibrahim, Kehe Huan. Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro. Chemico-biological interactions. vol 278. 2017-12-12. PMID:29080797. |
modulations of dnmt1 and hdac1 are involved in the ota-induced cytotoxicity and apoptosis in vitro. |
2017-12-12 |
2023-08-13 |
Not clear |
| Yajiao Zhou, Fang Gan, Lili Hou, Xuan Zhou, Yassin Abdulrahim Adam Ibrahim, Kehe Huan. Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro. Chemico-biological interactions. vol 278. 2017-12-12. PMID:29080797. |
furthermore, inhibition of dnmt1 or hdac1 by their inhibitor reversed the decreases of cell viability and increases of ldh activity and apoptosis induced by ota, respectively. |
2017-12-12 |
2023-08-13 |
Not clear |
| Yajiao Zhou, Fang Gan, Lili Hou, Xuan Zhou, Yassin Abdulrahim Adam Ibrahim, Kehe Huan. Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro. Chemico-biological interactions. vol 278. 2017-12-12. PMID:29080797. |
in conclusion, the observed effects indicate that the critical modulation of dnmt1 and hdac1 is related to ota-induced cytotoxicity and apoptosis. |
2017-12-12 |
2023-08-13 |
Not clear |
| Manjola Balliu, Cristina Cellai, Matteo Lulli, Anna Laurenzana, Eugenio Torre, Alessandro Maria Vannucchi, Francesco Paolett. HDAC1 controls CIP2A transcription in human colorectal cancer cells. Oncotarget. vol 7. issue 18. 2017-12-06. PMID:27029072. |
these results are the first evidence that the inhibition of hdac1 by (s)-2 downregulates cip2a transcription and unleashes pp2a activity, thus inducing growth arrest and apoptosis in crc cells. |
2017-12-06 |
2023-08-13 |
mouse |
| Dhanusha A Nalawansha, Inosha D Gomes, Magdalene K Wambua, Mary Kay H Pflu. HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation. Cell chemical biology. vol 24. issue 4. 2017-11-21. PMID:28392145. |
histone deacetylase 1 (hdac1) is an epigenetic enzyme that regulates key cellular processes, such as cell proliferation, apoptosis, and cell survival, by deacetylating histone substrates. |
2017-11-21 |
2023-08-13 |
Not clear |
| Yang Hao, Guodong Wang, Chao Lin, Dong Li, Zhonghao Ji, Fei Gao, Zhanjun Li, Dianfeng Liu, Dongxu Wan. Valproic Acid Induces Decreased Expression of H19 Promoting Cell Apoptosis in A549 Cells. DNA and cell biology. vol 36. issue 6. 2017-09-08. PMID:28328238. |
taken together, our results suggest that h19 expression was suppressed by vpa through hdac1 and dnmt1 and decreased h19 expression correlated with cell apoptosis in a549 cells. |
2017-09-08 |
2023-08-13 |
Not clear |
| Md Zubbair Malik, Md Jahoor Alam, Romana Ishrat, Subhash M Agarwal, R K Brojen Sing. Control of apoptosis by SMAR1. Molecular bioSystems. vol 13. issue 2. 2017-07-24. PMID:27934984. |
smar1 can also regulate apoptosis in the presence of hdac1, depending on the stress induced by it. |
2017-07-24 |
2023-08-13 |
Not clear |
| Bo Ra You, Woo Hyun Par. The levels of HDAC1 and thioredoxin1 are related to the death of mesothelioma cells by suberoylanilide hydroxamic acid. International journal of oncology. vol 48. issue 5. 2016-12-26. PMID:26936390. |
all the tested caspase inhibitors attenuated apoptosis in saha-treated phi cells whereas hdac1 sirna enhanced the apoptotic cell death. |
2016-12-26 |
2023-08-13 |
human |
| Bo Tang, Wei Wu, Qing Zhang, Yongjin Sun, Yifen Cui, Fei Wu, Xiaowei Wei, Guangying Qi, Xingsi Liang, Fang Tang, Yunqian Li, Wenhai Fa. Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells. Scientific reports. vol 5. 2016-09-13. PMID:26521947. |
the presence of hdac1 inhibitor, butyrate or parthenolide, significantly enforced irradiation-induced glioma cell apoptosis. |
2016-09-13 |
2023-08-13 |
human |
| Jienny Lee, Jeong Su Byeon, Keum Sil Lee, Na-Yeon Gu, Gyeong Been Lee, Hee-Ryang Kim, In-Soo Cho, Sang-Ho Ch. Chondrogenic potential and anti-senescence effect of hypoxia on canine adipose mesenchymal stem cells. Veterinary research communications. vol 40. issue 1. 2016-08-11. PMID:26661466. |
also, we found that hypoxia strongly expressed anti-senescence related genes such as hdac1 (histone deacetylase 1), dnmt1 (dna (cytosine-5)-methyltransferase 1), bcl-2 (inhibitor of apoptosis), tert (telomerase reverse transcriptase), ldha (lactate dehydrogenase a), slc2a1 (glucose transporter), and dkc1 (telomere holoenzyme complex) and differentiation potential of cad-mscs into chondrocytes, than seen under the normoxic culture conditions. |
2016-08-11 |
2023-08-13 |
Not clear |
| Lilach Moyal, Nataly Feldbaum, Neta Goldfeiz, Ada Rephaeli, Abraham Nudelman, Michal Weitman, Nataly Tarasenko, Batia Gorovitz, Leah Maron, Shiran Yehezkel, Iris Amitay-Laish, Ido Lubin, Emmilia Hoda. The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin. PloS one. vol 11. issue 1. 2016-07-15. PMID:26752418. |
both drugs induced apoptosis in mf/ss cell lines, saha had a greater effect on myla cell line, while an-7 induced greater apoptosis in spbl; both caused an accumulation of acetylated histone h3, but an-7 was associated with earlier kinetics; and both caused a downregulation of the hdac1 protein in mf/ss cell lines. |
2016-07-15 |
2023-08-13 |
Not clear |
| Sarah Hawtree, Munitta Muthana, J Mark Wilkinson, Mohammed Akil, Anthony G Wilso. Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis. Human molecular genetics. vol 24. issue 19. 2016-07-06. PMID:26152200. |
hdac1 expression in rasfs was inhibited using small interfering rna (sirna) technology to assess effects on invasiveness, migration, proliferation and apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| Yi-Min Liu, Hsueh-Yun Lee, Mei-Jung Lai, Shiow-Lin Pan, Hsiang-Ling Huang, Fei-Chiao Kuo, Mei-Chuan Chen, Jing-Ping Lio. Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. Organic & biomolecular chemistry. vol 13. issue 40. 2016-04-12. PMID:26309122. |
the results indicate that compound 6, 4-[5-fluoro-2,6-dioxo-3-(tetrahydro-furan-2-yl)-3,6-dihydro-2h-pyrimidin-1-ylmethyl]-n-hydroxy-benzamide, exhibits potent antiproliferative activity, apoptosis induction with cleavage of caspase and parp, and enhanced tendency to inhibit hdac6 (ic50 = 12.4 nm) activity over hdac1 (ic50 = 1710 nm) and hdac2 (ic50 = 5500 nm). |
2016-04-12 |
2023-08-13 |
Not clear |
| Michael Aschermann, Pavel Jans. [Drug therapy of pulmonary arterial hypertension in 2014]. Vnitrni lekarstvi. vol 60. issue 4. 2015-10-26. PMID:24985985. |
anti-inflammatory agents: inhibitor of elastase, antagonist of b cells, immunosuppressive agents, inhibitor of hdac1; 3. agents affecting metabolism: nitrites, ppar antagonists, antioxidants, serotonin receptor antagonist and serotonin transporter blockers, statins, inhibitors of rho-kinase; 4. apoptosis inductors of smooth muscle cells: tyrosine-kinase inhibitors, elastase inhibitors; 5. agents influencing vascular regeneration: apelin, treatment targeted to endothelial cells, replacement of bmpr2. |
2015-10-26 |
2023-08-13 |
Not clear |
| Valérie Plaisance, Laure Rolland, Valéry Gmyr, Jean-Sébastien Annicotte, Julie Kerr-Conte, François Pattou, Amar Abderrahman. The class I histone deacetylase inhibitor MS-275 prevents pancreatic beta cell death induced by palmitate. Journal of diabetes research. vol 2014. 2015-07-07. PMID:25610877. |
silencing of hdac3, but not of hdac1, mimicked the effects of ms-275 on the expression of the two er stress markers and apoptosis. |
2015-07-07 |
2023-08-13 |
human |