| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Preeti Patel, Vijay K Patel, Avineesh Singh, Talha Jawaid, Mehnaz Kamal, Harish Raja. Identification of Hydroxamic Acid Based Selective HDAC1 Inhibitors: Computer Aided Drug Design Studies. Current computer-aided drug design. vol 15. issue 2. 2019-07-05. PMID:29732991. |
thus, hdac1 inhibitors have emerged as the potential therapeutic leads against multiple human cancers, as they can block the activity of particular hdacs, renovate the expression of several tumour suppressor genes and bring about cell differentiation, cell cycle arrest and apoptosis. |
2019-07-05 |
2023-08-13 |
human |
| Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Le. HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. International journal of molecular sciences. vol 20. issue 2. 2019-05-01. PMID:30669676. |
hdac1 and hdac2 double knockout triggers cell apoptosis in advanced thyroid cancer. |
2019-05-01 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
hdac1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. |
2019-03-25 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
the tunel assay was used to evaluate the role of hdac1 in nsclc apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
furthermore, downregulation of hdac1 inhibited cell proliferation, prevented cell migration, decreased cell invasion, reduced tumor angiogenesis and induced cell apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Yi Li, Zhengyi Zhang, Xiangnan Zhou, Rui Li, Yan Cheng, Bo Shang, Yu Han, Bin Liu, Xiaodong Xi. Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness. Circulation journal : official journal of the Japanese Circulation Society. vol 82. issue 1. 2019-03-08. PMID:28747611. |
hdac1 inhibition improved cell viability, decreased lactate dehydrogenase leakage, cell apoptosis, malondialdehyde concentration, cell volume, and particles on the cell surface, and increased superoxide dismutase activity. |
2019-03-08 |
2023-08-13 |
Not clear |
| Moumita Datta, Ori Staszewski, Elena Raschi, Maximilian Frosch, Nora Hagemeyer, Tuan Leng Tay, Thomas Blank, Mario Kreutzfeldt, Doron Merkler, Stephanie Ziegler-Waldkirch, Patrick Matthias, Melanie Meyer-Luehmann, Marco Prin. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. vol 48. issue 3. 2018-11-27. PMID:29548672. |
mechanistically, the promoters of pro-apoptotic and cell cycle genes were hyperacetylated in absence of hdac1 and hdac2, leading to increased apoptosis and reduced survival. |
2018-11-27 |
2023-08-13 |
mouse |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
inhibition of mir‑34a prevents endothelial cell apoptosis by directly targeting hdac1 in the setting of atherosclerosis. |
2018-08-14 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
this indicated that mir‑34a inhibitor promoted cell viability and prevented cell apoptosis of haecs through regulating hdac1. |
2018-08-14 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
in conclusion, it was demonstrated that mir‑34a promoted atherosclerotic formation by modulating the proliferation and apoptosis of haecs, and regulating the expression of apoptosis‑related proteins by targeting hdac1. |
2018-08-14 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of hdac1 and oxidative stress. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
histone deacetylase1 (hdac1) is an epigenetic regulator in cellular apoptosis. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
we found that hg treatment decreased cell vitality, upregulated hdac1 protein level, promoted reactive oxygen species production, induced cell cycle arrest and cell apoptosis in hmec-1 cells, which were all rectified by vac. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
both scavenging reactive oxygen species and inhibition of hdac1 alleviated the apoptosis of hmec-1 cells in response to hg. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
taken together, these data suggested that vac protected against hg-induced endothelial cell apoptosis via inhibition of reactive oxygen species accumulation and hdac1 expression. |
2018-07-27 |
2023-08-13 |
human |
| Vincent Pillonel, Nina Reichert, Chun Cao, Marinus R Heideman, Teppei Yamaguchi, Gabriele Matthias, Alexandar Tzankov, Patrick Matthia. Histone deacetylase 1 plays a predominant pro-oncogenic role in Eμ-myc driven B cell lymphoma. Scientific reports. vol 6. 2018-07-10. PMID:27886239. |
our data show that hdac1 and hdac2 impact on eμ-myc b cell proliferation and apoptosis and suggest that a critical level of hdac activity may be required for eμ-myc tumorigenesis and proper b cell development. |
2018-07-10 |
2023-08-13 |
mouse |
| Hengyu Zhou, Ying Cai, Dina Liu, Menghui Li, Yu Sha, Wenlu Zhang, Kai Wang, Jianping Gong, Ni Tang, Ailong Huang, Jie Xi. Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21 Cell proliferation. vol 51. issue 3. 2018-06-26. PMID:29484736. |
pharmacological or transcriptional inhibition of both hdac1 and 2 leads to cell cycle blockage and apoptosis via p21 histone deacetylases (hdacs) are commonly dysregulated in cancer and represent promising therapeutic targets. |
2018-06-26 |
2023-08-13 |
Not clear |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
knockdown of hdac1 expression suppresses invasion and induces apoptosis in glioma cells. |
2018-04-23 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
downregulation of hdac1 inhibited cell proliferation, prevented invasion of glioma cell lines, and induced cell apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |