| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Mei Chen, Xian-Biao Xie, Qing Zhao, Fang Wang, Yang Bai, Jun-Qiang Yin, Hong Jiang, Xiao-Lin Xie, Qiang Jia, Gang Huan. Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells. Molecular medicine reports. vol 11. issue 1. 2015-06-24. PMID:25333250. |
the c-myc/s-phase kinase-associated protein 2 (skp2) and histone deacetylase (hdac)1/2 pathways were found to exert an important role in amp-induced a549 cell apoptosis, as increased levels of c-myc mrna and reduced levels of c-myc/skp2 and hdac1 and 2 proteins following amp treatment were observed. |
2015-06-24 |
2023-08-13 |
human |
| Y Kang, H Nian, P Rajendran, E Kim, W M Dashwood, J T Pinto, L A Boardman, S N Thibodeau, P J Limburg, C V Löhr, W H Bisson, D E Williams, E Ho, R H Dashwoo. HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell death & disease. vol 5. 2015-06-18. PMID:25321483. |
interestingly, the repressive role of hdac8 could be uncoupled from hdac1 to trigger bmf-mediated apoptosis. |
2015-06-18 |
2023-08-13 |
human |
| Hanxu Zhuang, Xudong Ma, Yadong Lai, Xiangnong Xu, Xiaozhong Wan. [Effect of siRNA targeting HDAC1 gene on proliferation, apoptosis, histone acetylation, and histone methylation in gastric cancer cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 34. issue 2. 2014-12-22. PMID:24589606. |
[effect of sirna targeting hdac1 gene on proliferation, apoptosis, histone acetylation, and histone methylation in gastric cancer cells in vitro]. |
2014-12-22 |
2023-08-12 |
Not clear |
| Hanxu Zhuang, Xudong Ma, Yadong Lai, Xiangnong Xu, Xiaozhong Wan. [Effect of siRNA targeting HDAC1 gene on proliferation, apoptosis, histone acetylation, and histone methylation in gastric cancer cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 34. issue 2. 2014-12-22. PMID:24589606. |
to investigate the effect of silencing histone deacetylases 1 (hdac1) gene by rna interference on the proliferation, apoptosis and histone modulation in gastric cancer mgc-803 cell line. |
2014-12-22 |
2023-08-12 |
Not clear |
| Sanjeev Shukla, Pingfu Fu, Sanjay Gupt. Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24563225. |
apigenin treatment resulted in the inhibition of class i histone deacetylases and hdac1 protein expression, thereby increasing the acetylation of ku70 and the dissociation of bax resulting in apoptosis of cancer cells. |
2014-11-12 |
2023-08-12 |
mouse |
| Qi Shen, Wanfen Tang, Jie Sun, Lifeng Feng, Hongchuan Jin, Xian Wan. Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer. American journal of translational research. vol 6. issue 5. 2014-10-31. PMID:25360218. |
therefore, the high expression of hdac1 can downregulate cradd to confer gastric cancer cells the resistance to caspase 2-dependent apoptosis. |
2014-10-31 |
2023-08-13 |
Not clear |
| Astrid Hagelkruys, Sabine Lagger, Julia Krahmer, Alexandra Leopoldi, Matthias Artaker, Oliver Pusch, Jürgen Zezula, Simon Weissmann, Yunli Xie, Christian Schöfer, Michaela Schlederer, Gerald Brosch, Patrick Matthias, Jim Selfridge, Hans Lassmann, Jürgen A Knoblich, Christian Seise. A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449838. |
by contrast, combined deletion of hdac1 and hdac2 resulted in impaired chromatin structure, dna damage, apoptosis and embryonic lethality. |
2014-03-20 |
2023-08-12 |
mouse |
| Jiwoon Lee, Bum-Kyu Lee, Jeffrey M Gros. Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Human molecular genetics. vol 22. issue 17. 2014-02-19. PMID:23669349. |
together, these data support a model in which p53-dependent apoptosis needs to be tightly regulated for normal optic cup formation and that bcl6a, bcor, rnf2 and hdac1 activities mediate this regulation. |
2014-02-19 |
2023-08-12 |
xenopus_laevis |
| Yang Han, Yong Zhang, Lian-he Yang, Xiao-yi Mi, Shun-dong Dai, Qing-chang Li, Hong-tao Xu, Juan-han Yu, Guang Li, Jing Zhao, Chong Han, Xi-ming Yuan, En-hua Wan. X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer. Radiation oncology (London, England). vol 7. 2013-06-10. PMID:23110995. |
the aims of this study were to investigate the relationships between hdac1, hdac2, clinicopathologic characteristics, patient prognosis and apoptosis, to clarify the mechanism of upregulation of the axis inhibitor axin (an important regulator of the wnt pathway) by x-radiation and to elucidate the effect of sirna on radiation therapy of non-small cell lung cancer (nsclc). |
2013-06-10 |
2023-08-12 |
Not clear |
| Sook-Ja Lee, Haerim Jang, Chaehwa Par. Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. International journal of molecular medicine. vol 29. issue 2. 2012-04-13. PMID:22076034. |
maspin inhibited histone deacetylase 1 (hdac1) and thus increased the acetylation of ku70 and the dissociation of bax from ku70, which led to the induction of apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Pengpeng Ma, Hua Pan, Rusty L Montgomery, Eric N Olson, Richard M Schult. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 8. 2012-04-12. PMID:22223663. |
compensatory functions of histone deacetylase 1 (hdac1) and hdac2 regulate transcription and apoptosis during mouse oocyte development. |
2012-04-12 |
2023-08-12 |
mouse |
| José García, Gianluigi Franci, Raquel Pereira, Rosaria Benedetti, Angela Nebbioso, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Lucia Altucci, Angel R de Ler. Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. Bioorganic & medicinal chemistry. vol 19. issue 12. 2011-11-22. PMID:21215647. |
whereas the derivatives of psammaplin a with modifications in the length of the connecting chain, the oxime bond and the disulfide unit showed lower potency, the analogues with changes on the bromotyrosine ring exhibited activities comparable to those of the parent compound in the inhibition of hdac1 and in the induction of apoptosis. |
2011-11-22 |
2023-08-12 |
human |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
expression of a dominant-negative mutant of hdac1 or downregulation of hdac1 by rnai both suppressed tgf-β1-induced apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
in addition, overexpression of hdac1 enhanced tgf-β1-induced apoptosis, and the rescue of hdac1 expression in hdac1 rnai cells restored the apoptotic response of cells to tgf-β1. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
these data indicate that hdac1 functions as a proapoptotic factor in tgf-β1-induced apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
taken together, our data demonstrate that hdac1 and 2 reciprocally affect cell viability by differential regulation of erk1/2; these observations provide insight into the roles and potential mechanisms of hdac1 and 2 in apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| Jennifer Jurkin, Gordin Zupkovitz, Sabine Lagger, Reinhard Grausenburger, Astrid Hagelkruys, Lukas Kenner, Christian Seise. Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis. Cell cycle (Georgetown, Tex.). vol 10. issue 3. 2011-07-04. PMID:21270520. |
combined ablation of hdac1 and hdac2 in different cell types led to a severe proliferation defects or enhanced apoptosis supporting the idea that both enzymes are relevant targets for tumor therapy. |
2011-07-04 |
2023-08-12 |
Not clear |
| M A Khan, S Mittal, S Kumar, J Sengupta, D Ghos. Quantitative analysis of six gene products as candidate markers of early placental villi development in the human. Indian journal of physiology and pharmacology. vol 54. issue 4. 2011-06-30. PMID:21675027. |
taking together our previous array based data and the present study we conclude that a categorical balance exists between the expression of erbb2 and hdac1 genes affecting cell proliferation and differentiation in one hand, and cxcr4 and tnfrsf1a affecting chemotaxis, inflammatory response and apoptosis on the other hand. |
2011-06-30 |
2023-08-12 |
human |
| Sabine Lagger, Dominique Meunier, Mario Mikula, Reinhard Brunmeir, Michaela Schlederer, Matthias Artaker, Oliver Pusch, Gerda Egger, Astrid Hagelkruys, Wolfgang Mikulits, Georg Weitzer, Ernst W Muellner, Martin Susani, Lukas Kenner, Christian Seise. Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. The EMBO journal. vol 29. issue 23. 2011-01-12. PMID:20967026. |
surprisingly, loss of hdac1 was not only linked to increased apoptosis, but also to significantly enhanced proliferation. |
2011-01-12 |
2023-08-12 |
mouse |
| Roel H Wilting, Eva Yanover, Marinus R Heideman, Heinz Jacobs, James Horner, Jaco van der Torre, Ronald A DePinho, Jan-Hermen Dannenber. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. The EMBO journal. vol 29. issue 15. 2010-08-26. PMID:20571512. |
dual inactivation of hdac1 and hdac2 results in apoptosis of megakaryocytes and thrombocytopenia. |
2010-08-26 |
2023-08-12 |
Not clear |