| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luyang Wang, Anning Du, Yan Lu, Yunxi Zhao, Ming Qiu, Zhenyang Su, Huanyu Shu, Hui Shen, Wei Sun, Xiangqing Kon. Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-β-Catenin Signaling Axis. Journal of the American Heart Association. 2023-05-09. PMID:37158154. |
pi16 also inhibited hdac1 (class i histone deacetylase) expression, and overexpression hdac1 abolished the inhibition of apoptosis and wnt signaling of pi16. |
2023-05-09 |
2023-08-14 |
mouse |
| Wenjun Jiao, Weifang Li, Tianyi Li, Tao Feng, Cong Wu, Di Zha. Induced pluripotent stem cell-derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury. Cell biology and toxicology. 2023-02-15. PMID:36790503. |
the in vitro studies suggested that ipsc-derived evs, sfpq or hdac1 overexpression, or hif-2α silencing diminished cell injury and apoptosis but elevated proliferation in retinal müller cells. |
2023-02-15 |
2023-08-14 |
rat |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seise. A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. PLoS genetics. vol 18. issue 8. 2022-08-22. PMID:35994477. |
individual inactivation of hdac1 or hdac2 has only mild effects on cell viability, while hdac3 inactivation or loss results in dna damage and apoptosis. |
2022-08-22 |
2023-08-14 |
human |
| Hao Cui, Zan Hu, Kang Yang, Jingkun Huang, Yichao Wu, Quanwei Chen, Ran Wei, Penfeng Wang, Hui Wang, Hongmei Li, Yadong Chen, Tao Lu, Yuqin Yao, Yong Zh. Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer. European journal of medicinal chemistry. vol 238. 2022-06-01. PMID:35649291. |
compound iic showed good inhibitory activity against hdac1 and hct116 cells and showed higher sensitivity to activating the expression of the trail protein and promoting the apoptosis of hct-116 cells compared with onc201. |
2022-06-01 |
2023-08-13 |
Not clear |
| Shengkai Zhou, Peng Liu, Guobao Zhang, Zhaoyun Cheng, Sheng Wang, Jian Zha. HDAC1 depletion alleviates coronary heart disease via the microRNA-182-mediated TGF-β/Smad signaling pathway. Journal of cardiovascular pharmacology. 2022-03-15. PMID:35289769. |
using elisa, rt-qpcr, he staining, tunel assay and immunohistochemistry, we observed that hdac1 downregulation promoted cardiac function, restored lipid levels, reduced myocardial injury markers and inflammatory factors, and alleviated myocardial tissue damage and apoptosis in chd rats. |
2022-03-15 |
2023-08-13 |
rat |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
septic mice were injected with hdac1 low expression-, mir-124-5p high expression- or hmgb1 low expression-related structures to observe cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and apoptosis in myocardial tissues of septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
restored mir-124-5p/depleted hdac1 or hmgb1 recovered the cardiac function, improved cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and inhibit ed cardiomyocyte apoptosis in septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Zhitao Ren, Nishikant A Raut, Temitope O Lawal, Shital R Patel, Simon M Lee, Gail B Mahad. Peonidin-3-O-glucoside and cyanidin increase osteoblast differentiation and reduce RANKL-induced bone resorption in transgenic medaka. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34704297. |
in addition, treatment of serum starvation of hfob osteoblasts with anthocyanins and resveratrol at 1.0 μg/ml reduced apoptosis, the bax/bcl-2 ratio, p53, and hdac1 expression, but increased sirt1/3 and pgc1α mrna expression, suggesting mitochondrial and epigenetic regulation. |
2021-11-25 |
2023-08-13 |
human |
| Jui-Sheng Chen, Hao-Kuang Wang, Chien-Yu Hsu, Yu-Ting Su, Jia-Shing Chen, Cheng-Loong Liang, Patrick Ching-Ho Hsieh, Cheng-Chun Wu, Aij-Lie Kwa. HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34381129. |
we found that hdac1 inhibition promoted the infarct volume, neuronal loss, dna damage, neuronal apoptosis after stroke, and levels of reactive oxygen species and inflammation cytokines. |
2021-11-12 |
2023-08-13 |
rat |
| Sonali Bahl, Hongbo Ling, Nuwan P N Acharige, Irene Santos-Barriopedro, Mary Kay H Pflum, Edward Set. EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33976119. |
by deacetylating histones and non-histone proteins, hdac1 has a profound effect on the regulation of gene transcription and many processes related to cell growth and cell death, including cell cycle progression, dna repair, and apoptosis. |
2021-10-14 |
2023-08-13 |
human |
| Longzhou Zhang, Zengjin Liu, Yang Dong, Lingchang Kon. Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma. IUBMB life. vol 73. issue 5. 2021-09-21. PMID:33715270. |
moreover, overexpression of hdac1 resulted in a significant increase in dna replication activity, a significant decline in apoptosis and cell cycle arrest in gbm cells. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xuming Zhu, Matthew Leboeuf, Fang Liu, Marina Grachtchouk, John T Seykora, Edward E Morrisey, Andrzej A Dlugosz, Sarah E Milla. HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53. The Journal of investigative dermatology. 2021-09-20. PMID:34284046. |
we find that homozygous epidermal codeletion of hdac1 and hdac2 in adult mouse epidermis causes reduced basal cell proliferation, apoptosis, inappropriate differentiation, and eventual loss of hdac1/2-null keratinocytes. |
2021-09-20 |
2023-08-13 |
mouse |
| Min Woo Shin, Se Lim Kim, Hee Chan Yang, Sung Kyun Yim, Seung Young Seo, Soo Teik Lee, Hee-Kwon Kim, Sang-Wook Ki. The HDAC1 Inhibitor CBUD-1001 Enhances TRAIL-induced Apoptosis in Colorectal Cancer Cells. Anticancer research. vol 41. issue 9. 2021-09-13. PMID:34475055. |
the hdac1 inhibitor cbud-1001 enhances trail-induced apoptosis in colorectal cancer cells. |
2021-09-13 |
2023-08-13 |
Not clear |
| Qiongwei Wu, Wenying Zhang, Yu Liu, Yuhua Huang, Huiheng Wu, Chengbin M. Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer. Oncology letters. vol 22. issue 4. 2021-08-26. PMID:34429761. |
the effects of hdac1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by cck-8, flow cytometry, wound-healing, transwell chamber and |
2021-08-26 |
2023-08-13 |
Not clear |
| Jiangtao Guo, Xuqing Cao, Wei Zhao, Hong Zhu, Xiaoli Ma, Chunfang Hao, Lili Wu, Mingzhu Zhang, Yashan Yang, Jingtian Zhao, Kunting Chen, Zhe Yi. MicroRNA-449 targets histone deacetylase 1 to regulate the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis. Annals of palliative medicine. vol 10. issue 7. 2021-08-09. PMID:34353082. |
the study aimed to explore the effects of microrna (mir)-449 and histone deacetylase 1 (hdac1) on the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis. |
2021-08-09 |
2023-08-13 |
Not clear |
| Se Lim Kim, Minh Thanh La, Min Woo Shin, Sang-Wook Kim, Hee-Kwon Ki. A novel HDAC1 inhibitor, CBUD‑1001, exerts anticancer effects by modulating the apoptosis and EMT of colorectal cancer cells. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945468. |
a novel hdac1 inhibitor, cbud‑1001, exerts anticancer effects by modulating the apoptosis and emt of colorectal cancer cells. |
2021-07-14 |
2023-08-13 |
Not clear |
| Meng Gao, Chao Wan. [The role of histone deacetylases 1/2 in regulating murine oogenesis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230954. |
hdac1 and 2 jointly regulate the global transcription and the incidence of apoptosis of growing oocytes and affect its subsequent growth and development, which reflects their compensatory function. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yin-Gi Jang, Eul-Bee Ko, Kyung-Chul Cho. Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32615369. |
western blot analysis revealed down-regulated expression of hdac1 and 2, leading to up-regulation of acetyl-p53 expression at the protein level, subsequent to down-regulating the expression of cell-cycle-related genes, i.e., proliferating cell nuclear antigen (pcna), cyclin d1 and e1, up-regulating the expression of cell cycle arrest gene p21 and regulating the expression of apoptosis intrinsic pathway-related genes, such as bax, bcl-2, cleaved caspase-3 and poly (adp-ribose) polymerase 1 in both pca cell lines. |
2021-05-31 |
2023-08-13 |
mouse |
| Shanji Nan, Ying Wang, Chengbi Xu, Haitao Wan. Interfering microRNA-410 attenuates atherosclerosis via the HDAC1/KLF5/IKBα/NF-κB axis. Molecular therapy. Nucleic acids. vol 24. 2021-05-14. PMID:33981482. |
furthermore, silencing mir-410 or overexpressing hdac1 increased cell viability and suppressed apoptosis and an inflammatory reaction in huvecs in atherosclerosis. |
2021-05-14 |
2023-08-13 |
mouse |