| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prabal Singh Maharjan, Hitesh Kumar Bhattara. Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death. Journal of oncology. vol 2022. 2022-07-07. PMID:35794980. |
the extrinsic pathway of apoptosis starts with the activation of the fas receptor by singlet oxygen that leads to activation of the caspase-7 and caspase-3. |
2022-07-07 |
2023-08-14 |
Not clear |
| Allie L Lundberg, Nicole M Jaskiewicz, Abigail M Maucieri, David H Townso. Stimulatory effects of TGFα in granulosa cells of bovine small antral follicles. Journal of animal science. vol 100. issue 7. 2022-06-30. PMID:35772748. |
additionally, prior exposure of the bgc to tgfα (100 ng/ml) failed to prevent fas ligand (100 ng/ml)-induced apoptosis, as measured by caspase 3/7 activity (p < 0.05, n = 7 ovary pairs). |
2022-06-30 |
2023-08-14 |
cattle |
| Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Carmen Ferrer-Moure, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Alejandro Jiménez, Agustín F González-River. High blood Fas concentrations in non-survivor patients with traumatic brain injury. Internal and emergency medicine. 2022-06-27. PMID:35759184. |
fas is one of the main death receptors of the extrinsic pathway of apoptosis. |
2022-06-27 |
2023-08-14 |
Not clear |
| Na Qu, Ruizhe Wang, Yiming Meng, Ning Liu, Jingbo Zhai, Fengping Sha. Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor. International immunopharmacology. vol 110. 2022-06-23. PMID:35738090. |
in these studies methionine enkephalin (menk) is shown to inhibit cervical tumor cell proliferation in vitro in association with an increase in the expression of apoptosis markers and mediators, including an increase in fas, caspase 8, and caspase 3 expression and intrinsic expression of the signaling pathway mediator bax. |
2022-06-23 |
2023-08-14 |
mouse |
| Dominika Kwiatkowska, Ewelina Mazur, Adam Reic. YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance. Frontiers in oncology. vol 12. 2022-06-20. PMID:35719931. |
it regulates programmed cell death 1 (pd1) and lymphocyte-activation gene 3 (lag3) by binding to its promoters, as well as suppresses both fas and trail by negatively regulating dr5 transcription and expression and interaction with the silencer region of the fas promoter, rendering cells resistant to apoptosis. |
2022-06-20 |
2023-08-14 |
Not clear |
| Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Ga. MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS. European journal of histochemistry : EJH. vol 66. issue 2. 2022-05-31. PMID:35638591. |
we first found oxidized low-density lipoprotein (ox-ldl) induced fas and cell apoptosis in huvecs. |
2022-05-31 |
2023-08-13 |
Not clear |
| Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Ga. MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS. European journal of histochemistry : EJH. vol 66. issue 2. 2022-05-31. PMID:35638591. |
after that, the knockdown of fas and overexpression of mir-130a-5p together were observed to aggregate ox-ldl-induced reduction of cell viability and apoptosis, cell cycle progression, cell proliferation, cell migration and invasion. |
2022-05-31 |
2023-08-13 |
Not clear |
| Xiao-Bo Zhang, Si-Qi Xu, Yi-Geng Hui, Hai-Yu Zhou, Yi-Cun Hu, Rui-Hao Zhang, Xi-Dan Gao, Chang-Ming Zhen. Lactotransferrin promotes intervertebral disc degeneration by regulating Fas and inhibiting human nucleus pulposus cell apoptosis. Aging. vol 14. issue undefined. 2022-05-25. PMID:35613904. |
lactotransferrin promotes intervertebral disc degeneration by regulating fas and inhibiting human nucleus pulposus cell apoptosis. |
2022-05-25 |
2023-08-13 |
human |
| Samah Alharb. Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-20. PMID:35594708. |
in conclusion, reducing the circulatory ratio of ag/uag ratio by exogenous administration of uag attenuates hfd-induced hepatic steatosis by suppressing lipogenesis, stimulating fas oxidation, preventing oxidative stress, inflammation, er stress, and apoptosis. |
2022-05-20 |
2023-08-13 |
rat |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
after exposure to cd, the level of oxidative stress in head kidney lymphocytes increased, and the mrna and protein expression of apoptosis-related markers fas, fadd, caspase8 and caspase3 increased significantly (p < 0.05), which led to lymphocytes apoptosis. |
2022-05-16 |
2023-08-13 |
Not clear |
| Fei Yang, Kangping Xu, Sha Zhang, Jinlin Zhang, Yaoren Qiu, Jin Luo, Guishan Tan, Zhenxing Zou, Wenxuan Wang, Fenghua Kan. Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer. Bioorganic & medicinal chemistry. vol 66. 2022-05-15. PMID:35569251. |
further mechanism studies indicated the ability of 7d in disrupting y925 autophosphorylation of fak, reducing formation of focal adhesions (fas) and stress fibers (sfs) as well as inducing apoptosis of tnbc cells. |
2022-05-15 |
2023-08-13 |
Not clear |
| Galina Rodionov, Michal Rosenzwaig, Michal Schrift Tzadok, Moran Kvint, Elazar Gevir, Elina Zorde-Khvalevsky, Amnon Peled, Shai Yarkoni, Amos Ofe. Short treatment of peripheral blood cells product with Fas ligand using closed automated cell processing system significantly reduces immune cell reactivity of the graft in vitro and in vivo. Bone marrow transplantation. 2022-05-10. PMID:35538142. |
we demonstrate that a short treatment of mpbcs with fas ligand (fasl, cd95l) for 2 h using a closed automated cell processing system selectively induces apoptosis of specific donor t cells, b cells and antigen presenting cells, but, critically, not cd34 |
2022-05-10 |
2023-08-13 |
Not clear |
| Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Don. Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 237. 2022-04-29. PMID:35487176. |
in addition, we found that dfz caused excessive apoptosis in spleen tissue by tunel staining and expression levels of apoptosis-related genes (caspase3, caspase8, caspase9, fas, bax, bcl-2, and p53). |
2022-04-29 |
2023-08-13 |
cat |
| Qianmin Ou, Lingping Tan, Yiting Shao, Fangcao Lei, Weiying Huang, Ning Yang, Yan Qu, Zeyuan Cao, Luhan Niu, Yao Liu, Xiaoxing Kou, Songtao Sh. Electrostatic Charge-Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis. Small (Weinheim an der Bergstrasse, Germany). 2022-04-28. PMID:35481721. |
moreover, apovs switch neutrophils netosis to apoptosis via the apov-fas ligand (fasl)-activated fas pathway. |
2022-04-28 |
2023-08-13 |
mouse |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| b' Ilias Tsochantaridis, Aglaia Pappa, Egemen Dere, Ferda Ar\\xc4\\xb. Zn(II) 5,5-Diethylbarbiturate complex selectively induces apoptosis in breast cancer and breast cancer stem-like cells. Chemistry & biodiversity. 2022-03-07. PMID:35254725.' |
intrinsic apoptosis pathway in mcf-7 cells and extrinsic apoptosis pathway in mda-mb-231 cells was determined by western blot (parp, cleave parp, bax, cox4, rip, caspase 8, split caspase 8, dr4 and b-actin) and rt-pcr (parp, fas, bcl-2, tnf10a, p53) analysis. |
2022-03-07 |
2023-08-13 |
human |
| Sofie M R Starbæk, Malene Rask Andersen, Louise Brogaard, Anna Spinelli, Victoria Rapson, Helena Aagaard Glud, Lars E Larsen, Peter M H Heegaard, Hans Nauwynck, Kerstin Skovgaar. Innate antiviral responses in porcine nasal mucosal explants inoculated with influenza A virus are comparable with responses in respiratory tissues after viral infection. Immunobiology. vol 227. issue 3. 2022-03-07. PMID:35255458. |
upregulation (2-43 fold) of genes involved in inflammation, including il1a and il6, and apoptosis, including fas and casp3, and downregulation of genes involved in viral recognition (mda5 (ifih1)), interferon response (ifna), and response to virus (oas1, ifit1, mx1) was observed. |
2022-03-07 |
2023-08-13 |
Not clear |
| Binghua Liu, Guangling Li, Jun Yang, Xiaohui Li, Hao Wang, Jing Yang, Haishen Wen, Feng H. The mechanism of immune related signal pathway Egr2-FasL-Fas in transcription regulation and methylated modification of Paralichthys olivaceus under acute hypoxia stress. Fish & shellfish immunology. 2022-02-27. PMID:35219829. |
apoptosis genes egr2, fas and fasl are related to immune responses. |
2022-02-27 |
2023-08-13 |
Not clear |
| Huihui Tian, Mengxia Ding, Yujie Guo, Zhaoyan Zhu, Yange Yu, Yadong Tian, Kui Li, Guirong Sun, Ruirui Jiang, Ruili Han, Fengbin Yan, Xiangtao Kan. Effect of HSPA8 on the proliferation, apoptosis and immune function of chicken macrophages. The international journal of biochemistry & cell biology. 2022-02-26. PMID:35217190. |
transfection of the hspa8 interference fragment significantly downregulated the level of hspa8 expression in hd11 cells; significantly inhibited the proliferation of hd11 cells and the expression of pcna, ccnd1 and cdk1; increased the number of cells in the g1 phase and decreased the number of cells in the s phase; increased the rate of apoptosis, downregulated the expression of bcl-2 and upregulated the expression levels of fas and fasl; and inhibited the expression of the lps-induced cytokines il-1β and nf-κb. |
2022-02-26 |
2023-08-13 |
chicken |
| Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Y. All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P Antioxidants (Basel, Switzerland). vol 11. issue 2. 2022-02-25. PMID:35204227. |
atra treatment also attenuated tgev-induced apoptosis in ipec-j2 cells by downregulating the expression of caspase-3, which is related to the inhibition of death receptor (fas and caspase-8) and mitochondrial (bax, bcl-2, and caspase-9) pathways. |
2022-02-25 |
2023-08-13 |
Not clear |