| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Li, Luqi Li, Xun Qiu, Jing Zhang, Zichun Hu. The interaction of CFLAR with p130Cas promotes cell migration. Biochimica et biophysica acta. Molecular cell research. 2022-11-18. PMID:36400248. |
casp8 and fadd like apoptosis regulator (cflar) is a key anti-apoptotic regulator for resistance to apoptosis mediated by fas and trail. |
2022-11-18 |
2023-08-14 |
human |
| Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung Seok Lee, Stefan Tangl, Ulrike Kuchler, Julie Marchesan, Layla Panahipour, Stefan Lettner, Eva Matalová, Reinhard Grube. FasL is a catabolic factor in alveolar bone homeostasis. Journal of clinical periodontology. 2022-11-17. PMID:36384160. |
fas ligand (fasl) belongs to the tumor necrosis factor (tnf) superfamily regulating bone turnover, inflammation, and apoptosis. |
2022-11-17 |
2023-08-14 |
Not clear |
| Hui-Ju Yang, Bharath Kumar Velmurugan, Mu-Kuan Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Hsin-Yu Ho, Ming-Ju Hsieh, Jiunn-Liang K. 7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling. Journal of cellular and molecular medicine. 2022-10-29. PMID:36308422. |
specifically, 7-epitaxol increased fas, tnf-r1, dr5, dcr3 and dcr2 expressions, reduced bcl-2 and bcl-xl (anti-apoptotic proteins) expressions, and increased bid and bim l/s (pre-apoptotic proteins) expressions, leading to activation of caspase-mediated cancer cell apoptosis. |
2022-10-29 |
2023-08-14 |
Not clear |
| Tatiana V Sokolova, Yulia M Zabrodskaya, Anastasia V Litovchenko, Natalia M Paramonova, Vugar R Kasumov, Svetlana V Kravtsova, Ekaterina N Skiteva, Daria A Sitovskaya, Elena D Bazhanov. Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293411. |
levels of proinflammatory cytokines that play a role in apoptosis (tnf-α, fas, nf-kb) were increased. |
2022-10-27 |
2023-08-14 |
Not clear |
| Jinyong Chen, Feng Liu, Wangxing Hu, Yi Qian, Dilin Xu, Chenyang Gao, Zhiru Zeng, Si Cheng, Lan Xie, Kaixiang Yu, Gangjie Zhu, Xianbao Li. FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation. Stem cells international. vol 2022. 2022-10-17. PMID:36248256. |
extrinsic apoptosis pathways play an important role in the apoptosis of transplanted mscs, and fas apoptosis inhibitory molecule (faim) is involved in regulation of the extrinsic apoptosis pathway. |
2022-10-17 |
2023-08-14 |
Not clear |
| Hiroaki Kaku, Allison R Balaj, Thomas L Rothstei. Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233145. |
we previously found that fas apoptosis inhibitory molecule (faim) protects cells from stress-induced cell death by preventing abnormal generation of protein aggregates similar to the effect of small heat shock proteins (hsps). |
2022-10-14 |
2023-08-14 |
human |
| Jian Zhou, Hengquan Wang, Leina Jia, Yu Ma, Xiaolan Wang, Lingqin Zhu, Kai Wang, Pengju Zhang, Huifang Yan. Mechanism of 2,4-Dichlorophenoxyacetic acid-induced damage to rat testis via Fas/FasL pathway and the protective effect of Lycium barbarum polysaccharides. Environmental toxicology. vol 37. issue 11. 2022-10-10. PMID:36214342. |
depletion of fas by specific shrna transfection reversed the effects of 2,4-d in tm4 cells, further confirming the involvement of death receptor pathway in 2,4-d-mediated apoptosis of sertoli cells. |
2022-10-10 |
2023-08-14 |
rat |
| Uttom Kumar, Marcos Castellanos-Uribe, Sean T May, Ernesto Yagü. Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer. Gene. 2022-10-04. PMID:36195266. |
both cal51 and caldox stress signatures share 12 common genes (trim22, fas, spata18, sulf2, cdkn1a, gdf15, myo6, cxcl5, crot, eppk1, zmat3 and cd44), with roles in the above-mentioned pathways, indicating that these cells have similar functional responses to doxorubicin relaying on the p53 control of apoptosis. |
2022-10-04 |
2023-08-14 |
Not clear |
| Jiayang Cai, Zhang Ye, Yuanyuan Hu, Yixuan Wang, Liguo Ye, Lun Gao, Qian Sun, Shiao Tong, Zhiqiang Sun, Ji'an Yang, Qianxue Che. FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration. Frontiers in oncology. vol 12. 2022-10-03. PMID:36185230. |
fas apoptosis inhibitory molecule 2 (faim2) is an important member of the transmembrane bax inhibitor motif containing (tmbim) family. |
2022-10-03 |
2023-08-14 |
Not clear |
| Zhili Xia, Minzhen Li, Meng Hu, Yanyan Lin, Lawrence Lawer Atteh, Wenkang Fu, Long Gao, Mingzhen Bai, Chongfei Huang, Ping Yue, Yu Liu, Wenbo Men. Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway. Frontiers in oncology. vol 12. 2022-10-03. PMID:36185307. |
activated atm increased p-chk2-t68 and p-p53-s15, which promoted the expression of fas, dr4 and dr5 and triggered cell apoptosis. |
2022-10-03 |
2023-08-14 |
Not clear |
| b' Milena G Milutinovi\\xc4\\x87, Nevena N Milivojevi\\xc4\\x87, Nevena M \\xc4\\x90or\\xc4\\x91evi\\xc4\\x87, Danijela D Nikodijevi\\xc4\\x87, Sne\\xc5\\xbeana R Radisavljevi\\xc4\\x87, Ana S \\xc4\\x90ekovi\\xc4\\x87 Kesi\\xc4\\x87, Sne\\xc5\\xbeana D Markovi\\xc4\\x8. Gold(III) complexes with phenanthroline-derivatives ligands induce apoptosis in human colorectal and breast cancer cell lines. Journal of pharmaceutical sciences. 2022-09-26. PMID:36162493.' |
in the hct-116 cells apoptosis was activated by external apoptotic pathway, via increase of fas receptor protein expression and caspase 8 gene expression. |
2022-09-26 |
2023-08-14 |
human |
| Pradip Bajgain, Alejandro G Torres Chavez, Kishore Balasubramanian, Lindsey Fleckenstein, Premal Lulla, Helen E Heslop, Juan Vera, Ann M Lee. Secreted Fas decoys enhance the antitumor activity of engineered and bystander T cells in Fas ligand-expressing solid tumors. Cancer immunology research. 2022-09-19. PMID:36122411. |
one such suppressive agent abundantly expressed in solid tumors is fas ligand (fasl), which can trigger apoptosis of fas-expressing effector cells like t cells and natural killer (nk) cells. |
2022-09-19 |
2023-08-14 |
Not clear |
| Margarita L Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castañeda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoz. Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077527. |
in this study, we aimed to determine the effect of fgf2 administration on the placental gene expression of the vascular endothelial growth factor (vegfa), vegf receptor 2 (vegfr2), placental growth factor, endoglin (eng), superoxide dismutase 1 (sod1), catalase (cat), thioredoxin (txn), tumor protein p53 (p53), bcl2 apoptosis regulator, fas cell surface death receptor (fas), and caspase 3, in a sprague dawley rat pe model, which was induced by l-name. |
2022-09-09 |
2023-08-14 |
rat |
| Y Tan, J-N Qin, H-Q Wan, S-M Zhao, Q Zeng, C Zhang, S-L Q. PIWI/piRNA-mediated regulation of signaling pathways in cell apoptosis. European review for medical and pharmacological sciences. vol 26. issue 16. 2022-09-06. PMID:36066141. |
in addition, researchers have found that the piwis/pirnas play a regulatory role in cell apoptosis, proliferation, and necrosis by regulating key signaling pathways, such as pi3k/akt signaling pathway, stat signaling pathway, tgf-β signaling pathway, and fas signaling pathway at the transcriptional or post-transcriptional level. |
2022-09-06 |
2023-08-14 |
Not clear |
| Wei Luo, Jiaxin Dai, Jianmin Liu, Yongmei Huang, Ziqiong Zheng, Pei Xu, Yi M. PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition. Molecular metabolism. 2022-09-02. PMID:36055580. |
pituitary adenylate cyclase-activating polypeptide (pacap) was reported to attenuate hepatic lipid accumulation in overnutrition-related metabolic disorder, mediated by up-regulation of fas apoptosis inhibitory molecule (faim). |
2022-09-02 |
2023-08-14 |
Not clear |
| Li Liu, Wei Zhou, Ming-Yu Li, Lan Zhou, Liang Zhang, Wen-Yi Wang, Zhi-Xian Gong, Kun A. [Effect of electroacupuncture of "Zusanli"(ST36) and "Guanyuan" (CV4) on apoptosis and expression of apoptosis-related proteins of synoviocytes in adjuvant-induced arthritis rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 8. 2022-08-29. PMID:36036103. |
to observe the effect of electroacupuncture (ea) of "zusanli"(st36) and "guanyuan"(cv4) on the apoptosis rate of synoviocytes and protein expression of fas, fasl and caspase-3 in synovial tissue of adjuvant-induced arthritis (aia) rats, so as to explore its mechanisms underlying improvement of rheumatoid arthritis （ra）. |
2022-08-29 |
2023-08-14 |
rat |
| Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q Gabrielski, Lixin Zheng, Tovah E Markowitz, Waipan Chan, Jian Song, Arun K Boddapati, Keita Saeki, Björn Häupl, Ann Y Park, Yan H Cheng, Jing Cui, Thomas Oellerich, Michael J Lenard. Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 33. 2022-08-08. PMID:35939714. |
loss of ebf4 increases the half-life of the c-flip protein, and its presence in the fas signaling complex impairs caspase-8 cleavage and apoptosis. |
2022-08-08 |
2023-08-14 |
human |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Rongrong Zhao, Zeyuan Yu, Xiaorong Mao, Ya Zheng, Yuping Wang, Yongning Zho. Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway. Experimental cell research. 2022-07-21. PMID:35863455. |
the multi-omics and verification results showed that ube2s knockout-induced apoptosis and proliferation inhibition of gc cells was related to upregulation of fas and the activation of the fas-mediated apoptotic pathway. |
2022-07-21 |
2023-08-14 |
Not clear |
| Farkas Sarnyai, Éva Kereszturi, Kitti Szirmai, Judit Mátyási, Johanna Iman Al-Hag, Tamás Csizmadia, Péter Lőw, Péter Szelényi, Viola Tamási, Kinga Tibori, Veronika Zámbó, Blanka Tóth, Miklós Csal. Different Metabolism and Toxicity of TRANS Fatty Acids, Elaidate and Vaccenate Compared to Cis-Oleate in HepG2 Cells. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806300. |
cellular fas, triacylglycerols, diacylglycerols and ceramides were quantitated using chromatography, markers of stress and apoptosis were assessed at mrna and protein levels, ultrastructural changes were examined by electron microscopy and viability was evaluated by mtt assay. |
2022-07-09 |
2023-08-14 |
human |