| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huanhuan Ma, Muhammad Suleman, Fengqiong Zhang, Tingyan Cao, Shixiong Wen, Dachao Sun, Lili Chen, Bin Jiang, Yue Wang, Furong Lin, Jinyang Wang, Boan Li, Qinxi L. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-27. PMID:38148593. |
resistance to immunotherapy in colorectal cancer (crc) is associated with obstruction of fas (apo-1 or cd95)-dependent apoptosis, a hallmark of cancer. |
2023-12-27 |
2023-12-29 |
mouse |
| Huanhuan Ma, Muhammad Suleman, Fengqiong Zhang, Tingyan Cao, Shixiong Wen, Dachao Sun, Lili Chen, Bin Jiang, Yue Wang, Furong Lin, Jinyang Wang, Boan Li, Qinxi L. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-27. PMID:38148593. |
knockout or inhibition of pir dramatically increases fas expression, fas-dependent apoptosis and attenuates colorectal tumor formation in mice. |
2023-12-27 |
2023-12-29 |
mouse |
| Aoife Costigan, Emilie Hollville, Seamus J Marti. Discriminating Between Apoptosis, Necrosis, Necroptosis, and Ferroptosis by Microscopy and Flow Cytometry. Current protocols. vol 3. issue 12. 2023-12-19. PMID:38112058. |
numerous physiological as well as pathological stimuli trigger apoptosis, such as engagement of plasma-membrane-associated fas, trail, or tnf receptors, growth factor deprivation, hypoxia, radiation, and exposure to diverse cytotoxic drugs. |
2023-12-19 |
2023-12-21 |
Not clear |
| Ming-Ju Hsieh, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, Yi-Ching Chuang, Mu-Kuan Che. Hellebrigenin induces oral cancer cell apoptosis by modulating MAPK signalling and XIAP expression. Journal of cellular and molecular medicine. 2023-12-04. PMID:38044583. |
the hellebrigenin treatment also increased fas, dr5, dcr2 and dcr3 expressions in oral cancer cells, indicating the compound causes oral cancer cell apoptosis through both intrinsic and extrinsic pathways. |
2023-12-04 |
2023-12-10 |
human |
| Yurong Du, Lei Liu, Weiliang Yan, Yang Li, Yuanzhe Li, Kang Cui, Pu Yu, Zhuoyu Gu, WanCun Zhang, Jianguo Feng, Zhen Li, Hao Tang, Yabing Du, Huan Zha. The anticancer mechanisms of exopolysaccharide from Weissella cibaria D-2 on colorectal cancer via apoptosis induction. Scientific reports. vol 13. issue 1. 2023-11-30. PMID:38036594. |
furthermore, we revealed that d-2-eps promoted the apoptosis of crc cells by increasing the levels of fas, fasl and activating caspase-8/caspase-3, indicating that d-2-eps might induce apoptosis through the extrinsic fas/fasl pathway. |
2023-11-30 |
2023-12-10 |
Not clear |
| Agnieszka Szyposzynska, Aleksandra Bielawska-Pohl, Marek Murawski, Rafal Sozanski, Grzegorz Chodaczek, Aleksandra Klimcza. Mesenchymal Stem Cell Microvesicles from Adipose Tissue: Unraveling Their Impact on Primary Ovarian Cancer Cells and Their Therapeutic Opportunities. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958844. |
the results suggests that the anti-cancer effect of hatmsc2-mvs, with high probability, is contributed by the delivery of molecules that induce cell cycle arrest and apoptosis (p21, tumor suppressor p53, executor caspase 3) and proapoptotic regulators (bad, bim, fas, fasl, p27, trail-r1, trail-r2), and their presence has been confirmed by apoptotic protein antibody array. |
2023-11-14 |
2023-11-20 |
human |
| Xiaopeng Meng, Yiran Yang, Jing Zhang, Jianting Su, Gang Li, Shuxia Li. Synergistic toxicity of some food additives used in non-alcoholic beverages on renal tubular epithelial cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953561. |
the current study implied the synergistic cytotoxic effect caused by multiple fas at no toxic dosages via activated cellular transduction pathways regulating cell survival and apoptosis function, which warning of the synergistic toxic effects of different types of fas. |
2023-11-13 |
2023-11-20 |
human |
| Taku Fujimura, Koji Yoshino, Motoki Nakamura, Hiroshi Kato, Takamichi Ito, Takeo Maekawa, Yasuhiro Fujisawa, Shigeto Matsushita, Ryo Amagai, Emi Yamazaki, Manami Takahashi, Erika Tamabuchi, Akira Hashimoto, Yumi Kambayashi, Naoya Yamazaki, Toshio Miyata, Yoshihide Asan. Efficacy and safety of TM5614 in combination with paclitaxel in the treatment of paclitaxel-resistant cutaneous angiosarcoma: Phase II study protocol. Experimental dermatology. 2023-11-10. PMID:37946551. |
since pai-1 protects endothelial cells from fas ligand-mediated apoptosis, pai-1 inhibition might induce apoptosis of endothelial cell-derived tumours such as cas. |
2023-11-10 |
2023-11-20 |
Not clear |
| Dacheng Zhao, Jinwen He, Xiaobing Zhao, Xiaoyun Sheng, Zhiwei Feng, Xingwen Wang, Chengjun Zhang, Shenghong Wang, Bin Geng, Yayi Xi. A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis. International journal of biological macromolecules. 2023-11-04. PMID:37924900. |
the results showed that overexpression of c-fos leads to an increase in downstream fas protein, which subsequently leads to osteoblast apoptosis and hinders osteogenesis. |
2023-11-04 |
2023-11-08 |
Not clear |
| Teng Ge, Bo Ning, Yongqing Wu, Xiaolin Chen, Hongfei Qi, Haifang Wang, Mingjun Zha. MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia-reperfusion injury. Molecular and cellular biochemistry. 2023-10-25. PMID:37878166. |
microrna-139 modulates the extrinsic death signal of fas, while microrna-145 regulates endoplasmic reticulum calcium overload, both of which exert regulatory effects on cardiomyocyte apoptosis. |
2023-10-25 |
2023-11-08 |
Not clear |
| Yanping Qin, Weitao Wan, Jiangwei Li, Zhongyu Wang, Yue Yang, Jun Li, Haitao Ma, Ziniu Yu, Zhiming Xiang, Yuehuan Zhan. A novel Fas ligand plays an important role in cell apoptosis of Frontiers in immunology. vol 14. 2023-10-24. PMID:37868973. |
a novel fas ligand plays an important role in cell apoptosis of apoptosis regulates normal development, homeostasis, immune tolerance and response to environmental stress by eliminating unwanted or diseased cells, and plays a key role in non-specific immunity of invertebrates. |
2023-10-24 |
2023-11-08 |
Not clear |
| Ying Cai, Binyu Zhu, Xiaoting Shan, Lingli Zhou, Xujie Sun, Anqi Xia, Binhao Wu, Yang Yu, Helen He Zhu, Pengcheng Zhang, Yaping L. Inhibiting Endothelial Cell-Mediated T Lymphocyte Apoptosis with Integrin-Targeting Peptide-Drug Conjugate Filaments for Chemoimmunotherapy of Triple-Negative Breast Cancer. Advanced materials (Deerfield Beach, Fla.). 2023-10-17. PMID:37847869. |
tumor-associated endothelial cells (tecs) limit anti-tumor immunity via inducing apoptosis of infiltrating t lymphocytes through a fas ligand (fasl)-mediated mechanism. |
2023-10-17 |
2023-11-08 |
Not clear |
| Christopher Failing, Jennifer R Blase, Kelly Walkovic. Understanding the Spectrum of Immune Dysregulation Manifestations in Autoimmune Lymphoproliferative Syndrome and Autoimmune Lymphoproliferative Syndrome-like Disorders. Rheumatic diseases clinics of North America. vol 49. issue 4. 2023-10-11. PMID:37821199. |
as a disorder of immune dysregulation, autoimmune lymphoproliferative syndrome (alps) stems from pathogenic variants in the first apoptosis signal-mediated apoptosis (fas) and fas-ligand pathway that result in elevations of cd3+ tcrαβ+ cd4- cd8- t cells along with chronic lymphoproliferation, a heightened risk for malignancy, and importantly for the rheumatologist, increased risk of autoimmunity. |
2023-10-11 |
2023-10-15 |
Not clear |
| Tik Shing Cheung, Chiara Giacomini, Matteo Cereda, Alvaro Avivar-Valderas, Daria Capece, Giuliana Minani Bertolino, Olga delaRosa, Ryan Hicks, Rachele Ciccocioppo, Guido Franzoso, Antonio Galleu, Francesca D Ciccarelli, Francesco Dazz. Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome that correlates with clinical responses in Crohn's disease patients. Molecular therapy : the journal of the American Society of Gene Therapy. 2023-10-08. PMID:37805713. |
we analyzed the transcriptomes of mscs undergoing apoptosis and identified several immunomodulatory factors and chemokines dependent on caspase activation following fas stimulation. |
2023-10-08 |
2023-10-15 |
human |
| Haiyi Chen, Yue Guo, Shengqing Ye, Jintu Zhang, Haotian Zhang, Na Liu, Rui Zhou, Tingjun Hou, Hongguang Xia, Yu Kang, Mojie Dua. On the Dynamic Mechanism of Long-Flexible Fatty Acid Binding to Fatty Acid Binding Protein: Resolving the Long-Standing Debate. Journal of chemical information and modeling. 2023-08-14. PMID:37574904. |
fatty acids (fas) are one of the essential energy sources for physiological processes, and they play a vital role in regulating immune and inflammatory responses, promoting cell differentiation and apoptosis, and inhibiting tumor growth. |
2023-08-14 |
2023-08-16 |
Not clear |
| Jalal Naghinezhad, Anita Alenabi, Hossein Ayatollahi, Maryam Sheikhi, Mohammad Hadi Sadeghian, Zahra Khoshnegah, Samaneh Boroumand-Noughab. Expression of DR4, DR5, FAS, Caspase-8 and, DDIAS Genes in AML Patients. Medical journal of the Islamic Republic of Iran. vol 37. 2023-08-14. PMID:37575689. |
in this study, gene expression levels of 5 key players of apoptosis, including dr4, dr5, fas, caspase 8, and dna damage-induced apoptosis suppressor (ddias), have been evaluated in aml patients compared with controls, aiming to evaluate their possible role and prognostic impact. |
2023-08-14 |
2023-08-16 |
Not clear |
| Jiayi M Sun, Wing-Yuk Chow, Gufeng Xu, M John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing Ng, Aaron M Taylor, Alexander Yu, Jason E Farrar, Donald A Barkauskas, Richard Gorlick, Jaime M Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong Man, Ching C Lau, On Behalf Of The Target Osteosarcoma Consortiu. The Role of FAS Receptor Methylation in Osteosarcoma Metastasis. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569529. |
the interaction of fasl and its cell surface receptor, fas, triggers apoptosis in normal cells; however, this function is altered in cancer cells. |
2023-08-12 |
2023-08-16 |
mouse |
| Fangfang Ge, Yulu Wang, Amit Sharma, Yu Yang, Hongde Liu, Markus Essler, Ulrich Jaehde, Ingo G H Schmidt-Wol. Cytokine-Induced Killer Cells in Combination with Heat Shock Protein 90 Inhibitors Functioning via the Fas/FasL Axis Provides Rationale for a Potential Clinical Benefit in Burkitt's lymphoma. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569852. |
subsequent analyses revealed that the increased expression of fas on the surface of bl cells, which induces caspase 3/7-dependent apoptosis, may account for this effect. |
2023-08-12 |
2023-08-16 |
Not clear |
| Sujan Kumar Mondal, Derick Haas, Jie Han, Theresa L Whitesid. Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells. Communications biology. vol 6. issue 1. 2023-08-04. PMID:37542121. |
here we show that tumor cell-derived exosomes (tex) carrying surface pdl-1, pd-1, fas, fasl, trail, ctla-4 and tgf-β1 induce apoptosis of cd8 |
2023-08-04 |
2023-08-14 |
Not clear |
| Robert Sulak, Xiaonan Liu, Adrian Smedowsk. The concept of gene therapy for glaucoma: the dream that has not come true yet. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488850. |
reported gene therapy-based neuroprotection of retinal ganglion cells is targeting specific genes translating to growth factors (i.e., brain derived neurotrophic factor, and its receptor trkb), regulation of apoptosis and neurodegeneration (i.e., bcl-xl, xiap, fas system, nicotinamide mononucleotide adenylyl transferase 2, digit3 and sarm1), immunomodulation (i.e., crry, c3 complement), modulation of neuroinflammation (i.e., erythropoietin), reduction of excitotoxicity (i.e., camkiiα) and transcription regulation (i.e., max, nrf2). |
2023-07-25 |
2023-08-14 |
mouse |