| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| Hanbo Liu, Miaojuan Chen, Fen Ning, Yixin Ye, Qinsheng Lu, Shenjiao Lu, Yaoyun Duan, Xiaowen Gan, Mingguang Zhao, Kaimin Guo, Gendie E Las. Extravillous trophoblast cell derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p. Molecular human reproduction. 2023-06-27. PMID:37369038. |
furthermore, fas ligand was also expressed on the evt-exosomes and may play a coordinated role in apoptosis induction. |
2023-06-27 |
2023-08-14 |
Not clear |
| Guojun Yao, Ling Deng, Xinquan Long, Yufan Zhou, Xiang Zho. An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis. Aging. vol 15. 2023-06-24. PMID:37354488. |
focal adhesions (fas) allow cells to contact the extracellular matrix, helping to maintain tension and enabling signal transmission in cell migration, differentiation, and apoptosis. |
2023-06-24 |
2023-08-14 |
Not clear |
| Seham Abou Shousha, Suzan Baheeg, Hossam Ghoneim, Malak Zoheir, Mahmoud Hemida, Yasmine Shahin. The effect of Fas/FasL pathway blocking on apoptosis and stemness within breast cancer tumor microenvironment (preclinical study). Breast disease. vol 42. issue 1. 2023-06-19. PMID:37334575. |
fas/fasl expression is linked to the maintenance of cancer stem cells (cscs) within the tme, contributing to tumor aggressiveness, metastasis, recurrence, and chemoresistance.this study is considered the first study designed to block the overexpressed fasl on the tumor cells within tme mimicking tissue culture system using rfas molecules and supplementing the fas enriched tissue culture system with blocked fas - peripheral blood mononuclear cells pbmcs (using anti-fas mab) to protect them from tumor counterattack and augment their ability to induce tumor cell apoptosis and stemness inhibition.a significantly increased level of apoptosis and decreased expression of cd 44 (cscs marker) was observed within the east tumor tissue culture system enriched with fas molecules and anti-fas treated pbmcs and the one enriched with fas molecules only compared to the breast tumor tissues cultured alone (p < 0.001). |
2023-06-19 |
2023-08-14 |
Not clear |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
we stimulated tm4 cells, a mouse sertoli cell line, with lps (200 or 1000 ng/ml) or ril-18 (0.1-100 ng/ml) at levels that induced leydig cell apoptosis in our previous study and assessed caspase 3 cleavage and the mrna expression of inflammatory cytokines and markers of apoptotic pathways (tnfr1, fasl, fas, fadd) after stimulation. |
2023-06-01 |
2023-08-14 |
mouse |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
treatment with ril-18 increased il18r1 mrna and induced inflammation, but decreased tnfr1 and had little influence on apoptosis, as indicated by tnfα, fasl, fas, fadd and cleaved caspase 3. |
2023-06-01 |
2023-08-14 |
mouse |
| Lili Guo, Yang Xia, Hao Li, Zifei Wang, Hui Xu, Xiangyu Dai, Yaqin Zhang, Hao Zhang, Wenhu Fan, Feng Wei, Qun Li, Ling Zhang, Limian Cao, Shangxin Zhang, Wanglai Hu, Hao G. FIT links c-Myc and P53 acetylation by recruiting RBBP7 during colorectal carcinogenesis. Cancer gene therapy. 2023-05-24. PMID:37225855. |
in this study, we discovered that the lncrna fit, which was downregulated in crc clinical samples, was transcriptionally suppressed by c-myc in vitro and promoted crc cell apoptosis by inducing fas expression. |
2023-05-24 |
2023-08-14 |
mouse |
| Lulin Wu, Tianhui Jiang, Zhiping Fu, Luqi Wang, Hongjie You, Jingyi Xue, Dali Lu. Connexin 43 dephosphorylation at serine 282 induces spontaneous arrhythmia and increases susceptibility to ischemia/reperfusion injury. Heliyon. vol 9. issue 5. 2023-05-23. PMID:37215881. |
previously we found that deficiency in cx43 s282 phosphorylation could impair intercellular communication and contribute to cardiomyocyte apoptosis by activating p38 mitogen-activated protein kinase (p38 mapk)/factor-associated suicide (fas)/fas-associating protein with a novel death domain (fadd) pathway, which is involved in myocardium injury in ischemia/reperfusion ( |
2023-05-23 |
2023-08-14 |
Not clear |
| Zhen Guo, ZiBo Li, MengLing Zhang, MeiHua Bao, BinSheng He, XiaoLong Zho. LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing. Scientific reports. vol 13. issue 1. 2023-05-22. PMID:37217794. |
lncrna fas-as1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and fas splicing. |
2023-05-22 |
2023-08-14 |
Not clear |
| Zhen Guo, ZiBo Li, MengLing Zhang, MeiHua Bao, BinSheng He, XiaoLong Zho. LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing. Scientific reports. vol 13. issue 1. 2023-05-22. PMID:37217794. |
we also proved fas-as1 could affect fas splicing isoform sfas/mfas expression ratio, and apoptotic protein expression, thus leading to increased apoptosis. |
2023-05-22 |
2023-08-14 |
Not clear |
| Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pul. Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy. Molecular therapy. Nucleic acids. vol 32. 2023-05-18. PMID:37200859. |
activation of the fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing car t cell efficacy. |
2023-05-18 |
2023-08-14 |
Not clear |
| Ming-Yue Li, Li-Zhong Liu, Qihang Xin, Jiaying Zhou, Xiaoyang Zhang, Rui Zhang, Zangshu Wu, Junbo Yi, Ming Don. Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet β-cell apoptosis and dysfunction. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023-05-17. PMID:37196823. |
pancreatic β-cell apoptosis is a key feature of diabetes and can be induced by chronic exposure to saturated fatty acids (fas). |
2023-05-17 |
2023-08-14 |
mouse |
| Hao Xu, Juan Li, Qinming Fei, Libo Jian. Contribution of Immune Cells to Intervertebral Disc Degeneration and the Potential of Immunotherapy. Connective tissue research. 2023-05-10. PMID:37161923. |
the ivd is considered to be an immunologically-privileged site given the presence of physical and biological barriers that include an avascular microenvironment, a high proteoglycan concentration, high physical pressure, the presence of apoptosis inducers such as fas ligand, and the presence of notochordal cells. |
2023-05-10 |
2023-08-14 |
Not clear |
| Retraction: Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells. Medical gas research. vol 13. issue 4. 2023-04-20. PMID:37077123. |
retraction: carbon monoxide inhibits fas activating antibody-induced apoptosis in endothelial cells. |
2023-04-20 |
2023-08-14 |
Not clear |
| Amin Soltani, Milad Shahini Shams Abadi, Mohammad Raeisi, Mahnoush Kouhihabibidehkordi, Farzane Eshaghi, Omid Mohreh, Mahmoud Rafieian-Kopae. Apoptosis-inducing Plant-based phenolic compounds are effective on leukemia cell lines. Current pharmaceutical design. 2023-04-18. PMID:37070446. |
phenols, with anticancer potency at different degrees, serve to induce apoptosis through different pathways, including both extrinsic (fas) and intrinsic (calcium release, ros increase, dna degradation, and mitochondrial membrane impairment). |
2023-04-18 |
2023-08-14 |
Not clear |
| Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Luis Ramos-Gómez, Jordi Solé-Violan, Juan J Cáceres, Alejandro Jiménez, Agustín F González-River. Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage. World journal of critical care medicine. vol 12. issue 2. 2023-04-10. PMID:37034020. |
however, there have been no data on the association between blood concentrations of soluble fas (sfas) (the main surface death receptor of the extrinsic apoptosis pathway) and the prognosis of spontaneous intracranial hypotension (sih) patients. |
2023-04-10 |
2023-08-14 |
Not clear |
| Narges Bazgir, Azin Tahvildari, Zahra Chavoshzade, Mahnaz Jamee, Zahra Golchehre, Abdollah Karimi, Naghi Dara, Mazdak Fallahi, Mohammad Keramatipour, Arezou Karamzade, Samin Sharafia. A rare immunological disease, caspase 8 deficiency: case report and literature review. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. vol 19. issue 1. 2023-04-10. PMID:37038193. |
caspase-8 is a molecule in the fas pathway that initiates apoptosis. |
2023-04-10 |
2023-08-14 |
Not clear |
| Leonardo Lorente, Sergio T Rodriguez, Pablo Sanz, Agustín F González-Rivero, Antonia Pérez-Cejas, Javier Padilla, Dácil Díaz, Antonio González, María M Martín, Alejandro Jiménez, Purificación Cerro, Julián Portero, Manuel A Barrer. Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations. World journal of clinical cases. vol 11. issue 8. 2023-03-27. PMID:36970008. |
fas ligand (fasl) is one ligand that activates extrinsic apoptosis pathway. |
2023-03-27 |
2023-08-14 |
Not clear |
| Mohamed I Khalil, Canchai Yang, Lexi Vu, Smriti Chadha, Harrison Nabors, Craig Welbon, Claire D James, Iain M Morgan, William C Spanos, Dohun Pyeo. HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. PLoS pathogens. vol 19. issue 3. 2023-03-03. PMID:36867660. |
the knockdown of marchf8 expression in human hpv-positive hnc cells restores cell surface expression of the tumor necrosis factor receptor superfamily (tnfrsf) death receptors, fas, trail-r1, and trail-r2, and enhances apoptosis. |
2023-03-03 |
2023-08-14 |
mouse |
| Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Ch. Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury. Frontiers in molecular neuroscience. vol 15. 2023-02-24. PMID:36824441. |
very early exposure to ee significantly downregulated fas/fasl-mediated apoptosis, decreased expression of fas, fas-associated death domain, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as bax and bcl-2, in the cerebral cortex and the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |